Guest guest Posted February 14, 2010 Report Share Posted February 14, 2010 yes to heterogeneous but that would not mean anything in this situation because someone’s levels on tests could be way to low and there could STILL be too much of it entering neurons... That's interesting. I've just reached the conclusion that my son's calcium levels were too low. The authors are very careful to stress that autism is a heterogeneous condition - with a lot of individual variation. So they could have found this in just the sample they looked at, but it's different in others. Sue > > > > > basically too much calcium enters neurons (in autism), causing mitochondrial > > dysfunction. (and other bad things ...) > > > > > > Natasa > > > > > > > > > > [Attachment(s) <#TopText> from Sally Eva included below] > > > > Theresa Binstock posted this on ABMD and I saved it. I don't understand > > it. We need Natasa to explain > > Sally > > > > Altered calcium homeostasis in autism-spectrum disorders: > > evidence from biochemical and genetic studies of the > > mitochondrial aspartate/glutamate carrier AGC1 > > > > L Palmieri, V Papaleo, V Porcelli, P Scarcia, L Gaita, R Sacco, J Hager, > > F Rousseau, P Curatolo, B Manzi, R Militerni, C Bravaccio, S Trillo, > > C Schneider, R Melmed, M Elia, C Lenti, M Saccani, T Pascucci, > > S Puglisi-Allegra, K-L " Tiny " Reichelt and A M Persico > > > > Mol Psychiatry 15: 38-52; advance online publication, July 8, 2008; > > doi:10.1038/mp.2008.63 > > > > Abstract <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html> > > > > Full Text <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html> > > > > PDF <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf> > > > > Supplementary information > > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html> > > > > . > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 14, 2010 Report Share Posted February 14, 2010 yes to heterogeneous but that would not mean anything in this situation because someone’s levels on tests could be way to low and there could STILL be too much of it entering neurons... That's interesting. I've just reached the conclusion that my son's calcium levels were too low. The authors are very careful to stress that autism is a heterogeneous condition - with a lot of individual variation. So they could have found this in just the sample they looked at, but it's different in others. Sue > > > > > basically too much calcium enters neurons (in autism), causing mitochondrial > > dysfunction. (and other bad things ...) > > > > > > Natasa > > > > > > > > > > [Attachment(s) <#TopText> from Sally Eva included below] > > > > Theresa Binstock posted this on ABMD and I saved it. I don't understand > > it. We need Natasa to explain > > Sally > > > > Altered calcium homeostasis in autism-spectrum disorders: > > evidence from biochemical and genetic studies of the > > mitochondrial aspartate/glutamate carrier AGC1 > > > > L Palmieri, V Papaleo, V Porcelli, P Scarcia, L Gaita, R Sacco, J Hager, > > F Rousseau, P Curatolo, B Manzi, R Militerni, C Bravaccio, S Trillo, > > C Schneider, R Melmed, M Elia, C Lenti, M Saccani, T Pascucci, > > S Puglisi-Allegra, K-L " Tiny " Reichelt and A M Persico > > > > Mol Psychiatry 15: 38-52; advance online publication, July 8, 2008; > > doi:10.1038/mp.2008.63 > > > > Abstract <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html> > > > > Full Text <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html> > > > > PDF <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf> > > > > Supplementary information > > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html> > > > > . > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 14, 2010 Report Share Posted February 14, 2010 yes to heterogeneous but that would not mean anything in this situation because someone’s levels on tests could be way to low and there could STILL be too much of it entering neurons... That's interesting. I've just reached the conclusion that my son's calcium levels were too low. The authors are very careful to stress that autism is a heterogeneous condition - with a lot of individual variation. So they could have found this in just the sample they looked at, but it's different in others. Sue > > > > > basically too much calcium enters neurons (in autism), causing mitochondrial > > dysfunction. (and other bad things ...) > > > > > > Natasa > > > > > > > > > > [Attachment(s) <#TopText> from Sally Eva included below] > > > > Theresa Binstock posted this on ABMD and I saved it. I don't understand > > it. We need Natasa to explain > > Sally > > > > Altered calcium homeostasis in autism-spectrum disorders: > > evidence from biochemical and genetic studies of the > > mitochondrial aspartate/glutamate carrier AGC1 > > > > L Palmieri, V Papaleo, V Porcelli, P Scarcia, L Gaita, R Sacco, J Hager, > > F Rousseau, P Curatolo, B Manzi, R Militerni, C Bravaccio, S Trillo, > > C Schneider, R Melmed, M Elia, C Lenti, M Saccani, T Pascucci, > > S Puglisi-Allegra, K-L " Tiny " Reichelt and A M Persico > > > > Mol Psychiatry 15: 38-52; advance online publication, July 8, 2008; > > doi:10.1038/mp.2008.63 > > > > Abstract <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html> > > > > Full Text <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html> > > > > PDF <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf> > > > > Supplementary information > > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html> > > > > . > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 15, 2010 Report Share Posted February 15, 2010 Margaret, I feel the same way even when I follow up links I usually do not understand them and if I do I find another link that contradicts ! BUT I am lucky because of the dramatic stopping of the eye gouging by supplementing with calcium ! This also helped win my husband over which was also hugely important. When I start to doubt again I think about what must have been suffering and how easy it was to stop it but I do realise this was and still is very hit and miss for us. The other things we have tried have been slow improvements and so harder to hang on to. We also saw some definate positives with HBOT and juicing. Perhaps if there was a section on here with a profile of the child with test results and a list of any definite positives and in what area ? x Margaret wrote: > > Am I the only one who feels like giving up? I really would appreciate > an explanation rather than a set of links because I can't spend my > life following up everything.It would be helpful if every single > member of the list didn't have to reinvent the wheel for themselves - > information overload is destructive and we are all suffering from it. > I've got massive problems with my son't education and simply can't > follow up these links. In fact I have read so much contradictory > information here over the years and seen so many fads come and go that > it is hard to have any faith in anything that's posted here any more, > apart from the most simple biomed approaches which might help a bit. > What would be helpful are clear explanations in layman's terms,please. > Does anyone else remember the promises for TD DMPS. Where are all the > cures? > Margaret > > > > > > > > Lead-calcium interactions in cellular lead toxicity. > > > > > > > http://www.ncbi.nlm.nih.gov/pubmed/8247414?itool=EntrezSystem2.PEntrez.Pubmed.Pu\ bmed_ResultsPanel.Pubmed_RVDocSum & ordinalpos=8 > <http://www.ncbi.nlm.nih.gov/pubmed/8247414?itool=EntrezSystem2.PEntrez.Pubmed.P\ ubmed_ResultsPanel.Pubmed_RVDocSum & ordinalpos=8> > > <<Pb2+ disturbs intracellular Ca2+ homeostasis.>> > > > > Sally Eva schrieb: > > > [Attachment(s) <#TopText> from Sally Eva included below] > > > > > > Theresa Binstock posted this on ABMD and I saved it. I don't > understand > > > it. We need Natasa to explain > > > Sally > > > > > > Altered calcium homeostasis in autism-spectrum disorders: > > > evidence from biochemical and genetic studies of the > > > mitochondrial aspartate/glutamate carrier AGC1 > > > > > > L Palmieri, V Papaleo, V Porcelli, P Scarcia, L Gaita, R Sacco, J > Hager, > > > F Rousseau, P Curatolo, B Manzi, R Militerni, C Bravaccio, S Trillo, > > > C Schneider, R Melmed, M Elia, C Lenti, M Saccani, T Pascucci, > > > S Puglisi-Allegra, K-L " Tiny " Reichelt and A M Persico > > > > > > Mol Psychiatry 15: 38-52; advance online publication, July 8, 2008; > > > doi:10.1038/mp.2008.63 > > > > > > Abstract > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html> > > > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html>>> > > > > > > Full Text > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html> > > > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html>>> > > > > > > PDF <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf> > > > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf>>> > > > > > > Supplementary information > > > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html> > > > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html>>> > > > > > > . > > > > > > > > > ---------------------------------------------------------- > > > > > > > > > No virus found in this incoming message. > > > Checked by AVG - www.avg.com > > > Version: 8.5.435 / Virus Database: 271.1.1/2687 - Release Date: > 02/14/10 07:35:00 > > > > > > > > > > > ------------------------------------------------------------------------ > > > No virus found in this incoming message. > Checked by AVG - www.avg.com > Version: 8.5.435 / Virus Database: 271.1.1/2687 - Release Date: 02/14/10 07:35:00 > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 15, 2010 Report Share Posted February 15, 2010 Margaret, Sally posted a study by Binstock about : Altered calcium homeostasis in autism-spectrum disorders... It rang a bell with me and I looked up the relationship of calcium with 'lead'. I found 3 studies last night which I posted. ..All 3 articles I posted remarked on how 'lead' disrupts calcium metabolism. ('Lead' has no use in the body at all but calcium is super important. ) I suppose I should have said also that by clearing the 'lead' out, the calcium metabolism might return in the direction of normal. More than disrupting calcium metabolism, 'lead' seems to virtually mess up everything (depressing thyroid, depressing dopmine and acetylcholine) and it stresses out the body which alone would explain the adrenal exhaustion I centred on before Christmas. In any case, like the mercury, the 'lead' has got to be cleared out and then we can see what's left to do. I've got several studies showing that it is clearable with simple things like Vitamin B1. I haven't heard of any of the children reacting to B1 (I touched wood while writing this:-)) Mandi's got 'Benfotiamine' on stock which is a good B1 product. Margaret schrieb: > > Am I the only one who feels like giving up? I really would appreciate > an explanation rather than a set of links because I can't spend my > life following up everything.It would be helpful if every single > member of the list didn't have to reinvent the wheel for themselves - > information overload is destructive and we are all suffering from it. > I've got massive problems with my son't education and simply can't > follow up these links. In fact I have read so much contradictory > information here over the years and seen so many fads come and go that > it is hard to have any faith in anything that's posted here any more, > apart from the most simple biomed approaches which might help a bit. > What would be helpful are clear explanations in layman's terms,please. > Does anyone else remember the promises for TD DMPS. Where are all the > cures? > Margaret > > > > > > > > Lead-calcium interactions in cellular lead toxicity. > > > > > > > http://www.ncbi.nlm.nih.gov/pubmed/8247414?itool=EntrezSystem2.PEntrez.Pubmed.Pu\ bmed_ResultsPanel.Pubmed_RVDocSum & ordinalpos=8 > <http://www.ncbi.nlm.nih.gov/pubmed/8247414?itool=EntrezSystem2.PEntrez.Pubmed.P\ ubmed_ResultsPanel.Pubmed_RVDocSum & ordinalpos=8> > > <<Pb2+ disturbs intracellular Ca2+ homeostasis.>> > > > > Sally Eva schrieb: > > > [Attachment(s) <#TopText> from Sally Eva included below] > > > > > > Theresa Binstock posted this on ABMD and I saved it. I don't > understand > > > it. We need Natasa to explain > > > Sally > > > > > > Altered calcium homeostasis in autism-spectrum disorders: > > > evidence from biochemical and genetic studies of the > > > mitochondrial aspartate/glutamate carrier AGC1 > > > > > > L Palmieri, V Papaleo, V Porcelli, P Scarcia, L Gaita, R Sacco, J > Hager, > > > F Rousseau, P Curatolo, B Manzi, R Militerni, C Bravaccio, S Trillo, > > > C Schneider, R Melmed, M Elia, C Lenti, M Saccani, T Pascucci, > > > S Puglisi-Allegra, K-L " Tiny " Reichelt and A M Persico > > > > > > Mol Psychiatry 15: 38-52; advance online publication, July 8, 2008; > > > doi:10.1038/mp.2008.63 > > > > > > Abstract > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html> > > > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html>>> > > > > > > Full Text > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html> > > > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html>>> > > > > > > PDF <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf> > > > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf>>> > > > > > > Supplementary information > > > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html> > > > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html>>> > > > > > > . > > > > > > > > > ---------------------------------------------------------- > > > > > > > > > No virus found in this incoming message. > > > Checked by AVG - www.avg.com > > > Version: 8.5.435 / Virus Database: 271.1.1/2687 - Release Date: > 02/14/10 07:35:00 > > > > > > > > > > > ------------------------------------------------------------------------ > > > No virus found in this incoming message. > Checked by AVG - www.avg.com > Version: 8.5.435 / Virus Database: 271.1.1/2688 - Release Date: 02/14/10 19:35:00 > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 15, 2010 Report Share Posted February 15, 2010 we have been here before, yes many toxins interefere with calcium metabolism, if they are in there it would help if you clear them but there could be hundreds more left that do the same thing. Also things like emf radiation. Imo infections are crucial. You can clear all you like if central nervous system is infected both latent/sleeping and active infections will be causing calcium abnormalities and mito dysfunction etc. we have been down this road here so many times so not going to elaborate any more, try the archives if subject is of interest or http://autismcalciumchannelopathy.com/Infectious_Agents.html nx Margaret, Sally posted a study by Binstock about : Altered calcium homeostasis in autism-spectrum disorders... It rang a bell with me and I looked up the relationship of calcium with 'lead'. I found 3 studies last night which I posted. ..All 3 articles I posted remarked on how 'lead' disrupts calcium metabolism. ('Lead' has no use in the body at all but calcium is super important. ) I suppose I should have said also that by clearing the 'lead' out, the calcium metabolism might return in the direction of normal. More than disrupting calcium metabolism, 'lead' seems to virtually mess up everything (depressing thyroid, depressing dopmine and acetylcholine) and it stresses out the body which alone would explain the adrenal exhaustion I centred on before Christmas. In any case, like the mercury, the 'lead' has got to be cleared out and then we can see what's left to do. I've got several studies showing that it is clearable with simple things like Vitamin B1. I haven't heard of any of the children reacting to B1 (I touched wood while writing this:-)) Mandi's got 'Benfotiamine' on stock which is a good B1 product. Margaret schrieb: > > Am I the only one who feels like giving up? I really would appreciate > an explanation rather than a set of links because I can't spend my > life following up everything.It would be helpful if every single > member of the list didn't have to reinvent the wheel for themselves - > information overload is destructive and we are all suffering from it. > I've got massive problems with my son't education and simply can't > follow up these links. In fact I have read so much contradictory > information here over the years and seen so many fads come and go that > it is hard to have any faith in anything that's posted here any more, > apart from the most simple biomed approaches which might help a bit. > What would be helpful are clear explanations in layman's terms,please. > Does anyone else remember the promises for TD DMPS. Where are all the > cures? > Margaret > > > > > > > > Lead-calcium interactions in cellular lead toxicity. > > > > > > > http://www.ncbi.nlm.nih.gov/pubmed/8247414?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum & ordinalpos=8 > <http://www.ncbi.nlm.nih.gov/pubmed/8247414?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum & ordinalpos=8> > > <<Pb2+ disturbs intracellular Ca2+ homeostasis.>> > > > > Sally Eva schrieb: > > > [Attachment(s) <#TopText> from Sally Eva included below] > > > > > > Theresa Binstock posted this on ABMD and I saved it. I don't > understand > > > it. We need Natasa to explain > > > Sally > > > > > > Altered calcium homeostasis in autism-spectrum disorders: > > > evidence from biochemical and genetic studies of the > > > mitochondrial aspartate/glutamate carrier AGC1 > > > > > > L Palmieri, V Papaleo, V Porcelli, P Scarcia, L Gaita, R Sacco, J > Hager, > > > F Rousseau, P Curatolo, B Manzi, R Militerni, C Bravaccio, S Trillo, > > > C Schneider, R Melmed, M Elia, C Lenti, M Saccani, T Pascucci, > > > S Puglisi-Allegra, K-L " Tiny " Reichelt and A M Persico > > > > > > Mol Psychiatry 15: 38-52; advance online publication, July 8, 2008; > > > doi:10.1038/mp.2008.63 > > > > > > Abstract > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html> > > > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html>>> > > > > > > Full Text > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html> > > > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html>>> > > > > > > PDF <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf> > > > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf>>> > > > > > > Supplementary information > > > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html> > > > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html>>> > > > > > > . > > > > > > > > > ---------------------------------------------------------- > > > > > > > > > No virus found in this incoming message. > > > Checked by AVG - www.avg.com > > > Version: 8.5.435 / Virus Database: 271.1.1/2687 - Release Date: > 02/14/10 07:35:00 > > > > > > > > > > > ------------------------------------------------------------------------ > > > No virus found in this incoming message. > Checked by AVG - www.avg.com > Version: 8.5.435 / Virus Database: 271.1.1/2688 - Release Date: 02/14/10 19:35:00 > > ------------------------------------ DISCLAIMER No information contained in this post is to be construed as medical advice. If you need medical advice, please seek it from a suitably qualified practitioner. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 15, 2010 Report Share Posted February 15, 2010 'Lead' suppresses the immune system. No question by the experts on that point. So theoretically if you cleared 'lead', you could possibly go 'some way' to resurrecting the immune system so it can do it's job properly. You can stamp out the viral/bacterial fires with all the supplements we have stacked in our cupboards everytime they erupt or better would be to make sure the central sprinkling system is working so it can do the job for us. At least let's try and tackle this logically and go step-by-step and then see what's left to do So I would say, get rid of the stuff like 'lead' which has no business in the human body and then go from there.....getting rid of the 'lead' would also go some way in reducing the oxidative stress which would take some heat off the poor adrenal glands.....that can only be good:-)) All the kids seem to have a lot of lead......which reminds me, I need to investigate exactly how to ascertain best ways to test for it....In the old days, they used to look at the red blood called under a microscope and if they saw a few cells with black little dots, it was a positive sign. Its called punctuate basophilia or basophilic stippling. Neno/Natasa schrieb: > > > > we have been here before, yes many toxins interefere with calcium > metabolism, if they are in there it would help if you clear them > but there could be hundreds more left that do the same thing. Also > things like emf radiation. Imo infections are crucial. You can > clear all you like if central nervous system is infected both > latent/sleeping and active infections will be causing calcium > abnormalities and mito dysfunction etc. we have been down this > road here so many times so not going to elaborate any more, try > the archives if subject is of interest or > http://autismcalciumchannelopathy.com/Infectious_Agents.html > <http://autismcalciumchannelopathy.com/Infectious_Agents.html> > > nx > > > > > > Margaret, > > Sally posted a study by Binstock about : Altered calcium > homeostasis in autism-spectrum disorders... > > It rang a bell with me and I looked up the relationship of calcium > with > 'lead'. I found 3 studies last night which I posted. ..All 3 > articles I > posted remarked on how 'lead' disrupts calcium metabolism. ('Lead' > has > no use in the body at all but calcium is super important. ) > > I suppose I should have said also that by clearing the 'lead' out, > the > calcium metabolism might return in the direction of normal. More than > disrupting calcium metabolism, 'lead' seems to virtually mess up > everything (depressing thyroid, depressing dopmine and acetylcholine) > and it stresses out the body which alone would explain the adrenal > exhaustion I centred on before Christmas. > > In any case, like the mercury, the 'lead' has got to be cleared > out and > then we can see what's left to do. I've got several studies > showing that > it is clearable with simple things like Vitamin B1. I haven't > heard of > any of the children reacting to B1 (I touched wood while writing > this:-)) Mandi's got 'Benfotiamine' on stock which is a good B1 > product. > > > > > Margaret schrieb: > > > > Am I the only one who feels like giving up? I really would > appreciate > > an explanation rather than a set of links because I can't spend my > > life following up everything.It would be helpful if every single > > member of the list didn't have to reinvent the wheel for > themselves - > > information overload is destructive and we are all suffering from > it. > > I've got massive problems with my son't education and simply can't > > follow up these links. In fact I have read so much contradictory > > information here over the years and seen so many fads come and go > that > > it is hard to have any faith in anything that's posted here any > more, > > apart from the most simple biomed approaches which might help a bit. > > What would be helpful are clear explanations in layman's > terms,please. > > Does anyone else remember the promises for TD DMPS. Where are all > the > > cures? > > Margaret > > > > > > > > > > > > > Lead-calcium interactions in cellular lead toxicity. > > > > > > > > > > > http://www.ncbi.nlm.nih.gov/pubmed/8247414?itool=EntrezSystem2.PEntrez.Pubmed.Pu\ bmed_ResultsPanel.Pubmed_RVDocSum & ordinalpos=8 > <http://www.ncbi.nlm.nih.gov/pubmed/8247414?itool=EntrezSystem2.PEntrez.Pubmed.P\ ubmed_ResultsPanel.Pubmed_RVDocSum & ordinalpos=8> > > > <http://www.ncbi.nlm.nih.gov/pubmed/8247414?itool=EntrezSystem2.PEntrez.Pubmed.P\ ubmed_ResultsPanel.Pubmed_RVDocSum & ordinalpos=8> > <http://www.ncbi.nlm.nih.gov/pubmed/8247414?itool=EntrezSystem2.PEntrez.Pubmed.P\ ubmed_ResultsPanel.Pubmed_RVDocSum & ordinalpos=8> > > > <<Pb2+ disturbs intracellular Ca2+ homeostasis.>> > > > > > > Sally Eva schrieb: > > > > [Attachment(s) <#TopText> from Sally Eva included below] > > > > > > > > Theresa Binstock posted this on ABMD and I saved it. I don't > > understand > > > > it. We need Natasa to explain > > > > Sally > > > > > > > > Altered calcium homeostasis in autism-spectrum disorders: > > > > evidence from biochemical and genetic studies of the > > > > mitochondrial aspartate/glutamate carrier AGC1 > > > > > > > > L Palmieri, V Papaleo, V Porcelli, P Scarcia, L Gaita, R > Sacco, J > > Hager, > > > > F Rousseau, P Curatolo, B Manzi, R Militerni, C Bravaccio, S > Trillo, > > > > C Schneider, R Melmed, M Elia, C Lenti, M Saccani, T Pascucci, > > > > S Puglisi-Allegra, K-L " Tiny " Reichelt and A M Persico > > > > > > > > Mol Psychiatry 15: 38-52; advance online publication, July 8, > 2008; > > > > doi:10.1038/mp.2008.63 > > > > > > > > Abstract > > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html> > > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html> > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html> > > > > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html> > > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html> > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html>>> > > > > > > > > Full Text > > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html> > > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html> > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html> > > > > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html> > > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html> > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html>>> > > > > > > > > PDF > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf> > > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf> > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf> > > > > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf> > > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf> > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf>>> > > > > > > > > Supplementary information > > > > > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html> > > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html> > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html> > > > > > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html> > > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html> > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html>>> > > > > > > > > . > > > > > > > > > > > > ---------------------------------------------------------- > > > > > > > > > > > > No virus found in this incoming message. > > > > Checked by AVG - www.avg.com > > > > Version: 8.5.435 / Virus Database: 271.1.1/2687 - Release Date: > > 02/14/10 07:35:00 > > > > > > > > > > > > > > > > > ------------------------------------------------------------------------ > > > > > > No virus found in this incoming message. > > Checked by AVG - www.avg.com > > Version: 8.5.435 / Virus Database: 271.1.1/2688 - Release Date: > 02/14/10 19:35:00 > > > > > > > > > ------------------------------------ > > DISCLAIMER > No information contained in this post is to be construed as > medical advice. If you need medical advice, please seek it from a > suitably qualified practitioner. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 15, 2010 Report Share Posted February 15, 2010 Margaret, I think we all know how you are feeling. There have been many times I wanted to give up. There have been times when I just would just lie on my kitchen floor and cry. I allowed myself time to feel sorry for myself and then picked myself off the floor and looked for a new approach. Calcium is a tricky one. Yes we desperately need it, but too much can be bad as well. Some can metabolize it and some can't. For my son he can not tolerate supplemental calcium so I make sure I get as much calcium contain foods into him as I can. Some days are better than others. I used to worry a great deal about calcium, but what I have found is the natural sources have been sufficient for my son. If I was chelating I would be supplementing regardless due to the fact that the good and bad metals are being excreted. We have been GFCF plus Sara's diet for a year and one half so I depended on other sources of calcium. We have just now been experimenting with goat's cheese with some success. Calcium protects the bones and teeth from lead by inhibiting lead absorption. If there is a deficiency, lead can be absorbed and deposited in teeth and bones. The amino acid lysine is needed for calcium absorption. A diet high in protein, fat and or sugar affects the uptake of calcium. Oxalic acid (almonds, beet greens, cashews, chard, cocoa, kale, soybeans, spinach) can interfere with calcium absorption by binding with calcium in the intestines and producing insoluble salts that cannot be absorbed. However casual consumption should not pose a problem. Calcium supplements are more effective when taken in smaller doses throughout the day, and before bed. When taken at night, it promotes sound sleep. Several vitamin companies use D1-calcium-phosphate in their products but do not list it. This form of calcium is insoluble and interferes with absorption of other nutrients when taken with a multivitamin. Calcium citrate is best absorbed in an acidic environment, and usually our kids run more acidic than alkaline so this may be the best choice. But as you are well aware, all our kids are different so again it may not be the best choice for some. The thing to look for is if the supplement you are considering lists the "elemental calcium" content. This refers to the amount of calcium available for the body to absorb. I hope this helps and you find your way again. Never give up! Always follow your instinct. Sharon From: Margaret <m.collins9@...>Autism Treatment Sent: Mon, February 15, 2010 6:41:16 AMSubject: Re: Altered calcium homeostasis in autism-spectrum disorders: mitochondrial aspartate/glutamate carrier AGC1 Thank you . I am thinking I need to do a training as a nutritionist, but a course that is very careful to teach students about scientific method. It's so easy just to end up adding supplement after supplement with no clear idea how they all work together and how one should select doses. (I wish someone would come up with a horse pill that contains everything one would need while doing low and slow oral DMSA.)Margaret> > >> > >> > > Lead-calcium interactions in cellular lead toxicity.> > >> > >> > > > > http://www.ncbi. nlm.nih.gov/ pubmed/8247414? itool=EntrezSyst em2.PEntrez. Pubmed.Pubmed_ ResultsPanel. Pubmed_RVDocSum & ordinalpos= 8 > > <http://www.ncbi. nlm.nih.gov/ pubmed/8247414? itool=EntrezSyst em2.PEntrez. Pubmed.Pubmed_ ResultsPanel. Pubmed_RVDocSum & ordinalpos= 8>> > > <<Pb2+ disturbs intracellular Ca2+ homeostasis. >>> > >> > > Sally Eva schrieb:> > > > [Attachment( s) <#TopText> from Sally Eva included below]> > > >> > > > Theresa Binstock posted this on ABMD and I saved it. I don't > > understand> > > > it. We need Natasa to explain> > > > Sally> > > >> > > > Altered calcium homeostasis in autism-spectrum disorders:> > > > evidence from biochemical and genetic studies of the> > > > mitochondrial aspartate/glutamate carrier AGC1> > > >> > > > L Palmieri, V Papaleo, V Porcelli, P Scarcia, L Gaita, R Sacco, J > > Hager,> > > > F Rousseau, P Curatolo, B Manzi, R Militerni, C Bravaccio, S Trillo,> > > > C Schneider, R Melmed, M Elia, C Lenti, M Saccani, T Pascucci,> > > > S Puglisi-Allegra, K-L "Tiny" Reichelt and A M Persico> > > >> > > > Mol Psychiatry 15: 38-52; advance online publication, July 8, 2008;> > > > doi:10.1038/ mp.2008.63> > > >> > > > Abstract > > <http://www.nature. com/mp/journal/ v15/n1/abs/ mp200863a. html > > <http://www.nature. com/mp/journal/ v15/n1/abs/ mp200863a. html>> > > > <http://www.nature. com/mp/journal/ v15/n1/abs/ mp200863a. html > > <http://www.nature. com/mp/journal/ v15/n1/abs/ mp200863a. html>>>> > > >> > > > Full Text > > <http://www.nature. com/mp/journal/ v15/n1/full/ mp200863a. html > > <http://www.nature. com/mp/journal/ v15/n1/full/ mp200863a. html>> > > > <http://www.nature. com/mp/journal/ v15/n1/full/ mp200863a. html > > <http://www.nature. com/mp/journal/ v15/n1/full/ mp200863a. html>>>> > > >> > > > PDF <http://www.nature. com/mp/journal/ v15/n1/pdf/ mp200863a. pdf > > <http://www.nature. com/mp/journal/ v15/n1/pdf/ mp200863a. pdf>> > > > <http://www.nature. com/mp/journal/ v15/n1/pdf/ mp200863a. pdf > > <http://www.nature. com/mp/journal/ v15/n1/pdf/ mp200863a. pdf>>>> > > >> > > > Supplementary information> > > > <http://www.nature. com/mp/journal/ v15/n1/suppinfo/ mp200863s1. html > > <http://www.nature. com/mp/journal/ v15/n1/suppinfo/ mp200863s1. html>> > > > <http://www.nature. com/mp/journal/ v15/n1/suppinfo/ mp200863s1. html > > <http://www.nature. com/mp/journal/ v15/n1/suppinfo/ mp200863s1. html>>>> > > >> > > > .> > > >> > > >> > > > ------------ --------- --------- --------- --------- --------- -> > > >> > > >> > > > No virus found in this incoming message.> > > > Checked by AVG - www.avg.com> > > > Version: 8.5.435 / Virus Database: 271.1.1/2687 - Release Date: > > 02/14/10 07:35:00> > > >> > > >> > >> >> > > > ------------ --------- --------- --------- --------- --------- -> >> >> > No virus found in this incoming message.> > Checked by AVG - www.avg.com > > Version: 8.5.435 / Virus Database: 271.1.1/2688 - Release Date: 02/14/10 19:35:00> >> >> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 15, 2010 Report Share Posted February 15, 2010 According to what I have read so far, lead (pb) is definately disturbing the calcium metabolism. I agree it might make sense to supp with calcium to stop the introduction of lead but time and time again, we have seen so many problems with this so we have to re-think. I think the thing to do as you suggest is to prevent the introduction of lead but with something other than calcium (at least for the kids who can't tolerate it well) at the same time it is being cleared. I have downloaded lots of studies and am going through everything peu a peu to see how to do this...... Low vitamin D however definately does not help. It seems to be associated with higher blood lead. I need some time to read everything so that I have a better idea of what's going on. :-) Sue schrieb: > > But you can't assume that it's lead that's causing the problem - can > you? Unless of course you know lead levels are high. Poor thyroid > function, low vitamin D, low melatonin, poor absorption will all > depress available calcium levels. Some of these could be genetic and > lead might have nothing to do with it. I'd address calcium first, > because it's preferentially absorbed by the gut and will inhibit > decalcification of bones and teeth that might introduce stored lead > into the system and is cheap and easy. > > Sue > > > > > > > > > > > > > > > > > Lead-calcium interactions in cellular lead toxicity. > > > > > > > > > > > > > > > > > > > > http://www.ncbi.nlm.nih.gov/pubmed/8247414?itool=EntrezSystem2.PEntrez.Pubmed.Pu\ bmed_ResultsPanel.Pubmed_RVDocSum & ordinalpos=8 > <http://www.ncbi.nlm.nih.gov/pubmed/8247414?itool=EntrezSystem2.PEntrez.Pubmed.P\ ubmed_ResultsPanel.Pubmed_RVDocSum & ordinalpos=8> > > > > <http://www.ncbi.nlm.nih.gov/pubmed/8247414?itool=EntrezSystem2.PEntrez.Pubmed.P\ ubmed_ResultsPanel.Pubmed_RVDocSum & ordinalpos=8 > <http://www.ncbi.nlm.nih.gov/pubmed/8247414?itool=EntrezSystem2.PEntrez.Pubmed.P\ ubmed_ResultsPanel.Pubmed_RVDocSum & ordinalpos=8>> > > > > > > > > <http://www.ncbi.nlm.nih.gov/pubmed/8247414?itool=EntrezSystem2.PEntrez.Pubmed.P\ ubmed_ResultsPanel.Pubmed_RVDocSum & ordinalpos=8 > <http://www.ncbi.nlm.nih.gov/pubmed/8247414?itool=EntrezSystem2.PEntrez.Pubmed.P\ ubmed_ResultsPanel.Pubmed_RVDocSum & ordinalpos=8>> > > > > <http://www.ncbi.nlm.nih.gov/pubmed/8247414?itool=EntrezSystem2.PEntrez.Pubmed.P\ ubmed_ResultsPanel.Pubmed_RVDocSum & ordinalpos=8 > <http://www.ncbi.nlm.nih.gov/pubmed/8247414?itool=EntrezSystem2.PEntrez.Pubmed.P\ ubmed_ResultsPanel.Pubmed_RVDocSum & ordinalpos=8>> > > > > > <<Pb2+ disturbs intracellular Ca2+ homeostasis.>> > > > > > > > > > > Sally Eva schrieb: > > > > > > [Attachment(s) <#TopText> from Sally Eva included below] > > > > > > > > > > > > Theresa Binstock posted this on ABMD and I saved it. I don't > > > > understand > > > > > > it. We need Natasa to explain > > > > > > Sally > > > > > > > > > > > > Altered calcium homeostasis in autism-spectrum disorders: > > > > > > evidence from biochemical and genetic studies of the > > > > > > mitochondrial aspartate/glutamate carrier AGC1 > > > > > > > > > > > > L Palmieri, V Papaleo, V Porcelli, P Scarcia, L Gaita, R > > > Sacco, J > > > > Hager, > > > > > > F Rousseau, P Curatolo, B Manzi, R Militerni, C Bravaccio, S > > > Trillo, > > > > > > C Schneider, R Melmed, M Elia, C Lenti, M Saccani, T Pascucci, > > > > > > S Puglisi-Allegra, K-L " Tiny " Reichelt and A M Persico > > > > > > > > > > > > Mol Psychiatry 15: 38-52; advance online publication, July 8, > > > 2008; > > > > > > doi:10.1038/mp.2008.63 > > > > > > > > > > > > Abstract > > > > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html> > > > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html>> > > > > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html>> > > > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html>> > > > > > > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html> > > > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html>> > > > > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html>> > > > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html>>>> > > > > > > > > > > > > Full Text > > > > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html> > > > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html>> > > > > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html>> > > > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html>> > > > > > > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html> > > > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html>> > > > > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html>> > > > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html>>>> > > > > > > > > > > > > PDF > > > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf> > > > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf>> > > > > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf>> > > > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf>> > > > > > > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf> > > > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf>> > > > > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf>> > > > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf>>>> > > > > > > > > > > > > Supplementary information > > > > > > > > > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html> > > > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html>> > > > > > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html>> > > > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html>> > > > > > > > > > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html> > > > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html>> > > > > > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html>> > > > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html>>>> > > > > > > > > > > > > . > > > > > > > > > > > > > > > > > > ---------------------------------------------------------- > > > > > > > > > > > > > > > > > > No virus found in this incoming message. > > > > > > Checked by AVG - www.avg.com > > > > > > Version: 8.5.435 / Virus Database: 271.1.1/2687 - Release Date: > > > > 02/14/10 07:35:00 > > > > > > > > > > > > > > > > > > > > > > > > > > > > > ---------------------------------------------------------- > > > > > > > > > > > > No virus found in this incoming message. > > > > Checked by AVG - www.avg.com > > > > Version: 8.5.435 / Virus Database: 271.1.1/2688 - Release Date: > > > 02/14/10 19:35:00 > > > > > > > > > > > > > > > > > > > > > > > ------------------------------------ > > > > > > DISCLAIMER > > > No information contained in this post is to be construed as > > > medical advice. If you need medical advice, please seek it from a > > > suitably qualified practitioner. > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 15, 2010 Report Share Posted February 15, 2010 According to what I have read so far, lead (pb) is definately disturbing the calcium metabolism. I agree it might make sense to supp with calcium to stop the introduction of lead but time and time again, we have seen so many problems with this so we have to re-think. I think the thing to do as you suggest is to prevent the introduction of lead but with something other than calcium (at least for the kids who can't tolerate it well) at the same time it is being cleared. I have downloaded lots of studies and am going through everything peu a peu to see how to do this...... Low vitamin D however definately does not help. It seems to be associated with higher blood lead. I need some time to read everything so that I have a better idea of what's going on. :-) Sue schrieb: > > But you can't assume that it's lead that's causing the problem - can > you? Unless of course you know lead levels are high. Poor thyroid > function, low vitamin D, low melatonin, poor absorption will all > depress available calcium levels. Some of these could be genetic and > lead might have nothing to do with it. I'd address calcium first, > because it's preferentially absorbed by the gut and will inhibit > decalcification of bones and teeth that might introduce stored lead > into the system and is cheap and easy. > > Sue > > > > > > > > > > > > > > > > > Lead-calcium interactions in cellular lead toxicity. > > > > > > > > > > > > > > > > > > > > http://www.ncbi.nlm.nih.gov/pubmed/8247414?itool=EntrezSystem2.PEntrez.Pubmed.Pu\ bmed_ResultsPanel.Pubmed_RVDocSum & ordinalpos=8 > <http://www.ncbi.nlm.nih.gov/pubmed/8247414?itool=EntrezSystem2.PEntrez.Pubmed.P\ ubmed_ResultsPanel.Pubmed_RVDocSum & ordinalpos=8> > > > > <http://www.ncbi.nlm.nih.gov/pubmed/8247414?itool=EntrezSystem2.PEntrez.Pubmed.P\ ubmed_ResultsPanel.Pubmed_RVDocSum & ordinalpos=8 > <http://www.ncbi.nlm.nih.gov/pubmed/8247414?itool=EntrezSystem2.PEntrez.Pubmed.P\ ubmed_ResultsPanel.Pubmed_RVDocSum & ordinalpos=8>> > > > > > > > > <http://www.ncbi.nlm.nih.gov/pubmed/8247414?itool=EntrezSystem2.PEntrez.Pubmed.P\ ubmed_ResultsPanel.Pubmed_RVDocSum & ordinalpos=8 > <http://www.ncbi.nlm.nih.gov/pubmed/8247414?itool=EntrezSystem2.PEntrez.Pubmed.P\ ubmed_ResultsPanel.Pubmed_RVDocSum & ordinalpos=8>> > > > > <http://www.ncbi.nlm.nih.gov/pubmed/8247414?itool=EntrezSystem2.PEntrez.Pubmed.P\ ubmed_ResultsPanel.Pubmed_RVDocSum & ordinalpos=8 > <http://www.ncbi.nlm.nih.gov/pubmed/8247414?itool=EntrezSystem2.PEntrez.Pubmed.P\ ubmed_ResultsPanel.Pubmed_RVDocSum & ordinalpos=8>> > > > > > <<Pb2+ disturbs intracellular Ca2+ homeostasis.>> > > > > > > > > > > Sally Eva schrieb: > > > > > > [Attachment(s) <#TopText> from Sally Eva included below] > > > > > > > > > > > > Theresa Binstock posted this on ABMD and I saved it. I don't > > > > understand > > > > > > it. We need Natasa to explain > > > > > > Sally > > > > > > > > > > > > Altered calcium homeostasis in autism-spectrum disorders: > > > > > > evidence from biochemical and genetic studies of the > > > > > > mitochondrial aspartate/glutamate carrier AGC1 > > > > > > > > > > > > L Palmieri, V Papaleo, V Porcelli, P Scarcia, L Gaita, R > > > Sacco, J > > > > Hager, > > > > > > F Rousseau, P Curatolo, B Manzi, R Militerni, C Bravaccio, S > > > Trillo, > > > > > > C Schneider, R Melmed, M Elia, C Lenti, M Saccani, T Pascucci, > > > > > > S Puglisi-Allegra, K-L " Tiny " Reichelt and A M Persico > > > > > > > > > > > > Mol Psychiatry 15: 38-52; advance online publication, July 8, > > > 2008; > > > > > > doi:10.1038/mp.2008.63 > > > > > > > > > > > > Abstract > > > > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html> > > > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html>> > > > > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html>> > > > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html>> > > > > > > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html> > > > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html>> > > > > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html>> > > > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html>>>> > > > > > > > > > > > > Full Text > > > > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html> > > > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html>> > > > > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html>> > > > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html>> > > > > > > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html> > > > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html>> > > > > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html>> > > > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html>>>> > > > > > > > > > > > > PDF > > > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf> > > > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf>> > > > > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf>> > > > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf>> > > > > > > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf> > > > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf>> > > > > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf>> > > > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf>>>> > > > > > > > > > > > > Supplementary information > > > > > > > > > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html> > > > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html>> > > > > > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html>> > > > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html>> > > > > > > > > > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html> > > > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html>> > > > > > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html>> > > > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html>>>> > > > > > > > > > > > > . > > > > > > > > > > > > > > > > > > ---------------------------------------------------------- > > > > > > > > > > > > > > > > > > No virus found in this incoming message. > > > > > > Checked by AVG - www.avg.com > > > > > > Version: 8.5.435 / Virus Database: 271.1.1/2687 - Release Date: > > > > 02/14/10 07:35:00 > > > > > > > > > > > > > > > > > > > > > > > > > > > > > ---------------------------------------------------------- > > > > > > > > > > > > No virus found in this incoming message. > > > > Checked by AVG - www.avg.com > > > > Version: 8.5.435 / Virus Database: 271.1.1/2688 - Release Date: > > > 02/14/10 19:35:00 > > > > > > > > > > > > > > > > > > > > > > > ------------------------------------ > > > > > > DISCLAIMER > > > No information contained in this post is to be construed as > > > medical advice. If you need medical advice, please seek it from a > > > suitably qualified practitioner. > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 15, 2010 Report Share Posted February 15, 2010 yes it does but so do many other things. you cannot automatically assume it is lead in individual kids According to what I have read so far, lead (pb) is definately disturbing the calcium metabolism. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 15, 2010 Report Share Posted February 15, 2010 'Lead' is definately causing calcium dysregulation. At least according to the studies I posted......and I have a lot of other studies downloaded to support this. I never said it was the only thing causing 'the problem', at least I don't think I ever said that. I have suggested that we get the 'lead' out as it's not supposed to be in the body anyway and has no use whatsoever as far as I've read.. It seems to be causing a lot of problems, left, right and center and raises a lot of flags IMO as far as autism is concerned. If we can get the 'lead' out of the way, making sure re-entry is prevented, we can see what's what and go from there. I am thinking about this as a process of elimination. Neno/Natasa schrieb: > > > yes it does but so do many other things. > > you cannot automatically assume it is lead in individual kids > > > > > > According to what I have read so far, lead (pb) is definately > disturbing > the calcium metabolism. > > > ------------------------------------------------------------------------ > > > No virus found in this incoming message. > Checked by AVG - www.avg.com > Version: 8.5.435 / Virus Database: 271.1.1/2689 - Release Date: 02/15/10 07:35:00 > > Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.