Re: Shouldn't bethancol/urocholine be compounded

May 2, 2006

Hi I just wanted to say that my son moved from one end of the spectrum to the other on bethancol. I will post more tonight. It is my understanding that most DANs have it compounded into liquid form (with stevia). Giving it straight in pills means there is a lot of casein in it so anyone who is considering might want to double check and have it compounded. Urocholine was HUGE for us in many ways. Among other things, my son regained his peripheral vision. But we have always use a compounded version. Dr. Megson is not our DAN, but our DAN got the "formula" from Megson's office I believe. Also, the kids that respond almost always have a strong family history of thyroid and parathyroid conditions. Thanks Veranatasa778 <neno@...> wrote: Hi Anita and others,as vitamin A protocol has been mentioned here a lot I thought you might be interested in this write-up on Megson's work. (for what it is worth... it seems to me this protocol goes towards repairing damage caused by viruses/toxins, not so much it being an antiviral protocol as such...)G-alpha Protein Abnormalities - The Megson Protocol: Vitamin A and Bethanecol (Urecholine)In 1999 Dr. Megson of the University of Virginia presented her research findings at the Defeat Autism Now! (DAN!) Conference. Dr. Megson discovered that G-alpha protein receptors (LINKED TO POTASSIUM / CALCIUM CHANNELS?!) on the surface of cells were disrupted in autistic children with genetic susceptibilities to this defect. G proteins are cell surface molecules which, when activated, transmit signals to the inside of the cell that in turn cause a

variety of chemical reactions to occur.The abnormal G-alpha protein receptors found in autistic children were associated with defective receptors for retinoids (vitamin A and its analogs) in the brain and intestinal tract. Vitamin A is necessary for vision, the prevention of night blindness (nb CACNA MUTATION in New Zealand monogenetic Calcium Channel syndrome causing night blindness and autism!!!), sensory perception, language processing and attention. Children of families with a history of night blindness, pseudo-hypo-parathyroidism or adenoma (benign tumor) of the thyroid or pituitary gland were found to be more prone to this G-alpha protein abnormality.Dr. Megson found a connection between the measles and pertussis vaccinations and G-alpha protein defects. She discovered that the pertussis toxin found in the DPT vaccine (normally injected at 2, 4, 6 and 18 months of age) separates the G-alpha protein from retinoid (vitamin A) receptors. It

also promotes a chronic auto-immune reaction (monocytic [a type of white cell] infiltration) of the deep layer (lamina propria) in the gut lining (mucosa).This in turn leads to a chemical disconnect of the G-alpha protein pathways and the regulating retinoid (Vitamin A) switch, which results in the non-specific branch of the immune system being turned on. Unfortunately, without the proper functioning of the retinoid switch the immune system canÕt be turned off!!The measles virus, part of the MMR vaccination, also plays a role in the g-alpha protein problem. Measles vaccination is associated with lower vitamin A levels and vitamin A in its natural form (cis-vitamin A) is necessary for activating the retinoid receptors.The antibodies to the measles virus also disrupt the Òmolecular glueÓ that connects one cell to another and which is so essential cell-to-cell communication and gut mucosal integrity. The absorption of vitamin A from the

intestinal tract requires an intact gut mucosal surface, the right acidity (pH) and the presence of bile.Dr. Megson also found that there is an important difference between natural (cis-retinoic acid) Vitamin A (found in fish oils) and the synthetic vitamin A palmitate found in infant formulas and commercial vitamins. The artificial Vitamin A palmitate binds the free G-alpha protein and by so doing deactivates the Òoff switchÓ for multiple metabolic pathways involved in vision, cell growth, hormonal regulation and the metabolism of lipids (fats), proteins and glycogen, a storage form of glucose.Fortunately, Dr. Megson was able to find a simple and inexpensive solution for this biochemical dilemma: cod liver oil and Urocholine (Bethanecol). This protocol has been used in over 500 patients without any side effects. In the first phase loading with vitamin A in its natural form, preferably from toxin-free cod liver oil) is started and continued for 2-3 months.

This is followed by the introduction of Bethanecol, a parasympathetic nervous system stimulator that promotes the utilization of vitamin A in cells.The treatment is especially effective for those experiencing any of the following symptoms: malabsorption, divergent gaze, speech delay, dry skin, poor social skills, night blindness, soft stools and dry eyes.The recommended dosage of mercury & dioxin-free cod liver oil is as follows:20-30 lbs 850-1250 IU31-45 lbs 2500 IU46-75 lbs 3750 IU76-125 lbs 5000 IU>125 lbs 7500 IUGood brands of cod liver oil include Nordic Naturals, Eskimo 3, Pharmax, CarlsonÕs and KirkmanÕsThe bethanecol comes as thin, scored 10 mg tablets. They can be halved or quartered or crushed and dissolved in water. Bethanecol remains stable in a watery solution for at least 30 days. DonÕt start the Bethanecol until the child has been on the cod liver oil for at least two months. Continue the

cod liver oil while on the Bethanecol.Suggested oral daily dosages of bethanecol are as follows:Less Than 5 years start with 2.5 mg5-8 years start with 5-7.5 mgAbove 8 years start with 10 mgMaximum dosage is 12.5 mgIf the initial dosage of bethanecol doesnÕt result in signs of improved functioning then the dose may be increased by increments of 2.5 mg per dose to maximum of 12.5 mg. A sign of too much bethanecol is constricted pupils.Hope this helps someone,Natasa

May 2, 2006

Hi I just wanted to say that my son moved from one end of the spectrum to the other on bethancol. I will post more tonight. It is my understanding that most DANs have it compounded into liquid form (with stevia). Giving it straight in pills means there is a lot of casein in it so anyone who is considering might want to double check and have it compounded. Urocholine was HUGE for us in many ways. Among other things, my son regained his peripheral vision. But we have always use a compounded version. Dr. Megson is not our DAN, but our DAN got the "formula" from Megson's office I believe. Also, the kids that respond almost always have a strong family history of thyroid and parathyroid conditions. Thanks Veranatasa778 <neno@...> wrote: Hi Anita and others,as vitamin A protocol has been mentioned here a lot I thought you might be interested in this write-up on Megson's work. (for what it is worth... it seems to me this protocol goes towards repairing damage caused by viruses/toxins, not so much it being an antiviral protocol as such...)G-alpha Protein Abnormalities - The Megson Protocol: Vitamin A and Bethanecol (Urecholine)In 1999 Dr. Megson of the University of Virginia presented her research findings at the Defeat Autism Now! (DAN!) Conference. Dr. Megson discovered that G-alpha protein receptors (LINKED TO POTASSIUM / CALCIUM CHANNELS?!) on the surface of cells were disrupted in autistic children with genetic susceptibilities to this defect. G proteins are cell surface molecules which, when activated, transmit signals to the inside of the cell that in turn cause a

variety of chemical reactions to occur.The abnormal G-alpha protein receptors found in autistic children were associated with defective receptors for retinoids (vitamin A and its analogs) in the brain and intestinal tract. Vitamin A is necessary for vision, the prevention of night blindness (nb CACNA MUTATION in New Zealand monogenetic Calcium Channel syndrome causing night blindness and autism!!!), sensory perception, language processing and attention. Children of families with a history of night blindness, pseudo-hypo-parathyroidism or adenoma (benign tumor) of the thyroid or pituitary gland were found to be more prone to this G-alpha protein abnormality.Dr. Megson found a connection between the measles and pertussis vaccinations and G-alpha protein defects. She discovered that the pertussis toxin found in the DPT vaccine (normally injected at 2, 4, 6 and 18 months of age) separates the G-alpha protein from retinoid (vitamin A) receptors. It

also promotes a chronic auto-immune reaction (monocytic [a type of white cell] infiltration) of the deep layer (lamina propria) in the gut lining (mucosa).This in turn leads to a chemical disconnect of the G-alpha protein pathways and the regulating retinoid (Vitamin A) switch, which results in the non-specific branch of the immune system being turned on. Unfortunately, without the proper functioning of the retinoid switch the immune system canÕt be turned off!!The measles virus, part of the MMR vaccination, also plays a role in the g-alpha protein problem. Measles vaccination is associated with lower vitamin A levels and vitamin A in its natural form (cis-vitamin A) is necessary for activating the retinoid receptors.The antibodies to the measles virus also disrupt the Òmolecular glueÓ that connects one cell to another and which is so essential cell-to-cell communication and gut mucosal integrity. The absorption of vitamin A from the

intestinal tract requires an intact gut mucosal surface, the right acidity (pH) and the presence of bile.Dr. Megson also found that there is an important difference between natural (cis-retinoic acid) Vitamin A (found in fish oils) and the synthetic vitamin A palmitate found in infant formulas and commercial vitamins. The artificial Vitamin A palmitate binds the free G-alpha protein and by so doing deactivates the Òoff switchÓ for multiple metabolic pathways involved in vision, cell growth, hormonal regulation and the metabolism of lipids (fats), proteins and glycogen, a storage form of glucose.Fortunately, Dr. Megson was able to find a simple and inexpensive solution for this biochemical dilemma: cod liver oil and Urocholine (Bethanecol). This protocol has been used in over 500 patients without any side effects. In the first phase loading with vitamin A in its natural form, preferably from toxin-free cod liver oil) is started and continued for 2-3 months.

This is followed by the introduction of Bethanecol, a parasympathetic nervous system stimulator that promotes the utilization of vitamin A in cells.The treatment is especially effective for those experiencing any of the following symptoms: malabsorption, divergent gaze, speech delay, dry skin, poor social skills, night blindness, soft stools and dry eyes.The recommended dosage of mercury & dioxin-free cod liver oil is as follows:20-30 lbs 850-1250 IU31-45 lbs 2500 IU46-75 lbs 3750 IU76-125 lbs 5000 IU>125 lbs 7500 IUGood brands of cod liver oil include Nordic Naturals, Eskimo 3, Pharmax, CarlsonÕs and KirkmanÕsThe bethanecol comes as thin, scored 10 mg tablets. They can be halved or quartered or crushed and dissolved in water. Bethanecol remains stable in a watery solution for at least 30 days. DonÕt start the Bethanecol until the child has been on the cod liver oil for at least two months. Continue the

cod liver oil while on the Bethanecol.Suggested oral daily dosages of bethanecol are as follows:Less Than 5 years start with 2.5 mg5-8 years start with 5-7.5 mgAbove 8 years start with 10 mgMaximum dosage is 12.5 mgIf the initial dosage of bethanecol doesnÕt result in signs of improved functioning then the dose may be increased by increments of 2.5 mg per dose to maximum of 12.5 mg. A sign of too much bethanecol is constricted pupils.Hope this helps someone,Natasa

May 2, 2006

Vera,

That's great news about the your son's response to bethanocol. I have to say, most mom's that I know did not have any positives from the bethanocol and decided to stop using it. Can I ask how long you used it before you noticed a positive effect? and do you still use it for your son?

Sheryl

Re: Shouldn't bethancol/urocholine be compounded

Hi

I just wanted to say that my son moved from one end of the spectrum to the other on bethancol. I will post more tonight. It is my understanding that most DANs have it compounded into liquid form (with stevia). Giving it straight in pills means there is a lot of casein in it so anyone who is considering might want to double check and have it compounded.

Urocholine was HUGE for us in many ways. Among other things, my son regained his peripheral vision. But we have always use a compounded version. Dr. Megson is not our DAN, but our DAN got the "formula" from Megson's office I believe.

Also, the kids that respond almost always have a strong family history of thyroid and parathyroid conditions.

Thanks

Veranatasa778 <neno@...> wrote:

Hi Anita and others,as vitamin A protocol has been mentioned here a lot I thought you might be interested in this write-up on Megson's work. (for what it is worth... it seems to me this protocol goes towards repairing damage caused by viruses/toxins, not so much it being an antiviral protocol as such...)G-alpha Protein Abnormalities - The Megson Protocol: Vitamin A and Bethanecol (Urecholine)In 1999 Dr. Megson of the University of Virginia presented her research findings at the Defeat Autism Now! (DAN!) Conference. Dr. Megson discovered that G-alpha protein receptors (LINKED TO POTASSIUM / CALCIUM CHANNELS?!) on the surface of cells were disrupted in autistic children with genetic susceptibilities to this defect. G proteins are cell surface molecules which, when activated, transmit signals to the inside of the cell that in turn cause a variety of chemical reactions to occur.The abnormal G-alpha protein receptors found in autistic children were associated with defective receptors for retinoids (vitamin A and its analogs) in the brain and intestinal tract. Vitamin A is necessary for vision, the prevention of night blindness (nb CACNA MUTATION in New Zealand monogenetic Calcium Channel syndrome causing night blindness and autism!!!), sensory perception, language processing and attention. Children of families with a history of night blindness, pseudo-hypo-parathyroidism or adenoma (benign tumor) of the thyroid or pituitary gland were found to be more prone to this G-alpha protein abnormality.Dr. Megson found a connection between the measles and pertussis vaccinations and G-alpha protein defects. She discovered that the pertussis toxin found in the DPT vaccine (normally injected at 2, 4, 6 and 18 months of age) separates the G-alpha protein from retinoid (vitamin A) receptors. It also promotes a chronic auto-immune reaction (monocytic [a type of white cell] infiltration) of the deep layer (lamina propria) in the gut lining (mucosa).This in turn leads to a chemical disconnect of the G-alpha protein pathways and the regulating retinoid (Vitamin A) switch, which results in the non-specific branch of the immune system being turned on. Unfortunately, without the proper functioning of the retinoid switch the immune system canÕt be turned off!!The measles virus, part of the MMR vaccination, also plays a role in the g-alpha protein problem. Measles vaccination is associated with lower vitamin A levels and vitamin A in its natural form (cis-vitamin A) is necessary for activating the retinoid receptors.The antibodies to the measles virus also disrupt the Òmolecular glueÓ that connects one cell to another and which is so essential cell-to-cell communication and gut mucosal integrity. The absorption of vitamin A from the intestinal tract requires an intact gut mucosal surface, the right acidity (pH) and the presence of bile.Dr. Megson also found that there is an important difference between natural (cis-retinoic acid) Vitamin A (found in fish oils) and the synthetic vitamin A palmitate found in infant formulas and commercial vitamins. The artificial Vitamin A palmitate binds the free G-alpha protein and by so doing deactivates the Òoff switchÓ for multiple metabolic pathways involved in vision, cell growth, hormonal regulation and the metabolism of lipids (fats), proteins and glycogen, a storage form of glucose.Fortunately, Dr. Megson was able to find a simple and inexpensive solution for this biochemical dilemma: cod liver oil and Urocholine (Bethanecol). This protocol has been used in over 500 patients without any side effects. In the first phase loading with vitamin A in its natural form, preferably from toxin-free cod liver oil) is started and continued for 2-3 months. This is followed by the introduction of Bethanecol, a parasympathetic nervous system stimulator that promotes the utilization of vitamin A in cells.The treatment is especially effective for those experiencing any of the following symptoms: malabsorption, divergent gaze, speech delay, dry skin, poor social skills, night blindness, soft stools and dry eyes.The recommended dosage of mercury & dioxin-free cod liver oil is as follows:20-30 lbs 850-1250 IU31-45 lbs 2500 IU46-75 lbs 3750 IU76-125 lbs 5000 IU>125 lbs 7500 IUGood brands of cod liver oil include Nordic Naturals, Eskimo 3, Pharmax, CarlsonÕs and KirkmanÕsThe bethanecol comes as thin, scored 10 mg tablets. They can be halved or quartered or crushed and dissolved in water. Bethanecol remains stable in a watery solution for at least 30 days. DonÕt start the Bethanecol until the child has been on the cod liver oil for at least two months. Continue the cod liver oil while on the Bethanecol.Suggested oral daily dosages of bethanecol are as follows:Less Than 5 years start with 2.5 mg5-8 years start with 5-7.5 mgAbove 8 years start with 10 mgMaximum dosage is 12.5 mgIf the initial dosage of bethanecol doesnÕt result in signs of improved functioning then the dose may be increased by increments of 2.5 mg per dose to maximum of 12.5 mg. A sign of too much bethanecol is constricted pupils.Hope this helps someone,Natasa

May 2, 2006

Vera,

That's great news about the your son's response to bethanocol. I have to say, most mom's that I know did not have any positives from the bethanocol and decided to stop using it. Can I ask how long you used it before you noticed a positive effect? and do you still use it for your son?

Sheryl

Re: Shouldn't bethancol/urocholine be compounded

Hi

I just wanted to say that my son moved from one end of the spectrum to the other on bethancol. I will post more tonight. It is my understanding that most DANs have it compounded into liquid form (with stevia). Giving it straight in pills means there is a lot of casein in it so anyone who is considering might want to double check and have it compounded.

Urocholine was HUGE for us in many ways. Among other things, my son regained his peripheral vision. But we have always use a compounded version. Dr. Megson is not our DAN, but our DAN got the "formula" from Megson's office I believe.

Also, the kids that respond almost always have a strong family history of thyroid and parathyroid conditions.

Thanks

Veranatasa778 <neno@...> wrote:

Hi Anita and others,as vitamin A protocol has been mentioned here a lot I thought you might be interested in this write-up on Megson's work. (for what it is worth... it seems to me this protocol goes towards repairing damage caused by viruses/toxins, not so much it being an antiviral protocol as such...)G-alpha Protein Abnormalities - The Megson Protocol: Vitamin A and Bethanecol (Urecholine)In 1999 Dr. Megson of the University of Virginia presented her research findings at the Defeat Autism Now! (DAN!) Conference. Dr. Megson discovered that G-alpha protein receptors (LINKED TO POTASSIUM / CALCIUM CHANNELS?!) on the surface of cells were disrupted in autistic children with genetic susceptibilities to this defect. G proteins are cell surface molecules which, when activated, transmit signals to the inside of the cell that in turn cause a variety of chemical reactions to occur.The abnormal G-alpha protein receptors found in autistic children were associated with defective receptors for retinoids (vitamin A and its analogs) in the brain and intestinal tract. Vitamin A is necessary for vision, the prevention of night blindness (nb CACNA MUTATION in New Zealand monogenetic Calcium Channel syndrome causing night blindness and autism!!!), sensory perception, language processing and attention. Children of families with a history of night blindness, pseudo-hypo-parathyroidism or adenoma (benign tumor) of the thyroid or pituitary gland were found to be more prone to this G-alpha protein abnormality.Dr. Megson found a connection between the measles and pertussis vaccinations and G-alpha protein defects. She discovered that the pertussis toxin found in the DPT vaccine (normally injected at 2, 4, 6 and 18 months of age) separates the G-alpha protein from retinoid (vitamin A) receptors. It also promotes a chronic auto-immune reaction (monocytic [a type of white cell] infiltration) of the deep layer (lamina propria) in the gut lining (mucosa).This in turn leads to a chemical disconnect of the G-alpha protein pathways and the regulating retinoid (Vitamin A) switch, which results in the non-specific branch of the immune system being turned on. Unfortunately, without the proper functioning of the retinoid switch the immune system canÕt be turned off!!The measles virus, part of the MMR vaccination, also plays a role in the g-alpha protein problem. Measles vaccination is associated with lower vitamin A levels and vitamin A in its natural form (cis-vitamin A) is necessary for activating the retinoid receptors.The antibodies to the measles virus also disrupt the Òmolecular glueÓ that connects one cell to another and which is so essential cell-to-cell communication and gut mucosal integrity. The absorption of vitamin A from the intestinal tract requires an intact gut mucosal surface, the right acidity (pH) and the presence of bile.Dr. Megson also found that there is an important difference between natural (cis-retinoic acid) Vitamin A (found in fish oils) and the synthetic vitamin A palmitate found in infant formulas and commercial vitamins. The artificial Vitamin A palmitate binds the free G-alpha protein and by so doing deactivates the Òoff switchÓ for multiple metabolic pathways involved in vision, cell growth, hormonal regulation and the metabolism of lipids (fats), proteins and glycogen, a storage form of glucose.Fortunately, Dr. Megson was able to find a simple and inexpensive solution for this biochemical dilemma: cod liver oil and Urocholine (Bethanecol). This protocol has been used in over 500 patients without any side effects. In the first phase loading with vitamin A in its natural form, preferably from toxin-free cod liver oil) is started and continued for 2-3 months. This is followed by the introduction of Bethanecol, a parasympathetic nervous system stimulator that promotes the utilization of vitamin A in cells.The treatment is especially effective for those experiencing any of the following symptoms: malabsorption, divergent gaze, speech delay, dry skin, poor social skills, night blindness, soft stools and dry eyes.The recommended dosage of mercury & dioxin-free cod liver oil is as follows:20-30 lbs 850-1250 IU31-45 lbs 2500 IU46-75 lbs 3750 IU76-125 lbs 5000 IU>125 lbs 7500 IUGood brands of cod liver oil include Nordic Naturals, Eskimo 3, Pharmax, CarlsonÕs and KirkmanÕsThe bethanecol comes as thin, scored 10 mg tablets. They can be halved or quartered or crushed and dissolved in water. Bethanecol remains stable in a watery solution for at least 30 days. DonÕt start the Bethanecol until the child has been on the cod liver oil for at least two months. Continue the cod liver oil while on the Bethanecol.Suggested oral daily dosages of bethanecol are as follows:Less Than 5 years start with 2.5 mg5-8 years start with 5-7.5 mgAbove 8 years start with 10 mgMaximum dosage is 12.5 mgIf the initial dosage of bethanecol doesnÕt result in signs of improved functioning then the dose may be increased by increments of 2.5 mg per dose to maximum of 12.5 mg. A sign of too much bethanecol is constricted pupils.Hope this helps someone,Natasa

May 2, 2006

Vera and Natasha

Thanks for posting. That was very informative. I guess that for me this is the first time I have been in the hands of a physician that has a few connections and is willing to try this. His understanding is that since my son has been on CLO for two years, bringing his dose up to Megson's recommended dose of 3750 ui of vit A for 4 weeks should be enough rather than the 2-3 months recommended. As well he suggested that if nothing happens with 10mg that we should double it to 20mg the next day. So of course being in a position of having to trust a physian for the first time since starting down this path. I am uncomfortable when I know that the recomendation is not to exceed 12.5 mg. Any thoughts here would greatly appreciated.

I guess what I am asking is if you have tried this protocal what dosing did you personally use and is it something that you carry on using for weeks, months or years? I am just more comfortable hearing from parents. This is the first time that we are actually trying something that is not a nutricutical and I am a little apprehensive to say the least even though it does seem to be pretty safe from what I have read. Just having to trust a physician again makes my knees shake. Hahaha I am sure that many of you understand.

We chose this because does have the dilated pupils and side glancing and sphincter muscle issues which relate to the parasympathetic nervous system also because of damage from the DPTP(which is the only vaccine he recieved) that Natasha mentioned. You mention the thyroid and I didn't know about that but I do know that my father has that issue so who knows it may be that we have this family history.

I appoligize as I know that this is not exactly on topic for this list, it is just I am list fatigued and noticed reference to Megson. If anyone has a suggestion for another list i could post this question to that would be helpful as well.

thanks again

susan

Re: Shouldn't bethancol/urocholine be compounded

Hi

I just wanted to say that my son moved from one end of the spectrum to the other on bethancol. I will post more tonight. It is my understanding that most DANs have it compounded into liquid form (with stevia). Giving it straight in pills means there is a lot of casein in it so anyone who is considering might want to double check and have it compounded.

Urocholine was HUGE for us in many ways. Among other things, my son regained his peripheral vision. But we have always use a compounded version. Dr. Megson is not our DAN, but our DAN got the "formula" from Megson's office I believe.

Also, the kids that respond almost always have a strong family history of thyroid and parathyroid conditions.

Thanks

Veranatasa778 <neno@...> wrote:

Hi Anita and others,as vitamin A protocol has been mentioned here a lot I thought you might be interested in this write-up on Megson's work. (for what it is worth... it seems to me this protocol goes towards repairing damage caused by viruses/toxins, not so much it being an antiviral protocol as such...)G-alpha Protein Abnormalities - The Megson Protocol: Vitamin A and Bethanecol (Urecholine)In 1999 Dr. Megson of the University of Virginia presented her research findings at the Defeat Autism Now! (DAN!) Conference. Dr. Megson discovered that G-alpha protein receptors (LINKED TO POTASSIUM / CALCIUM CHANNELS?!) on the surface of cells were disrupted in autistic children with genetic susceptibilities to this defect. G proteins are cell surface molecules which, when activated, transmit signals to the inside of the cell that in turn cause a variety of chemical reactions to occur.The abnormal G-alpha protein receptors found in autistic children were associated with defective receptors for retinoids (vitamin A and its analogs) in the brain and intestinal tract. Vitamin A is necessary for vision, the prevention of night blindness (nb CACNA MUTATION in New Zealand monogenetic Calcium Channel syndrome causing night blindness and autism!!!), sensory perception, language processing and attention. Children of families with a history of night blindness, pseudo-hypo-parathyroidism or adenoma (benign tumor) of the thyroid or pituitary gland were found to be more prone to this G-alpha protein abnormality.Dr. Megson found a connection between the measles and pertussis vaccinations and G-alpha protein defects. She discovered that the pertussis toxin found in the DPT vaccine (normally injected at 2, 4, 6 and 18 months of age) separates the G-alpha protein from retinoid (vitamin A) receptors. It also promotes a chronic auto-immune reaction (monocytic [a type of white cell] infiltration) of the deep layer (lamina propria) in the gut lining (mucosa).This in turn leads to a chemical disconnect of the G-alpha protein pathways and the regulating retinoid (Vitamin A) switch, which results in the non-specific branch of the immune system being turned on. Unfortunately, without the proper functioning of the retinoid switch the immune system canÕt be turned off!!The measles virus, part of the MMR vaccination, also plays a role in the g-alpha protein problem. Measles vaccination is associated with lower vitamin A levels and vitamin A in its natural form (cis-vitamin A) is necessary for activating the retinoid receptors.The antibodies to the measles virus also disrupt the Òmolecular glueÓ that connects one cell to another and which is so essential cell-to-cell communication and gut mucosal integrity. The absorption of vitamin A from the intestinal tract requires an intact gut mucosal surface, the right acidity (pH) and the presence of bile.Dr. Megson also found that there is an important difference between natural (cis-retinoic acid) Vitamin A (found in fish oils) and the synthetic vitamin A palmitate found in infant formulas and commercial vitamins. The artificial Vitamin A palmitate binds the free G-alpha protein and by so doing deactivates the Òoff switchÓ for multiple metabolic pathways involved in vision, cell growth, hormonal regulation and the metabolism of lipids (fats), proteins and glycogen, a storage form of glucose.Fortunately, Dr. Megson was able to find a simple and inexpensive solution for this biochemical dilemma: cod liver oil and Urocholine (Bethanecol). This protocol has been used in over 500 patients without any side effects. In the first phase loading with vitamin A in its natural form, preferably from toxin-free cod liver oil) is started and continued for 2-3 months. This is followed by the introduction of Bethanecol, a parasympathetic nervous system stimulator that promotes the utilization of vitamin A in cells.The treatment is especially effective for those experiencing any of the following symptoms: malabsorption, divergent gaze, speech delay, dry skin, poor social skills, night blindness, soft stools and dry eyes.The recommended dosage of mercury & dioxin-free cod liver oil is as follows:20-30 lbs 850-1250 IU31-45 lbs 2500 IU46-75 lbs 3750 IU76-125 lbs 5000 IU>125 lbs 7500 IUGood brands of cod liver oil include Nordic Naturals, Eskimo 3, Pharmax, CarlsonÕs and KirkmanÕsThe bethanecol comes as thin, scored 10 mg tablets. They can be halved or quartered or crushed and dissolved in water. Bethanecol remains stable in a watery solution for at least 30 days. DonÕt start the Bethanecol until the child has been on the cod liver oil for at least two months. Continue the cod liver oil while on the Bethanecol.Suggested oral daily dosages of bethanecol are as follows:Less Than 5 years start with 2.5 mg5-8 years start with 5-7.5 mgAbove 8 years start with 10 mgMaximum dosage is 12.5 mgIf the initial dosage of bethanecol doesnÕt result in signs of improved functioning then the dose may be increased by increments of 2.5 mg per dose to maximum of 12.5 mg. A sign of too much bethanecol is constricted pupils.Hope this helps someone,Natasa

May 2, 2006

Vera and Natasha

Thanks for posting. That was very informative. I guess that for me this is the first time I have been in the hands of a physician that has a few connections and is willing to try this. His understanding is that since my son has been on CLO for two years, bringing his dose up to Megson's recommended dose of 3750 ui of vit A for 4 weeks should be enough rather than the 2-3 months recommended. As well he suggested that if nothing happens with 10mg that we should double it to 20mg the next day. So of course being in a position of having to trust a physian for the first time since starting down this path. I am uncomfortable when I know that the recomendation is not to exceed 12.5 mg. Any thoughts here would greatly appreciated.

I guess what I am asking is if you have tried this protocal what dosing did you personally use and is it something that you carry on using for weeks, months or years? I am just more comfortable hearing from parents. This is the first time that we are actually trying something that is not a nutricutical and I am a little apprehensive to say the least even though it does seem to be pretty safe from what I have read. Just having to trust a physician again makes my knees shake. Hahaha I am sure that many of you understand.

We chose this because does have the dilated pupils and side glancing and sphincter muscle issues which relate to the parasympathetic nervous system also because of damage from the DPTP(which is the only vaccine he recieved) that Natasha mentioned. You mention the thyroid and I didn't know about that but I do know that my father has that issue so who knows it may be that we have this family history.

I appoligize as I know that this is not exactly on topic for this list, it is just I am list fatigued and noticed reference to Megson. If anyone has a suggestion for another list i could post this question to that would be helpful as well.

thanks again

susan

Re: Shouldn't bethancol/urocholine be compounded

Hi

I just wanted to say that my son moved from one end of the spectrum to the other on bethancol. I will post more tonight. It is my understanding that most DANs have it compounded into liquid form (with stevia). Giving it straight in pills means there is a lot of casein in it so anyone who is considering might want to double check and have it compounded.

Urocholine was HUGE for us in many ways. Among other things, my son regained his peripheral vision. But we have always use a compounded version. Dr. Megson is not our DAN, but our DAN got the "formula" from Megson's office I believe.

Also, the kids that respond almost always have a strong family history of thyroid and parathyroid conditions.

Thanks

Veranatasa778 <neno@...> wrote:

Hi Anita and others,as vitamin A protocol has been mentioned here a lot I thought you might be interested in this write-up on Megson's work. (for what it is worth... it seems to me this protocol goes towards repairing damage caused by viruses/toxins, not so much it being an antiviral protocol as such...)G-alpha Protein Abnormalities - The Megson Protocol: Vitamin A and Bethanecol (Urecholine)In 1999 Dr. Megson of the University of Virginia presented her research findings at the Defeat Autism Now! (DAN!) Conference. Dr. Megson discovered that G-alpha protein receptors (LINKED TO POTASSIUM / CALCIUM CHANNELS?!) on the surface of cells were disrupted in autistic children with genetic susceptibilities to this defect. G proteins are cell surface molecules which, when activated, transmit signals to the inside of the cell that in turn cause a variety of chemical reactions to occur.The abnormal G-alpha protein receptors found in autistic children were associated with defective receptors for retinoids (vitamin A and its analogs) in the brain and intestinal tract. Vitamin A is necessary for vision, the prevention of night blindness (nb CACNA MUTATION in New Zealand monogenetic Calcium Channel syndrome causing night blindness and autism!!!), sensory perception, language processing and attention. Children of families with a history of night blindness, pseudo-hypo-parathyroidism or adenoma (benign tumor) of the thyroid or pituitary gland were found to be more prone to this G-alpha protein abnormality.Dr. Megson found a connection between the measles and pertussis vaccinations and G-alpha protein defects. She discovered that the pertussis toxin found in the DPT vaccine (normally injected at 2, 4, 6 and 18 months of age) separates the G-alpha protein from retinoid (vitamin A) receptors. It also promotes a chronic auto-immune reaction (monocytic [a type of white cell] infiltration) of the deep layer (lamina propria) in the gut lining (mucosa).This in turn leads to a chemical disconnect of the G-alpha protein pathways and the regulating retinoid (Vitamin A) switch, which results in the non-specific branch of the immune system being turned on. Unfortunately, without the proper functioning of the retinoid switch the immune system canÕt be turned off!!The measles virus, part of the MMR vaccination, also plays a role in the g-alpha protein problem. Measles vaccination is associated with lower vitamin A levels and vitamin A in its natural form (cis-vitamin A) is necessary for activating the retinoid receptors.The antibodies to the measles virus also disrupt the Òmolecular glueÓ that connects one cell to another and which is so essential cell-to-cell communication and gut mucosal integrity. The absorption of vitamin A from the intestinal tract requires an intact gut mucosal surface, the right acidity (pH) and the presence of bile.Dr. Megson also found that there is an important difference between natural (cis-retinoic acid) Vitamin A (found in fish oils) and the synthetic vitamin A palmitate found in infant formulas and commercial vitamins. The artificial Vitamin A palmitate binds the free G-alpha protein and by so doing deactivates the Òoff switchÓ for multiple metabolic pathways involved in vision, cell growth, hormonal regulation and the metabolism of lipids (fats), proteins and glycogen, a storage form of glucose.Fortunately, Dr. Megson was able to find a simple and inexpensive solution for this biochemical dilemma: cod liver oil and Urocholine (Bethanecol). This protocol has been used in over 500 patients without any side effects. In the first phase loading with vitamin A in its natural form, preferably from toxin-free cod liver oil) is started and continued for 2-3 months. This is followed by the introduction of Bethanecol, a parasympathetic nervous system stimulator that promotes the utilization of vitamin A in cells.The treatment is especially effective for those experiencing any of the following symptoms: malabsorption, divergent gaze, speech delay, dry skin, poor social skills, night blindness, soft stools and dry eyes.The recommended dosage of mercury & dioxin-free cod liver oil is as follows:20-30 lbs 850-1250 IU31-45 lbs 2500 IU46-75 lbs 3750 IU76-125 lbs 5000 IU>125 lbs 7500 IUGood brands of cod liver oil include Nordic Naturals, Eskimo 3, Pharmax, CarlsonÕs and KirkmanÕsThe bethanecol comes as thin, scored 10 mg tablets. They can be halved or quartered or crushed and dissolved in water. Bethanecol remains stable in a watery solution for at least 30 days. DonÕt start the Bethanecol until the child has been on the cod liver oil for at least two months. Continue the cod liver oil while on the Bethanecol.Suggested oral daily dosages of bethanecol are as follows:Less Than 5 years start with 2.5 mg5-8 years start with 5-7.5 mgAbove 8 years start with 10 mgMaximum dosage is 12.5 mgIf the initial dosage of bethanecol doesnÕt result in signs of improved functioning then the dose may be increased by increments of 2.5 mg per dose to maximum of 12.5 mg. A sign of too much bethanecol is constricted pupils.Hope this helps someone,Natasa

May 3, 2006

Natasa,

This totally describes CJ and my family history. Every female except

myself and my sister in my family on both sides have hypothyroidism. I'm going

to bring this to my DAN for the next visit. Thanks, -

>From: The Schwartz Family <ams1088@...>

>Date: Tue May 02 11:10:31 CDT 2006

>mb12 valtrex

>Subject: Re: Shouldn't bethancol/urocholine be compounded

>Vera, That's great news about the your son's response to bethanocol. I have to

say, most mom's that I know did not have any positives from the bethanocol and

decided to stop using it. Can I ask how long you used it before you noticed a

positive effect? and do you still use it for your son? Sheryl ----- Original

Message ----- From: Vera mb12 valtrex Sent:

Tuesday, May 02, 2006 11:58 AM Subject: Re: Shouldn't

bethancol/urocholine be compounded

> Hi I just wanted to say that my son moved from one end of the spectrum to

the other on bethancol. I will post more tonight. It is my understanding

that most DANs have it compounded into liquid form (with stevia). Giving it

straight in pills means there is a lot of casein in it so anyone who is

considering might want to double check and have it compounded. Urocholine

was HUGE for us in many ways. Among other things, my son regained his

peripheral vision. But we have always use a compounded version. Dr. Megson

is not our DAN, but our DAN got the " formula " from Megson's office I believe.

Also, the kids that respond almost always have a strong family history of

thyroid and parathyroid conditions. Thanks Vera

>

>natasa778 <neno@...> wrote: Hi Anita and others,

>as vitamin A protocol has been mentioned here a lot I thought you might be

interested in this write-up on Megson's work.

>(for what it is worth... it seems to me this protocol goes towards

repairing damage caused by viruses/toxins, not so much it being an antiviral

protocol as such...)

>

>G-alpha Protein Abnormalities - The Megson Protocol: Vitamin A and

Bethanecol (Urecholine)

>

>In 1999 Dr. Megson of the University of Virginia presented her

research findings at the Defeat Autism Now! (DAN!) Conference. Dr. Megson

discovered that G-alpha protein receptors (LINKED TO POTASSIUM / CALCIUM

CHANNELS?!) on the surface of cells were disrupted in autistic children with

genetic susceptibilities to this defect. G proteins are cell surface

molecules which, when activated, transmit signals to the inside of the cell

that in turn cause a variety of chemical reactions to occur.

>

>The abnormal G-alpha protein receptors found in autistic children were

associated with defective receptors for retinoids (vitamin A and its

analogs) in the brain and intestinal tract. Vitamin A is necessary for

vision, the prevention of night blindness (nb CACNA MUTATION in New Zealand

monogenetic Calcium Channel syndrome causing night blindness and autism!!!),

sensory perception, language processing and attention. Children of families

with a history of night blindness, pseudo-hypo-parathyroidism or adenoma

(benign tumor) of the thyroid or pituitary gland were found to be more prone

to this G-alpha protein abnormality.

>

>Dr. Megson found a connection between the measles and pertussis

vaccinations and G-alpha protein defects. She discovered that the pertussis

toxin found in the DPT vaccine (normally injected at 2, 4, 6 and 18 months

of age) separates the G-alpha protein from retinoid (vitamin A) receptors.

It also promotes a chronic auto-immune reaction (monocytic [a type of white

cell] infiltration) of the deep layer (lamina propria) in the gut lining

(mucosa).

>

>This in turn leads to a chemical disconnect of the G-alpha protein pathways

and the regulating retinoid (Vitamin A) switch, which results in the

non-specific branch of the immune system being turned on. Unfortunately,

without the proper functioning of the retinoid switch the immune system

canÕt be turned off!!

>

>The measles virus, part of the MMR vaccination, also plays a role in the

g-alpha protein problem. Measles vaccination is associated with lower

vitamin A levels and vitamin A in its natural form (cis-vitamin A) is

necessary for activating the retinoid receptors.

>

>The antibodies to the measles virus also disrupt the Òmolecular glueÓ that

connects one cell to another and which is so essential cell-to-cell

communication and gut mucosal integrity. The absorption of vitamin A from

the intestinal tract requires an intact gut mucosal surface, the right

acidity (pH) and the presence of bile.

>

>Dr. Megson also found that there is an important difference between natural

(cis-retinoic acid) Vitamin A (found in fish oils) and the synthetic vitamin

A palmitate found in infant formulas and commercial vitamins. The artificial

Vitamin A palmitate binds the free G-alpha protein and by so doing

deactivates the Òoff switchÓ for multiple metabolic pathways involved in

vision, cell growth, hormonal regulation and the metabolism of lipids

(fats), proteins and glycogen, a storage form of glucose.

>

>Fortunately, Dr. Megson was able to find a simple and inexpensive solution

for this biochemical dilemma: cod liver oil and Urocholine (Bethanecol).

This protocol has been used in over 500 patients without any side effects.

In the first phase loading with vitamin A in its natural form, preferably

from toxin-free cod liver oil) is started and continued for 2-3 months. This

is followed by the introduction of Bethanecol, a parasympathetic nervous

system stimulator that promotes the utilization of vitamin A in cells.

>

>The treatment is especially effective for those experiencing any of the

following symptoms: malabsorption, divergent gaze, speech delay, dry skin,

poor social skills, night blindness, soft stools and dry eyes.

>

>The recommended dosage of mercury & dioxin-free cod liver oil is as

follows:

>

>20-30 lbs 850-1250 IU

>31-45 lbs 2500 IU

>46-75 lbs 3750 IU

>76-125 lbs 5000 IU

>>125 lbs 7500 IU

>

>Good brands of cod liver oil include Nordic Naturals, Eskimo 3, Pharmax,

CarlsonÕs and KirkmanÕs

>

>The bethanecol comes as thin, scored 10 mg tablets. They can be halved or

quartered or crushed and dissolved in water. Bethanecol remains stable in a

watery solution for at least 30 days. DonÕt start the Bethanecol until the

child has been on the cod liver oil for at least two months. Continue the

cod liver oil while on the Bethanecol.

>

>Suggested oral daily dosages of bethanecol are as follows:

>

>Less Than 5 years start with 2.5 mg

>5-8 years start with 5-7.5 mg

>Above 8 years start with 10 mg

>Maximum dosage is 12.5 mg

>

>If the initial dosage of bethanecol doesnÕt result in signs of improved

functioning then the dose may be increased by increments of 2.5 mg per dose

to maximum of 12.5 mg. A sign of too much bethanecol is constricted pupils.

>

>Hope this helps someone,

>Natasa

>

May 3, 2006