RE: Re: A New Autism One Radio Show/Dopamine 4 Receptors

July 9, 2006

Stan:

Since it was mentioned below that Dr. Deth has extensively studied Dopamine 4 receptors, I would

be curious as to what his opinion on Risperdal is, because, like it or not,

this is the most prescribed drug (by mainstream neuros,

psychiatrists) right now and it is being studied heavily at the National

Institute of Mental Health for ASD treatment, and from what I have read, Risperdal has an affinity for Dopamine 4 receptors. I am curious what he thinks about its

use, good, bad or ugly and if there is a specific sub-type of ASD that responds

to it or whether it should be avoided at all costs….

Fischer

Re: A New Autism One Radio Show

>

> Hi Stan, Dr Deth is definitely the guy for this - he has

done quite a

> lot of research on dopamine receptors, notably D4 receptors. These

are

> linked to calcium channels. In his Autism One presentation he

talks A

> LOT about membrane fluidity. This would be closer to my real

question -

> ie interdependence between these receptors and channels and how

these

> modulate each other, with the focus being on L-type calcium

channels.

>

> My question is NOT related to problems of calcium processing as

such, as

> those problems would be downstream of membrane dysfunctions and I

am

> sure Dr Deth has not gone into that area (Alison, I believe that

> somehow our kids' problems are related to membrane dysfunctions,

we need

> guys like and to help figure out how exactly, and how

to go

> about testing and treatment - VitA/bethanacol treatment is one of

the

> possible answers, for some of our kids!).

>

> Megson presented on both 2005 and 2006 Autism One. This year's

> presentation focused closely on calcium channelopathy and one of

the

> possible treatments for channel modulation. Not sure if Dr Deth

saw it,

> but I believe the two presentation would link up nicely to form a

BIG

> piece of the puzzle...

>

> Natasa

>

July 9, 2006

Stan:

Since it was mentioned below that Dr. Deth has extensively studied Dopamine 4 receptors, I would

be curious as to what his opinion on Risperdal is, because, like it or not,

this is the most prescribed drug (by mainstream neuros,

psychiatrists) right now and it is being studied heavily at the National

Institute of Mental Health for ASD treatment, and from what I have read, Risperdal has an affinity for Dopamine 4 receptors. I am curious what he thinks about its

use, good, bad or ugly and if there is a specific sub-type of ASD that responds

to it or whether it should be avoided at all costs….

Fischer

Re: A New Autism One Radio Show

>

> Hi Stan, Dr Deth is definitely the guy for this - he has

done quite a

> lot of research on dopamine receptors, notably D4 receptors. These

are

> linked to calcium channels. In his Autism One presentation he

talks A

> LOT about membrane fluidity. This would be closer to my real

question -

> ie interdependence between these receptors and channels and how

these

> modulate each other, with the focus being on L-type calcium

channels.

>

> My question is NOT related to problems of calcium processing as

such, as

> those problems would be downstream of membrane dysfunctions and I

am

> sure Dr Deth has not gone into that area (Alison, I believe that

> somehow our kids' problems are related to membrane dysfunctions,

we need

> guys like and to help figure out how exactly, and how

to go

> about testing and treatment - VitA/bethanacol treatment is one of

the

> possible answers, for some of our kids!).

>

> Megson presented on both 2005 and 2006 Autism One. This year's

> presentation focused closely on calcium channelopathy and one of

the

> possible treatments for channel modulation. Not sure if Dr Deth

saw it,

> but I believe the two presentation would link up nicely to form a

BIG

> piece of the puzzle...

>

> Natasa

>

July 10, 2006

Good question . If you are

considering this though, I would like to let you know of my 16yr old ASD

brother who took it for 2 years. He developed very disturbing ticks, head

jerking, etc. These are common side effects with risperdal. -

From: mb12 valtrex

[mailto:mb12 valtrex ] On

Behalf Of K. Fischer

Sent: Sunday, July 09, 2006 10:50

PM

mb12 valtrex

Subject: RE: Re: A

New Autism One Radio Show/Dopamine 4 Receptors

Stan:

Since it was mentioned below that Dr. Deth

has extensively studied Dopamine 4 receptors, I would be curious as to what his

opinion on Risperdal is, because, like it or not, this is the most prescribed

drug (by mainstream neuros, psychiatrists) right now

and it is being studied heavily at the National Institute of Mental Health for

ASD treatment, and from what I have read, Risperdal

has an affinity for Dopamine 4 receptors. I am curious what he thinks

about its use, good, bad or ugly and if there is a specific sub-type of ASD

that responds to it or whether it should be avoided at all costs….

Fischer

-----Original

Message-----

From: mb12 valtrex

[mailto:mb12 valtrex ] On

Behalf Of curemyreed

Sent: Saturday, July 08, 2006 5:43

PM

mb12 valtrex

Subject: Re: A New

Autism One Radio Show; bethanechol FYI

Hi, Vera.

Your posts on another site are what brought Bethanechol

to my attention. I discussed it with 's DAN! doc during our

last visit in March and we gave it a try. I wanted to tell you that

for my daughter ALL visual stimming stopped with the addition of

this medication to her regime! Thanks for sharing---this has made a

big difference in 's life.

Penni

> Thanks Natasa,

> Ever since I read Megson's bethanacol treatment I knew it

would definitely relate to CJ's issues. He fits all of the profiles

(it seems he fits every single profile of all treatments though). I

tried introducing more Vitamin A through NN children DHA CLO but he

is having trouble digesting too much of the oil. I am trying to

work up VERY slowly. I don't know if he will ever make it to the

point of tolerating as much as Megson recommends but maybe that just

shows how much he needs the bethanacol for it to work. This feels

like the never ending road…..-

> BTW, you are really starting to sound like a biologist and

immunologist. You're soaking it all in like a sponge, I think I've

hit " overwhelm " mode so my sponge is a little full at the moment. I

need to catch up. LOL!

>

> ---------------------------------

>

> From: mb12 valtrex

[mailto:mb12 valtrex ]

On Behalf Of natasa778

> Sent: Friday, July 07, 2006 7:29 AM

> mb12 valtrex

> Subject: Re: A New Autism One Radio Show

>

> Hi Stan, Dr Deth is definitely the guy for this - he has

done quite a

> lot of research on dopamine receptors, notably D4 receptors. These

are

> linked to calcium channels. In his Autism One presentation he

talks A

> LOT about membrane fluidity. This would be closer to my real

question -

> ie interdependence between these receptors and channels and how

these

> modulate each other, with the focus being on L-type calcium

channels.

>

> My question is NOT related to problems of calcium processing as

such, as

> those problems would be downstream of membrane dysfunctions and I

am

> sure Dr Deth has not gone into that area (Alison, I believe that

> somehow our kids' problems are related to membrane dysfunctions,

we need

> guys like and to help figure out how exactly, and how

to go

> about testing and treatment - VitA/bethanacol treatment is one of

the

> possible answers, for some of our kids!).

>

> Megson presented on both 2005 and 2006 Autism One. This year's

> presentation focused closely on calcium channelopathy and one of

the

> possible treatments for channel modulation. Not sure if Dr Deth

saw it,

> but I believe the two presentation would link up nicely to form a

BIG

> piece of the puzzle...

>

> Natasa

>

July 10, 2006

Good question . If you are

considering this though, I would like to let you know of my 16yr old ASD

brother who took it for 2 years. He developed very disturbing ticks, head

jerking, etc. These are common side effects with risperdal. -

From: mb12 valtrex

[mailto:mb12 valtrex ] On

Behalf Of K. Fischer

Sent: Sunday, July 09, 2006 10:50

PM

mb12 valtrex

Subject: RE: Re: A

New Autism One Radio Show/Dopamine 4 Receptors

Stan:

Since it was mentioned below that Dr. Deth

has extensively studied Dopamine 4 receptors, I would be curious as to what his

opinion on Risperdal is, because, like it or not, this is the most prescribed

drug (by mainstream neuros, psychiatrists) right now

and it is being studied heavily at the National Institute of Mental Health for

ASD treatment, and from what I have read, Risperdal

has an affinity for Dopamine 4 receptors. I am curious what he thinks

about its use, good, bad or ugly and if there is a specific sub-type of ASD

that responds to it or whether it should be avoided at all costs….

Fischer

-----Original

Message-----

From: mb12 valtrex

[mailto:mb12 valtrex ] On

Behalf Of curemyreed

Sent: Saturday, July 08, 2006 5:43

PM

mb12 valtrex

Subject: Re: A New

Autism One Radio Show; bethanechol FYI

Hi, Vera.

Your posts on another site are what brought Bethanechol

to my attention. I discussed it with 's DAN! doc during our

last visit in March and we gave it a try. I wanted to tell you that

for my daughter ALL visual stimming stopped with the addition of

this medication to her regime! Thanks for sharing---this has made a

big difference in 's life.

Penni

> Thanks Natasa,

> Ever since I read Megson's bethanacol treatment I knew it

would definitely relate to CJ's issues. He fits all of the profiles

(it seems he fits every single profile of all treatments though). I

tried introducing more Vitamin A through NN children DHA CLO but he

is having trouble digesting too much of the oil. I am trying to

work up VERY slowly. I don't know if he will ever make it to the

point of tolerating as much as Megson recommends but maybe that just

shows how much he needs the bethanacol for it to work. This feels

like the never ending road…..-

> BTW, you are really starting to sound like a biologist and

immunologist. You're soaking it all in like a sponge, I think I've

hit " overwhelm " mode so my sponge is a little full at the moment. I

need to catch up. LOL!

>

> ---------------------------------

>

> From: mb12 valtrex

[mailto:mb12 valtrex ]

On Behalf Of natasa778

> Sent: Friday, July 07, 2006 7:29 AM

> mb12 valtrex

> Subject: Re: A New Autism One Radio Show

>

> Hi Stan, Dr Deth is definitely the guy for this - he has

done quite a

> lot of research on dopamine receptors, notably D4 receptors. These

are

> linked to calcium channels. In his Autism One presentation he

talks A

> LOT about membrane fluidity. This would be closer to my real

question -

> ie interdependence between these receptors and channels and how

these

> modulate each other, with the focus being on L-type calcium

channels.

>

> My question is NOT related to problems of calcium processing as

such, as

> those problems would be downstream of membrane dysfunctions and I

am

> sure Dr Deth has not gone into that area (Alison, I believe that

> somehow our kids' problems are related to membrane dysfunctions,

we need

> guys like and to help figure out how exactly, and how

to go

> about testing and treatment - VitA/bethanacol treatment is one of

the

> possible answers, for some of our kids!).

>

> Megson presented on both 2005 and 2006 Autism One. This year's

> presentation focused closely on calcium channelopathy and one of

the

> possible treatments for channel modulation. Not sure if Dr Deth

saw it,

> but I believe the two presentation would link up nicely to form a

BIG

> piece of the puzzle...

>

> Natasa

>

July 10, 2006

i am very interested on this topic too as i just had to start my ds on risperdal due to major hyperactivity, impulsivity and pica bad. six years of bio medical interventions, many improvements for my tough nut. however, cannot seem to lick the hyperness, impulsivity, pica. i believe cause is toxic metals in his body (we just began chelating about 8 mos ago).

because of my health issues, i had to make a very hard decision to put him on risperdal. it has slowed him down a tad but he just started and we are going low and slow. i told my son's developmental ped that rx meds to control him is my last resort. so, here i am.

i will be following the info on the dopamine 4 receptors. if anyone has good info or sites, pls post. tx much!

vicki

July 10, 2006

i am very interested on this topic too as i just had to start my ds on risperdal due to major hyperactivity, impulsivity and pica bad. six years of bio medical interventions, many improvements for my tough nut. however, cannot seem to lick the hyperness, impulsivity, pica. i believe cause is toxic metals in his body (we just began chelating about 8 mos ago).

because of my health issues, i had to make a very hard decision to put him on risperdal. it has slowed him down a tad but he just started and we are going low and slow. i told my son's developmental ped that rx meds to control him is my last resort. so, here i am.

i will be following the info on the dopamine 4 receptors. if anyone has good info or sites, pls post. tx much!

vicki

July 10, 2006

tx laura for the info. i have heard about possibility of tics. i was just running out of options as i have been dealing with the hyperness, et. al for over 6 yrs and have tried sooooo many things to no avail. i just hope that when the metals and viruses start coming down/out, i will see positive changes and so my son will not have to be on risperdal for very long. maybe wishful thinking...

my son even took the neurotransmitter test and it showed low dopamine and serotonin levels and high on the excitotoxins norepinephrne (epinephrine/norepinephrine ratio very high). gaba was high as at the time i was using this suppliment and also 5-htp.

glutamine levels elevated (glutamine in the body is converted to glutamate which is an excitatory brain chemical). possible brain inflammation due to overload of excitotoxins. but anyway, in my son's particular case, his body is not converting enough glutamate into GABA. most is staying as glutamate causing excitotoxicity in the brain.

because of all this, my son was put on a trial of "namenda" (a glutamate receptor antagonist used for alzheimers pts). helps to bloc excess glutamate. started him low and slow. started out okay but didn't help with the hyperness, etc. after a short while, my son became very aggressive and behaviors out of control. i had to stop.

tried the products by neurosciences which was supposed to help balance the brain chemicals, etc. didn't work either. a true tough nut i say!

so, here we are, risperdal. there was a double-blind placebo controlled trial of risperidone done at ucla a few yrs ago. the objective was to evaluate the short-term efficacy and tolerability of risperidone in children and teens with asd. the results of this particular study showed that subjects treated with risperidone were significantly improved compared with those treated with the placebo in he areas of irritability, stereotypy and hyperactivity.

anyway, im not a fan of rx meds. but, i did give it my best shot and will continue to find ways to help my son. so much is paying off already. just have to get the hyperness, impulsivity, pica, and sensory down. i hope to do this with the viral and chelation protocols.

vicki

July 10, 2006

tx laura for the info. i have heard about possibility of tics. i was just running out of options as i have been dealing with the hyperness, et. al for over 6 yrs and have tried sooooo many things to no avail. i just hope that when the metals and viruses start coming down/out, i will see positive changes and so my son will not have to be on risperdal for very long. maybe wishful thinking...

my son even took the neurotransmitter test and it showed low dopamine and serotonin levels and high on the excitotoxins norepinephrne (epinephrine/norepinephrine ratio very high). gaba was high as at the time i was using this suppliment and also 5-htp.

glutamine levels elevated (glutamine in the body is converted to glutamate which is an excitatory brain chemical). possible brain inflammation due to overload of excitotoxins. but anyway, in my son's particular case, his body is not converting enough glutamate into GABA. most is staying as glutamate causing excitotoxicity in the brain.

because of all this, my son was put on a trial of "namenda" (a glutamate receptor antagonist used for alzheimers pts). helps to bloc excess glutamate. started him low and slow. started out okay but didn't help with the hyperness, etc. after a short while, my son became very aggressive and behaviors out of control. i had to stop.

tried the products by neurosciences which was supposed to help balance the brain chemicals, etc. didn't work either. a true tough nut i say!

so, here we are, risperdal. there was a double-blind placebo controlled trial of risperidone done at ucla a few yrs ago. the objective was to evaluate the short-term efficacy and tolerability of risperidone in children and teens with asd. the results of this particular study showed that subjects treated with risperidone were significantly improved compared with those treated with the placebo in he areas of irritability, stereotypy and hyperactivity.

anyway, im not a fan of rx meds. but, i did give it my best shot and will continue to find ways to help my son. so much is paying off already. just have to get the hyperness, impulsivity, pica, and sensory down. i hope to do this with the viral and chelation protocols.

vicki

July 10, 2006

My

son’s neuro has offered an rx

for low dose risperdal but, I just can’t bring

myself to use it for the exact reasons and side-effects you just described,

however, I do know two preschoolers who have done amazing on it, but their “symptoms”

aren’t similar to my sons….But because it prescribed so often, I

would like to learn more about what it is doing exactly….and actually,

how Dopamine 4 receptors are implicated, because for some kids this drug works

dead on, but others its not good, or the side effects are not worth it. I have heard some parents are giving

plenty of Vitamin E when kids are on risperdal to

avoid tics, don’t know if this works, but have heard there is a connection

somehow (maybe because vitamin E is also important for Tourette’s

syndrome, which involves tics/involuntary movements???)

Re: A New Autism One Radio Show

>

> Hi Stan, Dr Deth is definitely the guy for this - he has

done quite a

> lot of research on dopamine receptors, notably D4 receptors. These

are

> linked to calcium channels. In his Autism One presentation he

talks A

> LOT about membrane fluidity. This would be closer to my real

question -

> ie interdependence between these receptors and channels and how

these

> modulate each other, with the focus being on L-type calcium

channels.

>

> My question is NOT related to problems of calcium processing as

such, as

> those problems would be downstream of membrane dysfunctions and I

am

> sure Dr Deth has not gone into that area (Alison, I believe that

> somehow our kids' problems are related to membrane dysfunctions,

we need

> guys like and to help figure out how exactly, and how

to go

> about testing and treatment - VitA/bethanacol treatment is one of

the

> possible answers, for some of our kids!).

>

> Megson presented on both 2005 and 2006 Autism One. This year's

> presentation focused closely on calcium channelopathy and one of

the

> possible treatments for channel modulation. Not sure if Dr Deth

saw it,

> but I believe the two presentation would link up nicely to form a

BIG

> piece of the puzzle...

>

> Natasa

>

July 10, 2006

My

son’s neuro has offered an rx

for low dose risperdal but, I just can’t bring

myself to use it for the exact reasons and side-effects you just described,

however, I do know two preschoolers who have done amazing on it, but their “symptoms”

aren’t similar to my sons….But because it prescribed so often, I

would like to learn more about what it is doing exactly….and actually,

how Dopamine 4 receptors are implicated, because for some kids this drug works

dead on, but others its not good, or the side effects are not worth it. I have heard some parents are giving

plenty of Vitamin E when kids are on risperdal to

avoid tics, don’t know if this works, but have heard there is a connection

somehow (maybe because vitamin E is also important for Tourette’s

syndrome, which involves tics/involuntary movements???)

Re: A New Autism One Radio Show

>

> Hi Stan, Dr Deth is definitely the guy for this - he has

done quite a

> lot of research on dopamine receptors, notably D4 receptors. These

are

> linked to calcium channels. In his Autism One presentation he

talks A

> LOT about membrane fluidity. This would be closer to my real

question -

> ie interdependence between these receptors and channels and how

these

> modulate each other, with the focus being on L-type calcium

channels.

>

> My question is NOT related to problems of calcium processing as

such, as

> those problems would be downstream of membrane dysfunctions and I

am

> sure Dr Deth has not gone into that area (Alison, I believe that

> somehow our kids' problems are related to membrane dysfunctions,

we need

> guys like and to help figure out how exactly, and how

to go

> about testing and treatment - VitA/bethanacol treatment is one of

the

> possible answers, for some of our kids!).

>

> Megson presented on both 2005 and 2006 Autism One. This year's

> presentation focused closely on calcium channelopathy and one of

the

> possible treatments for channel modulation. Not sure if Dr Deth

saw it,

> but I believe the two presentation would link up nicely to form a

BIG

> piece of the puzzle...

>

> Natasa

>

July 13, 2006

Hey

Vicki, my son’s neurologist says that risperidone

is the most well tolerated and successful drug with his ASD patients, he says

70% usually respond well, whereas other rx

medications (like stimulants, SSRIs, anti-convulsants) are far less in response rates (either no

improvement, kid gets worse, or side effects are unbearable). The problem for me, is that my son was

barely 3 when he offered it and I just thought it was too young to try it at

that age and my son’s main issues are with language development and less

with the “autistic” issues, but let me tell you something, if

something were to help my son tremendously, as this med can with certain kids,

I wouldn’t hesitate for a second to give it a try at a very low dose….As

a side note, has your son ever tolerated B6/mag for glutamate to GABA

conversion? My son sometimes

responds really well to this, he too has high glutamine…(But

sometimes it can be too much, I really have to play with it, or only give it

every few days).

Larua

Re: Re: A

New Autism One Radio Show/Dopamine 4 Receptors

tx

laura for the info. i have heard about possibility of tics. i was

just running out of options as i have been dealing with the hyperness, et. al

for over 6 yrs and have tried sooooo many things to no avail. i just hope

that when the metals and viruses start coming down/out, i will see positive

changes and so my son will not have to be on risperdal for very long. maybe

wishful thinking...

my son

even took the neurotransmitter test and it showed low dopamine and serotonin

levels and high on the excitotoxins norepinephrne (epinephrine/norepinephrine

ratio very high). gaba was high as at the time i was using this suppliment and

also 5-htp.

glutamine

levels elevated (glutamine in the body is converted to glutamate which is an

excitatory brain chemical). possible brain inflammation due to overload

of excitotoxins. but anyway, in my son's particular case, his body is not

converting enough glutamate into GABA. most is staying as glutamate causing

excitotoxicity in the brain.

because

of all this, my son was put on a trial of " namenda " (a glutamate

receptor antagonist used for alzheimers pts). helps to bloc excess

glutamate. started him low and slow. started out okay but didn't

help with the hyperness, etc. after a short while, my son became very

aggressive and behaviors out of control. i had to stop.

tried

the products by neurosciences which was supposed to help balance the brain

chemicals, etc. didn't work either. a true tough nut i say!

so,

here we are, risperdal. there was a double-blind placebo controlled trial

of risperidone done at ucla a few yrs ago. the objective was to evaluate

the short-term efficacy and tolerability of risperidone in children and teens

with asd. the results of this particular study showed that subjects

treated with risperidone were significantly improved compared with those

treated with the placebo in he areas of irritability, stereotypy and

hyperactivity.

anyway,

im not a fan of rx meds. but, i did give it my best shot and will continue to

find ways to help my son. so much is paying off already. just have to get

the hyperness, impulsivity, pica, and sensory down. i hope to do this

with the viral and chelation protocols.

vicki

July 13, 2006