Re: Vitamin E -The rest of the story....

[Guest guest]

I was stunned by the results of the tocotrienol study because Vitamin E studies

and trials, which often show no improvement for common chronic disease, are

usually designed to fail! They use SYNTHETIC forms, they UNDERDOSE, and they

almost never include the TOCOTRIENOLS. I've seen many cancer and heart health

studies where the patients were given a measly 50 i.u. of synthetic tocopherol

and then they conclude that " Taking vitamin E supplements is worthless " . This

recent study uses the real thing (albeit in a capsule).

Specifically Vitamin E will hold up under boiling of food, but not frying or

deep-frying. You can find it in all nuts and seeds, vegetable oils, dark leafy

greens, avocados, tomatoes, sprouts, eggs and many other foods. In addition to

dietary, I get mine from SWANSONS VITAMINS. Get the super-duper forms with all

the various components (it's more expensive, but worth it!)

Here's more than you ever wanted to know about VITAMIN E....

Will Winter

________________________________________________________________________________\

_____

VITAMIN E (Tocopherol)

________________________________________________________________________________\

______

General - oil-soluble; anti-sterility factor; oil-soluble antioxidant;

Vitamin E is the official designation for alpha tocopherol, a fat-soluble

nutrient found in the diet in varying amounts. Until recently it was thought

that alpha tocopherol was the most active tocopherol and as such only official

vitamin E activity (IU) is given to alpha tocopherol.

The term vitamin E is now used to refer to all tocol and trienal derivatives.

The tocols are alpha, beta, delta and gamma tocopherol, and the trienals are

alpha, beta, delta and gamma tocotrienol.

Gamma tocopherol, a potent antioxidant of ozone and nitric oxide is now shown to

be as important as alpha tocopherol. The National Academy of Sciences now

suggests that vitamin E formulas contain both tocopherols and that gamma

tocopherol be the predominant one.

Tocotrienols have potent anti-oxidant activity, but their turnover rate in human

tissues is rapid and therefore unlikely to provide more than transitory effect,

and little benefit as a nutritional supplement.

Vitamin E esters such as alpha tocopheryl acetate and alpha tocopheryl succinate

are not antioxidants in that form and must first be enzymatically de-esterified

in the gut to the biologically active tocopherols before they function in the

human system. This is an inefficient process and and more than 50% of the ester

may not be converted.

History: " anti-sterility factor " described in 1911; isolated in 1936; identified

in 1938; recognized as essential for humans in 1968; deficiency syndrome

described in 1977;

Nutrition

Sources: wheat germ, wheat germ oil, whole grain, unrefined vegetable oil, nuts,

seeds, eggs, whole grains, green leafy vegetables;

Supplements: " dry " E acetate or succinate, d-alpha tocopherol, gamma/alpha

tocopherols, multivitamin, multi-mineral-vitamin formulations;

Absorption from small intestine, along with fats; 40 to 60% is absorbed into

lymph (in chylomicrons); remainder is discarded in feces;

Improved by: edible fats & oils; by taking with a meal; vitamin C prevents its

oxidation; vitamin A aids in transport; manganese & selenium;

Antagonized by: salts & sugar/acid chelates of iron & copper (oxides,

carbonates, gluconates, succinates, acetates, etc.); oxygen; rancid food oils;

processed foods; mineral oil; oral contraceptives; freezing; oxidizing agents,

ozone & nitrogen oxides;

Stability: destroyed by light & oxygen; heat-stable in boiling, but destroyed

during frying & deep frying; some lost in frozen storage; storage at room

temperature may decrease vitamin E content of foods by up to 50% within 2 weeks;

encapsulation protects vitamin E against destruction;

Storage: largely in adipose tissue, liver & muscle; high concentrations also

found in blood platelets, pituitary, adrenals, testes, ovaries;

Metabolism: plasma levels drop to half within a few days when vitamin E is

withdrawn from foods; frank deficiency may take several months to develop;

Functions of vitamin E

Chief activity in all cells & tissues is anti-oxidant; prevents oxygen from

destroying many other compounds, including vitamin A & C, unsaturated fatty

acids & membranes (phospholipids); (Note: oxygen is vital to cell respiration,

but will damage cells if antioxidants fail to keep it under control);

Vital to digestion & metabolism of unsaturated fats; Protects cells from

damaging pollutants, peroxides & free radicals formed from organic molecules

during normal metabolic processes; protects lungs against air pollution;

Protects membrane integrity of cells in circulatory, digestive, respiratory,

excretory & nervous systems; protects vitamin A against destruction by free

radicals;

Stimulates development & tone of skeletal, heart & digestive tract muscles;

Retards aging processes of cells; prolongs life of red blood cells;

Vitamin E & C reduces the formation of nitrosamines (carcinogen) in bacon;

Gamma tocopherol plays a critical role in the defence against cancer and

cardiovascular disease by inhibiting the process of inflammation more

effectively that alpha tocopherol.

Quantities

Measurement: 1 mg d-alpha tocopherol = 1.49 International Units (IU);

1 mg dl-alpha tocopheryl acetate = 1 IU = 1 tocopherol equivalent (TE);

Optimum: (SONA) average ranges from 70 to 800 IU; increases with amount of

unsaturated fatty acids in diet; high intake of unsaturated fats increases the

rate of oxidative destruction of vitamin E, which sacrifices itself to spare fat

& membranes;

Individual optimum must be determined for each individual;

Minimum: (DRI) average is set at 15 mg (22 IU);

Less than RDA: estimated at 20 - 40% of population, due to reliance on processed

foods;

Deficiency from: insufficient intake; poor absorption (inflammatory bowel

disease, cystic fibrosis, premature birth); lack of fats in diet; mineral oil;

iron & copper salts; injury & tissue destruction, which rapidly use up body's

supplies; rancid oils; increased requirement (premature infants, pregnant &

lactating women); - intake of vitamin E from foods has fallen 95% since 1900,

due to removal during food processing; deficiency is widespread in

un-supplemented diets;

Symptoms include: formation of peroxides, dienes & free radicals within cells,

formed by oxidation of membrane fats & of soluble factors in cell cytoplasm;

rupture of cell membranes; destruction or irreparable damage to nearby cells by

substances spilling from ruptured cells; damage transmitted to future

generations of cells; shortened red blood cell life; production of age pigment

spots (ceroid pigments; lipofuscin);

First clinical signs of deficiency: ruptured red blood cells (haemolysis),

followed by abnormal deposits of fat in heart & muscles, shrinkage of connective

tissues & /or muscle degeneration;

Prolonged deficiency impairs absorption of fat & fat soluble vitamins, can lead

to degeneration of the testes in men; nephritis from kidney tubule blockage by

dead cells; blockage of bile duct; chronic pancreatitis; chronic

gastrointestinal disorders; thrombotic conditions of the cardiovascular system;

infertility in men & women; progressive neuro-muscular disease in children &

adults (nutritional muscular dystrophy); formation of age pigments (lipofuscin);

vitamin E deficiency anaemia from oxidative destruction of red blood cells;

premature infants especially at risk — haemolytic anaemia, intraventricular

haemorrhage, retrolenticular fibroplasias that can lead to blindness;

Toxicity: virtually impossible to overdose on vitamin E; 200 times RDA (up to

3,000 IU/day) is safe for most people;

Very high intake may increase bleeding tendency in patients on anti-coagulant

drugs;

Extreme supplementation may increase blood pressure in some people; hypertensive

individuals start with low quantities & increase by 100 IU/week;

Persons with rheumatic heart conditions may have to limit vitamin E intake to

150 IU/day; supervision by nutritionally competent health care professional is

recommended;

Therapy with vitamin E

100-1,600 IU/day is usual therapeutic range; up to 3,200 IU/day used in

menopause;

Corrects the foregoing deficiency conditions if degeneration of the tissue has

not progressed to irreparable damage;

Reverses nutritional muscular dystrophy;

Protects brain & nerves, muscles, heart & arteries, glands & reproductive organs

from oxidative damage throughout life;

Russian athletes use up to 150 IU/2-hour training to spare oxygen & promote

endurance;

Improves varicose veins, inflamed veins with blood clots (thrombophlebitis) &

intermittent claudication; soothes dry itchy skin; regulates menstrual flow;

prevents & alleviates some migraine headaches; prevents miscarriages;

Protects lungs from damage due to smog; retards aging; preventive against cancer

& heart disease, as well as general degeneration;

Up to 100 IU/day used in premature infants, to protect cell membranes in brain,

nerves, heart & muscles from oxidative destruction; to prevent blindness & brain

damage;

Cystic fibrosis requires 400 IU/day or more because of poor absorption;

Topical use as anti-inflammatory agent, in cosmetics, to heal wounds & to

protect skin against UV & other damage; retard skin aging;

Gamma tocopherol may inhibit prostate cancer & lung cancer.

[Guest guest]

We resolved an umbilical hernia in our infant son with topical vit E

complex application, plus a squirt in the mouth from a punctured capsule.

It went from an inch in diameter protruding " outy " to proper and flat

within 2 days.

Thanks for pointing out that the " official research " neglected to use

the real thing. I wonder if they drive cars with only one out of four

wheels. Hmmm what would that say about working brain areas?? L

On Wed, Jan 18, 2012 at 4:43 PM, holisticminnesota <holistic@...>wrote:

> I was stunned by the results of the tocotrienol study because Vitamin E

> studies and trials, which often show no improvement for common chronic

> disease, are usually designed to fail! They use SYNTHETIC forms, they

> UNDERDOSE, and they almost never include the TOCOTRIENOLS. I've seen many

> cancer and heart health studies where the patients were given a measly 50

> i.u. of synthetic tocopherol and then they conclude that " Taking vitamin E

> supplements is worthless " . This recent study uses the real thing (albeit

> in a capsule).

>

> Specifically Vitamin E will hold up under boiling of food, but not frying

> or deep-frying. You can find it in all nuts and seeds, vegetable oils, dark

> leafy greens, avocados, tomatoes, sprouts, eggs and many other foods. In

> addition to dietary, I get mine from SWANSONS VITAMINS. Get the super-duper

> forms with all the various components (it's more expensive, but worth it!)

>

> Here's more than you ever wanted to know about VITAMIN E....

> Will Winter

>

>

________________________________________________________________________________\

_____

> VITAMIN E (Tocopherol)

>

>

________________________________________________________________________________\

______

> General - oil-soluble; anti-sterility factor; oil-soluble antioxidant;

>

> Vitamin E is the official designation for alpha tocopherol, a fat-soluble

> nutrient found in the diet in varying amounts. Until recently it was

> thought that alpha tocopherol was the most active tocopherol and as such

> only official vitamin E activity (IU) is given to alpha tocopherol.

> The term vitamin E is now used to refer to all tocol and trienal

> derivatives. The tocols are alpha, beta, delta and gamma tocopherol, and

> the trienals are alpha, beta, delta and gamma tocotrienol.

> Gamma tocopherol, a potent antioxidant of ozone and nitric oxide is now

> shown to be as important as alpha tocopherol. The National Academy of

> Sciences now suggests that vitamin E formulas contain both tocopherols and

> that gamma tocopherol be the predominant one.

> Tocotrienols have potent anti-oxidant activity, but their turnover rate in

> human tissues is rapid and therefore unlikely to provide more than

> transitory effect, and little benefit as a nutritional supplement.

> Vitamin E esters such as alpha tocopheryl acetate and alpha tocopheryl

> succinate are not antioxidants in that form and must first be enzymatically

> de-esterified in the gut to the biologically active tocopherols before they

> function in the human system. This is an inefficient process and and more

> than 50% of the ester may not be converted.

> History: " anti-sterility factor " described in 1911; isolated in 1936;

> identified in 1938; recognized as essential for humans in 1968; deficiency

> syndrome described in 1977;

> Nutrition

>

> Sources: wheat germ, wheat germ oil, whole grain, unrefined vegetable oil,

> nuts, seeds, eggs, whole grains, green leafy vegetables;

> Supplements: " dry " E acetate or succinate, d-alpha tocopherol, gamma/alpha

> tocopherols, multivitamin, multi-mineral-vitamin formulations;

> Absorption from small intestine, along with fats; 40 to 60% is absorbed

> into lymph (in chylomicrons); remainder is discarded in feces;

> Improved by: edible fats & oils; by taking with a meal; vitamin C prevents

> its oxidation; vitamin A aids in transport; manganese & selenium;

> Antagonized by: salts & sugar/acid chelates of iron & copper (oxides,

> carbonates, gluconates, succinates, acetates, etc.); oxygen; rancid food

> oils; processed foods; mineral oil; oral contraceptives; freezing;

> oxidizing agents, ozone & nitrogen oxides;

> Stability: destroyed by light & oxygen; heat-stable in boiling, but

> destroyed during frying & deep frying; some lost in frozen storage; storage

> at room temperature may decrease vitamin E content of foods by up to 50%

> within 2 weeks; encapsulation protects vitamin E against destruction;

> Storage: largely in adipose tissue, liver & muscle; high concentrations

> also found in blood platelets, pituitary, adrenals, testes, ovaries;

> Metabolism: plasma levels drop to half within a few days when vitamin E is

> withdrawn from foods; frank deficiency may take several months to develop;

> Functions of vitamin E

> Chief activity in all cells & tissues is anti-oxidant; prevents oxygen

> from destroying many other compounds, including vitamin A & C, unsaturated

> fatty acids & membranes (phospholipids); (Note: oxygen is vital to cell

> respiration, but will damage cells if antioxidants fail to keep it under

> control);

> Vital to digestion & metabolism of unsaturated fats; Protects cells from

> damaging pollutants, peroxides & free radicals formed from organic

> molecules during normal metabolic processes; protects lungs against air

> pollution;

> Protects membrane integrity of cells in circulatory, digestive,

> respiratory, excretory & nervous systems; protects vitamin A against

> destruction by free radicals;

> Stimulates development & tone of skeletal, heart & digestive tract muscles;

> Retards aging processes of cells; prolongs life of red blood cells;

> Vitamin E & C reduces the formation of nitrosamines (carcinogen) in bacon;

> Gamma tocopherol plays a critical role in the defence against cancer and

> cardiovascular disease by inhibiting the process of inflammation more

> effectively that alpha tocopherol.

> Quantities

>

> Measurement: 1 mg d-alpha tocopherol = 1.49 International Units (IU);

> 1 mg dl-alpha tocopheryl acetate = 1 IU = 1 tocopherol equivalent (TE);

> Optimum: (SONA) average ranges from 70 to 800 IU; increases with amount of

> unsaturated fatty acids in diet; high intake of unsaturated fats increases

> the rate of oxidative destruction of vitamin E, which sacrifices itself to

> spare fat & membranes;

> Individual optimum must be determined for each individual;

> Minimum: (DRI) average is set at 15 mg (22 IU);

> Less than RDA: estimated at 20 - 40% of population, due to reliance on

> processed foods;

> Deficiency from: insufficient intake; poor absorption (inflammatory bowel

> disease, cystic fibrosis, premature birth); lack of fats in diet; mineral

> oil; iron & copper salts; injury & tissue destruction, which rapidly use up

> body's supplies; rancid oils; increased requirement (premature infants,

> pregnant & lactating women); - intake of vitamin E from foods has fallen

> 95% since 1900, due to removal during food processing; deficiency is

> widespread in un-supplemented diets;

> Symptoms include: formation of peroxides, dienes & free radicals within

> cells, formed by oxidation of membrane fats & of soluble factors in cell

> cytoplasm; rupture of cell membranes; destruction or irreparable damage to

> nearby cells by substances spilling from ruptured cells; damage transmitted

> to future generations of cells; shortened red blood cell life; production

> of age pigment spots (ceroid pigments; lipofuscin);

> First clinical signs of deficiency: ruptured red blood cells (haemolysis),

> followed by abnormal deposits of fat in heart & muscles, shrinkage of

> connective tissues & /or muscle degeneration;

> Prolonged deficiency impairs absorption of fat & fat soluble vitamins, can

> lead to degeneration of the testes in men; nephritis from kidney tubule

> blockage by dead cells; blockage of bile duct; chronic pancreatitis;

> chronic gastrointestinal disorders; thrombotic conditions of the

> cardiovascular system; infertility in men & women; progressive

> neuro-muscular disease in children & adults (nutritional muscular

> dystrophy); formation of age pigments (lipofuscin); vitamin E deficiency

> anaemia from oxidative destruction of red blood cells; premature infants

> especially at risk — haemolytic anaemia, intraventricular haemorrhage,

> retrolenticular fibroplasias that can lead to blindness;

> Toxicity: virtually impossible to overdose on vitamin E; 200 times RDA (up

> to 3,000 IU/day) is safe for most people;

> Very high intake may increase bleeding tendency in patients on

> anti-coagulant drugs;

> Extreme supplementation may increase blood pressure in some people;

> hypertensive individuals start with low quantities & increase by 100

> IU/week;

> Persons with rheumatic heart conditions may have to limit vitamin E intake

> to 150 IU/day; supervision by nutritionally competent health care

> professional is recommended;

> Therapy with vitamin E

>

> 100-1,600 IU/day is usual therapeutic range; up to 3,200 IU/day used in

> menopause;

> Corrects the foregoing deficiency conditions if degeneration of the tissue

> has not progressed to irreparable damage;

> Reverses nutritional muscular dystrophy;

> Protects brain & nerves, muscles, heart & arteries, glands & reproductive

> organs from oxidative damage throughout life;

> Russian athletes use up to 150 IU/2-hour training to spare oxygen &

> promote endurance;

> Improves varicose veins, inflamed veins with blood clots

> (thrombophlebitis) & intermittent claudication; soothes dry itchy skin;

> regulates menstrual flow; prevents & alleviates some migraine headaches;

> prevents miscarriages;

> Protects lungs from damage due to smog; retards aging; preventive against

> cancer & heart disease, as well as general degeneration;

> Up to 100 IU/day used in premature infants, to protect cell membranes in

> brain, nerves, heart & muscles from oxidative destruction; to prevent

> blindness & brain damage;

> Cystic fibrosis requires 400 IU/day or more because of poor absorption;

> Topical use as anti-inflammatory agent, in cosmetics, to heal wounds & to

> protect skin against UV & other damage; retard skin aging;

> Gamma tocopherol may inhibit prostate cancer & lung cancer.

>

>

>

>

> ------------------------------------

>

>