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Painkillers: Tylenol better than Ibuprofen?TITLE: Ibuprofen-induced hepatotoxicity in patients with chronic hepatitisC: a case series.Hepatitis C is a common chronic infection. Nonsteroidal anti-inflammatorydrugs are commonly ingested both over-the-counter and by prescription. Thiscase report describes three cases where ibuprofen use leads to a marked risein hepatic transaminases with one case repeating on rechallenge. These casessupport the recommendation of acetaminophen over nonsteroidalantiinflammatory drug use in patients with chronic hepatitis C.AUTHOR: Riley TR 3rd, JP, Penn State Geisinger Health System, TheMilton S. Hershey Medical Center, The Pennsylvania State University,Department of

Medicine, Hershey 17033-0850, USA. SOURCE: Am J Gastroenterol1998 Sep;93(9):1563- 1565------------ ----OTC Medications Can Cause Problems For Hepatitis C PatientsHERSHEY, PA -- Sept. 16, 1998 -- Patients with chronic hepatitis C oftentake the over-the-counter non-steroidal drug Ibuprofen, otherwise known asMotrin or Advil, to combat joint pain that often accompanies the disease.However, even a low dose could lead to unsuspecting liver damage."Patients frequently suffer from joint pain. Often, even physicians willprescribe ibuprofen when they should prescribe Tylenol," explained Riley, III, M.D., assistant professor of medicine at Penn State's College ofMedicine. "The correct

recommendation to help the patient is a low dose ofTylenol, about two grams per day. That means the patient can take one extrastrength Tylenol -- 500 mg -- every six hours or take two every 12 hours."Riley and his colleagues describe three cases in an article published inthis month's issue of the American Journal of Gastroenterology.In each of these three cases the patients have hepatitis C and tookover-the-counter ibuprofen. After doing so they all had a flare-up of theirhepatitis."Many physicians don't want to prescribe Tylenol because it has a reputationof causing liver damage. As long as it is prescribed in the low doses wehave discussed it is definitely the best treatment," explained Riley, who isalso the medical director for the liver transplant program at The Milton S.Hershey Medical Center of the Penn State Geisinger Health System.He said where patients with chronic hepatitis C usually have mild elevationsin their liver enzymes in the blood, after taking the over-the-counterIbuprofen these patients experience a 10-fold rise in their enzymes,suggesting significant liver injury.He added that if too much medication is taken the patient risks speeding upthe process of going from chronic hepatitis to cirrhosis of the liver. Rileysaid that about four million Americans are infected with hepatitis C."Many patients can live with hepatitis for perhaps 50 years. However, if toomuch of the wrong medication is taken or if the patient consumes a lot ofalcohol, the process from hepatitis to cirrhosis can speed up," Riley said.This articles focuses on three cases. Riley said further study is needed ofa large group of patients with hepatitis C to determine perhaps an evenbetter

approach to this growing problem.Sheena <mom4possums2002@...> wrote: Nearly 4 months ago..Thanks, Jax, but truth be told, I'm still plenty scared and still looking to learn as much as I can.. What you all have taught me is to look out for ME.. I don't like to see myself or anyone taken advantage of, or not given proper care and treatment and we all know there's way too much of that going on.. What the heck

ever happened to the Oath that physicians take, that is nothing more than a sham with many, it seems.. Hugs, Sheena Jackie on <redjaxjm > wrote: Sheena,,, YOU amaze me honey,, I remember when you came here,, you were so afraid and wanted to learn about this disease and LOOK AT YOU NOW!!! WHAT a SELF ADVOCATE YOU have become! Im so proud of you! hugs jaxSheena <mom4possums2002 > wrote: I am fighting doctors on near a daily basis and haven't even been

allowed to start treatment. You go, don't let them do that to you! And call your drug company, they will help you in your fight. Never trust most doctors 100%, you have to be your own healer.. My prayers are with you.. Hugs, Sheena richlee7 <rnewton8tampabay (DOT) rr.com> wrote: genotype 1 and i just took the shot before i read your message. i am sure they will be upset.and from now on i will get all my labs copied to my house so i can read them myself and look for red flags. from now on i am going to be taking a more proactive approach to my treatment as it is my

life, and a simple error such as this with labwork can ultimately have a effect on a svr or make someone have to start treatment over again, and i dam sure dont want to have to do that. > what effect does missing an interferon shot have on getting an svr > on treatment. i have a situation. my doctor told me not to take my > next interferon shot till he had my next labs, and he was suppose to > get back to me yesterday and still no word. my last lab had a WBC > count that was low (1.9) so they wanted to check it again and if it > was still low give and if so give me some neupogen to bring it up > to normal. i still have not been able to get in touch with my doctor > or have heard anything and i was due for my interferon shot > yesterday. i

dont want to throw my schedule off or lose a week or > interrupt treatment. this has me worried. > > also how low is a 1.9 for a wbc count? > > if i dont hear from him by today i am going to just take the shot > anyway as i dont want to interrupt my treatment, i have already > cleared the virus at 6 weeks and i dont want to fuck my chances of > getting an svr.> > what would you do in this situation if you could not get a hold of > your doctor?> > > > > > > Jackie> __________________________________________________

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