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RE: OLE, Valtrex, adenosine... are things more than what they seem?

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Natasa I just learnt from Yasko that COMT mutation kids break

dopamine more slowly than kids without the mutation. The COMT

mutation kids also are more sensitive to methyl groups and will need

forms of B-12 other than methyl, such as hydroxy or cyano. These

kids also have smaller viral and metal loads, and can tend to be bi-

polar as you have to watch their dopamine levels carefully with

supplementation, more mood swings and tantrums? Undoubtedly

depending on mutations, the OLE possibly does different things to

different kids.

Gayatri

>

> Hi Stan, and others,

>

> following the post on adenosine, adenosine receptor modulation and

> possible benefits we are seeing in our kids during Valrex therapy

being

> related to regulation of those rather than purely its antiviral

> properties ... here is another thought:

>

> someone mentioned to me recently that OLE has antihypertensive

> properties (protects against high blood pressure), I researched

this a

> bit as this is the direction we want to go in with our son (cannot

get

> Valtrex rx) and wanted to find out as much as possible about it.

So, it

> turns out that OLE does have those properties, it has been used

for this

> purpose for centuries, and even more interestingly, its high blood

> pressure regulation mechanism is thought to be related to its

CALCIUM

> CHANNEL BLOCKING PROPERTIES! ... which brings me back to adenosine

and

> g-protein coupled receptors, to Megson's treatment protocols,

> (possibly to LDN, as dopamine receptors are closely related and

regulate

> those channels as well).

>

> Ok, could that be that here we have another antiviral that helps

some of

> our autistic kids through mechanism other than purely attacking of

> viruses????

>

> I hope this discussion continues...

>

> Natasa

>

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Natasa I just learnt from Yasko that COMT mutation kids break

dopamine more slowly than kids without the mutation. The COMT

mutation kids also are more sensitive to methyl groups and will need

forms of B-12 other than methyl, such as hydroxy or cyano. These

kids also have smaller viral and metal loads, and can tend to be bi-

polar as you have to watch their dopamine levels carefully with

supplementation, more mood swings and tantrums? Undoubtedly

depending on mutations, the OLE possibly does different things to

different kids.

Gayatri

>

> Hi Stan, and others,

>

> following the post on adenosine, adenosine receptor modulation and

> possible benefits we are seeing in our kids during Valrex therapy

being

> related to regulation of those rather than purely its antiviral

> properties ... here is another thought:

>

> someone mentioned to me recently that OLE has antihypertensive

> properties (protects against high blood pressure), I researched

this a

> bit as this is the direction we want to go in with our son (cannot

get

> Valtrex rx) and wanted to find out as much as possible about it.

So, it

> turns out that OLE does have those properties, it has been used

for this

> purpose for centuries, and even more interestingly, its high blood

> pressure regulation mechanism is thought to be related to its

CALCIUM

> CHANNEL BLOCKING PROPERTIES! ... which brings me back to adenosine

and

> g-protein coupled receptors, to Megson's treatment protocols,

> (possibly to LDN, as dopamine receptors are closely related and

regulate

> those channels as well).

>

> Ok, could that be that here we have another antiviral that helps

some of

> our autistic kids through mechanism other than purely attacking of

> viruses????

>

> I hope this discussion continues...

>

> Natasa

>

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Guest guest

Natasa I just learnt from Yasko that COMT mutation kids break

dopamine more slowly than kids without the mutation. The COMT

mutation kids also are more sensitive to methyl groups and will need

forms of B-12 other than methyl, such as hydroxy or cyano. These

kids also have smaller viral and metal loads, and can tend to be bi-

polar as you have to watch their dopamine levels carefully with

supplementation, more mood swings and tantrums? Undoubtedly

depending on mutations, the OLE possibly does different things to

different kids.

Gayatri

>

> Hi Stan, and others,

>

> following the post on adenosine, adenosine receptor modulation and

> possible benefits we are seeing in our kids during Valrex therapy

being

> related to regulation of those rather than purely its antiviral

> properties ... here is another thought:

>

> someone mentioned to me recently that OLE has antihypertensive

> properties (protects against high blood pressure), I researched

this a

> bit as this is the direction we want to go in with our son (cannot

get

> Valtrex rx) and wanted to find out as much as possible about it.

So, it

> turns out that OLE does have those properties, it has been used

for this

> purpose for centuries, and even more interestingly, its high blood

> pressure regulation mechanism is thought to be related to its

CALCIUM

> CHANNEL BLOCKING PROPERTIES! ... which brings me back to adenosine

and

> g-protein coupled receptors, to Megson's treatment protocols,

> (possibly to LDN, as dopamine receptors are closely related and

regulate

> those channels as well).

>

> Ok, could that be that here we have another antiviral that helps

some of

> our autistic kids through mechanism other than purely attacking of

> viruses????

>

> I hope this discussion continues...

>

> Natasa

>

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Guest guest

Gayatri,

Is the COMT++ that tends to be bi-polar or COMT-- that tends to be

bipolar?

Will restoring their methylation cycle prevent them from becoming

bi-polar in future?

If they have a lower virus and metal load, does it still mean the

virus and metals that they do have are causing the autisic symptoms?

I heard that COMT++ tend to detox faster than COMT--.

I just got my genetics back last week and I'm still learning.

My uncle is bi-polar and had a hellaious life. I would like my son

to avoid this path at all costs!

---- Original Message ----

From: gayatri_rampal@...

mb12 valtrex

Subject: Re: OLE, Valtrex, adenosine... are things more

than what they seem?

Date: Tue, 30 May 2006 15:40:40 -0000

><html><body>

>

>

>Natasa I just learnt from Yasko that COMT mutation kids break <BR>

>dopamine more slowly than kids without the mutation. The COMT <BR>

>mutation kids also are more sensitive to methyl groups and will need

><BR>

>forms of B-12 other than methyl, such as hydroxy or cyano. These <BR>

>kids also have smaller viral and metal loads, and can tend to be

>bi-<BR>

>polar as you have to watch their dopamine levels carefully with <BR>

>supplementation, more mood swings and tantrums? Undoubtedly <BR>

>depending on mutations, the OLE possibly does different things to

><BR>

>different kids.<BR>

><BR>

>Gayatri<BR>

><BR>

><BR>

>><BR>

>> Hi Stan, and others,<BR>

>> <BR>

>> following the post on adenosine, adenosine receptor modulation

>and<BR>

>> possible benefits we are seeing in our kids during Valrex

>therapy <BR>

>being<BR>

>> related to regulation of those rather than purely its

>antiviral<BR>

>> properties ... here is another thought:<BR>

>> <BR>

>> someone mentioned to me recently that OLE has

>antihypertensive<BR>

>> properties (protects against high blood pressure), I researched

><BR>

>this a<BR>

>> bit as this is the direction we want to go in with our son

>(cannot <BR>

>get<BR>

>> Valtrex rx) and wanted to find out as much as possible about it.

><BR>

>So, it<BR>

>> turns out that OLE does have those properties, it has been used

><BR>

>for this<BR>

>> purpose for centuries, and even more interestingly, its high

>blood<BR>

>> pressure regulation mechanism is thought to be related to its

><BR>

>CALCIUM<BR>

>> CHANNEL BLOCKING PROPERTIES! ... which brings me back to

>adenosine <BR>

>and<BR>

>> g-protein coupled receptors, to Megson's treatment

>protocols,<BR>

>> (possibly to LDN, as dopamine receptors are closely related and

><BR>

>regulate<BR>

>> those channels as well).<BR>

>> <BR>

>> Ok, could that be that here we have another antiviral that helps

><BR>

>some of<BR>

>> our autistic kids through mechanism other than purely attacking

>of<BR>

>> viruses????<BR>

>> <BR>

>> I hope this discussion continues...<BR>

>> <BR>

>> Natasa<BR>

>><BR>

><BR>

><BR>

><BR>

><BR>

>

>

>

><!-- |**|begin egp html banner|**| -->

>

> <br><br>

> <div style= " width:500px; text-align:right; margin-bottom:1px;

>color:#909090; " >

> <tt>

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Share on other sites

Guest guest

Gayatri,

Is the COMT++ that tends to be bi-polar or COMT-- that tends to be

bipolar?

Will restoring their methylation cycle prevent them from becoming

bi-polar in future?

If they have a lower virus and metal load, does it still mean the

virus and metals that they do have are causing the autisic symptoms?

I heard that COMT++ tend to detox faster than COMT--.

I just got my genetics back last week and I'm still learning.

My uncle is bi-polar and had a hellaious life. I would like my son

to avoid this path at all costs!

---- Original Message ----

From: gayatri_rampal@...

mb12 valtrex

Subject: Re: OLE, Valtrex, adenosine... are things more

than what they seem?

Date: Tue, 30 May 2006 15:40:40 -0000

><html><body>

>

>

>Natasa I just learnt from Yasko that COMT mutation kids break <BR>

>dopamine more slowly than kids without the mutation. The COMT <BR>

>mutation kids also are more sensitive to methyl groups and will need

><BR>

>forms of B-12 other than methyl, such as hydroxy or cyano. These <BR>

>kids also have smaller viral and metal loads, and can tend to be

>bi-<BR>

>polar as you have to watch their dopamine levels carefully with <BR>

>supplementation, more mood swings and tantrums? Undoubtedly <BR>

>depending on mutations, the OLE possibly does different things to

><BR>

>different kids.<BR>

><BR>

>Gayatri<BR>

><BR>

><BR>

>><BR>

>> Hi Stan, and others,<BR>

>> <BR>

>> following the post on adenosine, adenosine receptor modulation

>and<BR>

>> possible benefits we are seeing in our kids during Valrex

>therapy <BR>

>being<BR>

>> related to regulation of those rather than purely its

>antiviral<BR>

>> properties ... here is another thought:<BR>

>> <BR>

>> someone mentioned to me recently that OLE has

>antihypertensive<BR>

>> properties (protects against high blood pressure), I researched

><BR>

>this a<BR>

>> bit as this is the direction we want to go in with our son

>(cannot <BR>

>get<BR>

>> Valtrex rx) and wanted to find out as much as possible about it.

><BR>

>So, it<BR>

>> turns out that OLE does have those properties, it has been used

><BR>

>for this<BR>

>> purpose for centuries, and even more interestingly, its high

>blood<BR>

>> pressure regulation mechanism is thought to be related to its

><BR>

>CALCIUM<BR>

>> CHANNEL BLOCKING PROPERTIES! ... which brings me back to

>adenosine <BR>

>and<BR>

>> g-protein coupled receptors, to Megson's treatment

>protocols,<BR>

>> (possibly to LDN, as dopamine receptors are closely related and

><BR>

>regulate<BR>

>> those channels as well).<BR>

>> <BR>

>> Ok, could that be that here we have another antiviral that helps

><BR>

>some of<BR>

>> our autistic kids through mechanism other than purely attacking

>of<BR>

>> viruses????<BR>

>> <BR>

>> I hope this discussion continues...<BR>

>> <BR>

>> Natasa<BR>

>><BR>

><BR>

><BR>

><BR>

><BR>

>

>

>

><!-- |**|begin egp html banner|**| -->

>

> <br><br>

> <div style= " width:500px; text-align:right; margin-bottom:1px;

>color:#909090; " >

> <tt>

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Guest guest

Gayatri, I didn't mean to imply that OLE might be doing different things

to different individuals, rather that the results we see might be due to

mechanisms other than those that are commonly known and expected...

Natasa

> >

> > Hi Stan, and others,

> >

> > following the post on adenosine, adenosine receptor modulation and

> > possible benefits we are seeing in our kids during Valrex therapy

> being

> > related to regulation of those rather than purely its antiviral

> > properties ... here is another thought:

> >

> > someone mentioned to me recently that OLE has antihypertensive

> > properties (protects against high blood pressure), I researched

> this a

> > bit as this is the direction we want to go in with our son (cannot

> get

> > Valtrex rx) and wanted to find out as much as possible about it.

> So, it

> > turns out that OLE does have those properties, it has been used

> for this

> > purpose for centuries, and even more interestingly, its high blood

> > pressure regulation mechanism is thought to be related to its

> CALCIUM

> > CHANNEL BLOCKING PROPERTIES! ... which brings me back to adenosine

> and

> > g-protein coupled receptors, to Megson's treatment protocols,

> > (possibly to LDN, as dopamine receptors are closely related and

> regulate

> > those channels as well).

> >

> > Ok, could that be that here we have another antiviral that helps

> some of

> > our autistic kids through mechanism other than purely attacking of

> > viruses????

> >

> > I hope this discussion continues...

> >

> > Natasa

> >

>

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Guest guest

Gayatri, I didn't mean to imply that OLE might be doing different things

to different individuals, rather that the results we see might be due to

mechanisms other than those that are commonly known and expected...

Natasa

> >

> > Hi Stan, and others,

> >

> > following the post on adenosine, adenosine receptor modulation and

> > possible benefits we are seeing in our kids during Valrex therapy

> being

> > related to regulation of those rather than purely its antiviral

> > properties ... here is another thought:

> >

> > someone mentioned to me recently that OLE has antihypertensive

> > properties (protects against high blood pressure), I researched

> this a

> > bit as this is the direction we want to go in with our son (cannot

> get

> > Valtrex rx) and wanted to find out as much as possible about it.

> So, it

> > turns out that OLE does have those properties, it has been used

> for this

> > purpose for centuries, and even more interestingly, its high blood

> > pressure regulation mechanism is thought to be related to its

> CALCIUM

> > CHANNEL BLOCKING PROPERTIES! ... which brings me back to adenosine

> and

> > g-protein coupled receptors, to Megson's treatment protocols,

> > (possibly to LDN, as dopamine receptors are closely related and

> regulate

> > those channels as well).

> >

> > Ok, could that be that here we have another antiviral that helps

> some of

> > our autistic kids through mechanism other than purely attacking of

> > viruses????

> >

> > I hope this discussion continues...

> >

> > Natasa

> >

>

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Guest guest

Natasa,

Looks like purines are released by calcium channel blockers.

Glutamate is also part of this picture!

> > >

> > > Hi Stan, and others,

> > >

> > > following the post on adenosine, adenosine receptor modulation

and

> > > possible benefits we are seeing in our kids during Valrex

therapy

> > being

> > > related to regulation of those rather than purely its antiviral

> > > properties ... here is another thought:

> > >

> > > someone mentioned to me recently that OLE has antihypertensive

> > > properties (protects against high blood pressure), I researched

> > this a

> > > bit as this is the direction we want to go in with our son

(cannot

> > get

> > > Valtrex rx) and wanted to find out as much as possible about

it.

> > So, it

> > > turns out that OLE does have those properties, it has been used

> > for this

> > > purpose for centuries, and even more interestingly, its high

blood

> > > pressure regulation mechanism is thought to be related to its

> > CALCIUM

> > > CHANNEL BLOCKING PROPERTIES! ... which brings me back to

adenosine

> > and

> > > g-protein coupled receptors, to Megson's treatment

protocols,

> > > (possibly to LDN, as dopamine receptors are closely related and

> > regulate

> > > those channels as well).

> > >

> > > Ok, could that be that here we have another antiviral that

helps

> > some of

> > > our autistic kids through mechanism other than purely

attacking of

> > > viruses????

> > >

> > > I hope this discussion continues...

> > >

> > > Natasa

> > >

> >

>

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Guest guest

Natasa,

Looks like purines are released by calcium channel blockers.

Glutamate is also part of this picture!

> > >

> > > Hi Stan, and others,

> > >

> > > following the post on adenosine, adenosine receptor modulation

and

> > > possible benefits we are seeing in our kids during Valrex

therapy

> > being

> > > related to regulation of those rather than purely its antiviral

> > > properties ... here is another thought:

> > >

> > > someone mentioned to me recently that OLE has antihypertensive

> > > properties (protects against high blood pressure), I researched

> > this a

> > > bit as this is the direction we want to go in with our son

(cannot

> > get

> > > Valtrex rx) and wanted to find out as much as possible about

it.

> > So, it

> > > turns out that OLE does have those properties, it has been used

> > for this

> > > purpose for centuries, and even more interestingly, its high

blood

> > > pressure regulation mechanism is thought to be related to its

> > CALCIUM

> > > CHANNEL BLOCKING PROPERTIES! ... which brings me back to

adenosine

> > and

> > > g-protein coupled receptors, to Megson's treatment

protocols,

> > > (possibly to LDN, as dopamine receptors are closely related and

> > regulate

> > > those channels as well).

> > >

> > > Ok, could that be that here we have another antiviral that

helps

> > some of

> > > our autistic kids through mechanism other than purely

attacking of

> > > viruses????

> > >

> > > I hope this discussion continues...

> > >

> > > Natasa

> > >

> >

>

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Guest guest

, do you have more details or links to this?

Thanks,

Natasa

> > > >

> > > > Hi Stan, and others,

> > > >

> > > > following the post on adenosine, adenosine receptor modulation

> and

> > > > possible benefits we are seeing in our kids during Valrex

> therapy

> > > being

> > > > related to regulation of those rather than purely its antiviral

> > > > properties ... here is another thought:

> > > >

> > > > someone mentioned to me recently that OLE has antihypertensive

> > > > properties (protects against high blood pressure), I researched

> > > this a

> > > > bit as this is the direction we want to go in with our son

> (cannot

> > > get

> > > > Valtrex rx) and wanted to find out as much as possible about

> it.

> > > So, it

> > > > turns out that OLE does have those properties, it has been used

> > > for this

> > > > purpose for centuries, and even more interestingly, its high

> blood

> > > > pressure regulation mechanism is thought to be related to its

> > > CALCIUM

> > > > CHANNEL BLOCKING PROPERTIES! ... which brings me back to

> adenosine

> > > and

> > > > g-protein coupled receptors, to Megson's treatment

> protocols,

> > > > (possibly to LDN, as dopamine receptors are closely related and

> > > regulate

> > > > those channels as well).

> > > >

> > > > Ok, could that be that here we have another antiviral that

> helps

> > > some of

> > > > our autistic kids through mechanism other than purely

> attacking of

> > > > viruses????

> > > >

> > > > I hope this discussion continues...

> > > >

> > > > Natasa

> > > >

> > >

> >

>

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Guest guest

, do you have more details or links to this?

Thanks,

Natasa

> > > >

> > > > Hi Stan, and others,

> > > >

> > > > following the post on adenosine, adenosine receptor modulation

> and

> > > > possible benefits we are seeing in our kids during Valrex

> therapy

> > > being

> > > > related to regulation of those rather than purely its antiviral

> > > > properties ... here is another thought:

> > > >

> > > > someone mentioned to me recently that OLE has antihypertensive

> > > > properties (protects against high blood pressure), I researched

> > > this a

> > > > bit as this is the direction we want to go in with our son

> (cannot

> > > get

> > > > Valtrex rx) and wanted to find out as much as possible about

> it.

> > > So, it

> > > > turns out that OLE does have those properties, it has been used

> > > for this

> > > > purpose for centuries, and even more interestingly, its high

> blood

> > > > pressure regulation mechanism is thought to be related to its

> > > CALCIUM

> > > > CHANNEL BLOCKING PROPERTIES! ... which brings me back to

> adenosine

> > > and

> > > > g-protein coupled receptors, to Megson's treatment

> protocols,

> > > > (possibly to LDN, as dopamine receptors are closely related and

> > > regulate

> > > > those channels as well).

> > > >

> > > > Ok, could that be that here we have another antiviral that

> helps

> > > some of

> > > > our autistic kids through mechanism other than purely

> attacking of

> > > > viruses????

> > > >

> > > > I hope this discussion continues...

> > > >

> > > > Natasa

> > > >

> > >

> >

>

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Guest guest

I got my genetics last week too and am learning as well. I saw

the starter DVD yesterday and am fairly certain that the COMT++ kids

tend to be bi-polar. I think what causes autism is impaired

sulphation, impaired methylation, gut and other issues from the

mealses in the MMR (possibly compounded by a variant of the herpes

family), and finally viruses (including metals) and pathogens living

in an immune system compromised by the above. I think you have to

keep an eye on the sulphur chemistry (I think Yasko calls the whole

thing methylation) and fix methylation and detox/rid the body of

viruses, bacteria and metals. Amy Yasko believes you can do this by

working around the genetics by appropriate supplementation. I have

not read too much though, still reading and trying to learn.

Gayatri

<BR>

> >><BR>

> >> Hi Stan, and others,<BR>

> >> <BR>

> >> following the post on adenosine, adenosine receptor modulation

> >and<BR>

> >> possible benefits we are seeing in our kids during Valrex

> >therapy <BR>

> >being<BR>

> >> related to regulation of those rather than purely its

> >antiviral<BR>

> >> properties ... here is another thought:<BR>

> >> <BR>

> >> someone mentioned to me recently that OLE has

> >antihypertensive<BR>

> >> properties (protects against high blood pressure), I researched

> ><BR>

> >this a<BR>

> >> bit as this is the direction we want to go in with our son

> >(cannot <BR>

> >get<BR>

> >> Valtrex rx) and wanted to find out as much as possible about it.

> ><BR>

> >So, it<BR>

> >> turns out that OLE does have those properties, it has been used

> ><BR>

> >for this<BR>

> >> purpose for centuries, and even more interestingly, its high

> >blood<BR>

> >> pressure regulation mechanism is thought to be related to its

> ><BR>

> >CALCIUM<BR>

> >> CHANNEL BLOCKING PROPERTIES! ... which brings me back to

> >adenosine <BR>

> >and<BR>

> >> g-protein coupled receptors, to Megson's treatment

> >protocols,<BR>

> >> (possibly to LDN, as dopamine receptors are closely related and

> ><BR>

> >regulate<BR>

> >> those channels as well).<BR>

> >> <BR>

> >> Ok, could that be that here we have another antiviral that helps

> ><BR>

> >some of<BR>

> >> our autistic kids through mechanism other than purely attacking

> >of<BR>

> >> viruses????<BR>

> >> <BR>

> >> I hope this discussion continues...<BR>

> >> <BR>

> >> Natasa<BR>

> >><BR>

> ><BR>

> ><BR>

> ><BR>

> ><BR>

> >

> >

> >

> ><!-- |**|begin egp html banner|**| -->

> >

> > <br><br>

> > <div style= " width:500px; text-align:right; margin-bottom:1px;

> >color:#909090; " >

> > <tt>

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Guest guest

I got my genetics last week too and am learning as well. I saw

the starter DVD yesterday and am fairly certain that the COMT++ kids

tend to be bi-polar. I think what causes autism is impaired

sulphation, impaired methylation, gut and other issues from the

mealses in the MMR (possibly compounded by a variant of the herpes

family), and finally viruses (including metals) and pathogens living

in an immune system compromised by the above. I think you have to

keep an eye on the sulphur chemistry (I think Yasko calls the whole

thing methylation) and fix methylation and detox/rid the body of

viruses, bacteria and metals. Amy Yasko believes you can do this by

working around the genetics by appropriate supplementation. I have

not read too much though, still reading and trying to learn.

Gayatri

<BR>

> >><BR>

> >> Hi Stan, and others,<BR>

> >> <BR>

> >> following the post on adenosine, adenosine receptor modulation

> >and<BR>

> >> possible benefits we are seeing in our kids during Valrex

> >therapy <BR>

> >being<BR>

> >> related to regulation of those rather than purely its

> >antiviral<BR>

> >> properties ... here is another thought:<BR>

> >> <BR>

> >> someone mentioned to me recently that OLE has

> >antihypertensive<BR>

> >> properties (protects against high blood pressure), I researched

> ><BR>

> >this a<BR>

> >> bit as this is the direction we want to go in with our son

> >(cannot <BR>

> >get<BR>

> >> Valtrex rx) and wanted to find out as much as possible about it.

> ><BR>

> >So, it<BR>

> >> turns out that OLE does have those properties, it has been used

> ><BR>

> >for this<BR>

> >> purpose for centuries, and even more interestingly, its high

> >blood<BR>

> >> pressure regulation mechanism is thought to be related to its

> ><BR>

> >CALCIUM<BR>

> >> CHANNEL BLOCKING PROPERTIES! ... which brings me back to

> >adenosine <BR>

> >and<BR>

> >> g-protein coupled receptors, to Megson's treatment

> >protocols,<BR>

> >> (possibly to LDN, as dopamine receptors are closely related and

> ><BR>

> >regulate<BR>

> >> those channels as well).<BR>

> >> <BR>

> >> Ok, could that be that here we have another antiviral that helps

> ><BR>

> >some of<BR>

> >> our autistic kids through mechanism other than purely attacking

> >of<BR>

> >> viruses????<BR>

> >> <BR>

> >> I hope this discussion continues...<BR>

> >> <BR>

> >> Natasa<BR>

> >><BR>

> ><BR>

> ><BR>

> ><BR>

> ><BR>

> >

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Natas,

I did a google search " purines calcium channel blockers " and came

up with pages of stuff. I'm still trying to sort through the biochem

of it all (which I'm sure you are much better at than I!) but I

think it is very intersting to see the inter-connectedness of these

things. I have always found it frustrating that purine metabolism

is known to be deranged in something like 40% of ASDs but no real

progess into why/how that we as parents are informed of. I also

wanted to understand how adenosine/purines might be be affected by

ayclovir. My son's speech improved overnight when we started

acyclovir, so I felt something other than it's antiviral activity

was at play. Just asking questions here!

> > > > >

> > > > > Hi Stan, and others,

> > > > >

> > > > > following the post on adenosine, adenosine receptor

modulation

> > and

> > > > > possible benefits we are seeing in our kids during Valrex

> > therapy

> > > > being

> > > > > related to regulation of those rather than purely its

antiviral

> > > > > properties ... here is another thought:

> > > > >

> > > > > someone mentioned to me recently that OLE has

antihypertensive

> > > > > properties (protects against high blood pressure), I

researched

> > > > this a

> > > > > bit as this is the direction we want to go in with our son

> > (cannot

> > > > get

> > > > > Valtrex rx) and wanted to find out as much as possible

about

> > it.

> > > > So, it

> > > > > turns out that OLE does have those properties, it has been

used

> > > > for this

> > > > > purpose for centuries, and even more interestingly, its

high

> > blood

> > > > > pressure regulation mechanism is thought to be related to

its

> > > > CALCIUM

> > > > > CHANNEL BLOCKING PROPERTIES! ... which brings me back to

> > adenosine

> > > > and

> > > > > g-protein coupled receptors, to Megson's treatment

> > protocols,

> > > > > (possibly to LDN, as dopamine receptors are closely

related and

> > > > regulate

> > > > > those channels as well).

> > > > >

> > > > > Ok, could that be that here we have another antiviral that

> > helps

> > > > some of

> > > > > our autistic kids through mechanism other than purely

> > attacking of

> > > > > viruses????

> > > > >

> > > > > I hope this discussion continues...

> > > > >

> > > > > Natasa

> > > > >

> > > >

> > >

> >

>

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Guest guest

Natas,

I did a google search " purines calcium channel blockers " and came

up with pages of stuff. I'm still trying to sort through the biochem

of it all (which I'm sure you are much better at than I!) but I

think it is very intersting to see the inter-connectedness of these

things. I have always found it frustrating that purine metabolism

is known to be deranged in something like 40% of ASDs but no real

progess into why/how that we as parents are informed of. I also

wanted to understand how adenosine/purines might be be affected by

ayclovir. My son's speech improved overnight when we started

acyclovir, so I felt something other than it's antiviral activity

was at play. Just asking questions here!

> > > > >

> > > > > Hi Stan, and others,

> > > > >

> > > > > following the post on adenosine, adenosine receptor

modulation

> > and

> > > > > possible benefits we are seeing in our kids during Valrex

> > therapy

> > > > being

> > > > > related to regulation of those rather than purely its

antiviral

> > > > > properties ... here is another thought:

> > > > >

> > > > > someone mentioned to me recently that OLE has

antihypertensive

> > > > > properties (protects against high blood pressure), I

researched

> > > > this a

> > > > > bit as this is the direction we want to go in with our son

> > (cannot

> > > > get

> > > > > Valtrex rx) and wanted to find out as much as possible

about

> > it.

> > > > So, it

> > > > > turns out that OLE does have those properties, it has been

used

> > > > for this

> > > > > purpose for centuries, and even more interestingly, its

high

> > blood

> > > > > pressure regulation mechanism is thought to be related to

its

> > > > CALCIUM

> > > > > CHANNEL BLOCKING PROPERTIES! ... which brings me back to

> > adenosine

> > > > and

> > > > > g-protein coupled receptors, to Megson's treatment

> > protocols,

> > > > > (possibly to LDN, as dopamine receptors are closely

related and

> > > > regulate

> > > > > those channels as well).

> > > > >

> > > > > Ok, could that be that here we have another antiviral that

> > helps

> > > > some of

> > > > > our autistic kids through mechanism other than purely

> > attacking of

> > > > > viruses????

> > > > >

> > > > > I hope this discussion continues...

> > > > >

> > > > > Natasa

> > > > >

> > > >

> > >

> >

>

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Guest guest

Natasa,

I just love your dedication, this stuff your posting is very valuable

and should be further discussed!! I'm going to try and reintroduce calcium

after another few weeks of valtrex (this time citrate form). I'll let you

know how it goes. Have you decided to try the OLE? I think some of CJ's

viral symptoms while using OLE in Dec were similar to what I saw during

healing regression period with valtrex. -

OLE, Valtrex, adenosine... are things more than what

they seem?

Hi Stan, and others,

following the post on adenosine, adenosine receptor modulation and

possible benefits we are seeing in our kids during Valrex therapy being

related to regulation of those rather than purely its antiviral

properties ... here is another thought:

someone mentioned to me recently that OLE has antihypertensive

properties (protects against high blood pressure), I researched this a

bit as this is the direction we want to go in with our son (cannot get

Valtrex rx) and wanted to find out as much as possible about it. So, it

turns out that OLE does have those properties, it has been used for this

purpose for centuries, and even more interestingly, its high blood

pressure regulation mechanism is thought to be related to its CALCIUM

CHANNEL BLOCKING PROPERTIES! ... which brings me back to adenosine and

g-protein coupled receptors, to Megson's treatment protocols,

(possibly to LDN, as dopamine receptors are closely related and regulate

those channels as well).

Ok, could that be that here we have another antiviral that helps some of

our autistic kids through mechanism other than purely attacking of

viruses????

I hope this discussion continues...

Natasa

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Share on other sites

Guest guest

Natasa,

I just love your dedication, this stuff your posting is very valuable

and should be further discussed!! I'm going to try and reintroduce calcium

after another few weeks of valtrex (this time citrate form). I'll let you

know how it goes. Have you decided to try the OLE? I think some of CJ's

viral symptoms while using OLE in Dec were similar to what I saw during

healing regression period with valtrex. -

OLE, Valtrex, adenosine... are things more than what

they seem?

Hi Stan, and others,

following the post on adenosine, adenosine receptor modulation and

possible benefits we are seeing in our kids during Valrex therapy being

related to regulation of those rather than purely its antiviral

properties ... here is another thought:

someone mentioned to me recently that OLE has antihypertensive

properties (protects against high blood pressure), I researched this a

bit as this is the direction we want to go in with our son (cannot get

Valtrex rx) and wanted to find out as much as possible about it. So, it

turns out that OLE does have those properties, it has been used for this

purpose for centuries, and even more interestingly, its high blood

pressure regulation mechanism is thought to be related to its CALCIUM

CHANNEL BLOCKING PROPERTIES! ... which brings me back to adenosine and

g-protein coupled receptors, to Megson's treatment protocols,

(possibly to LDN, as dopamine receptors are closely related and regulate

those channels as well).

Ok, could that be that here we have another antiviral that helps some of

our autistic kids through mechanism other than purely attacking of

viruses????

I hope this discussion continues...

Natasa

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Guest guest

We actually don't know the exact biochemistry as to why adeonosine

is modulated by Valtrex and acyclovir (by we, I mean this group as

well as the DAN! researchers... I'm sure someone at Glaxo knows, but

they refuse to disclose the information... I've called several

times).

What we do know is that it is modulating adenosine. I have a slide

that I borrowed from Dr. Baker that shows a small study of adenosine

levels before and after treatment of acyclovir (we now use Valtrex)

and the folks that were higher... lowered and the folks that were

low... raised. It's seemingly a normalization of adenosine. I have

a copy of this slide in my presentation which is on the autism one

website and also in the FILES directory of our groups.

What you observed is not too uncommon... execpt it happens more

often with Valtrex than acyclovir.

- Stan

> > > > > >

> > > > > > Hi Stan, and others,

> > > > > >

> > > > > > following the post on adenosine, adenosine receptor

> modulation

> > > and

> > > > > > possible benefits we are seeing in our kids during Valrex

> > > therapy

> > > > > being

> > > > > > related to regulation of those rather than purely its

> antiviral

> > > > > > properties ... here is another thought:

> > > > > >

> > > > > > someone mentioned to me recently that OLE has

> antihypertensive

> > > > > > properties (protects against high blood pressure), I

> researched

> > > > > this a

> > > > > > bit as this is the direction we want to go in with our

son

> > > (cannot

> > > > > get

> > > > > > Valtrex rx) and wanted to find out as much as possible

> about

> > > it.

> > > > > So, it

> > > > > > turns out that OLE does have those properties, it has

been

> used

> > > > > for this

> > > > > > purpose for centuries, and even more interestingly, its

> high

> > > blood

> > > > > > pressure regulation mechanism is thought to be related

to

> its

> > > > > CALCIUM

> > > > > > CHANNEL BLOCKING PROPERTIES! ... which brings me back to

> > > adenosine

> > > > > and

> > > > > > g-protein coupled receptors, to Megson's treatment

> > > protocols,

> > > > > > (possibly to LDN, as dopamine receptors are closely

> related and

> > > > > regulate

> > > > > > those channels as well).

> > > > > >

> > > > > > Ok, could that be that here we have another antiviral

that

> > > helps

> > > > > some of

> > > > > > our autistic kids through mechanism other than purely

> > > attacking of

> > > > > > viruses????

> > > > > >

> > > > > > I hope this discussion continues...

> > > > > >

> > > > > > Natasa

> > > > > >

> > > > >

> > > >

> > >

> >

>

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Guest guest

We actually don't know the exact biochemistry as to why adeonosine

is modulated by Valtrex and acyclovir (by we, I mean this group as

well as the DAN! researchers... I'm sure someone at Glaxo knows, but

they refuse to disclose the information... I've called several

times).

What we do know is that it is modulating adenosine. I have a slide

that I borrowed from Dr. Baker that shows a small study of adenosine

levels before and after treatment of acyclovir (we now use Valtrex)

and the folks that were higher... lowered and the folks that were

low... raised. It's seemingly a normalization of adenosine. I have

a copy of this slide in my presentation which is on the autism one

website and also in the FILES directory of our groups.

What you observed is not too uncommon... execpt it happens more

often with Valtrex than acyclovir.

- Stan

> > > > > >

> > > > > > Hi Stan, and others,

> > > > > >

> > > > > > following the post on adenosine, adenosine receptor

> modulation

> > > and

> > > > > > possible benefits we are seeing in our kids during Valrex

> > > therapy

> > > > > being

> > > > > > related to regulation of those rather than purely its

> antiviral

> > > > > > properties ... here is another thought:

> > > > > >

> > > > > > someone mentioned to me recently that OLE has

> antihypertensive

> > > > > > properties (protects against high blood pressure), I

> researched

> > > > > this a

> > > > > > bit as this is the direction we want to go in with our

son

> > > (cannot

> > > > > get

> > > > > > Valtrex rx) and wanted to find out as much as possible

> about

> > > it.

> > > > > So, it

> > > > > > turns out that OLE does have those properties, it has

been

> used

> > > > > for this

> > > > > > purpose for centuries, and even more interestingly, its

> high

> > > blood

> > > > > > pressure regulation mechanism is thought to be related

to

> its

> > > > > CALCIUM

> > > > > > CHANNEL BLOCKING PROPERTIES! ... which brings me back to

> > > adenosine

> > > > > and

> > > > > > g-protein coupled receptors, to Megson's treatment

> > > protocols,

> > > > > > (possibly to LDN, as dopamine receptors are closely

> related and

> > > > > regulate

> > > > > > those channels as well).

> > > > > >

> > > > > > Ok, could that be that here we have another antiviral

that

> > > helps

> > > > > some of

> > > > > > our autistic kids through mechanism other than purely

> > > attacking of

> > > > > > viruses????

> > > > > >

> > > > > > I hope this discussion continues...

> > > > > >

> > > > > > Natasa

> > > > > >

> > > > >

> > > >

> > >

> >

>

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Guest guest

If adenosine goes up following herpes infection that would make a nice

straighforward and simple explanation of why the levels come down on

Valtrex. What is really puzzling is the overall balancing effect - low

levels of adenosine being raised in some kids. Stan, do you have more

info on those cases, was there definitely a herpes virus in those kids

with low levels?

Natasa

> > > > > > >

> > > > > > > Hi Stan, and others,

> > > > > > >

> > > > > > > following the post on adenosine, adenosine receptor

> > modulation

> > > > and

> > > > > > > possible benefits we are seeing in our kids during Valrex

> > > > therapy

> > > > > > being

> > > > > > > related to regulation of those rather than purely its

> > antiviral

> > > > > > > properties ... here is another thought:

> > > > > > >

> > > > > > > someone mentioned to me recently that OLE has

> > antihypertensive

> > > > > > > properties (protects against high blood pressure), I

> > researched

> > > > > > this a

> > > > > > > bit as this is the direction we want to go in with our

> son

> > > > (cannot

> > > > > > get

> > > > > > > Valtrex rx) and wanted to find out as much as possible

> > about

> > > > it.

> > > > > > So, it

> > > > > > > turns out that OLE does have those properties, it has

> been

> > used

> > > > > > for this

> > > > > > > purpose for centuries, and even more interestingly, its

> > high

> > > > blood

> > > > > > > pressure regulation mechanism is thought to be related

> to

> > its

> > > > > > CALCIUM

> > > > > > > CHANNEL BLOCKING PROPERTIES! ... which brings me back to

> > > > adenosine

> > > > > > and

> > > > > > > g-protein coupled receptors, to Megson's treatment

> > > > protocols,

> > > > > > > (possibly to LDN, as dopamine receptors are closely

> > related and

> > > > > > regulate

> > > > > > > those channels as well).

> > > > > > >

> > > > > > > Ok, could that be that here we have another antiviral

> that

> > > > helps

> > > > > > some of

> > > > > > > our autistic kids through mechanism other than purely

> > > > attacking of

> > > > > > > viruses????

> > > > > > >

> > > > > > > I hope this discussion continues...

> > > > > > >

> > > > > > > Natasa

> > > > > > >

> > > > > >

> > > > >

> > > >

> > >

> >

>

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Share on other sites

Guest guest

If adenosine goes up following herpes infection that would make a nice

straighforward and simple explanation of why the levels come down on

Valtrex. What is really puzzling is the overall balancing effect - low

levels of adenosine being raised in some kids. Stan, do you have more

info on those cases, was there definitely a herpes virus in those kids

with low levels?

Natasa

> > > > > > >

> > > > > > > Hi Stan, and others,

> > > > > > >

> > > > > > > following the post on adenosine, adenosine receptor

> > modulation

> > > > and

> > > > > > > possible benefits we are seeing in our kids during Valrex

> > > > therapy

> > > > > > being

> > > > > > > related to regulation of those rather than purely its

> > antiviral

> > > > > > > properties ... here is another thought:

> > > > > > >

> > > > > > > someone mentioned to me recently that OLE has

> > antihypertensive

> > > > > > > properties (protects against high blood pressure), I

> > researched

> > > > > > this a

> > > > > > > bit as this is the direction we want to go in with our

> son

> > > > (cannot

> > > > > > get

> > > > > > > Valtrex rx) and wanted to find out as much as possible

> > about

> > > > it.

> > > > > > So, it

> > > > > > > turns out that OLE does have those properties, it has

> been

> > used

> > > > > > for this

> > > > > > > purpose for centuries, and even more interestingly, its

> > high

> > > > blood

> > > > > > > pressure regulation mechanism is thought to be related

> to

> > its

> > > > > > CALCIUM

> > > > > > > CHANNEL BLOCKING PROPERTIES! ... which brings me back to

> > > > adenosine

> > > > > > and

> > > > > > > g-protein coupled receptors, to Megson's treatment

> > > > protocols,

> > > > > > > (possibly to LDN, as dopamine receptors are closely

> > related and

> > > > > > regulate

> > > > > > > those channels as well).

> > > > > > >

> > > > > > > Ok, could that be that here we have another antiviral

> that

> > > > helps

> > > > > > some of

> > > > > > > our autistic kids through mechanism other than purely

> > > > attacking of

> > > > > > > viruses????

> > > > > > >

> > > > > > > I hope this discussion continues...

> > > > > > >

> > > > > > > Natasa

> > > > > > >

> > > > > >

> > > > >

> > > >

> > >

> >

>

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