Re: Re: Biolex, Inc. Announces Initiation Of Locteron(TM) Phase 2 Clinical Study In Chro

[Guest guest]

Well, I'm miffed! Cheap Medicare pharmacy didn't give me a gift bag!! lol Guess I'll live... Maybe they felt it justified when the drug prices were so exhorbitant, not that they are reasonable now.

Sharon

>This sounds great. Particularly that it is a more constant level of interferon without the peaks and valleys.The thing that I would be concerned about is that on 2 week dosing people would really have to make a schedule and stick to it. I can imagine that with the brain fog state that many of us are in thinking is this shot week or did I do it last week?I got the Pegasys "gift bag" and it has a journal to keep track of when you did your shot, date, time, where, and what week that you are on. It really helps to keep track.It also has a pill box with am and pm compartments for seven days. I would fill it every shot day and could see if I had missed a dose. I never did, but it was always reassurring to make sure that all of the compartments where empty.I don't know how many times that I would take my pills and five minutes later wonder if I had. I would just check to see if the compartment was empty.Lee

[Guest guest]

well write them and ask them for the travel bag that has all the info inside,, you should have gotten that from your doc!SHARON CROSBY <csharonxoxo@...> wrote: Well, I'm miffed! Cheap Medicare pharmacy didn't give me a gift bag!! lol Guess I'll live... Maybe they felt it justified when the drug prices were so exhorbitant, not that they are reasonable now. Sharon >This sounds great. Particularly that it is a more constant level of interferon without the peaks and valleys.The thing that I would be concerned about is that on 2 week dosing people would really have to make a schedule and stick to it. I can imagine that with the brain fog state that many of us are in thinking is this shot week or did I do it last week?I got the Pegasys "gift bag" and it has a journal to keep track of when you did your shot, date, time, where, and what week that you are on. It really helps to keep track.It also has a pill box with am and pm compartments for seven days. I would fill it

every shot day and could see if I had missed a dose. I never did, but it was always reassurring to make sure that all of the compartments where empty.I don't know how many times that I would take my pills and five minutes later wonder if I had. I would just check to see if the compartment was empty.Lee Jackie

[Guest guest]

I was just kidding, folks. I still have the little cooler and eye mask and the towel from the last round of treatment. I was just cracking fun, honestly.

Sharon> >

> > Well, I'm miffed! Cheap Medicare pharmacy didn't give me a gift > bag!! lol Guess I'll live... Maybe they felt it justified when > the drug prices were so exhorbitant, not that they are reasonable > now.> > Sharon> > > > >

[Guest guest]

I was just kidding, folks. I still have the little cooler and eye mask and the towel from the last round of treatment. I was just cracking fun, honestly.

Sharon> >

> > Well, I'm miffed! Cheap Medicare pharmacy didn't give me a gift > bag!! lol Guess I'll live... Maybe they felt it justified when > the drug prices were so exhorbitant, not that they are reasonable > now.> > Sharon> > > > >

[Guest guest]

hahahaa,, you rowdy girl,, SHARON CROSBY <csharonxoxo@...> wrote: I was just kidding, folks. I still have the little cooler and eye mask and the towel from the last round of treatment. I was just cracking fun, honestly. Sharon> > > > Well, I'm miffed! Cheap Medicare pharmacy didn't give me a gift > bag!! lol Guess

I'll live... Maybe they felt it justified when > the drug prices were so exhorbitant, not that they are reasonable > now.> > Sharon> > > > > Jackie

[Guest guest]

Lee,, I'd bet that the reason that the wellbutrin caused those halucinations was because it affects the dopamine and not the seretonin... I have heard that from others too and some ppl have very vivid dreams when they take wellbutrin.. my doc gave it to me but I never took it,, it scared me too much,, I'd rather deal with a little bit of increased depression that nightmares!Lee <leecuate@...> wrote: Its is a clear plastic eyemask (with a Pegasys logo) filled with a blue liquid. You freeze it and it gets really cold. You

cover your eyes with it and it stays frozen for about an hour.Lee> > > >> > > This sounds great.

Particularly that it is a more constant level > > of > > > interferon without the peaks and valleys.> > > The thing that I would be concerned about is that on 2 week > > dosing > > > people would really have to make a schedule and stick to it. I > > can > > > imagine that with the brain fog state that many of us are in > > > thinking is this shot week or did I do it last week?> > > I got the Pegasys "gift bag" and it has a journal to keep track > > of > > > when you did your shot, date, time, where, and what week that > > you > > > are on. It really helps to keep track.> > > It also has a pill box with am and pm compartments for seven > > days. I > > > would fill it every shot day and could see if I had missed a > > dose. I > > > never did, but it

was always reassurring to make sure that all > > of > > > the compartments where empty.> > > I don't know how many times that I would take my pills and five > > > minutes later wonder if I had. I would just check to see if the > > > compartment was empty.> > > > > > Lee> > >> >>Jackie

[Guest guest]

I can relate ...I had to have my husband give me my pills each day cause I would just space out and forget them lol

Re: Biolex, Inc. Announces Initiation Of Locteron Phase 2 Clinical Study In Chro

>This sounds great. Particularly that it is a more constant level of interferon without the peaks and valleys.The thing that I would be concerned about is that on 2 week dosing people would really have to make a schedule and stick to it. I can imagine that with the brain fog state that many of us are in thinking is this shot week or did I do it last week?I got the Pegasys "gift bag" and it has a journal to keep track of when you did your shot, date, time, where, and what week that you are on. It really helps to keep track.It also has a pill box with am and pm compartments for seven days. I would fill it every shot day and could see if I had missed a dose. I never did, but it was always reassurring to make sure that all of the compartments where empty.I don't know how many times that I would take my pills and five minutes later wonder if I had. I would just check to see if the compartment was empty.Lee> Biolex, Inc. Announces Initiation Of Locteron Phase 2 Clinical > Study In Chronic Hepatitis C > > > PITTSBORO, N.C., Jan. 30 /PRNewswire/ -- Biolex Therapeutics today > announced the initiation of a Phase 2a clinical trial of its lead > product candidate Locteron, a best-in-class controlled-release > interferon alfa. Locteron is being developed as a treatment for > chronic hepatitis C, a virus infecting more than four million people > in the United States. The Phase 2a study is designed to evaluate > Locteron in combination with the anti-viral drug ribavirin in > previously untreated chronic hepatitis C patients. Clinical > investigators in this study have commenced patient dosing and top-> line results are expected in the middle of 2007.> > Locteron combines BLX-883, a recombinant interferon alfa produced in > Biolex's proprietary LEX System(SM), with PolyActive, an advanced > controlled-release drug delivery technology developed by the > Company's co- development partner OctoPlus N.V. The pharmacokinetic > and pharmacodynamic results demonstrated in the Phase 1 study of > Locteron support dosing of hepatitis C patients once every two weeks, > a substantial improvement over currently marketed pegylated > interferons that require dosing every week. In addition, Locteron is > designed to reduce the severity and duration of certain side effects, > such as flu-like symptoms, by eliminating the undesirable early high > peak plasma levels (burst effect) that are typically observed with > currently marketed pegylated interferons and newer interferon product > candidates under development.> > This Phase 2a randomized study, known as SELECT-1 (Safety and > Efficacy of Locteron: European Clinical Trial-1), will evaluate a > range of up to four doses of Locteron given every two weeks in > combination with ribavirin in treatment-naive hepatitis C patients > with the geneotype-1 variant of the virus. The 32 patients in SELECT-> 1 will be treated for 12 weeks with the Locteron/ribavirin > combination, and the repeat-dose study will assess viral response, > safety and tolerability. Results from the study will be used to > select the doses of Locteron to be advanced to later-stage clinical > development.> > "We are pleased with the clinical progress of Locteron, and we see a > fairly predictable regulatory pathway based on interferon alfa's > proven mechanism of action," said Mr. Jan Turek, Biolex's Chief > Executive Officer. "Clinicians and other care providers have strongly > conveyed the need for more convenient treatments with fewer side > effects in hepatitis C, and we believe that Locteron has strong > potential to provide patients many advantages over currently > available therapies. In particular, the less frequent administration > and reduced side effects demonstrated in the Phase 1 clinical > evaluation of Locteron position this novel interferon to complement > existing treatment protocols as well as the array of new antiviral > agents currently under development."> > The potential benefits of Locteron are highlighted by the results of > a randomized, double-blind, placebo- and active-controlled dose-> escalation, healthy volunteer Phase 1 study of Locteron. As reported > at the European Association for the Study of Liver Disease (EASL) > conference in April 2006, the Phase 1 study demonstrated the safety > and tolerability of Locteron administered as a single dose. Notably, > flu-like symptoms among the groups receiving Locteron in the study > were reported to be less frequent, less severe and of shorter > duration than in the subjects receiving PEG-INTRON®, the currently > marketed interferon that served as the control. Additionally, the > administration of Locteron resulted in biomarker levels that were > equal to or greater than those measured in the participants receiving > PEG-INTRON in the study, and this bioactivity was sustained over a > two-week period, supporting the once every two week dosing profile of > Locteron. Specifically, none of the subjects administered the 80 mcg > dose of Locteron incurred any flu-like symptoms, yet the biomarker > levels for this group were equivalent to those measured in the PEG-> INTRON control group (all of whom incurred flu-like symptoms). > Furthermore, the group receiving the highest dose of Locteron, 320 > mcg, had flu-like symptoms that were milder and of shorter duration > that than the PEG-INTRON group, but had biomarker levels that > substantially exceeded those of the PEG-INTRON group.> > Locteron is an investigational therapeutic candidate and has not been > approved for sale by the United States Food and Drug Administration > or by any international regulatory agency.>

[Guest guest]

Yes, I love mine.

Re: Biolex, Inc. Announces Initiation Of Locteron Phase 2 Clinical Study In Chro

that blue ice gel works pretty good for headaches. i have been getting a lot of use out of it lately.>> Call Pegassist at1-877-734-2797. They will send you one for free. > Its a nice canvas bag that has literature, the journal, a fold up > water bottle, sharps container, pill box, a little travel cooler for > the syringes and one of the funniest things is a blue ice gel eye > mask for headaches.> > Lee