Re: Statins & Glyconutrients

[Guest guest]

Dr Graveline's office called yesterday and wanted to know if hubbywanted to be in a study for this. they picked 20 people. as I asked if I could post the request for the study and they did not want me to. the guy that called said so far they have had good results withthis, all the pains that all feel after taking a statin Is gone, with memoryback. I will have to check into this some more. but from the way they talked this is good stuff and would help with the diabetic's as well. so willkeep you all posted on what is going on.JudyinMO Statins & GlyconutrientsStatins & Glyconutrientshttp://www.spacedoc.net/statins_glyconutrients.html For the past five years I have been talking about the importance of the mevalonate pathway and the inevitable problems to come from inhibition of this vital biochemical complex especially at its very beginning. Think of the mevalonate pathway as a tree with multiple branches and then think of the effect of our statins drugs as “girding†this tree at the base, in our misguided efforts to block cholesterol. Our pharmaceutical industry threw caution to the wind 15 years ago when our national priority to lower cholesterol so fogged our minds that we (medical, pharmaceutical and the food industry) focused just on the cholesterol branch of the mevalonate pathway and completely disregarded the important consequences of collateral damage to the other main branches of our tree from our statin drugs. The predictable result of all this has been our bizarre spectrum of statin associated side effects ranging from cognitive, to myotoxic, neurotoxic, neurodegenerative and even behavioral. When our powerful statins cut our cholesterol 50%, our CoQ10 is also likely to be cut a similar amount and therein lay the problem, for CoQ10 has vital roles in energy production, cell wall integrity and mitochondrial anti-oxidation, all of which leads to the enormous variety of symptoms and problems we now are seeing.And what about another major branch of the mevalonate tree, that of dolichol? Recently I have learned much about the vital role of dolichols and it is time to share it with you. I have been talking of the consequences of statin associated dolichol inhibition for years now, calling attention to the importance of this substance in neuropeptide formation and our feelings of thought, sensation and emotion. More recently, I have pointed at dolichol inhibition as a possible cause of our statin associated behavioral side effects, such as irritability, hostility and depression, while wondering how, with so few proteins, such amazing subtlety of emotion could be created. Now, however, I have learned that along with peptide assembly within the endoplasmic reticulum of every cell is the process of sacharride attachment. It is here in the heart of every cell that our sacharrides (sugars) are attached to proteins to give a far broader range of diversity and information transfer than protein alone. This process is called glycosylation and it demands a ready supply of dolichol. No longer do we consider our sugars as just simple fuel. The effects of these eight vital sugars on the resulting peptide structure being created in the endoplasmic reticulum and companion piece, the Golgi apparatus, is just short of miraculous. And this attachment of sugars, this glycosylation, is completely dependent on dolichol’s orchestration. Throw in a statin and what do you have – an inevitable inhibition of dolichol (roughly comparable to the degree of cholesterol inhibition). The resulting effect upon our body of this dolichol theft is completely unpredictable for this is at the very center of cell communication and immunodefense. Dolichols may well be fully as important as CoQ10 in this unfortunate game of statin roulette that Big Pharma has placed us in. Statin damage is often additive to pre-existing impairment of glycolysis from aging, disease and poor nutrition. Glyconutrients, now increasingly available as a source of these vital sugars, may offer hope to thousands of statin damaged victims to help the body repair the effects of impaired glycolysis. It is much too early to talk of proof of effect for studies are only now in the planning stage. However, based upon my six years of research, I have an intuitive feeling of success and anxiously look forward to the results.Duane Graveline MD MPHFormer USAF Flight SurgeonFormer NASA AstronautRetired Family Doctor

[Guest guest]

Dr Graveline's office called yesterday and wanted to know if hubbywanted to be in a study for this. they picked 20 people. as I asked if I could post the request for the study and they did not want me to. the guy that called said so far they have had good results withthis, all the pains that all feel after taking a statin Is gone, with memoryback. I will have to check into this some more. but from the way they talked this is good stuff and would help with the diabetic's as well. so willkeep you all posted on what is going on.JudyinMO Statins & GlyconutrientsStatins & Glyconutrientshttp://www.spacedoc.net/statins_glyconutrients.html For the past five years I have been talking about the importance of the mevalonate pathway and the inevitable problems to come from inhibition of this vital biochemical complex especially at its very beginning. Think of the mevalonate pathway as a tree with multiple branches and then think of the effect of our statins drugs as “girding†this tree at the base, in our misguided efforts to block cholesterol. Our pharmaceutical industry threw caution to the wind 15 years ago when our national priority to lower cholesterol so fogged our minds that we (medical, pharmaceutical and the food industry) focused just on the cholesterol branch of the mevalonate pathway and completely disregarded the important consequences of collateral damage to the other main branches of our tree from our statin drugs. The predictable result of all this has been our bizarre spectrum of statin associated side effects ranging from cognitive, to myotoxic, neurotoxic, neurodegenerative and even behavioral. When our powerful statins cut our cholesterol 50%, our CoQ10 is also likely to be cut a similar amount and therein lay the problem, for CoQ10 has vital roles in energy production, cell wall integrity and mitochondrial anti-oxidation, all of which leads to the enormous variety of symptoms and problems we now are seeing.And what about another major branch of the mevalonate tree, that of dolichol? Recently I have learned much about the vital role of dolichols and it is time to share it with you. I have been talking of the consequences of statin associated dolichol inhibition for years now, calling attention to the importance of this substance in neuropeptide formation and our feelings of thought, sensation and emotion. More recently, I have pointed at dolichol inhibition as a possible cause of our statin associated behavioral side effects, such as irritability, hostility and depression, while wondering how, with so few proteins, such amazing subtlety of emotion could be created. Now, however, I have learned that along with peptide assembly within the endoplasmic reticulum of every cell is the process of sacharride attachment. It is here in the heart of every cell that our sacharrides (sugars) are attached to proteins to give a far broader range of diversity and information transfer than protein alone. This process is called glycosylation and it demands a ready supply of dolichol. No longer do we consider our sugars as just simple fuel. The effects of these eight vital sugars on the resulting peptide structure being created in the endoplasmic reticulum and companion piece, the Golgi apparatus, is just short of miraculous. And this attachment of sugars, this glycosylation, is completely dependent on dolichol’s orchestration. Throw in a statin and what do you have – an inevitable inhibition of dolichol (roughly comparable to the degree of cholesterol inhibition). The resulting effect upon our body of this dolichol theft is completely unpredictable for this is at the very center of cell communication and immunodefense. Dolichols may well be fully as important as CoQ10 in this unfortunate game of statin roulette that Big Pharma has placed us in. Statin damage is often additive to pre-existing impairment of glycolysis from aging, disease and poor nutrition. Glyconutrients, now increasingly available as a source of these vital sugars, may offer hope to thousands of statin damaged victims to help the body repair the effects of impaired glycolysis. It is much too early to talk of proof of effect for studies are only now in the planning stage. However, based upon my six years of research, I have an intuitive feeling of success and anxiously look forward to the results.Duane Graveline MD MPHFormer USAF Flight SurgeonFormer NASA AstronautRetired Family Doctor

[Guest guest]

surpriseshan2@... wrote:

>

> *Statins & Glyconutrients***

> http://www.spacedoc.net/statins_glyconutrients.html

>

>

> For the past five years I have been talking about the importance of the

> *mevalonate pathway* and the inevitable problems to come from inhibition

> of this vital biochemical complex especially at its very beginning.

>

> Think of the mevalonate pathway as a tree with multiple branches and

> then think of the effect of our *statins drugs as “girding†this tree at

> the base,* in our misguided efforts to block cholesterol.

>

> Our pharmaceutical industry threw caution to the wind 15 years ago when

> our national priority to lower cholesterol so fogged our minds that we

> (medical, pharmaceutical and the food industry) focused just on the

> cholesterol branch of the mevalonate pathway and completely disregarded

> the important consequences of collateral damage to the other main

> branches of our tree from our statin drugs.

>

> The predictable result of all this has been our bizarre spectrum of

> *statin associated side effects ranging from *cognitive, to myotoxic,

> neurotoxic, neurodegenerative and even behavioral.

>

> When our powerful statins cut our cholesterol 50%, our CoQ10 is also

> likely to be cut a similar amount and therein lay the problem, for*

> CoQ10 has vital roles in energy production, cell wall integrity and

> mitochondrial anti-oxidation*, all of which leads to the enormous

> variety of symptoms and problems we now are seeing.

>

> And what about another major branch of the mevalonate tree, that of

> *dolichol*? Recently I have learned much about the vital role of

> dolichols and it is time to share it with you. I have been talking of

> the consequences of statin associated dolichol inhibition for years now,

> calling attention to the importance of this substance in neuropeptide

> formation and our feelings of thought, sensation and emotion. More

> recently, I have pointed at dolichol inhibition as a possible cause of

> our statin associated behavioral side effects, such as irritability,

> hostility and depression, while wondering how, with so few proteins,

> such amazing subtlety of emotion could be created.

>

> Now, however, I have learned that along with peptide assembly within the

> endoplasmic reticulum of every cell is the process of sacharride

> attachment. It is here in the heart of every cell that our sacharrides

> (sugars) are attached to proteins to give a far broader range of

> diversity and information transfer than protein alone. This process is

> called glycosylation and it demands a ready supply of dolichol.

>

> No longer do we consider our sugars as just simple fuel. The effects of

> these eight vital sugars on the resulting peptide structure being

> created in the endoplasmic reticulum and companion piece, the Golgi

> apparatus, is just short of miraculous. And this attachment of sugars,

> this glycosylation, is completely dependent on dolichol’s orchestration.

> Throw in a statin and what do you have – an inevitable inhibition of

> dolichol (roughly comparable to the degree of cholesterol inhibition).

> The resulting effect upon our body of this dolichol theft is completely

> unpredictable for this is at the very center of cell communication and

> immunodefense.

>

> *Dolichols may well be fully as important as CoQ10 *in this unfortunate

> game of statin roulette that Big Pharma has placed us in. Statin damage

> is often additive to pre-existing impairment of glycolysis from aging,

> disease and poor nutrition. Glyconutrients, now increasingly available

> as a source of these vital sugars, may offer hope to thousands of statin

> damaged victims to *help the body repair the effects of impaired

> glycolysis.* It is much too early to talk of proof of effect for studies

> are only now in the planning stage. However, based upon my six years of

> research, I have an intuitive feeling of success and anxiously look

> forward to the results.

>

> Duane Graveline MD MPH

> Former USAF Flight Surgeon

> Former NASA Astronaut

> Retired Family Doctor

I've been aware of dolichol for quite some time but never found any information

of supplementation of even if supplementation is effective.

--

Steve - dudescholar3@...

Take World's Smallest Political Quiz at

http://www.theadvocates.org/quiz.html

" If a thousand old beliefs were ruined on our march

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[Guest guest]

They probably do not want a RUSH on this study was the reason they asked not to publicize the study. QUESTION: Does Lipitor actually cause some memory loss? I've heard about the bone and muscle reactions but not the memory thingy. Please advise because about 6-months ago I started finding myself "Searching" for the right words to say things....totally not like me. Thanks, =========================================================================LARRY FOSTER

<jaf11@...> wrote:  Dr Graveline's office called yesterday and wanted to know if hubby wanted to be in a study for this. they picked 20 people. as I asked if I could post the request for the study and they did not want me to. the guy that called said so far they have had good results with this, all the pains that all feel after taking a statin Is gone, with memory back. I will have to check into this some more. but from the way they talked this is good stuff and would help with the diabetic's as well. so will keep you all posted on what is going on. JudyinMO Statins & Glyconutrients Statins & Glyconutrientshttp://www.spacedoc.net/statins_glyconutrients.html For the past five years I have been talking about the importance of the mevalonate pathway and the inevitable problems to come from inhibition of this vital biochemical complex especially at its very beginning. Think of the mevalonate pathway as a tree with multiple branches and then think of the effect of

our statins drugs as “girding†this tree at the base, in our misguided efforts to block cholesterol. Our pharmaceutical industry threw caution to the wind 15 years ago when our national priority to lower cholesterol so fogged our minds that we (medical, pharmaceutical and the food industry) focused just on the cholesterol branch of the mevalonate pathway and completely disregarded the important consequences of collateral damage to the other main branches of our tree from our statin drugs. The predictable result of all this has been our bizarre spectrum of statin associated side effects ranging from cognitive, to myotoxic, neurotoxic, neurodegenerative and even behavioral. When our powerful statins cut our cholesterol 50%, our CoQ10 is also likely to be cut a similar amount and therein lay the problem, for CoQ10 has vital roles in energy production, cell wall integrity and mitochondrial anti-oxidation, all of which leads to

the enormous variety of symptoms and problems we now are seeing.And what about another major branch of the mevalonate tree, that of dolichol? Recently I have learned much about the vital role of dolichols and it is time to share it with you. I have been talking of the consequences of statin associated dolichol inhibition for years now, calling attention to the importance of this substance in neuropeptide formation and our feelings of thought, sensation and emotion. More recently, I have pointed at dolichol inhibition as a possible cause of our statin associated behavioral side effects, such as irritability, hostility and depression, while wondering how, with so few proteins, such amazing subtlety of emotion could be created. Now, however, I have learned that along with peptide assembly within the endoplasmic reticulum of every cell is the process of sacharride attachment. It is here in the heart of every cell that our sacharrides (sugars) are

attached to proteins to give a far broader range of diversity and information transfer than protein alone. This process is called glycosylation and it demands a ready supply of dolichol. No longer do we consider our sugars as just simple fuel. The effects of these eight vital sugars on the resulting peptide structure being created in the endoplasmic reticulum and companion piece, the Golgi apparatus, is just short of miraculous. And this attachment of sugars, this glycosylation, is completely dependent on dolichol’s orchestration. Throw in a statin and what do you have – an inevitable inhibition of dolichol (roughly comparable to the degree of cholesterol inhibition). The resulting effect upon our body of this dolichol theft is completely unpredictable for this is at the very center of cell communication and immunodefense. Dolichols may well be fully as important as CoQ10 in this unfortunate game of statin roulette that Big Pharma has placed us

in. Statin damage is often additive to pre-existing impairment of glycolysis from aging, disease and poor nutrition. Glyconutrients, now increasingly available as a source of these vital sugars, may offer hope to thousands of statin damaged victims to help the body repair the effects of impaired glycolysis. It is much too early to talk of proof of effect for studies are only now in the planning stage. However, based upon my six years of research, I have an intuitive feeling of success and anxiously look forward to the results.Duane Graveline MD MPHFormer USAF Flight SurgeonFormer NASA AstronautRetired Family Doctor

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[Guest guest]

, yes it did my husband. he could not finish a sentence. he would forget where we were going or what he was doing. he was only 49 at the time.. it hasgotten somewhat better he has his moments though. visit the spacedoc.nethe also had memory loss... if I remember right. not everyone is the same though.Good LuckJudyinMO Statins & GlyconutrientsStatins & Glyconutrientshttp://www.spacedoc.net/statins_glyconutrients.html For the past five years I have been talking about the importance of the mevalonate pathway and the inevitable problems to come from inhibition of this vital biochemical complex especially at its very beginning. Think of the mevalonate pathway as a tree with multiple branches and then think of the effect of our statins drugs as â?ogirdingâ? this tree at the base, in our misguided efforts to block cholesterol. Our pharmaceutical industry threw caution to the wind 15 years ago when our national priority to lower cholesterol so fogged our minds that we (medical, pharmaceutical and the food industry) focused just on the cholesterol branch of the mevalonate pathway and completely disregarded the important consequences of collateral damage to the other main branches of our tree from our statin drugs. The predictable result of all this has been our bizarre spectrum of statin associated side effects ranging from cognitive, to myotoxic, neurotoxic, neurodegenerative and even behavioral. When our powerful statins cut our cholesterol 50%, our CoQ10 is also likely to be cut a similar amount and therein lay the problem, for CoQ10 has vital roles in energy production, cell wall integrity and mitochondrial anti-oxidation, all of which leads to the enormous variety of symptoms and problems we now are seeing.And what about another major branch of the mevalonate tree, that of dolichol? Recently I have learned much about the vital role of dolichols and it is time to share it with you. I have been talking of the consequences of statin associated dolichol inhibition for years now, calling attention to the importance of this substance in neuropeptide formation and our feelings of thought, sensation and emotion. More recently, I have pointed at dolichol inhibition as a possible cause of our statin associated behavioral side effects, such as irritability, hostility and depression, while wondering how, with so few proteins, such amazing subtlety of emotion could be created. Now, however, I have learned that along with peptide assembly within the endoplasmic reticulum of every cell is the process of sacharride attachment. It is here in the heart of every cell that our sacharrides (sugars) are attached to proteins to give a far broader range of diversity and information transfer than protein alone. This process is called glycosylation and it demands a ready supply of dolichol. No longer do we consider our sugars as just simple fuel. The effects of these eight vital sugars on the resulting peptide structure being created in the endoplasmic reticulum and companion piece, the Golgi apparatus, is just short of miraculous. And this attachment of sugars, this glycosylation, is completely dependent on dolicholâ?Ts orchestration. Throw in a statin and what do you have â?" an inevitable inhibition of dolichol (roughly comparable to the degree of cholesterol inhibition). The resulting effect upon our body of this dolichol theft is completely unpredictable for this is at the very center of cell communication and immunodefense. Dolichols may well be fully as important as CoQ10 in this unfortunate game of statin roulette that Big Pharma has placed us in. Statin damage is often additive to pre-existing impairment of glycolysis from aging, disease and poor nutrition. Glyconutrients, now increasingly available as a source of these vital sugars, may offer hope to thousands of statin damaged victims to help the body repair the effects of impaired glycolysis. It is much too early to talk of proof of effect for studies are only now in the planning stage. However, based upon my six years of research, I have an intuitive feeling of success and anxiously look forward to the results.Duane Graveline MD MPHFormer USAF Flight SurgeonFormer NASA AstronautRetired Family DoctorNeed a vacation? Get great deals to amazing places on Travel.