Re: Gut and Individual Replies to All

[Guest guest]

,

Thanks for the info on the small intestine. I started to ask you to check

with the GI next time, but - duh! - here is the information highway at my

fingertips. If anyone is interested, check out this site that I found.

http://www.whfoods.com/genpage.php?tname=faq & dbid=16 If you scroll way down

on the page, there is a figure that actually gives an animation on

when/where the food goes. It looks like a pretty good explanation of the

whole digestive process.

I think that your idea of trying to correlate the gut issues is excellent.

I don't think I would be of much help as Sam has never had significant

problems in that area, at least since he has been on IVIG (now SubQ).

I will say that prior to his diagnosis and the Ig treatment, he had some

chronic problems with his stool. It was almost as if he always stayed at

the transitional stage that babies go through when their poop is kind of

green and slimy with weird yellow cottage cheese looking chunks and VERY

smelly. (Sorry, but a good description is sometimes necessary, even if it

is gross.) Usually it will solidify and normalize within a couple or three

weeks. Sam's never did. He often produced bizarre poop and had unexplained

diarrheas quite often. He didn't seem to suffer any gut pain with it, but

it was not normal. Oh yeah. And it seemed to be very acidic. He had the

saddest little bottom. It would blister if I didn't catch it within 5

minutes. When I expressed concern to the ped I was using at the time, she

would just say, " Oh, it's just transitional. He'll grow out of it. " I

don't think he grew out of it. I suspect that the IVIG corrected the

problem. Keep in mind that with his diagnosis - X-linked Hyper IgM

Syndrome - he has negligible IgA & IgG. Subclasses are not even an issue.

Before the treatment, he didn't have detectible IgG.

After his initial diagnosis, for a short while I assumed that the weird poop

was because of his lack of IgA. But then it cleared up and I felt that it

was because of the Ig replacement that it self-corrected. Sam has never had

a problem with it since then. I figured that the lack of IgA was not the

culprit, as it is unlikely there is enough of it in the IVIG treatments to

make much of a difference (though we're thankful for all we can get, since

he has never reacted negatively to them and tested negative for the IgA

antibody).

Although this does not speak much to your child's problem with constipation,

it does indicate some level of gut involvement.

Now I'm curious. Has any other Hyper IgM child had that problem prior to

IVIG treatment?

God bless,

Wenoka (AMY - 10 / Sam - 8, Hyper IgM, Sensory Integration Disorder,

Seizure Disorder / Christi - 4)

[Guest guest]

In a message dated 1/12/2005 9:59:16 PM Central Standard Time,

dietdoc@... writes:

> studying Ig4 subclass deficiency

FYI, had Ig4 subclass def and at that time the immuno said that

basically they didn't really know what Ig4 subclass did, so they felt it was not

a

significant finding.

Also FYI, she's never had any specific, cultured gut bug like c.diff or

giardia, she just gets all the gastro infections that are going around. She's

been

cultured for a few things a few times and everything.

Wow, I admire your ability to catch up with that very detailed response with

replies to so many people!! You must be the cut-and-paste goddess -- I'd be

blind from it!

(mom to , age 5-1/2, dairy intolerant-related GERD -- currently

has polysaccharide antibody def, previously had transient IgG, IgA, t-cell &

other defs... and also to Kate, born 9/19/02, dairy intolerant)

[Guest guest]

My immuno said the same thing.

Anyone else's child with Ig4 subclass deficiency and gut issues? Feel free to

write me directly. I am trying to wrap my head around this stuff.

bunneegirl@... wrote:

In a message dated 1/12/2005 9:59:16 PM Central Standard Time,

dietdoc@... writes:

> studying Ig4 subclass deficiency

FYI, had Ig4 subclass def and at that time the immuno said that

basically they didn't really know what Ig4 subclass did, so they felt it was not

a

significant finding.

Also FYI, she's never had any specific, cultured gut bug like c.diff or

giardia, she just gets all the gastro infections that are going around. She's

been

cultured for a few things a few times and everything.

Wow, I admire your ability to catch up with that very detailed response with

replies to so many people!! You must be the cut-and-paste goddess -- I'd be

blind from it!

(mom to , age 5-1/2, dairy intolerant-related GERD -- currently

has polysaccharide antibody def, previously had transient IgG, IgA, t-cell &

other defs... and also to Kate, born 9/19/02, dairy intolerant)

[Guest guest]

My immuno said the same thing.

Anyone else's child with Ig4 subclass deficiency and gut issues? Feel free to

write me directly. I am trying to wrap my head around this stuff.

bunneegirl@... wrote:

In a message dated 1/12/2005 9:59:16 PM Central Standard Time,

dietdoc@... writes:

> studying Ig4 subclass deficiency

FYI, had Ig4 subclass def and at that time the immuno said that

basically they didn't really know what Ig4 subclass did, so they felt it was not

a

significant finding.

Also FYI, she's never had any specific, cultured gut bug like c.diff or

giardia, she just gets all the gastro infections that are going around. She's

been

cultured for a few things a few times and everything.

Wow, I admire your ability to catch up with that very detailed response with

replies to so many people!! You must be the cut-and-paste goddess -- I'd be

blind from it!

(mom to , age 5-1/2, dairy intolerant-related GERD -- currently

has polysaccharide antibody def, previously had transient IgG, IgA, t-cell &

other defs... and also to Kate, born 9/19/02, dairy intolerant)

[Guest guest]

" After his initial diagnosis, for a short while I assumed that the weird poop

was because of his lack of IgA. But then it cleared up and I felt that it

was because of the Ig replacement that it self-corrected...I figured that the

lack of IgA was not the culprit... "

We were told that my daughter relapsed with a gut infection due to IgA

deficiency...probably to get us to stop trying to find answers...it gets on our

doc's nerves. BUT, when the immuno finally cranked up the IVIG, her GI

infection went away! I totally agree with you and once read that IgG, given in

large doses, can diffuse across the membranes and do the work of IgA.

" If anyone is interested, check out this site that I found. "

Loved it! The immune system-colon connection seems so obvious at this site.

Most of the micro-organisms reside in the colon! So, of course many of our guys

suffer from having those " helpful " bugs/microflora out of wack, undiagnosed food

allergies making a mess of the mucosa, etc.... and causing constipation,

diarrhea, vulnerabilities to gastro bugs, among other things... Just a

thought.

(mom to la, low everything and gut/colon problems under

investigation).

One reason food stays longer in the large intestine may be that the large

intestine is capable of generating nutrients from food. The food that makes it

into the large intestine is primarily fiber, and the large intestine contains an

ecosystem of bacteria that can ferment much of this fiber, producing many

nutrients necessary for the health of the colon cells. Colonic fermentation also

produces a series of short-chain fatty acids, including proprionate, acetate,

and butyrate, which are required for healthy colonic cell growth and have many

other health promoting functions in your body.

The friendly bacteria that are responsible for the primary amount of healthy

colonic fermentation are called the probiotics (pro-life) and include the

Bifidobacteria and Lactobaccillus genuses. Along with providing beneficial

fermentation products, probiotic bacteria keep pathogenic, or disease-promoting

bacteria, from colonizing your colon. Certain fibers in food, called prebiotics,

specifically support these probiotic bacteria. Prebiotics include such molecules

as inulin and fructooligosaccharides, which are found in chicory and Jerusalem

artichoke, and may include some other carbohydrates such as

galactooligosaccharides, arabinogalactans, and arabinoxylans, which are found in

soy and rice fibers, and in larch tree extracts.

Wenoka & <yhwhworship@...> wrote:

,

Thanks for the info on the small intestine. I started to ask you to check

with the GI next time, but - duh! - here is the information highway at my

fingertips. If anyone is interested, check out this site that I found.

http://www.whfoods.com/genpage.php?tname=faq & dbid=16 If you scroll way down

on the page, there is a figure that actually gives an animation on

when/where the food goes. It looks like a pretty good explanation of the

whole digestive process.

I think that your idea of trying to correlate the gut issues is excellent.

I don't think I would be of much help as Sam has never had significant

problems in that area, at least since he has been on IVIG (now SubQ).

I will say that prior to his diagnosis and the Ig treatment, he had some

chronic problems with his stool. It was almost as if he always stayed at

the transitional stage that babies go through when their poop is kind of

green and slimy with weird yellow cottage cheese looking chunks and VERY

smelly. (Sorry, but a good description is sometimes necessary, even if it

is gross.) Usually it will solidify and normalize within a couple or three

weeks. Sam's never did. He often produced bizarre poop and had unexplained

diarrheas quite often. He didn't seem to suffer any gut pain with it, but

it was not normal. Oh yeah. And it seemed to be very acidic. He had the

saddest little bottom. It would blister if I didn't catch it within 5

minutes. When I expressed concern to the ped I was using at the time, she

would just say, " Oh, it's just transitional. He'll grow out of it. " I

don't think he grew out of it. I suspect that the IVIG corrected the

problem. Keep in mind that with his diagnosis - X-linked Hyper IgM

Syndrome - he has negligible IgA & IgG. Subclasses are not even an issue.

Before the treatment, he didn't have detectible IgG.

After his initial diagnosis, for a short while I assumed that the weird poop

was because of his lack of IgA. But then it cleared up and I felt that it

was because of the Ig replacement that it self-corrected. Sam has never had

a problem with it since then. I figured that the lack of IgA was not the

culprit, as it is unlikely there is enough of it in the IVIG treatments to

make much of a difference (though we're thankful for all we can get, since

he has never reacted negatively to them and tested negative for the IgA

antibody).

Although this does not speak much to your child's problem with constipation,

it does indicate some level of gut involvement.

Now I'm curious. Has any other Hyper IgM child had that problem prior to

IVIG treatment?

God bless,

Wenoka (AMY - 10 / Sam - 8, Hyper IgM, Sensory Integration Disorder,

Seizure Disorder / Christi - 4)

This forum is open to parents and caregivers of children diagnosed with a

Primary Immune Deficiency. Opinions or medical advice stated here are the sole

responsibility of the poster and should not be taken as professional advice.

To unsubscribe -unsubscribegroups (DOT)

To search group archives go to: /messages

[Guest guest]

-

A while back, Dale did a whole post on why PID kids have gut problems -

might be worth you going back over to find it.

Dayna

Re: Gut and Individual Replies to All

" After his initial diagnosis, for a short while I assumed that the weird

poop

was because of his lack of IgA. But then it cleared up and I felt that

it

was because of the Ig replacement that it self-corrected...I figured

that the lack of IgA was not the culprit... "

We were told that my daughter relapsed with a gut infection due to IgA

deficiency...probably to get us to stop trying to find answers...it gets

on our doc's nerves. BUT, when the immuno finally cranked up the IVIG,

her GI infection went away! I totally agree with you and once read that

IgG, given in large doses, can diffuse across the membranes and do the

work of IgA.

" If anyone is interested, check out this site that I found. "

Loved it! The immune system-colon connection seems so obvious at this

site. Most of the micro-organisms reside in the colon! So, of course

many of our guys suffer from having those " helpful " bugs/microflora out

of wack, undiagnosed food allergies making a mess of the mucosa, etc....

and causing constipation, diarrhea, vulnerabilities to gastro bugs,

among other things... Just a thought.

(mom to la, low everything and gut/colon problems under

investigation).

One reason food stays longer in the large intestine may be that the

large intestine is capable of generating nutrients from food. The food

that makes it into the large intestine is primarily fiber, and the large

intestine contains an ecosystem of bacteria that can ferment much of

this fiber, producing many nutrients necessary for the health of the

colon cells. Colonic fermentation also produces a series of short-chain

fatty acids, including proprionate, acetate, and butyrate, which are

required for healthy colonic cell growth and have many other health

promoting functions in your body.

The friendly bacteria that are responsible for the primary amount of

healthy colonic fermentation are called the probiotics (pro-life) and

include the Bifidobacteria and Lactobaccillus genuses. Along with

providing beneficial fermentation products, probiotic bacteria keep

pathogenic, or disease-promoting bacteria, from colonizing your colon.

Certain fibers in food, called prebiotics, specifically support these

probiotic bacteria. Prebiotics include such molecules as inulin and

fructooligosaccharides, which are found in chicory and Jerusalem

artichoke, and may include some other carbohydrates such as

galactooligosaccharides, arabinogalactans, and arabinoxylans, which are

found in soy and rice fibers, and in larch tree extracts.

Wenoka & <yhwhworship@...> wrote:

,

Thanks for the info on the small intestine. I started to ask you to

check

with the GI next time, but - duh! - here is the information highway at

my

fingertips. If anyone is interested, check out this site that I found.

http://www.whfoods.com/genpage.php?tname=faq & dbid=16 If you scroll way

down

on the page, there is a figure that actually gives an animation on

when/where the food goes. It looks like a pretty good explanation of the

whole digestive process.

I think that your idea of trying to correlate the gut issues is

excellent.

I don't think I would be of much help as Sam has never had significant

problems in that area, at least since he has been on IVIG (now SubQ).

I will say that prior to his diagnosis and the Ig treatment, he had some

chronic problems with his stool. It was almost as if he always stayed at

the transitional stage that babies go through when their poop is kind of

green and slimy with weird yellow cottage cheese looking chunks and VERY

smelly. (Sorry, but a good description is sometimes necessary, even if

it

is gross.) Usually it will solidify and normalize within a couple or

three

weeks. Sam's never did. He often produced bizarre poop and had

unexplained

diarrheas quite often. He didn't seem to suffer any gut pain with it,

but

it was not normal. Oh yeah. And it seemed to be very acidic. He had the

saddest little bottom. It would blister if I didn't catch it within 5

minutes. When I expressed concern to the ped I was using at the time,

she

would just say, " Oh, it's just transitional. He'll grow out of it. " I

don't think he grew out of it. I suspect that the IVIG corrected the

problem. Keep in mind that with his diagnosis - X-linked Hyper IgM

Syndrome - he has negligible IgA & IgG. Subclasses are not even an

issue.

Before the treatment, he didn't have detectible IgG.

After his initial diagnosis, for a short while I assumed that the weird

poop

was because of his lack of IgA. But then it cleared up and I felt that

it

was because of the Ig replacement that it self-corrected. Sam has never

had

a problem with it since then. I figured that the lack of IgA was not the

culprit, as it is unlikely there is enough of it in the IVIG treatments

to

make much of a difference (though we're thankful for all we can get,

since

he has never reacted negatively to them and tested negative for the IgA

antibody).

Although this does not speak much to your child's problem with

constipation,

it does indicate some level of gut involvement.

Now I'm curious. Has any other Hyper IgM child had that problem prior to

IVIG treatment?

God bless,

Wenoka (AMY - 10 / Sam - 8, Hyper IgM, Sensory Integration Disorder,

Seizure Disorder / Christi - 4)

This forum is open to parents and caregivers of children diagnosed with

a Primary Immune Deficiency. Opinions or medical advice stated here are

the sole responsibility of the poster and should not be taken as

professional advice.

To unsubscribe -unsubscribegroups (DOT)

To search group archives go to:

/messages

[Guest guest]

-

A while back, Dale did a whole post on why PID kids have gut problems -

might be worth you going back over to find it.

Dayna

Re: Gut and Individual Replies to All

" After his initial diagnosis, for a short while I assumed that the weird

poop

was because of his lack of IgA. But then it cleared up and I felt that

it

was because of the Ig replacement that it self-corrected...I figured

that the lack of IgA was not the culprit... "

We were told that my daughter relapsed with a gut infection due to IgA

deficiency...probably to get us to stop trying to find answers...it gets

on our doc's nerves. BUT, when the immuno finally cranked up the IVIG,

her GI infection went away! I totally agree with you and once read that

IgG, given in large doses, can diffuse across the membranes and do the

work of IgA.

" If anyone is interested, check out this site that I found. "

Loved it! The immune system-colon connection seems so obvious at this

site. Most of the micro-organisms reside in the colon! So, of course

many of our guys suffer from having those " helpful " bugs/microflora out

of wack, undiagnosed food allergies making a mess of the mucosa, etc....

and causing constipation, diarrhea, vulnerabilities to gastro bugs,

among other things... Just a thought.

(mom to la, low everything and gut/colon problems under

investigation).

One reason food stays longer in the large intestine may be that the

large intestine is capable of generating nutrients from food. The food

that makes it into the large intestine is primarily fiber, and the large

intestine contains an ecosystem of bacteria that can ferment much of

this fiber, producing many nutrients necessary for the health of the

colon cells. Colonic fermentation also produces a series of short-chain

fatty acids, including proprionate, acetate, and butyrate, which are

required for healthy colonic cell growth and have many other health

promoting functions in your body.

The friendly bacteria that are responsible for the primary amount of

healthy colonic fermentation are called the probiotics (pro-life) and

include the Bifidobacteria and Lactobaccillus genuses. Along with

providing beneficial fermentation products, probiotic bacteria keep

pathogenic, or disease-promoting bacteria, from colonizing your colon.

Certain fibers in food, called prebiotics, specifically support these

probiotic bacteria. Prebiotics include such molecules as inulin and

fructooligosaccharides, which are found in chicory and Jerusalem

artichoke, and may include some other carbohydrates such as

galactooligosaccharides, arabinogalactans, and arabinoxylans, which are

found in soy and rice fibers, and in larch tree extracts.

Wenoka & <yhwhworship@...> wrote:

,

Thanks for the info on the small intestine. I started to ask you to

check

with the GI next time, but - duh! - here is the information highway at

my

fingertips. If anyone is interested, check out this site that I found.

http://www.whfoods.com/genpage.php?tname=faq & dbid=16 If you scroll way

down

on the page, there is a figure that actually gives an animation on

when/where the food goes. It looks like a pretty good explanation of the

whole digestive process.

I think that your idea of trying to correlate the gut issues is

excellent.

I don't think I would be of much help as Sam has never had significant

problems in that area, at least since he has been on IVIG (now SubQ).

I will say that prior to his diagnosis and the Ig treatment, he had some

chronic problems with his stool. It was almost as if he always stayed at

the transitional stage that babies go through when their poop is kind of

green and slimy with weird yellow cottage cheese looking chunks and VERY

smelly. (Sorry, but a good description is sometimes necessary, even if

it

is gross.) Usually it will solidify and normalize within a couple or

three

weeks. Sam's never did. He often produced bizarre poop and had

unexplained

diarrheas quite often. He didn't seem to suffer any gut pain with it,

but

it was not normal. Oh yeah. And it seemed to be very acidic. He had the

saddest little bottom. It would blister if I didn't catch it within 5

minutes. When I expressed concern to the ped I was using at the time,

she

would just say, " Oh, it's just transitional. He'll grow out of it. " I

don't think he grew out of it. I suspect that the IVIG corrected the

problem. Keep in mind that with his diagnosis - X-linked Hyper IgM

Syndrome - he has negligible IgA & IgG. Subclasses are not even an

issue.

Before the treatment, he didn't have detectible IgG.

After his initial diagnosis, for a short while I assumed that the weird

poop

was because of his lack of IgA. But then it cleared up and I felt that

it

was because of the Ig replacement that it self-corrected. Sam has never

had

a problem with it since then. I figured that the lack of IgA was not the

culprit, as it is unlikely there is enough of it in the IVIG treatments

to

make much of a difference (though we're thankful for all we can get,

since

he has never reacted negatively to them and tested negative for the IgA

antibody).

Although this does not speak much to your child's problem with

constipation,

it does indicate some level of gut involvement.

Now I'm curious. Has any other Hyper IgM child had that problem prior to

IVIG treatment?

God bless,

Wenoka (AMY - 10 / Sam - 8, Hyper IgM, Sensory Integration Disorder,

Seizure Disorder / Christi - 4)

This forum is open to parents and caregivers of children diagnosed with

a Primary Immune Deficiency. Opinions or medical advice stated here are

the sole responsibility of the poster and should not be taken as

professional advice.

To unsubscribe -unsubscribegroups (DOT)

To search group archives go to:

/messages

[Guest guest]

" Dale did a whole post on why PID kids have gut problems "

Wonderful. I will search for it shortly!

fladfam <fladfam@...> wrote:

-

A while back, Dale did a whole post on why PID kids have gut problems -

might be worth you going back over to find it.

Dayna

Re: Gut and Individual Replies to All

" After his initial diagnosis, for a short while I assumed that the weird

poop

was because of his lack of IgA. But then it cleared up and I felt that

it

was because of the Ig replacement that it self-corrected...I figured

that the lack of IgA was not the culprit... "

We were told that my daughter relapsed with a gut infection due to IgA

deficiency...probably to get us to stop trying to find answers...it gets

on our doc's nerves. BUT, when the immuno finally cranked up the IVIG,

her GI infection went away! I totally agree with you and once read that

IgG, given in large doses, can diffuse across the membranes and do the

work of IgA.

" If anyone is interested, check out this site that I found. "

Loved it! The immune system-colon connection seems so obvious at this

site. Most of the micro-organisms reside in the colon! So, of course

many of our guys suffer from having those " helpful " bugs/microflora out

of wack, undiagnosed food allergies making a mess of the mucosa, etc....

and causing constipation, diarrhea, vulnerabilities to gastro bugs,

among other things... Just a thought.

(mom to la, low everything and gut/colon problems under

investigation).

One reason food stays longer in the large intestine may be that the

large intestine is capable of generating nutrients from food. The food

that makes it into the large intestine is primarily fiber, and the large

intestine contains an ecosystem of bacteria that can ferment much of

this fiber, producing many nutrients necessary for the health of the

colon cells. Colonic fermentation also produces a series of short-chain

fatty acids, including proprionate, acetate, and butyrate, which are

required for healthy colonic cell growth and have many other health

promoting functions in your body.

The friendly bacteria that are responsible for the primary amount of

healthy colonic fermentation are called the probiotics (pro-life) and

include the Bifidobacteria and Lactobaccillus genuses. Along with

providing beneficial fermentation products, probiotic bacteria keep

pathogenic, or disease-promoting bacteria, from colonizing your colon.

Certain fibers in food, called prebiotics, specifically support these

probiotic bacteria. Prebiotics include such molecules as inulin and

fructooligosaccharides, which are found in chicory and Jerusalem

artichoke, and may include some other carbohydrates such as

galactooligosaccharides, arabinogalactans, and arabinoxylans, which are

found in soy and rice fibers, and in larch tree extracts.

Wenoka & <yhwhworship@...> wrote:

,

Thanks for the info on the small intestine. I started to ask you to

check

with the GI next time, but - duh! - here is the information highway at

my

fingertips. If anyone is interested, check out this site that I found.

http://www.whfoods.com/genpage.php?tname=faq & dbid=16 If you scroll way

down

on the page, there is a figure that actually gives an animation on

when/where the food goes. It looks like a pretty good explanation of the

whole digestive process.

I think that your idea of trying to correlate the gut issues is

excellent.

I don't think I would be of much help as Sam has never had significant

problems in that area, at least since he has been on IVIG (now SubQ).

I will say that prior to his diagnosis and the Ig treatment, he had some

chronic problems with his stool. It was almost as if he always stayed at

the transitional stage that babies go through when their poop is kind of

green and slimy with weird yellow cottage cheese looking chunks and VERY

smelly. (Sorry, but a good description is sometimes necessary, even if

it

is gross.) Usually it will solidify and normalize within a couple or

three

weeks. Sam's never did. He often produced bizarre poop and had

unexplained

diarrheas quite often. He didn't seem to suffer any gut pain with it,

but

it was not normal. Oh yeah. And it seemed to be very acidic. He had the

saddest little bottom. It would blister if I didn't catch it within 5

minutes. When I expressed concern to the ped I was using at the time,

she

would just say, " Oh, it's just transitional. He'll grow out of it. " I

don't think he grew out of it. I suspect that the IVIG corrected the

problem. Keep in mind that with his diagnosis - X-linked Hyper IgM

Syndrome - he has negligible IgA & IgG. Subclasses are not even an

issue.

Before the treatment, he didn't have detectible IgG.

After his initial diagnosis, for a short while I assumed that the weird

poop

was because of his lack of IgA. But then it cleared up and I felt that

it

was because of the Ig replacement that it self-corrected. Sam has never

had

a problem with it since then. I figured that the lack of IgA was not the

culprit, as it is unlikely there is enough of it in the IVIG treatments

to

make much of a difference (though we're thankful for all we can get,

since

he has never reacted negatively to them and tested negative for the IgA

antibody).

Although this does not speak much to your child's problem with

constipation,

it does indicate some level of gut involvement.

Now I'm curious. Has any other Hyper IgM child had that problem prior to

IVIG treatment?

God bless,

Wenoka (AMY - 10 / Sam - 8, Hyper IgM, Sensory Integration Disorder,

Seizure Disorder / Christi - 4)

This forum is open to parents and caregivers of children diagnosed with

a Primary Immune Deficiency. Opinions or medical advice stated here are

the sole responsibility of the poster and should not be taken as

professional advice.

To unsubscribe -unsubscribegroups (DOT)

To search group archives go to:

/messages

[Guest guest]

" Dale did a whole post on why PID kids have gut problems "

Wonderful. I will search for it shortly!

fladfam <fladfam@...> wrote:

-

A while back, Dale did a whole post on why PID kids have gut problems -

might be worth you going back over to find it.

Dayna

Re: Gut and Individual Replies to All

" After his initial diagnosis, for a short while I assumed that the weird

poop

was because of his lack of IgA. But then it cleared up and I felt that

it

was because of the Ig replacement that it self-corrected...I figured

that the lack of IgA was not the culprit... "

We were told that my daughter relapsed with a gut infection due to IgA

deficiency...probably to get us to stop trying to find answers...it gets

on our doc's nerves. BUT, when the immuno finally cranked up the IVIG,

her GI infection went away! I totally agree with you and once read that

IgG, given in large doses, can diffuse across the membranes and do the

work of IgA.

" If anyone is interested, check out this site that I found. "

Loved it! The immune system-colon connection seems so obvious at this

site. Most of the micro-organisms reside in the colon! So, of course

many of our guys suffer from having those " helpful " bugs/microflora out

of wack, undiagnosed food allergies making a mess of the mucosa, etc....

and causing constipation, diarrhea, vulnerabilities to gastro bugs,

among other things... Just a thought.

(mom to la, low everything and gut/colon problems under

investigation).

One reason food stays longer in the large intestine may be that the

large intestine is capable of generating nutrients from food. The food

that makes it into the large intestine is primarily fiber, and the large

intestine contains an ecosystem of bacteria that can ferment much of

this fiber, producing many nutrients necessary for the health of the

colon cells. Colonic fermentation also produces a series of short-chain

fatty acids, including proprionate, acetate, and butyrate, which are

required for healthy colonic cell growth and have many other health

promoting functions in your body.

The friendly bacteria that are responsible for the primary amount of

healthy colonic fermentation are called the probiotics (pro-life) and

include the Bifidobacteria and Lactobaccillus genuses. Along with

providing beneficial fermentation products, probiotic bacteria keep

pathogenic, or disease-promoting bacteria, from colonizing your colon.

Certain fibers in food, called prebiotics, specifically support these

probiotic bacteria. Prebiotics include such molecules as inulin and

fructooligosaccharides, which are found in chicory and Jerusalem

artichoke, and may include some other carbohydrates such as

galactooligosaccharides, arabinogalactans, and arabinoxylans, which are

found in soy and rice fibers, and in larch tree extracts.

Wenoka & <yhwhworship@...> wrote:

,

Thanks for the info on the small intestine. I started to ask you to

check

with the GI next time, but - duh! - here is the information highway at

my

fingertips. If anyone is interested, check out this site that I found.

http://www.whfoods.com/genpage.php?tname=faq & dbid=16 If you scroll way

down

on the page, there is a figure that actually gives an animation on

when/where the food goes. It looks like a pretty good explanation of the

whole digestive process.

I think that your idea of trying to correlate the gut issues is

excellent.

I don't think I would be of much help as Sam has never had significant

problems in that area, at least since he has been on IVIG (now SubQ).

I will say that prior to his diagnosis and the Ig treatment, he had some

chronic problems with his stool. It was almost as if he always stayed at

the transitional stage that babies go through when their poop is kind of

green and slimy with weird yellow cottage cheese looking chunks and VERY

smelly. (Sorry, but a good description is sometimes necessary, even if

it

is gross.) Usually it will solidify and normalize within a couple or

three

weeks. Sam's never did. He often produced bizarre poop and had

unexplained

diarrheas quite often. He didn't seem to suffer any gut pain with it,

but

it was not normal. Oh yeah. And it seemed to be very acidic. He had the

saddest little bottom. It would blister if I didn't catch it within 5

minutes. When I expressed concern to the ped I was using at the time,

she

would just say, " Oh, it's just transitional. He'll grow out of it. " I

don't think he grew out of it. I suspect that the IVIG corrected the

problem. Keep in mind that with his diagnosis - X-linked Hyper IgM

Syndrome - he has negligible IgA & IgG. Subclasses are not even an

issue.

Before the treatment, he didn't have detectible IgG.

After his initial diagnosis, for a short while I assumed that the weird

poop

was because of his lack of IgA. But then it cleared up and I felt that

it

was because of the Ig replacement that it self-corrected. Sam has never

had

a problem with it since then. I figured that the lack of IgA was not the

culprit, as it is unlikely there is enough of it in the IVIG treatments

to

make much of a difference (though we're thankful for all we can get,

since

he has never reacted negatively to them and tested negative for the IgA

antibody).

Although this does not speak much to your child's problem with

constipation,

it does indicate some level of gut involvement.

Now I'm curious. Has any other Hyper IgM child had that problem prior to

IVIG treatment?

God bless,

Wenoka (AMY - 10 / Sam - 8, Hyper IgM, Sensory Integration Disorder,

Seizure Disorder / Christi - 4)

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a Primary Immune Deficiency. Opinions or medical advice stated here are

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