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Lack of evidence of sexual transmission of hepatitis C among

monogamous couples: results of a 10-year prospective follow-up study.

American Journal of Gastroenterology. 2004, 99: 5, 855-859; 36 ref.

Vandelli C; Renzo F; Romano L; Tisminetzky S; Palma M de; et al

The risk of sexual transmission of hepatitis C virus (HCV) infection

was evaluated among 895 monogamous heterosexual partners of HCV

chronically infected individuals in a long-term prospective study,

which provided a follow-up period of 8,060 person-years. Seven

hundred and seventy-six (86.7%) spouses were followed for 10 yr,

corresponding to 7,760 person-years of observation. One hundred and

nineteen (13.3%) spouses (69 whose infected partners cleared the

virus following treatment and 50 who ended their relationship or were

lost at follow-up) contributed an additional 300 person-years.

All couples denied practicing anal intercourse or sex during

menstruation, as well as condom use. The average weekly rate of

sexual intercourse was 1.8. Three HCV infections were observed during

follow-up corresponding to an incidence rate of 0.37 per 1,000

person-

years. However, the infecting HCV genotype in one spouse (2a) was

different from that of the partner (1b), clearly excluding sexual

transmission. The remaining two couples had concordant genotypes, but

sequence analysis of the NS5b region of the HCV genome, coupled with

phylogenetic analysis showed that the corresponding partners carried

different viral isolates, again excluding the possibility of

intraspousal transmission of HCV.

Our data indicate that the risk of sexual transmission of HCV within

heterosexual monogamous couples is extremely low or even null. No

general recommendations for condom use seem required for individuals

in monogamous partnerships with HCV-infected partners.

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well hopefully THAT will shut some ppl up and stop the accusations.. thanks Janet jaxJanet <doc_jade@...> wrote: Lack of evidence of sexual transmission of hepatitis C amongmonogamous couples: results of a 10-year prospective follow-up study.American Journal of Gastroenterology. 2004, 99: 5, 855-859; 36 ref.Vandelli C; Renzo F; Romano L; Tisminetzky S; Palma M de; et alThe risk of sexual transmission of hepatitis C virus (HCV) infectionwas evaluated among 895 monogamous heterosexual partners of

HCVchronically infected individuals in a long-term prospective study,which provided a follow-up period of 8,060 person-years. Sevenhundred and seventy-six (86.7%) spouses were followed for 10 yr,corresponding to 7,760 person-years of observation. One hundred andnineteen (13.3%) spouses (69 whose infected partners cleared thevirus following treatment and 50 who ended their relationship or werelost at follow-up) contributed an additional 300 person-years.All couples denied practicing anal intercourse or sex duringmenstruation, as well as condom use. The average weekly rate ofsexual intercourse was 1.8. Three HCV infections were observed duringfollow-up corresponding to an incidence rate of 0.37 per 1,000 person-years. However, the infecting HCV genotype in one spouse (2a) wasdifferent from that of the partner (1b), clearly excluding sexualtransmission. The remaining two couples had concordant genotypes,

butsequence analysis of the NS5b region of the HCV genome, coupled withphylogenetic analysis showed that the corresponding partners carrieddifferent viral isolates, again excluding the possibility ofintraspousal transmission of HCV.Our data indicate that the risk of sexual transmission of HCV withinheterosexual monogamous couples is extremely low or even null. Nogeneral recommendations for condom use seem required for individualsin monogamous partnerships with HCV-infected partners.Jackie

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