Fw: NATAP: Maraviroc Gel Blocks Vaginal Infection

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CROI: Protection of Rhesus Macaques from Vaginal Infection by Maraviroc (solution), an Inhibitor of HIV-1 Entry via the CCR5 Co-receptor - (03/19/10)Gel-formulated MVC derived from prescription-grade tablets provided dose-dependent protection, half-maximally at 0.5 mM (0.25 mg/mL) and fully at 6 mM (3 mg/mL). These findings validate MVC development as a vaginal microbicide for women, and should guide clinical programs. Of note is that a single 300 mg tablet of prescription-grade MVC, which retails for ∼$15 in the USA, contains enough active drug to fully protect about 25 macaques, and by implication a similar number of women, if applied vaginally in a gel.