Guest guest Posted May 18, 2006 Report Share Posted May 18, 2006 Hi Natasa, It was actually adeonsine levels. The small study was done by Dr. Baker and published at a DAN! conference and netcasted about a year or two ago. It was spoken about again at the last Think Tank during my Valtex presenation and Dr. Baker included it in his presention on Thiols at this past conference. I was procrastinating finding the slide and uploading it, so thank you for the question. It's now in the FILES section as: " Acyclovir Adenosine Slide - Dr. Baker " Additionallly, this was an email earlier in the year from Jill PhD: " Acyclovir is a PNP (purine nucleoside phosphorylase) inhibitor - it inhibits this early step in de novo purine synthesis. Adenosine is a purine so its de novo synthesis would be inhibited and adenosine levels would drop. Sid and I have documented a decrease in adenosine levels with Acyclovir in kids with elevated levels - he presented it last year at DAN. I believe it blocks viral replication by the insertion of a pyrimidine analog that blocks DNA synthesis. " And if that isn't enough, I don't think it's the whole story, because in some cases where adenosine was low, alcyclovir seemed to raised it, so rather than a lowering effect it is a modulation effect. I would like to duplicate this work in another study. I'm working on that now. - Stan > > Hi Stan, I recall you mentioned there might be a connection between > Valtrex and adenosine (or adenosine receptors?) - could you please give > some more details. Was your observation/report based on changed > adenosine levels pre and post Valtrex or something else? Any idea what > might be at play there? > > TIA > Natasa > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 18, 2006 Report Share Posted May 18, 2006 Hi Natasa, It was actually adeonsine levels. The small study was done by Dr. Baker and published at a DAN! conference and netcasted about a year or two ago. It was spoken about again at the last Think Tank during my Valtex presenation and Dr. Baker included it in his presention on Thiols at this past conference. I was procrastinating finding the slide and uploading it, so thank you for the question. It's now in the FILES section as: " Acyclovir Adenosine Slide - Dr. Baker " Additionallly, this was an email earlier in the year from Jill PhD: " Acyclovir is a PNP (purine nucleoside phosphorylase) inhibitor - it inhibits this early step in de novo purine synthesis. Adenosine is a purine so its de novo synthesis would be inhibited and adenosine levels would drop. Sid and I have documented a decrease in adenosine levels with Acyclovir in kids with elevated levels - he presented it last year at DAN. I believe it blocks viral replication by the insertion of a pyrimidine analog that blocks DNA synthesis. " And if that isn't enough, I don't think it's the whole story, because in some cases where adenosine was low, alcyclovir seemed to raised it, so rather than a lowering effect it is a modulation effect. I would like to duplicate this work in another study. I'm working on that now. - Stan > > Hi Stan, I recall you mentioned there might be a connection between > Valtrex and adenosine (or adenosine receptors?) - could you please give > some more details. Was your observation/report based on changed > adenosine levels pre and post Valtrex or something else? Any idea what > might be at play there? > > TIA > Natasa > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 19, 2006 Report Share Posted May 19, 2006 That is really interesting and my feeling is it could turn out to be very important, not just in terms of regulating adenosine levels (which could be a downstream occurence) but of regulating adenosine RECEPTORS activities. have a look at this: http://www.people.memphis.edu/~pbridson/research.htm I especially liked the bit re acyclovir: "...These and related compounds selectively affect biological processes by interacting with enzymes or receptors in place of the natural ligands that they resemble." and: "it is well known that ... adenosine is a component of nucleic acids, and that its nucleotides ... play important roles in cellular metabolism. Less well known is the fact that adenosine itself regulates metabolic activity by acting as a neurotransmitter .... Ligands for adenosine receptors in the central nervous system may be useful in the treatment of cognitive disorders, Parkinson's disease, and psychoses.." Furthermore adenosine receptors are closely linked to many other channels and receptors on membrane surface, and notably many of those closely linked channels often pop up in monogenetic autism disorders... Natasa p.s. if anyone is remotely interested in a ligand/protein binding here is a great explanation: http://www.york.ac.uk/depts/chem/staff/elaborate/packages/binding/binding-why.html > >> > Hi Stan, I recall you mentioned there might be a connection between> > Valtrex and adenosine (or adenosine receptors?) - could you please give> > some more details. Was your observation/report based on changed> > adenosine levels pre and post Valtrex or something else? Any idea what> > might be at play there?> > > > TIA> > Natasa> >> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 19, 2006 Report Share Posted May 19, 2006 That is really interesting and my feeling is it could turn out to be very important, not just in terms of regulating adenosine levels (which could be a downstream occurence) but of regulating adenosine RECEPTORS activities. have a look at this: http://www.people.memphis.edu/~pbridson/research.htm I especially liked the bit re acyclovir: "...These and related compounds selectively affect biological processes by interacting with enzymes or receptors in place of the natural ligands that they resemble." and: "it is well known that ... adenosine is a component of nucleic acids, and that its nucleotides ... play important roles in cellular metabolism. Less well known is the fact that adenosine itself regulates metabolic activity by acting as a neurotransmitter .... Ligands for adenosine receptors in the central nervous system may be useful in the treatment of cognitive disorders, Parkinson's disease, and psychoses.." Furthermore adenosine receptors are closely linked to many other channels and receptors on membrane surface, and notably many of those closely linked channels often pop up in monogenetic autism disorders... Natasa p.s. if anyone is remotely interested in a ligand/protein binding here is a great explanation: http://www.york.ac.uk/depts/chem/staff/elaborate/packages/binding/binding-why.html > >> > Hi Stan, I recall you mentioned there might be a connection between> > Valtrex and adenosine (or adenosine receptors?) - could you please give> > some more details. Was your observation/report based on changed> > adenosine levels pre and post Valtrex or something else? Any idea what> > might be at play there?> > > > TIA> > Natasa> >> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 19, 2006 Report Share Posted May 19, 2006 Nice find. I wonder if that's part of the answer to the question about how Valtrex also raises low levels of adenosine. It actually may be replacing some missing element to adenosine in these kids to raise low levels but it also can block high levels. Really interesting. And it's a neurotransmitter. This is very interesting too. I took a peek at clinical symptoms of high adenosine and the first thing I found the article " Role of Endogenous Adenosine as a Modulator of Syncope Induced During Tilt Testing " http://circ.ahajournals.org/cgi/content/full/circulationaha;106/5/569 which led me to, " What you need to know about Vasovagal Syncope " http://www.londoncardiac.ca/pages/vvs.htm Both of which are talking about reduced blood flow. I don't know if it is related but we do know that SPECT scans indicate that our kids have reduced blood flow to parts of the brain. Again, it might be a stretch, but I thought that was interesting. [Also I noticed how high adenosine can cause immune supression in this article.] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi? cmd=Retrieve & db=pubmed & dopt=Abstract & list_uids=11992407 & query_hl=1 & itool=pub med_docsum Adenosine acts through an A3 receptor to prevent the induction of murine anti-CD3- activated killer T cells. [Then found an example of a person with a negative herpes PCR who had herpes on the brain and high adeonosine.] Clin Infect Dis. 2003 Jul 1;37(1):147-8. Related Articles, Links High levels of adenosine deaminase in a patient with herpetic encephalitis and initial negative PCR results. -Gomez M, -Ruz MA, Jimenez-Alonso J. Publication Types: Case Reports Letter PMID: 12830421 [PubMed - indexed for MEDLINE] So understanding more about adenosine and adenosine modulation may seem more and more important. I have to run for a bit, but I think this discussion will continue. - Stan > > > > > > Hi Stan, I recall you mentioned there might be a connection between > > > Valtrex and adenosine (or adenosine receptors?) - could you please > give > > > some more details. Was your observation/report based on changed > > > adenosine levels pre and post Valtrex or something else? Any idea > what > > > might be at play there? > > > > > > TIA > > > Natasa > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 19, 2006 Report Share Posted May 19, 2006 Nice find. I wonder if that's part of the answer to the question about how Valtrex also raises low levels of adenosine. It actually may be replacing some missing element to adenosine in these kids to raise low levels but it also can block high levels. Really interesting. And it's a neurotransmitter. This is very interesting too. I took a peek at clinical symptoms of high adenosine and the first thing I found the article " Role of Endogenous Adenosine as a Modulator of Syncope Induced During Tilt Testing " http://circ.ahajournals.org/cgi/content/full/circulationaha;106/5/569 which led me to, " What you need to know about Vasovagal Syncope " http://www.londoncardiac.ca/pages/vvs.htm Both of which are talking about reduced blood flow. I don't know if it is related but we do know that SPECT scans indicate that our kids have reduced blood flow to parts of the brain. Again, it might be a stretch, but I thought that was interesting. [Also I noticed how high adenosine can cause immune supression in this article.] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi? cmd=Retrieve & db=pubmed & dopt=Abstract & list_uids=11992407 & query_hl=1 & itool=pub med_docsum Adenosine acts through an A3 receptor to prevent the induction of murine anti-CD3- activated killer T cells. [Then found an example of a person with a negative herpes PCR who had herpes on the brain and high adeonosine.] Clin Infect Dis. 2003 Jul 1;37(1):147-8. Related Articles, Links High levels of adenosine deaminase in a patient with herpetic encephalitis and initial negative PCR results. -Gomez M, -Ruz MA, Jimenez-Alonso J. Publication Types: Case Reports Letter PMID: 12830421 [PubMed - indexed for MEDLINE] So understanding more about adenosine and adenosine modulation may seem more and more important. I have to run for a bit, but I think this discussion will continue. - Stan > > > > > > Hi Stan, I recall you mentioned there might be a connection between > > > Valtrex and adenosine (or adenosine receptors?) - could you please > give > > > some more details. Was your observation/report based on changed > > > adenosine levels pre and post Valtrex or something else? Any idea > what > > > might be at play there? > > > > > > TIA > > > Natasa > > > > > > Quote Link to comment Share on other sites More sharing options...
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