An amazing discovery!

[Guest guest]

I hope it isn't just me, because I sincerely hope this will be of value to all of you who continue to suffer from the horrible lingering effects of statin poisoning. But in just a week I've started feeling like a new person! It may depend on an individual's body chemistry and just what side effects were brought on by the drug, but if my experience is anything to go by, then this may be at least a very major part of the answer we've all been seeking. I must explain first however, that I mentioned this particular supplement back when I first joined this group, because at the time I thought it was helping me a lot in some ways, although not at all with some other problems brought on by the Lipitor. Now I think I understand why. Let me explain briefly that what I didn't know back then was that the Lipitor had triggered celiac disease, which at that time was not yet diagnosed. Now I scrupulously avoid anything

with the merest trace of wheat, so that problem is under control. Not cured, but at least I know how to avoid those particular symptoms. Getting back to the supplement, I had an acquaintance several years ago who convinced me to try glyconutrients, which some authorities were touting as a cure-all, and naturally you know what kind of scrutiny that brought upon the companies who were manufacturing and selling them. But while my GI problems weren't helped when I gave it a try, my muscle pain and weakness were, as were the ADD symptoms. But I got tired of being pressured to try more and more of this particular line of products, and since I entertained the thought--the hope--that my body might be healing on its own, I finally decided to stop taking the rather expensive products. I continued to feel better for a while until the celiac became full-blown, and I'm convinced if I hadn't finally been properly diagnosed when I

finally was--two years ago-- I probably wouldn't have survived much longer, as by that time I had lost about a quarter of my total body weight, and I was absorbing hardly any nutrition at all from the food I ate. Recently I got to wondering if it was only the celiac that had started my downturn, or if going off the glyconutrients might have also been a factor. In fact, what if going off them had something to do with the onset of the celiac disease, for which I'd been set up by the Lipitor?The brand I used back then got into trouble for their marketing practices (which also was a major reason why I stopped taking them), so I went looking for another good brand and then I placed my ordera couple of weeks ago. Well, after just a week of taking them, I'm starting to get some energy and stamina like I haven't had in years! I've been taking CoQ10 for a long time and a few months ago I added D-Ribose. Neither comes close to making the

difference this stuff has in just one week. So this evening I googled statins and glyconutrients, and to my amazement, it seems Dr. Graveline had already discovered them. I guess I haven't been going to his website as often as I should have, or I might have saved myself a lot of pain and misery. I don't know just when he posted the relevant material, but he confirmed my belief that the relief I'm noticing now isn't just a coincidence! I'm not going to mention the brand I'm using, but if anyone wants to email me privately, I'll be glad to answer. I'm sure there are other good brands out there, but if you want to do it on your own, try to find one that is referenced by some of the more respected alternative medicine authorities. Here are two of Dr. Graveline's postings on his website regarding glyconutrients: Statins & Glyconutrients For the past five years I have been talking about the importance of the mevalonate pathway and the inevitable problems to come from inhibition of this vital biochemical complex especially at its very beginning. Think of the mevalonate pathway as a tree with multiple branches and then think of the effect of our statins drugs as "girding" this tree at the base, in our misguided efforts to block cholesterol. Our pharmaceutical industry threw caution to the wind 15 years ago when our national priority to lower cholesterol so fogged our minds that we (medical, pharmaceutical and the food industry) focused just on the cholesterol branch of the mevalonate pathway and completely disregarded the important consequences of collateral damage to the other main branches of our tree from our statin drugs. The predictable result of all this has been our bizarre spectrum of statin associated side effects ranging from cognitive, to myotoxic,

neurotoxic, neurodegenerative and even behavioral. When our powerful statins cut our cholesterol 50%, our CoQ10 is also likely to be cut a similar amount and therein lay the problem, for CoQ10 has vital roles in energy production, cell wall integrity and mitochondrial anti-oxidation, all of which leads to the enormous variety of symptoms and problems we now are seeing. And what about another major branch of the mevalonate tree, that of dolichol? Recently I have learned much about the vital role of dolichols and it is time to share it with you. I have been talking of the consequences of statin associated dolichol inhibition for years now, calling attention to the importance of this substance in neuropeptide formation and our feelings of thought, sensation and emotion. More recently, I have pointed at dolichol inhibition as a possible cause of our statin associated behavioral side effects, such as irritability, hostility and depression, while

wondering how, with so few proteins, such amazing subtlety of emotion could be created. Now, however, I have learned that along with peptide assembly within the endoplasmic reticulum of every cell is the process of sacharride attachment. It is here in the heart of every cell that our saccharides (sugars) are attached to proteins to give a far broader range of diversity and information transfer than protein alone. This process is called glycosylation and it demands a ready supply of dolichol. No longer do we consider our sugars as just simple fuel. The effects of these eight vital sugars on the resulting peptide structure being created in the endoplasmic reticulum and companion piece, the Golgi apparatus, is just short of miraculous. And this attachment of sugars, this glycosylation, is completely dependent on dolichol's orchestration. Throw in a statin and what do you have - an inevitable inhibition of dolichol (roughly comparable to the degree of

cholesterol inhibition). The resulting effect upon our body of this dolichol theft is completely unpredictable for this is at the very center of cell communication and immunodefense. Dolichols may well be fully as important as CoQ10 in this unfortunate game of statin roulette that Big Pharma has placed us in. Statin damage is often additive to pre-existing impairment of glycolysis from aging, disease and poor nutrition. Glyconutrients, now increasingly available as a source of these vital sugars, may offer hope to thousands of statin damaged victims to help the body repair the effects of impaired glycolysis. It is much too early to talk of proof of effect for studies are only now in the planning stage. However, based upon my six years of research, I have an intuitive feeling of success and anxiously look forward to the results. Duane Graveline MD MPHFormer USAF Flight SurgeonFormer NASA AstronautRetired Family Doctor ----------------------------------------------------- Management Of Statin DamageDuane Graveline MD MPH Directing our attention to those already presenting with statin associated damage of whatever kind, I recommend stopping the statin and robust CoQ10 supplementation. CoQ10 has no maximum allowable dose, so progressive dosage elevations to 1500mg daily may be reasonable for a period of time to observe for response. The addition of Acetyl-L-carnitine and selenium must be considered for persistent muscle pain and weakness. These recommendations are based upon known mechanisms of action of statin drugs and results of recent research. A possible means to compensate for dolichol inhibition has recently been identified. Study of the effect of statins on dolichols and the process of glycosylation has revealed the possibility that glyconutrient supplementation may help restore normal operation of damaged

glycolytic pathways. Studies designed to evaluate possible benefits of this are just getting under way. Once validated, glyconutrient supplementation may become an effective treatment for statin damage unresponsive to other measures. No other specific therapies are in sight at this time. References: 1) Shovman. Immunol Res 25(3)2002.2) Meske. Eur J Neurosci 17, 2003.3) Pfrieger. Science 9 Nov, 2001.4) Muldoon. Am J Med 108(7), 2000. 5) Mooseman. Lancet 363, 2004.6) Hilgendorph. Internat J Clin Pharm and Therapeut 41(9), 2003. -----

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