Guest guest Posted June 30, 2001 Report Share Posted June 30, 2001 Hi Tina, I mean't to reply alot earlier, we've just been so busy around here that I seem to be behind on everything, LOL. In case you still need info, Stanleylab at Hopkins is one of the main places I know of that is focusing on bipolar, along with schizophrenia. The only thing I don't care for is the stuff on cats. The problem is our susceptability, not cats, other people,other animals, etc. Cheryl Their websites are http://www.stanleylab.org/ http://www.stanleyresearch.org/ This paper is interesting because it discusses how lithium upregulates bcl-2, not the safest way to offset the immune dysfunction. The stanley website has some research showing antiviral effects from lithium. That might be another way to link the viral component. http://www.nimh.nih.gov/sciadvances/0014.cfm This is some of what they have on OMIM http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=151430 B-CELL CLL/LYMPHOMA 2; BCL2 Alternative titles; symbols ONCOGENE B-CELL LEUKEMIA 2 LEUKEMIA, CHRONIC LYMPHATIC, TYPE 2, INCLUDED FOLLICULAR LYMPHOMA, INCLUDED Gene map locus 18q21.3 son et al. (1993) showed that the action of BCL2 in protecting cells from apoptosis is not by altering mitochondrial function; they found that human mutant cell lines that lack mitochondrial DNA can still be induced to die by apoptosis and that they can be protected from apoptosis by the overexpression of BCL2. Migheli et al. (1994) performed a light-microscopic immunohistochemical analysis of BCL2 protein expression in autopsy specimens of human brain and spinal cord in normal, aged individuals and those who had suffered from neurodegenerative diseases. BCL2 was strongly enriched within lipofuscin and autophagic vacuoles of neurons, and glial and vascular cells. Deng and Podack (1993) showed that transcription of the BCL2 gene is downregulated by interleukin-2 (IL2; 147680) deprivation and upregulated by IL2 addition. Deregulated expression of BCL2 was found to prolong the survival of cells of the cytotoxic T-cell line CTLL2 in the absence of IL-2. Hengartner and Horvitz (1994) presented evidence that the cell survival gene in Caenorhabditis elegans called ced-9 is a homolog of BCL2; thus, molecular mechanisms of programmed cell death have been conserved from nematodes to mammals. This lists everything that came up with a search for bcl-2 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search & DB=OMIM >From: Cure2000@... >Reply- > >Subject: Bi-polar Disorder >Date: Thu, 21 Jun 2001 13:16:49 EDT > >Hi Listers, >I have a Doc in Nevada City, Ca, that is interested in the Hypothesis. >I need info, abstracts, studies, web sites, etc. Discussing the virul link >for Bi-polar Manic Depression. Any info would be helpful. Thanx, >Tina > >Tina M. Hendrix >Cure2000@... >President, Coalition, Northern California >Neuro-Immune Dysfunction Syndromes >Autism Spectrum Disorder, ADD/ADHD, Learning Disorders, Hyperactivity, CFS, >etc. > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 2, 2001 Report Share Posted July 2, 2001 Thanx for the info Cheryl! Tina Tina M. Hendrix Cure2000@... President, Coalition, Northern California Neuro-Immune Dysfunction Syndromes Autism Spectrum Disorder, ADD/ADHD, Learning Disorders, Hyperactivity, CFS, etc. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 28, 2008 Report Share Posted July 28, 2008 We have been using Lithium Orotate with great results. --Patience Many wrote: > > I am also interested in treatment for bi-polar disorder. My son has > been given drugs such as risperidone, levomepromazine and olanzapine > but I do not see any benefits. I would like to know what has worked > in other cases and hope there will be some response. > Thank you. > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 28, 2008 Report Share Posted July 28, 2008 I have read quite a few of Dr. Blaylock's articles (and others) and I believe bipolar disorder is actually immune activation that causes brain inflammation. For my son, it is usually food that activates his immune system and causes the negative behaviors (in approx 12-20 hours). Here is an article that shows correlation of immune response with aggressive behavior: Stimulation of the Immune Response During Activation of the Dopaminergic System in Mice with Opposite Types of Behavior Authors: Idova G.V.1; Cheido M.A.1; Zhukova E.N.1; Devoino L.V.1 Source: Neuroscience and Behavioral Physiology, Volume 34, Number 4, May 2004 , pp. 417-421(5) Abstract: Studies reported here demonstrated that activation of the dopaminergic system induces increases in the immune response regardless of the type of behavior in mice (line CBA), i.e., in aggressive mice, submissive mice, and mice lacking experience of victory or defeat (controls). Changes in the activity of the dopaminergic system were induced with SKF-38393, a selective agonist of dopamine D1 receptors, and with p- chlorophenylalanine (PCPA), which we have previously shown to activate D2 receptors. In the aggressive form of behavior, which was characterized by strong (compared with controls) immune responses, SKF- 38393 and PCPA led to further increases in the immune response. In submissive mice, activation of the dopaminergic system altered the nature of the immune response, with immunostimulation, as in aggression. It is suggested that activation of the dopaminergic system in conditions of defined psychoemotional status fixed by acquisition of opposite types of behavior, induces the formation of a new neurochemical pattern – the dopaminergic set – which led to changes in the nature and intensity of the immune response. The UNDERLYING problem may be mercury. > > > > I am also interested in treatment for bi-polar disorder. My son has > > been given drugs such as risperidone, levomepromazine and olanzapine > > but I do not see any benefits. I would like to know what has worked > > in other cases and hope there will be some response. > > Thank you. > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 29, 2008 Report Share Posted July 29, 2008 I agree that toxins play a role in a person with a genetic predisposition towards bipolar. My husbands family has a strong occurrence of bipolar and my daughter has the MTHFR gene polymorphism which has been associated with depression, bipolar, schizophrenia and autism. If it were just the toxins, then every kid who is toxic would exhibit the same symptoms. My daughter will stay on lithium orotate, b12 shots, folic acid for the rest of her life due to her genetics. --Patience wrote: > > I have read quite a few of Dr. Blaylock's articles (and others) and I > believe bipolar disorder is actually immune activation that causes > brain inflammation. For my son, it is usually food that activates his > immune system and causes the negative behaviors (in approx 12-20 > hours). Here is an article that shows correlation of immune response > with aggressive behavior: > > Stimulation of the Immune Response During Activation of the > Dopaminergic System in Mice with Opposite Types of Behavior > Authors: Idova G.V.1; Cheido M.A.1; Zhukova E.N.1; Devoino L.V.1 > Source: Neuroscience and Behavioral Physiology, Volume 34, Number 4, > May 2004 , pp. 417-421(5) > > Abstract: > Studies reported here demonstrated that activation of the dopaminergic > system induces increases in the immune response regardless of the type > of behavior in mice (line CBA), i.e., in aggressive mice, submissive > mice, and mice lacking experience of victory or defeat (controls). > Changes in the activity of the dopaminergic system were induced with > SKF-38393, a selective agonist of dopamine D1 receptors, and with p- > chlorophenylalanine (PCPA), which we have previously shown to activate > D2 receptors. In the aggressive form of behavior, which was > characterized by strong (compared with controls) immune responses, SKF- > 38393 and PCPA led to further increases in the immune response. In > submissive mice, activation of the dopaminergic system altered the > nature of the immune response, with immunostimulation, as in > aggression. It is suggested that activation of the dopaminergic system > in conditions of defined psychoemotional status fixed by acquisition of > opposite types of behavior, induces the formation of a new > neurochemical pattern – the dopaminergic set – which led to changes in > the nature and intensity of the immune response. > > The UNDERLYING problem may be mercury. > > > > > > > > I am also interested in treatment for bi-polar disorder. My son has > > > been given drugs such as risperidone, levomepromazine and olanzapine > > > but I do not see any benefits. I would like to know what has worked > > > in other cases and hope there will be some response. > > > Thank you. > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 29, 2008 Report Share Posted July 29, 2008 > If it were just the toxins, then every kid who is toxic would exhibit > the same symptoms. My daughter will stay on lithium orotate, b12 shots, > folic acid for the rest of her life due to her genetics. You sound like a mainstream MD. Bipolar cannot be cured? Toxins CAUSE bipolar disorder. Maybe you should detox your daughter instead of giving her lifelong b12 shots... Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 29, 2008 Report Share Posted July 29, 2008 Many, Here's some information: http://www.theroadback.org/bipolar.htm Clinical Trial # 1 BACKGROUND: Epidemiological and *clinical studies suggest that increased intake of* eicosapentaenoic acid (EPA) alleviates unipolar depression. AIMS: To examine the efficacy of EPA in treating depression in bipolar disorder. METHOD: In a12-week, double-blind study individuals with bipolar depression were randomly assigned to adjunctive treatment with placebo (n=26) or with 1 g/day (n=24) or 2 g/day (n=25) of ethyl-EPA. Primary efficacy was assessed by the Hamilton Rating Scale for Depression (HRSD), with changes in the Young Mania Rating Scale and Clinical Global Impression Scale (CGI) as secondary outcome measures. RESULTS: There was no apparent benefit of 2 g over 1 g ethyl-EPA daily. Significant improvement was noted with ethyl-EPA treatment compared with placebo in the HRSD (P=0.04) and the CGI (P=0.004) scores. Both doses were well tolerated. CONCLUSIONS: Adjunctive ethyl-EPA is an effective and well-tolerated intervention in bipolar depression. *Source: * Section of Neurobiology of Psychosis, PO66, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK Clinical Trial # 2 INTRODUCTION: Epidemiologic studies have suggested that * consumption of cold water fish oils may have some protective function against depression*. *This proposition is supported by a series of biochemical and pharmacologic studies that have suggested that fatty acids may modulate neurotransmitter metabolism* and cell signal trans-duction in humans *and that abnormalities in fatty acid and eicosanoid metabolism may play a causal role in depression *. Aware of the critical need for antidepression treatments that might not carry the risk of precipitating a manic episode in bipolar patients, we decided to conduct an open-label add-on trial of eicosapentaenoic acid (EPA) in bipolar depression. * METHOD*: Twelve bipolar I *outpatients with depressive symptoms diagnosed by DSM-IV were treated with 1.5 to 2 g/day of the omega-3 fatty acid EPA for up to 6 months*. The study was conducted between September 2001 and January 2003. RESULTS: *Eight of the 10 patients who completed at least 1 month of follow-up achieved a 50% or greater reduction in Hamilton Rating Scale for Depression scores within 1 month.* *No patients developed hypomania or manic symptoms*. *No significant side effects were reported*. CONCLUSIONS: * Although the ultimate utility of omega-3 fatty acids in bipolar depression is still an open question, we believe that these initial results are encouraging, especially for mild to moderate bipolar depression, and justify the continuing exploration of its use.* On Mon, Jul 28, 2008 at 9:41 PM, Many <brayqn@...> wrote: > I am also interested in treatment for bi-polar disorder. My son has > been given drugs such as risperidone, levomepromazine and olanzapine > but I do not see any benefits. I would like to know what has worked > in other cases and hope there will be some response. > Thank you. > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 29, 2008 Report Share Posted July 29, 2008 " If it were just the toxins, then every kid who is toxic would exhibit the same symptoms. " Not necessarily. Timing of exposure is critical. People exposed to the same toxin at diferent developmental stages may have different symptoms. Jackie #### > > > > > > > > I am also interested in treatment for bi-polar disorder. My son has > > > > been given drugs such as risperidone, levomepromazine and olanzapine > > > > but I do not see any benefits. I would like to know what has worked > > > > in other cases and hope there will be some response. > > > > Thank you. > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 29, 2008 Report Share Posted July 29, 2008 I didn't mean to sound like a mainstream MD. It was mainstream MDs that convinced me to poison my daughter with vaccines in the first place. I was just adding some additional information for anyone who may be interested. I totally agree with you that toxins CAUSE illness!! For me it's just nice to know my daughters genetics so we can take preventative measures. I don't think it's so simplistic as just detoxifying the metals. It's also important to prevent future toxicity. She won the lottery in the depressive and inability to detoxify genes!! Unfortunately the world we live in today is fairly toxic. And yes we are detoxing her with chelation and other things (mb12, glutathione, antioxidants etc..). She is extremely mercury toxic and I believe this is the root cause of all her illnesses, which there were many. My daughter is definitely headed toward a full recovery and I intend to keep her that way. Also mb12 shots are one method of detox, mb12 supports methylation so maybe you weren't aware of this when you said " Maybe you should detox your daughter instead of giving her lifelong b12 shots... " We are also doing chelation... mkarty2007 wrote: > > > If it were just the toxins, then every kid who is toxic would exhibit > > the same symptoms. My daughter will stay on lithium orotate, b12 > shots, > > folic acid for the rest of her life due to her genetics. > > You sound like a mainstream MD. Bipolar cannot be cured? Toxins CAUSE > bipolar disorder. > > Maybe you should detox your daughter instead of giving her lifelong b12 > shots... > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 29, 2008 Report Share Posted July 29, 2008 True, timing is key and where the mercury settles is key. My mother did not become bipolar until adulthood, subsequently when she had more amalgams. She did not receive her first one until she was 16. Her mother had mental disturbances manifest in childhood, probably from playing with liquid mercury that came full circle in later teen years when she did have amalgams. Then when she went on to nursing school in the 50's and had vaccines and cleaned things with thimerosal. Then her illness became VERY clear. But they were not born bipolar. Timing and genetics and how much mercury and from where it came from. Was in injected or inhaled via amalgam vapor...many factors to consider. > > > > > > > > > > I am also interested in treatment for bi-polar disorder. My > son has > > > > > been given drugs such as risperidone, levomepromazine and > olanzapine > > > > > but I do not see any benefits. I would like to know what has > worked > > > > > in other cases and hope there will be some response. > > > > > Thank you. > > > > > > > > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 30, 2008 Report Share Posted July 30, 2008 There have been studies showing great success using high doses of omega three fatty acids. Interestingly, those subjects who did the best had never used drugs for their condition previously. Google Stoll bipolar and you should get some of the relevant hits. Anita > > I am also interested in treatment for bi-polar disorder. My son has > been given drugs such as risperidone, levomepromazine and olanzapine > but I do not see any benefits. I would like to know what has worked > in other cases and hope there will be some response. > Thank you. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 30, 2008 Report Share Posted July 30, 2008 Bi-polar has been reversed with high doses of various supplements (on a continual basis) and detoxification of heavy metals. You can get some books through the HANS organization about that topic. Google Abrahm Hoffer (hope I spelled that right!). Margot Kidder controls hers with nutrients. Google for True Hope supplements too. My friend's adult son (34) reversed his with heavy metal detox alone. He became sociable and communicative and stopped picking up viruses all the time. I think without the detox aspect, supplementation alone is a band-aid solution but a band-aid is better than an open wound. You have to experiment and find out what works best. A lack of amino acids in the brain is a huge problem with almost any " mental " disease and one that isn't too hard to remedy. Sharon Hoehner www.sharethecause.com/detoxqueen > > I am also interested in treatment for bi-polar disorder. My son has > been given drugs such as risperidone, levomepromazine and olanzapine > but I do not see any benefits. I would like to know what has worked > in other cases and hope there will be some response. > Thank you. > Quote Link to comment Share on other sites More sharing options...
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