a crucial question ....................... Statin Trials, Cholesterol

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forwarding.....

After the Vioxx scandal new clinical research regulations have come into force. Trials that begin enrolment of patients after 1 July 2005 must register before their start in a recognised trials registry to be considered for publication and they must be published within 90 days after the ending regardless of whether the results are positive, negative or inconclusive. Curiously, almost all of the major trials that have been published since then have failed. How can we explain the discrepancy between the the older positive trials and the negative recent ones? This is a crucial question put by the French researcher and THINCS member Michel de Lorgeril in this paper:

http://www.jstage.jst.go.jp/article/jln/19/1/65/_pdf

Uffe Ravnskov

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