Is this good news or false hope?

[Guest guest]

Hi there:

Our son, Eyal, was recently diagnosed with hypogam. We just had him

retested at another lab with different normal ranges and perhaps,

different measuring methods. (Both labs claim to have ranges

appropriate for Eyal's age at the time of testing.) His new

pediatrician says Eyal is fine, that he does not have hypogam, and

that we do not need to see a specialist. We hope this is true, but

know we have to be vigilant in making sure our son gets medical

treatment if he needs it. The lab info is provided below. I am

interested to see what you all think. I am also wondering if you

can suggest a worthy organization to make donations to that does

research to treating and preventing PID. Thanks, in advance, for

your thoughts. We are so grateful for the support and information

we have received so far, particularly from Ursula and .

Thank you, thank you, thank you.

His recent results at 1 year and 11 months are:

IGA 39 - normal (normal range 24 - 121 mg/dl)

IGG 503 - low (normal range 533 - 1078 mg/dl)

IGM 67 - normal (normal range 28 - 218 mg/dl)

IGE was not tested

IGA subclasses results are not back yet

IGG subclass 1 297 - normal (normal range 288 - 880 mg/dl)

IGG subclass 2 100 - normal (normal range 30 - 327 mg/dl)

IGG subclass 3 43 - normal (normal range 13 - 82 mg/dl)

IGG subclass 4 4 - normal (normal range 1 - 65 mg/dl)

His results in May when he was 20 months old were:

IGA 26.0 - low (normal range 46.0 - 154.0 mg/dl)

IGG 382 - low (normal range 495 - 738 mg/dl)

IGM 48 - low (normal range 51 - 189 mg/dl)

IGE <2 - normal or deficient? (normal range 0 - 18)

IGA subclass 1 20.6 - low (normal range 98.6 - 353.1 mg/dl)

IGA subclass 2 3.1 - low (normal range 11.6 - 78.5 mg/dl)

IGG subclasses were not tested

[Guest guest]

,

It could be good news in that often young children have a transient

form of hypogam. In a sense their immune system is born immature

and develops a little slower. However, I am curious to see if your

son had antibody testing. A person could have wonderful looking

numbers but they just don't work. If that was not done, I would

still insist on seeing a specialist to make sure all the proper

testing was done and take nothing for granted.

Good luck,

Kris

> Hi there:

>

> Our son, Eyal, was recently diagnosed with hypogam. We just had

him

> retested at another lab with different normal ranges and perhaps,

> different measuring methods. (Both labs claim to have ranges

> appropriate for Eyal's age at the time of testing.) His new

> pediatrician says Eyal is fine, that he does not have hypogam, and

> that we do not need to see a specialist. We hope this is true,

but

> know we have to be vigilant in making sure our son gets medical

> treatment if he needs it. The lab info is provided below. I am

> interested to see what you all think. I am also wondering if you

> can suggest a worthy organization to make donations to that does

> research to treating and preventing PID. Thanks, in advance, for

> your thoughts. We are so grateful for the support and information

> we have received so far, particularly from Ursula and .

> Thank you, thank you, thank you.

>

> His recent results at 1 year and 11 months are:

>

> IGA 39 - normal (normal range 24 - 121 mg/dl)

> IGG 503 - low (normal range 533 - 1078 mg/dl)

> IGM 67 - normal (normal range 28 - 218 mg/dl)

> IGE was not tested

> IGA subclasses results are not back yet

> IGG subclass 1 297 - normal (normal range 288 - 880 mg/dl)

> IGG subclass 2 100 - normal (normal range 30 - 327 mg/dl)

> IGG subclass 3 43 - normal (normal range 13 - 82 mg/dl)

> IGG subclass 4 4 - normal (normal range 1 - 65 mg/dl)

>

> His results in May when he was 20 months old were:

>

> IGA 26.0 - low (normal range 46.0 - 154.0 mg/dl)

> IGG 382 - low (normal range 495 - 738 mg/dl)

> IGM 48 - low (normal range 51 - 189 mg/dl)

> IGE <2 - normal or deficient? (normal range 0 - 18)

> IGA subclass 1 20.6 - low (normal range 98.6 - 353.1 mg/dl)

> IGA subclass 2 3.1 - low (normal range 11.6 - 78.5 mg/dl)

> IGG subclasses were not tested

[Guest guest]

Hi, Kris:

Thank you for the information about antibody testing. Antibody

testing is when we find out if he makes antibodies to vaccines,

right? That was definitely not done. His pediatrician did not want

to do it, so we can ask the specialist about that. Eyal had a CBC

done - is there anything I can look for to see if he makes

antibodies? Best wishes to you and your family,

(Eyal's mom - 2 years old with hypogam?)

> > Hi there:

> >

> > Our son, Eyal, was recently diagnosed with hypogam. We just had

> him

> > retested at another lab with different normal ranges and perhaps,

> > different measuring methods. (Both labs claim to have ranges

> > appropriate for Eyal's age at the time of testing.) His new

> > pediatrician says Eyal is fine, that he does not have hypogam,

and

> > that we do not need to see a specialist. We hope this is true,

> but

> > know we have to be vigilant in making sure our son gets medical

> > treatment if he needs it. The lab info is provided below. I am

> > interested to see what you all think. I am also wondering if you

> > can suggest a worthy organization to make donations to that does

> > research to treating and preventing PID. Thanks, in advance, for

> > your thoughts. We are so grateful for the support and

information

> > we have received so far, particularly from Ursula and .

> > Thank you, thank you, thank you.

> >

> > His recent results at 1 year and 11 months are:

> >

> > IGA 39 - normal (normal range 24 - 121 mg/dl)

> > IGG 503 - low (normal range 533 - 1078 mg/dl)

> > IGM 67 - normal (normal range 28 - 218 mg/dl)

> > IGE was not tested

> > IGA subclasses results are not back yet

> > IGG subclass 1 297 - normal (normal range 288 - 880 mg/dl)

> > IGG subclass 2 100 - normal (normal range 30 - 327 mg/dl)

> > IGG subclass 3 43 - normal (normal range 13 - 82 mg/dl)

> > IGG subclass 4 4 - normal (normal range 1 - 65 mg/dl)

> >

> > His results in May when he was 20 months old were:

> >

> > IGA 26.0 - low (normal range 46.0 - 154.0 mg/dl)

> > IGG 382 - low (normal range 495 - 738 mg/dl)

> > IGM 48 - low (normal range 51 - 189 mg/dl)

> > IGE <2 - normal or deficient? (normal range 0 - 18)

> > IGA subclass 1 20.6 - low (normal range 98.6 - 353.1 mg/dl)

> > IGA subclass 2 3.1 - low (normal range 11.6 - 78.5 mg/dl)

> > IGG subclasses were not tested

[Guest guest]

If he's clinically stable and having just the typical infections of toddler-hood

then you might be headed towards a resolving system. You do want to get titers

to his Prevnar and MMR. This will help know about function. His IgG could be

1200 but if there is no function then it's " blank " .

Ursula Holleman

mom to (12 yrs old) and Macey (10 yr. old with CVID, Diabetes Insipidus,

colonic inertia)

http://members.cox.net/maceyh

Immune Deficiency Foundation - Peer Contact for GA

http://www.primaryimmune.org

IDF Patient/Family Handbook

http://www.primaryimmune.org/pubs/book_pats/book_pats.htm

/

[Guest guest]

I agree with the others, get antibody testing done. I wouldn't hesitate to

see a specialist either, what would it hurt? We don't rely on our

pediatrician for anything other than dealing with very minor issues,

anything that could potentially be more complicated we self-refer.

And from what we were told, an IgE of <2 is great, that's one of those

levels that you want to be on the low side. Conner's IgE was over 2,419 the

first time we tested him! His docs couldn't believe it and told us it was

not a good thing!

Keep us posted!

Mom to Conner (11, Asperger's, mild CP, partial seizures, asthma, GERD,

immunodeficiency and resolved adrenal insufficiency),

Hayden (11, PDD-NOS, IBS and moderate hearing loss/aided),

Evan (11, asthma and mild hearing loss/unaided),

and Kelsey - (9 going on 19!)

Please visit us at www.caringbridge.org/in/connersmith

[Guest guest]

In a message dated 9/18/2005 2:11:17 PM Central Standard Time,

tripletsand1@... writes:

> We don't rely on our

> pediatrician for anything other than dealing with very minor issues

[Guest guest]

In a message dated 9/18/2005 2:11:17 PM Central Standard Time,

tripletsand1@... writes:

> We don't rely on our

> pediatrician for anything other than dealing with very minor issues

I agree. Our ped is wonderful, written up in Chicago magazine all the time as

one of the best peds, etc. etc. etc. BUT when he did 's first testing,

her IgA, IgG and IgM were ALL very low, but since he was familiar only with IgA

Deficiency, that's the only thing he noticed and told us about. I'm grateful

he had the idea to test at all, of course, but he is not an immunologist!!

Hope that helps --

(mom to , age 6-1/2, dairy intolerant-related GERD -- currently

has polysaccharide antibody def, previously had transient IgG, IgA, t-cell &

other defs... and also to Kate, age 3( my " baby " !), more dairy intolerant but

very healthy!)

[Guest guest]

In a message dated 9/18/2005 2:11:17 PM Central Standard Time,

tripletsand1@... writes:

> We don't rely on our

> pediatrician for anything other than dealing with very minor issues

I agree. Our ped is wonderful, written up in Chicago magazine all the time as

one of the best peds, etc. etc. etc. BUT when he did 's first testing,

her IgA, IgG and IgM were ALL very low, but since he was familiar only with IgA

Deficiency, that's the only thing he noticed and told us about. I'm grateful

he had the idea to test at all, of course, but he is not an immunologist!!

Hope that helps --

(mom to , age 6-1/2, dairy intolerant-related GERD -- currently

has polysaccharide antibody def, previously had transient IgG, IgA, t-cell &

other defs... and also to Kate, age 3( my " baby " !), more dairy intolerant but

very healthy!)