Guest guest Posted May 30, 2006 Report Share Posted May 30, 2006 Natasa I just learnt from Yasko that COMT mutation kids break dopamine more slowly than kids without the mutation. The COMT mutation kids also are more sensitive to methyl groups and will need forms of B-12 other than methyl, such as hydroxy or cyano. These kids also have smaller viral and metal loads, and can tend to be bi- polar as you have to watch their dopamine levels carefully with supplementation, more mood swings and tantrums? Undoubtedly depending on mutations, the OLE possibly does different things to different kids. Gayatri > > Hi Stan, and others, > > following the post on adenosine, adenosine receptor modulation and > possible benefits we are seeing in our kids during Valrex therapy being > related to regulation of those rather than purely its antiviral > properties ... here is another thought: > > someone mentioned to me recently that OLE has antihypertensive > properties (protects against high blood pressure), I researched this a > bit as this is the direction we want to go in with our son (cannot get > Valtrex rx) and wanted to find out as much as possible about it. So, it > turns out that OLE does have those properties, it has been used for this > purpose for centuries, and even more interestingly, its high blood > pressure regulation mechanism is thought to be related to its CALCIUM > CHANNEL BLOCKING PROPERTIES! ... which brings me back to adenosine and > g-protein coupled receptors, to Megson's treatment protocols, > (possibly to LDN, as dopamine receptors are closely related and regulate > those channels as well). > > Ok, could that be that here we have another antiviral that helps some of > our autistic kids through mechanism other than purely attacking of > viruses???? > > I hope this discussion continues... > > Natasa > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 30, 2006 Report Share Posted May 30, 2006 Natasa I just learnt from Yasko that COMT mutation kids break dopamine more slowly than kids without the mutation. The COMT mutation kids also are more sensitive to methyl groups and will need forms of B-12 other than methyl, such as hydroxy or cyano. These kids also have smaller viral and metal loads, and can tend to be bi- polar as you have to watch their dopamine levels carefully with supplementation, more mood swings and tantrums? Undoubtedly depending on mutations, the OLE possibly does different things to different kids. Gayatri > > Hi Stan, and others, > > following the post on adenosine, adenosine receptor modulation and > possible benefits we are seeing in our kids during Valrex therapy being > related to regulation of those rather than purely its antiviral > properties ... here is another thought: > > someone mentioned to me recently that OLE has antihypertensive > properties (protects against high blood pressure), I researched this a > bit as this is the direction we want to go in with our son (cannot get > Valtrex rx) and wanted to find out as much as possible about it. So, it > turns out that OLE does have those properties, it has been used for this > purpose for centuries, and even more interestingly, its high blood > pressure regulation mechanism is thought to be related to its CALCIUM > CHANNEL BLOCKING PROPERTIES! ... which brings me back to adenosine and > g-protein coupled receptors, to Megson's treatment protocols, > (possibly to LDN, as dopamine receptors are closely related and regulate > those channels as well). > > Ok, could that be that here we have another antiviral that helps some of > our autistic kids through mechanism other than purely attacking of > viruses???? > > I hope this discussion continues... > > Natasa > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 30, 2006 Report Share Posted May 30, 2006 Natasa I just learnt from Yasko that COMT mutation kids break dopamine more slowly than kids without the mutation. The COMT mutation kids also are more sensitive to methyl groups and will need forms of B-12 other than methyl, such as hydroxy or cyano. These kids also have smaller viral and metal loads, and can tend to be bi- polar as you have to watch their dopamine levels carefully with supplementation, more mood swings and tantrums? Undoubtedly depending on mutations, the OLE possibly does different things to different kids. Gayatri > > Hi Stan, and others, > > following the post on adenosine, adenosine receptor modulation and > possible benefits we are seeing in our kids during Valrex therapy being > related to regulation of those rather than purely its antiviral > properties ... here is another thought: > > someone mentioned to me recently that OLE has antihypertensive > properties (protects against high blood pressure), I researched this a > bit as this is the direction we want to go in with our son (cannot get > Valtrex rx) and wanted to find out as much as possible about it. So, it > turns out that OLE does have those properties, it has been used for this > purpose for centuries, and even more interestingly, its high blood > pressure regulation mechanism is thought to be related to its CALCIUM > CHANNEL BLOCKING PROPERTIES! ... which brings me back to adenosine and > g-protein coupled receptors, to Megson's treatment protocols, > (possibly to LDN, as dopamine receptors are closely related and regulate > those channels as well). > > Ok, could that be that here we have another antiviral that helps some of > our autistic kids through mechanism other than purely attacking of > viruses???? > > I hope this discussion continues... > > Natasa > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 30, 2006 Report Share Posted May 30, 2006 Gayatri, Is the COMT++ that tends to be bi-polar or COMT-- that tends to be bipolar? Will restoring their methylation cycle prevent them from becoming bi-polar in future? If they have a lower virus and metal load, does it still mean the virus and metals that they do have are causing the autisic symptoms? I heard that COMT++ tend to detox faster than COMT--. I just got my genetics back last week and I'm still learning. My uncle is bi-polar and had a hellaious life. I would like my son to avoid this path at all costs! ---- Original Message ---- From: gayatri_rampal@... mb12 valtrex Subject: Re: OLE, Valtrex, adenosine... are things more than what they seem? Date: Tue, 30 May 2006 15:40:40 -0000 ><html><body> > > >Natasa I just learnt from Yasko that COMT mutation kids break <BR> >dopamine more slowly than kids without the mutation. The COMT <BR> >mutation kids also are more sensitive to methyl groups and will need ><BR> >forms of B-12 other than methyl, such as hydroxy or cyano. These <BR> >kids also have smaller viral and metal loads, and can tend to be >bi-<BR> >polar as you have to watch their dopamine levels carefully with <BR> >supplementation, more mood swings and tantrums? Undoubtedly <BR> >depending on mutations, the OLE possibly does different things to ><BR> >different kids.<BR> ><BR> >Gayatri<BR> ><BR> ><BR> >><BR> >> Hi Stan, and others,<BR> >> <BR> >> following the post on adenosine, adenosine receptor modulation >and<BR> >> possible benefits we are seeing in our kids during Valrex >therapy <BR> >being<BR> >> related to regulation of those rather than purely its >antiviral<BR> >> properties ... here is another thought:<BR> >> <BR> >> someone mentioned to me recently that OLE has >antihypertensive<BR> >> properties (protects against high blood pressure), I researched ><BR> >this a<BR> >> bit as this is the direction we want to go in with our son >(cannot <BR> >get<BR> >> Valtrex rx) and wanted to find out as much as possible about it. ><BR> >So, it<BR> >> turns out that OLE does have those properties, it has been used ><BR> >for this<BR> >> purpose for centuries, and even more interestingly, its high >blood<BR> >> pressure regulation mechanism is thought to be related to its ><BR> >CALCIUM<BR> >> CHANNEL BLOCKING PROPERTIES! ... which brings me back to >adenosine <BR> >and<BR> >> g-protein coupled receptors, to Megson's treatment >protocols,<BR> >> (possibly to LDN, as dopamine receptors are closely related and ><BR> >regulate<BR> >> those channels as well).<BR> >> <BR> >> Ok, could that be that here we have another antiviral that helps ><BR> >some of<BR> >> our autistic kids through mechanism other than purely attacking >of<BR> >> viruses????<BR> >> <BR> >> I hope this discussion continues...<BR> >> <BR> >> Natasa<BR> >><BR> ><BR> ><BR> ><BR> ><BR> > > > ><!-- |**|begin egp html banner|**| --> > > <br><br> > <div style= " width:500px; text-align:right; margin-bottom:1px; >color:#909090; " > > <tt> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 30, 2006 Report Share Posted May 30, 2006 Gayatri, Is the COMT++ that tends to be bi-polar or COMT-- that tends to be bipolar? Will restoring their methylation cycle prevent them from becoming bi-polar in future? If they have a lower virus and metal load, does it still mean the virus and metals that they do have are causing the autisic symptoms? I heard that COMT++ tend to detox faster than COMT--. I just got my genetics back last week and I'm still learning. My uncle is bi-polar and had a hellaious life. I would like my son to avoid this path at all costs! ---- Original Message ---- From: gayatri_rampal@... mb12 valtrex Subject: Re: OLE, Valtrex, adenosine... are things more than what they seem? Date: Tue, 30 May 2006 15:40:40 -0000 ><html><body> > > >Natasa I just learnt from Yasko that COMT mutation kids break <BR> >dopamine more slowly than kids without the mutation. The COMT <BR> >mutation kids also are more sensitive to methyl groups and will need ><BR> >forms of B-12 other than methyl, such as hydroxy or cyano. These <BR> >kids also have smaller viral and metal loads, and can tend to be >bi-<BR> >polar as you have to watch their dopamine levels carefully with <BR> >supplementation, more mood swings and tantrums? Undoubtedly <BR> >depending on mutations, the OLE possibly does different things to ><BR> >different kids.<BR> ><BR> >Gayatri<BR> ><BR> ><BR> >><BR> >> Hi Stan, and others,<BR> >> <BR> >> following the post on adenosine, adenosine receptor modulation >and<BR> >> possible benefits we are seeing in our kids during Valrex >therapy <BR> >being<BR> >> related to regulation of those rather than purely its >antiviral<BR> >> properties ... here is another thought:<BR> >> <BR> >> someone mentioned to me recently that OLE has >antihypertensive<BR> >> properties (protects against high blood pressure), I researched ><BR> >this a<BR> >> bit as this is the direction we want to go in with our son >(cannot <BR> >get<BR> >> Valtrex rx) and wanted to find out as much as possible about it. ><BR> >So, it<BR> >> turns out that OLE does have those properties, it has been used ><BR> >for this<BR> >> purpose for centuries, and even more interestingly, its high >blood<BR> >> pressure regulation mechanism is thought to be related to its ><BR> >CALCIUM<BR> >> CHANNEL BLOCKING PROPERTIES! ... which brings me back to >adenosine <BR> >and<BR> >> g-protein coupled receptors, to Megson's treatment >protocols,<BR> >> (possibly to LDN, as dopamine receptors are closely related and ><BR> >regulate<BR> >> those channels as well).<BR> >> <BR> >> Ok, could that be that here we have another antiviral that helps ><BR> >some of<BR> >> our autistic kids through mechanism other than purely attacking >of<BR> >> viruses????<BR> >> <BR> >> I hope this discussion continues...<BR> >> <BR> >> Natasa<BR> >><BR> ><BR> ><BR> ><BR> ><BR> > > > ><!-- |**|begin egp html banner|**| --> > > <br><br> > <div style= " width:500px; text-align:right; margin-bottom:1px; >color:#909090; " > > <tt> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 30, 2006 Report Share Posted May 30, 2006 Gayatri, I didn't mean to imply that OLE might be doing different things to different individuals, rather that the results we see might be due to mechanisms other than those that are commonly known and expected... Natasa > > > > Hi Stan, and others, > > > > following the post on adenosine, adenosine receptor modulation and > > possible benefits we are seeing in our kids during Valrex therapy > being > > related to regulation of those rather than purely its antiviral > > properties ... here is another thought: > > > > someone mentioned to me recently that OLE has antihypertensive > > properties (protects against high blood pressure), I researched > this a > > bit as this is the direction we want to go in with our son (cannot > get > > Valtrex rx) and wanted to find out as much as possible about it. > So, it > > turns out that OLE does have those properties, it has been used > for this > > purpose for centuries, and even more interestingly, its high blood > > pressure regulation mechanism is thought to be related to its > CALCIUM > > CHANNEL BLOCKING PROPERTIES! ... which brings me back to adenosine > and > > g-protein coupled receptors, to Megson's treatment protocols, > > (possibly to LDN, as dopamine receptors are closely related and > regulate > > those channels as well). > > > > Ok, could that be that here we have another antiviral that helps > some of > > our autistic kids through mechanism other than purely attacking of > > viruses???? > > > > I hope this discussion continues... > > > > Natasa > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 30, 2006 Report Share Posted May 30, 2006 Gayatri, I didn't mean to imply that OLE might be doing different things to different individuals, rather that the results we see might be due to mechanisms other than those that are commonly known and expected... Natasa > > > > Hi Stan, and others, > > > > following the post on adenosine, adenosine receptor modulation and > > possible benefits we are seeing in our kids during Valrex therapy > being > > related to regulation of those rather than purely its antiviral > > properties ... here is another thought: > > > > someone mentioned to me recently that OLE has antihypertensive > > properties (protects against high blood pressure), I researched > this a > > bit as this is the direction we want to go in with our son (cannot > get > > Valtrex rx) and wanted to find out as much as possible about it. > So, it > > turns out that OLE does have those properties, it has been used > for this > > purpose for centuries, and even more interestingly, its high blood > > pressure regulation mechanism is thought to be related to its > CALCIUM > > CHANNEL BLOCKING PROPERTIES! ... which brings me back to adenosine > and > > g-protein coupled receptors, to Megson's treatment protocols, > > (possibly to LDN, as dopamine receptors are closely related and > regulate > > those channels as well). > > > > Ok, could that be that here we have another antiviral that helps > some of > > our autistic kids through mechanism other than purely attacking of > > viruses???? > > > > I hope this discussion continues... > > > > Natasa > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 30, 2006 Report Share Posted May 30, 2006 Natasa, Looks like purines are released by calcium channel blockers. Glutamate is also part of this picture! > > > > > > Hi Stan, and others, > > > > > > following the post on adenosine, adenosine receptor modulation and > > > possible benefits we are seeing in our kids during Valrex therapy > > being > > > related to regulation of those rather than purely its antiviral > > > properties ... here is another thought: > > > > > > someone mentioned to me recently that OLE has antihypertensive > > > properties (protects against high blood pressure), I researched > > this a > > > bit as this is the direction we want to go in with our son (cannot > > get > > > Valtrex rx) and wanted to find out as much as possible about it. > > So, it > > > turns out that OLE does have those properties, it has been used > > for this > > > purpose for centuries, and even more interestingly, its high blood > > > pressure regulation mechanism is thought to be related to its > > CALCIUM > > > CHANNEL BLOCKING PROPERTIES! ... which brings me back to adenosine > > and > > > g-protein coupled receptors, to Megson's treatment protocols, > > > (possibly to LDN, as dopamine receptors are closely related and > > regulate > > > those channels as well). > > > > > > Ok, could that be that here we have another antiviral that helps > > some of > > > our autistic kids through mechanism other than purely attacking of > > > viruses???? > > > > > > I hope this discussion continues... > > > > > > Natasa > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 30, 2006 Report Share Posted May 30, 2006 Natasa, Looks like purines are released by calcium channel blockers. Glutamate is also part of this picture! > > > > > > Hi Stan, and others, > > > > > > following the post on adenosine, adenosine receptor modulation and > > > possible benefits we are seeing in our kids during Valrex therapy > > being > > > related to regulation of those rather than purely its antiviral > > > properties ... here is another thought: > > > > > > someone mentioned to me recently that OLE has antihypertensive > > > properties (protects against high blood pressure), I researched > > this a > > > bit as this is the direction we want to go in with our son (cannot > > get > > > Valtrex rx) and wanted to find out as much as possible about it. > > So, it > > > turns out that OLE does have those properties, it has been used > > for this > > > purpose for centuries, and even more interestingly, its high blood > > > pressure regulation mechanism is thought to be related to its > > CALCIUM > > > CHANNEL BLOCKING PROPERTIES! ... which brings me back to adenosine > > and > > > g-protein coupled receptors, to Megson's treatment protocols, > > > (possibly to LDN, as dopamine receptors are closely related and > > regulate > > > those channels as well). > > > > > > Ok, could that be that here we have another antiviral that helps > > some of > > > our autistic kids through mechanism other than purely attacking of > > > viruses???? > > > > > > I hope this discussion continues... > > > > > > Natasa > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 30, 2006 Report Share Posted May 30, 2006 , do you have more details or links to this? Thanks, Natasa > > > > > > > > Hi Stan, and others, > > > > > > > > following the post on adenosine, adenosine receptor modulation > and > > > > possible benefits we are seeing in our kids during Valrex > therapy > > > being > > > > related to regulation of those rather than purely its antiviral > > > > properties ... here is another thought: > > > > > > > > someone mentioned to me recently that OLE has antihypertensive > > > > properties (protects against high blood pressure), I researched > > > this a > > > > bit as this is the direction we want to go in with our son > (cannot > > > get > > > > Valtrex rx) and wanted to find out as much as possible about > it. > > > So, it > > > > turns out that OLE does have those properties, it has been used > > > for this > > > > purpose for centuries, and even more interestingly, its high > blood > > > > pressure regulation mechanism is thought to be related to its > > > CALCIUM > > > > CHANNEL BLOCKING PROPERTIES! ... which brings me back to > adenosine > > > and > > > > g-protein coupled receptors, to Megson's treatment > protocols, > > > > (possibly to LDN, as dopamine receptors are closely related and > > > regulate > > > > those channels as well). > > > > > > > > Ok, could that be that here we have another antiviral that > helps > > > some of > > > > our autistic kids through mechanism other than purely > attacking of > > > > viruses???? > > > > > > > > I hope this discussion continues... > > > > > > > > Natasa > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 30, 2006 Report Share Posted May 30, 2006 , do you have more details or links to this? Thanks, Natasa > > > > > > > > Hi Stan, and others, > > > > > > > > following the post on adenosine, adenosine receptor modulation > and > > > > possible benefits we are seeing in our kids during Valrex > therapy > > > being > > > > related to regulation of those rather than purely its antiviral > > > > properties ... here is another thought: > > > > > > > > someone mentioned to me recently that OLE has antihypertensive > > > > properties (protects against high blood pressure), I researched > > > this a > > > > bit as this is the direction we want to go in with our son > (cannot > > > get > > > > Valtrex rx) and wanted to find out as much as possible about > it. > > > So, it > > > > turns out that OLE does have those properties, it has been used > > > for this > > > > purpose for centuries, and even more interestingly, its high > blood > > > > pressure regulation mechanism is thought to be related to its > > > CALCIUM > > > > CHANNEL BLOCKING PROPERTIES! ... which brings me back to > adenosine > > > and > > > > g-protein coupled receptors, to Megson's treatment > protocols, > > > > (possibly to LDN, as dopamine receptors are closely related and > > > regulate > > > > those channels as well). > > > > > > > > Ok, could that be that here we have another antiviral that > helps > > > some of > > > > our autistic kids through mechanism other than purely > attacking of > > > > viruses???? > > > > > > > > I hope this discussion continues... > > > > > > > > Natasa > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 30, 2006 Report Share Posted May 30, 2006 I got my genetics last week too and am learning as well. I saw the starter DVD yesterday and am fairly certain that the COMT++ kids tend to be bi-polar. I think what causes autism is impaired sulphation, impaired methylation, gut and other issues from the mealses in the MMR (possibly compounded by a variant of the herpes family), and finally viruses (including metals) and pathogens living in an immune system compromised by the above. I think you have to keep an eye on the sulphur chemistry (I think Yasko calls the whole thing methylation) and fix methylation and detox/rid the body of viruses, bacteria and metals. Amy Yasko believes you can do this by working around the genetics by appropriate supplementation. I have not read too much though, still reading and trying to learn. Gayatri <BR> > >><BR> > >> Hi Stan, and others,<BR> > >> <BR> > >> following the post on adenosine, adenosine receptor modulation > >and<BR> > >> possible benefits we are seeing in our kids during Valrex > >therapy <BR> > >being<BR> > >> related to regulation of those rather than purely its > >antiviral<BR> > >> properties ... here is another thought:<BR> > >> <BR> > >> someone mentioned to me recently that OLE has > >antihypertensive<BR> > >> properties (protects against high blood pressure), I researched > ><BR> > >this a<BR> > >> bit as this is the direction we want to go in with our son > >(cannot <BR> > >get<BR> > >> Valtrex rx) and wanted to find out as much as possible about it. > ><BR> > >So, it<BR> > >> turns out that OLE does have those properties, it has been used > ><BR> > >for this<BR> > >> purpose for centuries, and even more interestingly, its high > >blood<BR> > >> pressure regulation mechanism is thought to be related to its > ><BR> > >CALCIUM<BR> > >> CHANNEL BLOCKING PROPERTIES! ... which brings me back to > >adenosine <BR> > >and<BR> > >> g-protein coupled receptors, to Megson's treatment > >protocols,<BR> > >> (possibly to LDN, as dopamine receptors are closely related and > ><BR> > >regulate<BR> > >> those channels as well).<BR> > >> <BR> > >> Ok, could that be that here we have another antiviral that helps > ><BR> > >some of<BR> > >> our autistic kids through mechanism other than purely attacking > >of<BR> > >> viruses????<BR> > >> <BR> > >> I hope this discussion continues...<BR> > >> <BR> > >> Natasa<BR> > >><BR> > ><BR> > ><BR> > ><BR> > ><BR> > > > > > > > ><!-- |**|begin egp html banner|**| --> > > > > <br><br> > > <div style= " width:500px; text-align:right; margin-bottom:1px; > >color:#909090; " > > > <tt> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 30, 2006 Report Share Posted May 30, 2006 I got my genetics last week too and am learning as well. I saw the starter DVD yesterday and am fairly certain that the COMT++ kids tend to be bi-polar. I think what causes autism is impaired sulphation, impaired methylation, gut and other issues from the mealses in the MMR (possibly compounded by a variant of the herpes family), and finally viruses (including metals) and pathogens living in an immune system compromised by the above. I think you have to keep an eye on the sulphur chemistry (I think Yasko calls the whole thing methylation) and fix methylation and detox/rid the body of viruses, bacteria and metals. Amy Yasko believes you can do this by working around the genetics by appropriate supplementation. I have not read too much though, still reading and trying to learn. Gayatri <BR> > >><BR> > >> Hi Stan, and others,<BR> > >> <BR> > >> following the post on adenosine, adenosine receptor modulation > >and<BR> > >> possible benefits we are seeing in our kids during Valrex > >therapy <BR> > >being<BR> > >> related to regulation of those rather than purely its > >antiviral<BR> > >> properties ... here is another thought:<BR> > >> <BR> > >> someone mentioned to me recently that OLE has > >antihypertensive<BR> > >> properties (protects against high blood pressure), I researched > ><BR> > >this a<BR> > >> bit as this is the direction we want to go in with our son > >(cannot <BR> > >get<BR> > >> Valtrex rx) and wanted to find out as much as possible about it. > ><BR> > >So, it<BR> > >> turns out that OLE does have those properties, it has been used > ><BR> > >for this<BR> > >> purpose for centuries, and even more interestingly, its high > >blood<BR> > >> pressure regulation mechanism is thought to be related to its > ><BR> > >CALCIUM<BR> > >> CHANNEL BLOCKING PROPERTIES! ... which brings me back to > >adenosine <BR> > >and<BR> > >> g-protein coupled receptors, to Megson's treatment > >protocols,<BR> > >> (possibly to LDN, as dopamine receptors are closely related and > ><BR> > >regulate<BR> > >> those channels as well).<BR> > >> <BR> > >> Ok, could that be that here we have another antiviral that helps > ><BR> > >some of<BR> > >> our autistic kids through mechanism other than purely attacking > >of<BR> > >> viruses????<BR> > >> <BR> > >> I hope this discussion continues...<BR> > >> <BR> > >> Natasa<BR> > >><BR> > ><BR> > ><BR> > ><BR> > ><BR> > > > > > > > ><!-- |**|begin egp html banner|**| --> > > > > <br><br> > > <div style= " width:500px; text-align:right; margin-bottom:1px; > >color:#909090; " > > > <tt> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 30, 2006 Report Share Posted May 30, 2006 Natas, I did a google search " purines calcium channel blockers " and came up with pages of stuff. I'm still trying to sort through the biochem of it all (which I'm sure you are much better at than I!) but I think it is very intersting to see the inter-connectedness of these things. I have always found it frustrating that purine metabolism is known to be deranged in something like 40% of ASDs but no real progess into why/how that we as parents are informed of. I also wanted to understand how adenosine/purines might be be affected by ayclovir. My son's speech improved overnight when we started acyclovir, so I felt something other than it's antiviral activity was at play. Just asking questions here! > > > > > > > > > > Hi Stan, and others, > > > > > > > > > > following the post on adenosine, adenosine receptor modulation > > and > > > > > possible benefits we are seeing in our kids during Valrex > > therapy > > > > being > > > > > related to regulation of those rather than purely its antiviral > > > > > properties ... here is another thought: > > > > > > > > > > someone mentioned to me recently that OLE has antihypertensive > > > > > properties (protects against high blood pressure), I researched > > > > this a > > > > > bit as this is the direction we want to go in with our son > > (cannot > > > > get > > > > > Valtrex rx) and wanted to find out as much as possible about > > it. > > > > So, it > > > > > turns out that OLE does have those properties, it has been used > > > > for this > > > > > purpose for centuries, and even more interestingly, its high > > blood > > > > > pressure regulation mechanism is thought to be related to its > > > > CALCIUM > > > > > CHANNEL BLOCKING PROPERTIES! ... which brings me back to > > adenosine > > > > and > > > > > g-protein coupled receptors, to Megson's treatment > > protocols, > > > > > (possibly to LDN, as dopamine receptors are closely related and > > > > regulate > > > > > those channels as well). > > > > > > > > > > Ok, could that be that here we have another antiviral that > > helps > > > > some of > > > > > our autistic kids through mechanism other than purely > > attacking of > > > > > viruses???? > > > > > > > > > > I hope this discussion continues... > > > > > > > > > > Natasa > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 30, 2006 Report Share Posted May 30, 2006 Natas, I did a google search " purines calcium channel blockers " and came up with pages of stuff. I'm still trying to sort through the biochem of it all (which I'm sure you are much better at than I!) but I think it is very intersting to see the inter-connectedness of these things. I have always found it frustrating that purine metabolism is known to be deranged in something like 40% of ASDs but no real progess into why/how that we as parents are informed of. I also wanted to understand how adenosine/purines might be be affected by ayclovir. My son's speech improved overnight when we started acyclovir, so I felt something other than it's antiviral activity was at play. Just asking questions here! > > > > > > > > > > Hi Stan, and others, > > > > > > > > > > following the post on adenosine, adenosine receptor modulation > > and > > > > > possible benefits we are seeing in our kids during Valrex > > therapy > > > > being > > > > > related to regulation of those rather than purely its antiviral > > > > > properties ... here is another thought: > > > > > > > > > > someone mentioned to me recently that OLE has antihypertensive > > > > > properties (protects against high blood pressure), I researched > > > > this a > > > > > bit as this is the direction we want to go in with our son > > (cannot > > > > get > > > > > Valtrex rx) and wanted to find out as much as possible about > > it. > > > > So, it > > > > > turns out that OLE does have those properties, it has been used > > > > for this > > > > > purpose for centuries, and even more interestingly, its high > > blood > > > > > pressure regulation mechanism is thought to be related to its > > > > CALCIUM > > > > > CHANNEL BLOCKING PROPERTIES! ... which brings me back to > > adenosine > > > > and > > > > > g-protein coupled receptors, to Megson's treatment > > protocols, > > > > > (possibly to LDN, as dopamine receptors are closely related and > > > > regulate > > > > > those channels as well). > > > > > > > > > > Ok, could that be that here we have another antiviral that > > helps > > > > some of > > > > > our autistic kids through mechanism other than purely > > attacking of > > > > > viruses???? > > > > > > > > > > I hope this discussion continues... > > > > > > > > > > Natasa > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 31, 2006 Report Share Posted May 31, 2006 Natasa, I just love your dedication, this stuff your posting is very valuable and should be further discussed!! I'm going to try and reintroduce calcium after another few weeks of valtrex (this time citrate form). I'll let you know how it goes. Have you decided to try the OLE? I think some of CJ's viral symptoms while using OLE in Dec were similar to what I saw during healing regression period with valtrex. - OLE, Valtrex, adenosine... are things more than what they seem? Hi Stan, and others, following the post on adenosine, adenosine receptor modulation and possible benefits we are seeing in our kids during Valrex therapy being related to regulation of those rather than purely its antiviral properties ... here is another thought: someone mentioned to me recently that OLE has antihypertensive properties (protects against high blood pressure), I researched this a bit as this is the direction we want to go in with our son (cannot get Valtrex rx) and wanted to find out as much as possible about it. So, it turns out that OLE does have those properties, it has been used for this purpose for centuries, and even more interestingly, its high blood pressure regulation mechanism is thought to be related to its CALCIUM CHANNEL BLOCKING PROPERTIES! ... which brings me back to adenosine and g-protein coupled receptors, to Megson's treatment protocols, (possibly to LDN, as dopamine receptors are closely related and regulate those channels as well). Ok, could that be that here we have another antiviral that helps some of our autistic kids through mechanism other than purely attacking of viruses???? I hope this discussion continues... Natasa Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 31, 2006 Report Share Posted May 31, 2006 Natasa, I just love your dedication, this stuff your posting is very valuable and should be further discussed!! I'm going to try and reintroduce calcium after another few weeks of valtrex (this time citrate form). I'll let you know how it goes. Have you decided to try the OLE? I think some of CJ's viral symptoms while using OLE in Dec were similar to what I saw during healing regression period with valtrex. - OLE, Valtrex, adenosine... are things more than what they seem? Hi Stan, and others, following the post on adenosine, adenosine receptor modulation and possible benefits we are seeing in our kids during Valrex therapy being related to regulation of those rather than purely its antiviral properties ... here is another thought: someone mentioned to me recently that OLE has antihypertensive properties (protects against high blood pressure), I researched this a bit as this is the direction we want to go in with our son (cannot get Valtrex rx) and wanted to find out as much as possible about it. So, it turns out that OLE does have those properties, it has been used for this purpose for centuries, and even more interestingly, its high blood pressure regulation mechanism is thought to be related to its CALCIUM CHANNEL BLOCKING PROPERTIES! ... which brings me back to adenosine and g-protein coupled receptors, to Megson's treatment protocols, (possibly to LDN, as dopamine receptors are closely related and regulate those channels as well). Ok, could that be that here we have another antiviral that helps some of our autistic kids through mechanism other than purely attacking of viruses???? I hope this discussion continues... Natasa Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 31, 2006 Report Share Posted May 31, 2006 We actually don't know the exact biochemistry as to why adeonosine is modulated by Valtrex and acyclovir (by we, I mean this group as well as the DAN! researchers... I'm sure someone at Glaxo knows, but they refuse to disclose the information... I've called several times). What we do know is that it is modulating adenosine. I have a slide that I borrowed from Dr. Baker that shows a small study of adenosine levels before and after treatment of acyclovir (we now use Valtrex) and the folks that were higher... lowered and the folks that were low... raised. It's seemingly a normalization of adenosine. I have a copy of this slide in my presentation which is on the autism one website and also in the FILES directory of our groups. What you observed is not too uncommon... execpt it happens more often with Valtrex than acyclovir. - Stan > > > > > > > > > > > > Hi Stan, and others, > > > > > > > > > > > > following the post on adenosine, adenosine receptor > modulation > > > and > > > > > > possible benefits we are seeing in our kids during Valrex > > > therapy > > > > > being > > > > > > related to regulation of those rather than purely its > antiviral > > > > > > properties ... here is another thought: > > > > > > > > > > > > someone mentioned to me recently that OLE has > antihypertensive > > > > > > properties (protects against high blood pressure), I > researched > > > > > this a > > > > > > bit as this is the direction we want to go in with our son > > > (cannot > > > > > get > > > > > > Valtrex rx) and wanted to find out as much as possible > about > > > it. > > > > > So, it > > > > > > turns out that OLE does have those properties, it has been > used > > > > > for this > > > > > > purpose for centuries, and even more interestingly, its > high > > > blood > > > > > > pressure regulation mechanism is thought to be related to > its > > > > > CALCIUM > > > > > > CHANNEL BLOCKING PROPERTIES! ... which brings me back to > > > adenosine > > > > > and > > > > > > g-protein coupled receptors, to Megson's treatment > > > protocols, > > > > > > (possibly to LDN, as dopamine receptors are closely > related and > > > > > regulate > > > > > > those channels as well). > > > > > > > > > > > > Ok, could that be that here we have another antiviral that > > > helps > > > > > some of > > > > > > our autistic kids through mechanism other than purely > > > attacking of > > > > > > viruses???? > > > > > > > > > > > > I hope this discussion continues... > > > > > > > > > > > > Natasa > > > > > > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 31, 2006 Report Share Posted May 31, 2006 We actually don't know the exact biochemistry as to why adeonosine is modulated by Valtrex and acyclovir (by we, I mean this group as well as the DAN! researchers... I'm sure someone at Glaxo knows, but they refuse to disclose the information... I've called several times). What we do know is that it is modulating adenosine. I have a slide that I borrowed from Dr. Baker that shows a small study of adenosine levels before and after treatment of acyclovir (we now use Valtrex) and the folks that were higher... lowered and the folks that were low... raised. It's seemingly a normalization of adenosine. I have a copy of this slide in my presentation which is on the autism one website and also in the FILES directory of our groups. What you observed is not too uncommon... execpt it happens more often with Valtrex than acyclovir. - Stan > > > > > > > > > > > > Hi Stan, and others, > > > > > > > > > > > > following the post on adenosine, adenosine receptor > modulation > > > and > > > > > > possible benefits we are seeing in our kids during Valrex > > > therapy > > > > > being > > > > > > related to regulation of those rather than purely its > antiviral > > > > > > properties ... here is another thought: > > > > > > > > > > > > someone mentioned to me recently that OLE has > antihypertensive > > > > > > properties (protects against high blood pressure), I > researched > > > > > this a > > > > > > bit as this is the direction we want to go in with our son > > > (cannot > > > > > get > > > > > > Valtrex rx) and wanted to find out as much as possible > about > > > it. > > > > > So, it > > > > > > turns out that OLE does have those properties, it has been > used > > > > > for this > > > > > > purpose for centuries, and even more interestingly, its > high > > > blood > > > > > > pressure regulation mechanism is thought to be related to > its > > > > > CALCIUM > > > > > > CHANNEL BLOCKING PROPERTIES! ... which brings me back to > > > adenosine > > > > > and > > > > > > g-protein coupled receptors, to Megson's treatment > > > protocols, > > > > > > (possibly to LDN, as dopamine receptors are closely > related and > > > > > regulate > > > > > > those channels as well). > > > > > > > > > > > > Ok, could that be that here we have another antiviral that > > > helps > > > > > some of > > > > > > our autistic kids through mechanism other than purely > > > attacking of > > > > > > viruses???? > > > > > > > > > > > > I hope this discussion continues... > > > > > > > > > > > > Natasa > > > > > > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 31, 2006 Report Share Posted May 31, 2006 If adenosine goes up following herpes infection that would make a nice straighforward and simple explanation of why the levels come down on Valtrex. What is really puzzling is the overall balancing effect - low levels of adenosine being raised in some kids. Stan, do you have more info on those cases, was there definitely a herpes virus in those kids with low levels? Natasa > > > > > > > > > > > > > > Hi Stan, and others, > > > > > > > > > > > > > > following the post on adenosine, adenosine receptor > > modulation > > > > and > > > > > > > possible benefits we are seeing in our kids during Valrex > > > > therapy > > > > > > being > > > > > > > related to regulation of those rather than purely its > > antiviral > > > > > > > properties ... here is another thought: > > > > > > > > > > > > > > someone mentioned to me recently that OLE has > > antihypertensive > > > > > > > properties (protects against high blood pressure), I > > researched > > > > > > this a > > > > > > > bit as this is the direction we want to go in with our > son > > > > (cannot > > > > > > get > > > > > > > Valtrex rx) and wanted to find out as much as possible > > about > > > > it. > > > > > > So, it > > > > > > > turns out that OLE does have those properties, it has > been > > used > > > > > > for this > > > > > > > purpose for centuries, and even more interestingly, its > > high > > > > blood > > > > > > > pressure regulation mechanism is thought to be related > to > > its > > > > > > CALCIUM > > > > > > > CHANNEL BLOCKING PROPERTIES! ... which brings me back to > > > > adenosine > > > > > > and > > > > > > > g-protein coupled receptors, to Megson's treatment > > > > protocols, > > > > > > > (possibly to LDN, as dopamine receptors are closely > > related and > > > > > > regulate > > > > > > > those channels as well). > > > > > > > > > > > > > > Ok, could that be that here we have another antiviral > that > > > > helps > > > > > > some of > > > > > > > our autistic kids through mechanism other than purely > > > > attacking of > > > > > > > viruses???? > > > > > > > > > > > > > > I hope this discussion continues... > > > > > > > > > > > > > > Natasa > > > > > > > > > > > > > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 31, 2006 Report Share Posted May 31, 2006 If adenosine goes up following herpes infection that would make a nice straighforward and simple explanation of why the levels come down on Valtrex. What is really puzzling is the overall balancing effect - low levels of adenosine being raised in some kids. Stan, do you have more info on those cases, was there definitely a herpes virus in those kids with low levels? Natasa > > > > > > > > > > > > > > Hi Stan, and others, > > > > > > > > > > > > > > following the post on adenosine, adenosine receptor > > modulation > > > > and > > > > > > > possible benefits we are seeing in our kids during Valrex > > > > therapy > > > > > > being > > > > > > > related to regulation of those rather than purely its > > antiviral > > > > > > > properties ... here is another thought: > > > > > > > > > > > > > > someone mentioned to me recently that OLE has > > antihypertensive > > > > > > > properties (protects against high blood pressure), I > > researched > > > > > > this a > > > > > > > bit as this is the direction we want to go in with our > son > > > > (cannot > > > > > > get > > > > > > > Valtrex rx) and wanted to find out as much as possible > > about > > > > it. > > > > > > So, it > > > > > > > turns out that OLE does have those properties, it has > been > > used > > > > > > for this > > > > > > > purpose for centuries, and even more interestingly, its > > high > > > > blood > > > > > > > pressure regulation mechanism is thought to be related > to > > its > > > > > > CALCIUM > > > > > > > CHANNEL BLOCKING PROPERTIES! ... which brings me back to > > > > adenosine > > > > > > and > > > > > > > g-protein coupled receptors, to Megson's treatment > > > > protocols, > > > > > > > (possibly to LDN, as dopamine receptors are closely > > related and > > > > > > regulate > > > > > > > those channels as well). > > > > > > > > > > > > > > Ok, could that be that here we have another antiviral > that > > > > helps > > > > > > some of > > > > > > > our autistic kids through mechanism other than purely > > > > attacking of > > > > > > > viruses???? > > > > > > > > > > > > > > I hope this discussion continues... > > > > > > > > > > > > > > Natasa > > > > > > > > > > > > > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.