Re: Known harmful effects of vitamin c

March 25, 2006

Hi Liz I wonder WHY anyone would take such huge amounts of vit c??? TO me, that seems crazy,, I cannot think of any time a dose of 5 grams a day would be beneficial? People just need to be realistic and take moderate amounts of anything,, everything,, just makes sense to me,, good article tho, especially those of us with hep c need to be careful, ESPECIALLY if they have too much iron!elizabethnv1 <elizabethnv1@...> wrote: Known harmful effectsA primary concern is people with unusual or unaddressed iron overload conditions, including hemochromatosis. Vitamin C enhances iron absorption. If sufferers of iron overload conditions take gram sized doses of Vitamin C, they may worsen the iron overload due to enhanced iron absorption. Vitamin C causes diarrhea in everyone if taken in

quantities beyond a limit which is variable to the individual. Cathcart[3] has called this limit the Bowel Tolerance Limit and observed that it is higher in people with serious illness than those in good health. It ranges from 5 grams per day in the healthy to 300 grams per day in the seriously ill, such as those with AIDS and cancer. The diarrhea will cease as soon as the dose is reduced, and without harmful effect. Inadequate Glucose-6-phosphate dehydrogenase enzyme (G6PD) levels, a genetic condition, may predispose some individuals to hemolytic anemia after intake of specific oxidizing substances present in some food and drugs. This includes repeated, very large intravenous or oral dosages of vitamin C. There is a test available for G6PD deficiency [13]. High dose Vitamin E has been proposed as a potential protective factor. [edit]Other reports of harmful effectsReports of harmful effects of vitamin C tend to receive

great prominence in the world's media. As such, these reports tend to generate much debate and more research into Vitamin C. Some of the harmful effects described below have been proven to be unfounded in later studies, while other effects are still undergoing further analysis.In April 1998 the journal Nature reported alleged carcinogenic and teratogenic effects of excessive doses of vitamin C. The effects were noted in test tube experiments and on only two of the 20 markers of free radical damage to DNA. They have not been supported by further evidence from living organisms. [14] In April 2000, University of Southern California researchers reported a thickening of the arteries of the neck in persons taking high vitamin C doses. It was later pointed out by vitamin C advocates that this can be explained by vitamin C's collagen synthesising role leading to thicker and stronger artery walls. (ref.6 para 10) In June

2004, Duke University researchers reported an increased susceptibility to osteo-arthritis in guinea pigs fed a diet high in vitamin C. However, a 2003 study at Umeå University in Sweden, found that "the plasma levels of vitamin C, retinol and uric acid were inversely correlated to variables related to rheumatoid arthritis disease activity." A speculated increased risk of kidney stones may be a side effect of taking Vitamin C in larger than normal amounts. The potential mechanism of action is through the metabolism of Vitamin C (ascorbic acid) to dehydroascorbic acid, which is then metabolized to oxalic acid, a known constituent of kidney stones. However, this issue is still controversial, with evidence being presented for [15] and against [16] the possibility of this side effect. Vitamin B6 may mitigate this risk by decreasing oxalate production [17]. Additionally, thiamine may inhibit oxalate formation. Furthermore,

correcting any magnesium deficiency [7] may decrease the risk of kidney stones by decreasing oxalate crystallization. Increasing one's fluid intake also helps to preventing oxalate crystallization in the kidney. "Rebound scurvy" is a theoretical, never observed, condition that could occur when daily intake of Vitamin C is rapidly reduced from a very large amount to a relatively low amount. Advocates suggest this an exaggeration of the rebound effect which occurs because ascorbate-dependent enzyme reactions continue for 24-48 hours after intake is lowered, and use up vitamin C which is not being replenished. The effect is to lower one's serum vitamin C blood concentration to less than normal for a short amount of time. During this period of time there is a slight risk of cold or flu infection through reduced resistance. Within a couple of days the enzyme reactions shut down and blood serum returns to the normal level of

someone not taking large supplements. This is not scurvy, which takes weeks of zero vitamin C consumption to produce symptoms. It is something people who take large vitamin C supplements need to be aware of in order to manage phased rather than sudden changes to the amount taken. (ref.6 para 4) This is a theoretical risk for those taking supplements - e.g. if they find themselves severely ill, and in a hospital without the supplements, at a time when they need normal or better levels of vitamin C to fight the disease (ref.[3] and search for "The major problem"). Some writers [8] have identified a theoretical risk of poor Copper absorption from high doses of Vitamin C, although little experimental evidence supports this. However, ceruloplasmin levels seem specifically lowered by high vitamin C intake. In one study, 600 milligrams of Vitamin C daily did not decrease copper absorption or overall body copper status in young

men, but led to lower ceruloplasmin levels similar to those caused by copper deficiency [9]. In another, ceruloplasmin levels were significantly reduced [10]. There are stories circulating among some folk remedy proponants that doses of around 12 grams per day of Vitamin C can induce an abortion in women under 4 weeks of pregnancy. [11] This is not supported by scientific reseach however. [12] [edit]Sourcesing, Linus (1986) How to Live Longer and Feel Better W. H. Freeman and Company, ISBN 0-380-70289-4 Levy (September 2002) Vitamin C, Infectious Diseases, and Toxins, Xlibris Corporation (Paperback). ISBN 1401069630 (Note: Xlibris is a print on demand self-publishing house.) Hickey, Steve; , (May, 2004) Ascorbate: The Science of Vitamin C, Lulu Press, Inc. ISBN 1411607244 (Note: Lulu is a print on demand self-publishing house.) [edit]References & #8593; ish Crop Research

Institute -Development of a Yeast-Based Single-Step Process for the Manufacture of L-Ascorbic Acid (vitamin C) & #8593; British pharmacology professors debate with the US National Institutes of Health over the optimum vitamin c dose (from PR Newswire - 6th July 2004) [1] & #8593; a b c d e f F. Cathcart III M.D., Vitamin C, Titrating To Bowel Tolerance, Anascorbemia, and Acute Induced Scurvey, Allergy, Environmental, and Orthomolecular Medicine & #8593; Combs GF. The Vitamins, Fundamental Aspects in Nutrition and Health. 2nd ed. San Diego, CA: Academic Press, 2001:245-272 & #8593; Qi Chen and others. Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues. Proceedings of the National Academy of Sciences of the United States of America (PNAS) | September 20, 2005 | vol. 102 | no. 38 | 13604-13609 & #8593; Hickey, Steve

& , ; (March, 2005), Ridiculous Dietary Allowance, Lulu Press, Inc. ISBN 1411622219.(Note: Lulu is a print on demand self-publishing house.) & #8593; NCBI & #8593; acu-cell & #8593; NCBI & #8593; NCBI & #8593; Home Abortion Remedy - Vitamin C, 8 March 2006 & #8593; Vitamins C and E in spontaneous abortion Int J Vitam Nutr Res. 1976;46(3):291-6. Jackie

March 25, 2006

Believe it or not , for cancer patients those doses are reccomended . But yes those of us with advanced disease have to be careful because of iron overload , and the further damage it causes ..

Re: Known harmful effects of vitamin c

Hi Liz

I wonder WHY anyone would take such huge amounts of vit c??? TO me, that seems crazy,, I cannot think of any time a dose of 5 grams a day would be beneficial? People just need to be realistic and take moderate amounts of anything,, everything,, just makes sense to me,,

good article tho, especially those of us with hep c need to be careful, ESPECIALLY if they have too much iron!elizabethnv1 <elizabethnv1@...> wrote:

Known harmful effectsA primary concern is people with unusual or unaddressed iron overload conditions, including hemochromatosis. Vitamin C enhances iron absorption. If sufferers of iron overload conditions take gram sized doses of Vitamin C, they may worsen the iron overload due to enhanced iron absorption. Vitamin C causes diarrhea in everyone if taken in quantities beyond a limit which is variable to the individual. Cathcart[3] has called this limit the Bowel Tolerance Limit and observed that it is higher in people with serious illness than those in good health. It ranges from 5 grams per day in the healthy to 300 grams per day in the seriously ill, such as those with AIDS and cancer. The diarrhea will cease as soon as the dose is reduced, and without harmful effect. Inadequate Glucose-6-phosphate dehydrogenase enzyme (G6PD) levels, a genetic condition, may predispose some individuals to hemolytic anemia after intake of specific oxidizing substances present in some food and drugs. This includes repeated, very large intravenous or oral dosages of vitamin C. There is a test available for G6PD deficiency [13]. High dose Vitamin E has been proposed as a potential protective factor. [edit]Other reports of harmful effectsReports of harmful effects of vitamin C tend to receive great prominence in the world's media. As such, these reports tend to generate much debate and more research into Vitamin C. Some of the harmful effects described below have been proven to be unfounded in later studies, while other effects are still undergoing further analysis.In April 1998 the journal Nature reported alleged carcinogenic and teratogenic effects of excessive doses of vitamin C. The effects were noted in test tube experiments and on only two of the 20 markers of free radical damage to DNA. They have not been supported by further evidence from living organisms. [14] In April 2000, University of Southern California researchers reported a thickening of the arteries of the neck in persons taking high vitamin C doses. It was later pointed out by vitamin C advocates that this can be explained by vitamin C's collagen synthesising role leading to thicker and stronger artery walls. (ref.6 para 10) In June 2004, Duke University researchers reported an increased susceptibility to osteo-arthritis in guinea pigs fed a diet high in vitamin C. However, a 2003 study at Umeå University in Sweden, found that "the plasma levels of vitamin C, retinol and uric acid were inversely correlated to variables related to rheumatoid arthritis disease activity." A speculated increased risk of kidney stones may be a side effect of taking Vitamin C in larger than normal amounts. The potential mechanism of action is through the metabolism of Vitamin C (ascorbic acid) to dehydroascorbic acid, which is then metabolized to oxalic acid, a known constituent of kidney stones. However, this issue is still controversial, with evidence being presented for [15] and against [16] the possibility of this side effect. Vitamin B6 may mitigate this risk by decreasing oxalate production [17]. Additionally, thiamine may inhibit oxalate formation. Furthermore, correcting any magnesium deficiency [7] may decrease the risk of kidney stones by decreasing oxalate crystallization. Increasing one's fluid intake also helps to preventing oxalate crystallization in the kidney. "Rebound scurvy" is a theoretical, never observed, condition that could occur when daily intake of Vitamin C is rapidly reduced from a very large amount to a relatively low amount. Advocates suggest this an exaggeration of the rebound effect which occurs because ascorbate-dependent enzyme reactions continue for 24-48 hours after intake is lowered, and use up vitamin C which is not being replenished. The effect is to lower one's serum vitamin C blood concentration to less than normal for a short amount of time. During this period of time there is a slight risk of cold or flu infection through reduced resistance. Within a couple of days the enzyme reactions shut down and blood serum returns to the normal level of someone not taking large supplements. This is not scurvy, which takes weeks of zero vitamin C consumption to produce symptoms. It is something people who take large vitamin C supplements need to be aware of in order to manage phased rather than sudden changes to the amount taken. (ref.6 para 4) This is a theoretical risk for those taking supplements - e.g. if they find themselves severely ill, and in a hospital without the supplements, at a time when they need normal or better levels of vitamin C to fight the disease (ref.[3] and search for "The major problem"). Some writers [8] have identified a theoretical risk of poor Copper absorption from high doses of Vitamin C, although little experimental evidence supports this. However, ceruloplasmin levels seem specifically lowered by high vitamin C intake. In one study, 600 milligrams of Vitamin C daily did not decrease copper absorption or overall body copper status in young men, but led to lower ceruloplasmin levels similar to those caused by copper deficiency [9]. In another, ceruloplasmin levels were significantly reduced [10]. There are stories circulating among some folk remedy proponants that doses of around 12 grams per day of Vitamin C can induce an abortion in women under 4 weeks of pregnancy. [11] This is not supported by scientific reseach however. [12] [edit]Sourcesing, Linus (1986) How to Live Longer and Feel Better W. H. Freeman and Company, ISBN 0-380-70289-4 Levy (September 2002) Vitamin C, Infectious Diseases, and Toxins, Xlibris Corporation (Paperback). ISBN 1401069630 (Note: Xlibris is a print on demand self-publishing house.) Hickey, Steve; , (May, 2004) Ascorbate: The Science of Vitamin C, Lulu Press, Inc. ISBN 1411607244 (Note: Lulu is a print on demand self-publishing house.) [edit]References & #8593; ish Crop Research Institute -Development of a Yeast-Based Single-Step Process for the Manufacture of L-Ascorbic Acid (vitamin C) & #8593; British pharmacology professors debate with the US National Institutes of Health over the optimum vitamin c dose (from PR Newswire - 6th July 2004) [1] & #8593; a b c d e f F. Cathcart III M.D., Vitamin C, Titrating To Bowel Tolerance, Anascorbemia, and Acute Induced Scurvey, Allergy, Environmental, and Orthomolecular Medicine & #8593; Combs GF. The Vitamins, Fundamental Aspects in Nutrition and Health. 2nd ed. San Diego, CA: Academic Press, 2001:245-272 & #8593; Qi Chen and others. Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues. Proceedings of the National Academy of Sciences of the United States of America (PNAS) | September 20, 2005 | vol. 102 | no. 38 | 13604-13609 & #8593; Hickey, Steve & , ; (March, 2005), Ridiculous Dietary Allowance, Lulu Press, Inc. ISBN 1411622219.(Note: Lulu is a print on demand self-publishing house.) & #8593; NCBI & #8593; acu-cell & #8593; NCBI & #8593; NCBI & #8593; Home Abortion Remedy - Vitamin C, 8 March 2006 & #8593; Vitamins C and E in spontaneous abortion Int J Vitam Nutr Res. 1976;46(3):291-6. Jackie

March 25, 2006

Interesting. I think this subject should read "Virtually no Known harmful effects..." I would note that anyone taking high doses of Vit C should carefully monitor Fe intake.elizabethnv1 <elizabethnv1@...> wrote: Known harmful effectsA primary concern is people with unusual or unaddressed iron overload conditions, including hemochromatosis. Vitamin C enhances iron absorption. If sufferers of iron overload conditions take gram sized doses of Vitamin C, they may worsen the iron overload due to enhanced iron absorption. Vitamin C causes diarrhea in everyone if taken in quantities beyond a limit which is variable to the individual. Cathcart[3] has called this limit the Bowel Tolerance Limit and observed that it is higher in people with serious illness than those in good health. It ranges

from 5 grams per day in the healthy to 300 grams per day in the seriously ill, such as those with AIDS and cancer. The diarrhea will cease as soon as the dose is reduced, and without harmful effect. Inadequate Glucose-6-phosphate dehydrogenase enzyme (G6PD) levels, a genetic condition, may predispose some individuals to hemolytic anemia after intake of specific oxidizing substances present in some food and drugs. This includes repeated, very large intravenous or oral dosages of vitamin C. There is a test available for G6PD deficiency [13]. High dose Vitamin E has been proposed as a potential protective factor. [edit]Other reports of harmful effectsReports of harmful effects of vitamin C tend to receive great prominence in the world's media. As such, these reports tend to generate much debate and more research into Vitamin C. Some of the harmful effects described below have been proven to be unfounded in later

studies, while other effects are still undergoing further analysis.In April 1998 the journal Nature reported alleged carcinogenic and teratogenic effects of excessive doses of vitamin C. The effects were noted in test tube experiments and on only two of the 20 markers of free radical damage to DNA. They have not been supported by further evidence from living organisms. [14] In April 2000, University of Southern California researchers reported a thickening of the arteries of the neck in persons taking high vitamin C doses. It was later pointed out by vitamin C advocates that this can be explained by vitamin C's collagen synthesising role leading to thicker and stronger artery walls. (ref.6 para 10) In June 2004, Duke University researchers reported an increased susceptibility to osteo-arthritis in guinea pigs fed a diet high in vitamin C. However, a 2003 study at Ume?University in Sweden, found that "the plasma levels of

vitamin C, retinol and uric acid were inversely correlated to variables related to rheumatoid arthritis disease activity." A speculated increased risk of kidney stones may be a side effect of taking Vitamin C in larger than normal amounts. The potential mechanism of action is through the metabolism of Vitamin C (ascorbic acid) to dehydroascorbic acid, which is then metabolized to oxalic acid, a known constituent of kidney stones. However, this issue is still controversial, with evidence being presented for [15] and against [16] the possibility of this side effect. Vitamin B6 may mitigate this risk by decreasing oxalate production [17]. Additionally, thiamine may inhibit oxalate formation. Furthermore, correcting any magnesium deficiency [7] may decrease the risk of kidney stones by decreasing oxalate crystallization. Increasing one's fluid intake also helps to preventing oxalate crystallization in the kidney. "Rebound

scurvy" is a theoretical, never observed, condition that could occur when daily intake of Vitamin C is rapidly reduced from a very large amount to a relatively low amount. Advocates suggest this an exaggeration of the rebound effect which occurs because ascorbate-dependent enzyme reactions continue for 24-48 hours after intake is lowered, and use up vitamin C which is not being replenished. The effect is to lower one's serum vitamin C blood concentration to less than normal for a short amount of time. During this period of time there is a slight risk of cold or flu infection through reduced resistance. Within a couple of days the enzyme reactions shut down and blood serum returns to the normal level of someone not taking large supplements. This is not scurvy, which takes weeks of zero vitamin C consumption to produce symptoms. It is something people who take large vitamin C supplements need to be aware of in order to manage

phased rather than sudden changes to the amount taken. (ref.6 para 4) This is a theoretical risk for those taking supplements - e.g. if they find themselves severely ill, and in a hospital without the supplements, at a time when they need normal or better levels of vitamin C to fight the disease (ref.[3] and search for "The major problem"). Some writers [8] have identified a theoretical risk of poor Copper absorption from high doses of Vitamin C, although little experimental evidence supports this. However, ceruloplasmin levels seem specifically lowered by high vitamin C intake. In one study, 600 milligrams of Vitamin C daily did not decrease copper absorption or overall body copper status in young men, but led to lower ceruloplasmin levels similar to those caused by copper deficiency [9]. In another, ceruloplasmin levels were significantly reduced [10]. There are stories circulating among some folk remedy proponants that

doses of around 12 grams per day of Vitamin C can induce an abortion in women under 4 weeks of pregnancy. [11] This is not supported by scientific reseach however. [12] [edit]Sourcesing, Linus (1986) How to Live Longer and Feel Better W. H. Freeman and Company, ISBN 0-380-70289-4 Levy (September 2002) Vitamin C, Infectious Diseases, and Toxins, Xlibris Corporation (Paperback). ISBN 1401069630 (Note: Xlibris is a print on demand self-publishing house.) Hickey, Steve; , (May, 2004) Ascorbate: The Science of Vitamin C, Lulu Press, Inc. ISBN 1411607244 (Note: Lulu is a print on demand self-publishing house.) [edit]References¡ü ish Crop Research Institute -Development of a Yeast-Based Single-Step Process for the Manufacture of L-Ascorbic Acid (vitamin C) ¡ü British pharmacology professors debate with the US National Institutes of Health over the optimum vitamin c dose (from PR

Newswire - 6th July 2004) [1] ¡ü a b c d e f F. Cathcart III M.D., Vitamin C, Titrating To Bowel Tolerance, Anascorbemia, and Acute Induced Scurvey, Allergy, Environmental, and Orthomolecular Medicine ¡ü Combs GF. The Vitamins, Fundamental Aspects in Nutrition and Health. 2nd ed. San Diego, CA: Academic Press, 2001:245-272 ¡ü Qi Chen and others. Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues. Proceedings of the National Academy of Sciences of the United States of America (PNAS) | September 20, 2005 | vol. 102 | no. 38 | 13604-13609 ¡ü Hickey, Steve & , ; (March, 2005), Ridiculous Dietary Allowance, Lulu Press, Inc. ISBN 1411622219.(Note: Lulu is a print on demand self-publishing house.) ¡ü NCBI ¡ü acu-cell ¡ü NCBI ¡ü NCBI ¡ü Home Abortion Remedy - Vitamin C, 8 March 2006 ¡ü Vitamins C and E in

spontaneous abortion Int J Vitam Nutr Res. 1976;46(3):291-6. It's a pleasure having you join in our conversations. We hope you have found the support you need with us. If you are using email for your posts, for easy access to our group, just click the link-- Hepatitis C/Happy Posting

March 25, 2006

If you have hepatitis c iron is a big problem , so anything that can effect the iron levels should be carefully monitored by the doctor .

Re: Known harmful effects of vitamin c

Interesting. I think this subject should read "Virtually no Known harmful effects..." I would note that anyone taking high doses of Vit C should carefully monitor Fe intake.elizabethnv1 <elizabethnv1@...> wrote: Known harmful effectsA primary concern is people with unusual or unaddressed iron overload conditions, including hemochromatosis. Vitamin C enhances iron absorption. If sufferers of iron overload conditions take gram sized doses of Vitamin C, they may worsen the iron overload due to enhanced iron absorption. Vitamin C causes diarrhea in everyone if taken in quantities beyond a limit which is variable to the individual. Cathcart[3] has called this limit the Bowel Tolerance Limit and observed that it is higher in people with serious illness than those in good health. It ranges from 5 grams per day in the healthy to 300 grams per day in the seriously ill, such as those with AIDS and cancer. The diarrhea will cease as soon as the dose is reduced, and without harmful effect. Inadequate Glucose-6-phosphate dehydrogenase enzyme (G6PD) levels, a genetic condition, may predispose some individuals to hemolytic anemia after intake of specific oxidizing substances present in some food and drugs. This includes repeated, very large intravenous or oral dosages of vitamin C. There is a test available for G6PD deficiency [13]. High dose Vitamin E has been proposed as a potential protective factor. [edit]Other reports of harmful effectsReports of harmful effects of vitamin C tend to receive great prominence in the world's media. As such, these reports tend to generate much debate and more research into Vitamin C. Some of the harmful effects described below have been proven to be unfounded in later studies, while other effects are still undergoing further analysis.In April 1998 the journal Nature reported alleged carcinogenic and teratogenic effects of excessive doses of vitamin C. The effects were noted in test tube experiments and on only two of the 20 markers of free radical damage to DNA. They have not been supported by further evidence from living organisms. [14] In April 2000, University of Southern California researchers reported a thickening of the arteries of the neck in persons taking high vitamin C doses. It was later pointed out by vitamin C advocates that this can be explained by vitamin C's collagen synthesising role leading to thicker and stronger artery walls. (ref.6 para 10) In June 2004, Duke University researchers reported an increased susceptibility to osteo-arthritis in guinea pigs fed a diet high in vitamin C. However, a 2003 study at Ume?University in Sweden, found that "the plasma levels of vitamin C, retinol and uric acid were inversely correlated to variables related to rheumatoid arthritis disease activity." A speculated increased risk of kidney stones may be a side effect of taking Vitamin C in larger than normal amounts. The potential mechanism of action is through the metabolism of Vitamin C (ascorbic acid) to dehydroascorbic acid, which is then metabolized to oxalic acid, a known constituent of kidney stones. However, this issue is still controversial, with evidence being presented for [15] and against [16] the possibility of this side effect. Vitamin B6 may mitigate this risk by decreasing oxalate production [17]. Additionally, thiamine may inhibit oxalate formation. Furthermore, correcting any magnesium deficiency [7] may decrease the risk of kidney stones by decreasing oxalate crystallization. Increasing one's fluid intake also helps to preventing oxalate crystallization in the kidney. "Rebound scurvy" is a theoretical, never observed, condition that could occur when daily intake of Vitamin C is rapidly reduced from a very large amount to a relatively low amount. Advocates suggest this an exaggeration of the rebound effect which occurs because ascorbate-dependent enzyme reactions continue for 24-48 hours after intake is lowered, and use up vitamin C which is not being replenished. The effect is to lower one's serum vitamin C blood concentration to less than normal for a short amount of time. During this period of time there is a slight risk of cold or flu infection through reduced resistance. Within a couple of days the enzyme reactions shut down and blood serum returns to the normal level of someone not taking large supplements. This is not scurvy, which takes weeks of zero vitamin C consumption to produce symptoms. It is something people who take large vitamin C supplements need to be aware of in order to manage phased rather than sudden changes to the amount taken. (ref.6 para 4) This is a theoretical risk for those taking supplements - e.g. if they find themselves severely ill, and in a hospital without the supplements, at a time when they need normal or better levels of vitamin C to fight the disease (ref.[3] and search for "The major problem"). Some writers [8] have identified a theoretical risk of poor Copper absorption from high doses of Vitamin C, although little experimental evidence supports this. However, ceruloplasmin levels seem specifically lowered by high vitamin C intake. In one study, 600 milligrams of Vitamin C daily did not decrease copper absorption or overall body copper status in young men, but led to lower ceruloplasmin levels similar to those caused by copper deficiency [9]. In another, ceruloplasmin levels were significantly reduced [10]. There are stories circulating among some folk remedy proponants that doses of around 12 grams per day of Vitamin C can induce an abortion in women under 4 weeks of pregnancy. [11] This is not supported by scientific reseach however. [12] [edit]Sourcesing, Linus (1986) How to Live Longer and Feel Better W. H. Freeman and Company, ISBN 0-380-70289-4 Levy (September 2002) Vitamin C, Infectious Diseases, and Toxins, Xlibris Corporation (Paperback). ISBN 1401069630 (Note: Xlibris is a print on demand self-publishing house.) Hickey, Steve; , (May, 2004) Ascorbate: The Science of Vitamin C, Lulu Press, Inc. ISBN 1411607244 (Note: Lulu is a print on demand self-publishing house.) [edit]References¡ü ish Crop Research Institute -Development of a Yeast-Based Single-Step Process for the Manufacture of L-Ascorbic Acid (vitamin C) ¡ü British pharmacology professors debate with the US National Institutes of Health over the optimum vitamin c dose (from PR Newswire - 6th July 2004) [1] ¡ü a b c d e f F. Cathcart III M.D., Vitamin C, Titrating To Bowel Tolerance, Anascorbemia, and Acute Induced Scurvey, Allergy, Environmental, and Orthomolecular Medicine ¡ü Combs GF. The Vitamins, Fundamental Aspects in Nutrition and Health. 2nd ed. San Diego, CA: Academic Press, 2001:245-272 ¡ü Qi Chen and others. Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues. Proceedings of the National Academy of Sciences of the United States of America (PNAS) | September 20, 2005 | vol. 102 | no. 38 | 13604-13609 ¡ü Hickey, Steve & , ; (March, 2005), Ridiculous Dietary Allowance, Lulu Press, Inc. ISBN 1411622219.(Note: Lulu is a print on demand self-publishing house.) ¡ü NCBI ¡ü acu-cell ¡ü NCBI ¡ü NCBI ¡ü Home Abortion Remedy - Vitamin C, 8 March 2006 ¡ü Vitamins C and E in spontaneous abortion Int J Vitam Nutr Res. 1976;46(3):291-6. It's a pleasure having you join in our conversations. We hope you have found the support you need with us. If you are using email for your posts, for easy access to our group, just click the link-- Hepatitis C/Happy Posting

March 25, 2006

WOW! thats a lot of vit C,, but I guess IF you dont have iron overload,, its probably ok, but I cant imagine taking that much!!!elizabethnv1 <elizabethnv1@...> wrote: Believe it or not , for cancer patients those doses are reccomended . But yes those of us with advanced disease have to be careful because of iron overload , and the further damage it causes .. Re: Known harmful effects of vitamin c Hi Liz I wonder WHY anyone would take such huge amounts of vit c??? TO me, that seems crazy,, I cannot think of any time a dose of 5 grams a day would be beneficial? People just need to be realistic and take moderate amounts of anything,, everything,, just makes sense to me,, good article tho, especially those of us with hep c need to be careful, ESPECIALLY if they have too much iron!elizabethnv1 <elizabethnv1@...> wrote: Known harmful effectsA primary concern is people with unusual or unaddressed iron overload conditions, including hemochromatosis. Vitamin C enhances iron absorption. If sufferers of iron overload conditions take gram sized doses of Vitamin C, they may worsen the iron overload due to enhanced iron absorption. Vitamin C causes diarrhea in everyone if taken in quantities beyond a limit which is variable to the individual. Cathcart[3] has called this limit the Bowel Tolerance Limit and observed that it is higher in people with serious illness than those in good health. It ranges from 5 grams per day in the healthy to 300 grams per day in the seriously ill, such as those with AIDS and cancer. The diarrhea will cease as soon as the dose is reduced, and without harmful effect. Inadequate Glucose-6-phosphate dehydrogenase enzyme (G6PD) levels, a genetic condition, may predispose some individuals to hemolytic

anemia after intake of specific oxidizing substances present in some food and drugs. This includes repeated, very large intravenous or oral dosages of vitamin C. There is a test available for G6PD deficiency [13]. High dose Vitamin E has been proposed as a potential protective factor. [edit]Other reports of harmful effectsReports of harmful effects of vitamin C tend to receive great prominence in the world's media. As such, these reports tend to generate much debate and more research into Vitamin C. Some of the harmful effects described below have been proven to be unfounded in later studies, while other effects are still undergoing further analysis.In April 1998 the journal Nature reported alleged carcinogenic and teratogenic effects of excessive doses of vitamin C. The effects were noted in test tube experiments and on only two of the 20 markers of free radical damage to DNA. They have not been supported by

further evidence from living organisms. [14] In April 2000, University of Southern California researchers reported a thickening of the arteries of the neck in persons taking high vitamin C doses. It was later pointed out by vitamin C advocates that this can be explained by vitamin C's collagen synthesising role leading to thicker and stronger artery walls. (ref.6 para 10) In June 2004, Duke University researchers reported an increased susceptibility to osteo-arthritis in guinea pigs fed a diet high in vitamin C. However, a 2003 study at Umeå University in Sweden, found that "the plasma levels of vitamin C, retinol and uric acid were inversely correlated to variables related to rheumatoid arthritis disease activity." A speculated increased risk of kidney stones may be a side effect of taking Vitamin C in larger than normal amounts. The potential mechanism of action is through the metabolism of Vitamin C (ascorbic acid)

to dehydroascorbic acid, which is then metabolized to oxalic acid, a known constituent of kidney stones. However, this issue is still controversial, with evidence being presented for [15] and against [16] the possibility of this side effect. Vitamin B6 may mitigate this risk by decreasing oxalate production [17]. Additionally, thiamine may inhibit oxalate formation. Furthermore, correcting any magnesium deficiency [7] may decrease the risk of kidney stones by decreasing oxalate crystallization. Increasing one's fluid intake also helps to preventing oxalate crystallization in the kidney. "Rebound scurvy" is a theoretical, never observed, condition that could occur when daily intake of Vitamin C is rapidly reduced from a very large amount to a relatively low amount. Advocates suggest this an exaggeration of the rebound effect which occurs because ascorbate-dependent enzyme reactions continue for 24-48 hours after intake is

lowered, and use up vitamin C which is not being replenished. The effect is to lower one's serum vitamin C blood concentration to less than normal for a short amount of time. During this period of time there is a slight risk of cold or flu infection through reduced resistance. Within a couple of days the enzyme reactions shut down and blood serum returns to the normal level of someone not taking large supplements. This is not scurvy, which takes weeks of zero vitamin C consumption to produce symptoms. It is something people who take large vitamin C supplements need to be aware of in order to manage phased rather than sudden changes to the amount taken. (ref.6 para 4) This is a theoretical risk for those taking supplements - e.g. if they find themselves severely ill, and in a hospital without the supplements, at a time when they need normal or better levels of vitamin C to fight the disease (ref.[3] and search for "The major

problem"). Some writers [8] have identified a theoretical risk of poor Copper absorption from high doses of Vitamin C, although little experimental evidence supports this. However, ceruloplasmin levels seem specifically lowered by high vitamin C intake. In one study, 600 milligrams of Vitamin C daily did not decrease copper absorption or overall body copper status in young men, but led to lower ceruloplasmin levels similar to those caused by copper deficiency [9]. In another, ceruloplasmin levels were significantly reduced [10]. There are stories circulating among some folk remedy proponants that doses of around 12 grams per day of Vitamin C can induce an abortion in women under 4 weeks of pregnancy. [11] This is not supported by scientific reseach however. [12] [edit]Sourcesing, Linus (1986) How to Live Longer and Feel Better W. H. Freeman and Company, ISBN 0-380-70289-4 Levy (September 2002)

Vitamin C, Infectious Diseases, and Toxins, Xlibris Corporation (Paperback). ISBN 1401069630 (Note: Xlibris is a print on demand self-publishing house.) Hickey, Steve; , (May, 2004) Ascorbate: The Science of Vitamin C, Lulu Press, Inc. ISBN 1411607244 (Note: Lulu is a print on demand self-publishing house.) [edit]References & #8593; ish Crop Research Institute -Development of a Yeast-Based Single-Step Process for the Manufacture of L-Ascorbic Acid (vitamin C) & #8593; British pharmacology professors debate with the US National Institutes of Health over the optimum vitamin c dose (from PR Newswire - 6th July 2004) [1] & #8593; a b c d e f F. Cathcart III M.D., Vitamin C, Titrating To Bowel Tolerance, Anascorbemia, and Acute Induced Scurvey, Allergy, Environmental, and Orthomolecular Medicine & #8593; Combs GF. The Vitamins, Fundamental Aspects in Nutrition and Health. 2nd ed.

San Diego, CA: Academic Press, 2001:245-272 & #8593; Qi Chen and others. Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues. Proceedings of the National Academy of Sciences of the United States of America (PNAS) | September 20, 2005 | vol. 102 | no. 38 | 13604-13609 & #8593; Hickey, Steve & , ; (March, 2005), Ridiculous Dietary Allowance, Lulu Press, Inc. ISBN 1411622219.(Note: Lulu is a print on demand self-publishing house.) & #8593; NCBI & #8593; acu-cell & #8593; NCBI & #8593; NCBI & #8593; Home Abortion Remedy - Vitamin C, 8 March 2006 & #8593; Vitamins C and E in spontaneous abortion Int J Vitam Nutr Res. 1976;46(3):291-6. Jackie Jackie

March 25, 2006

Believe it or not alot of doc's that prescribe vit c for patients titrate the dosage according to the amount they can take before getting diarrhea ..lol

Re: Known harmful effects of vitamin c

Hi Liz

I wonder WHY anyone would take such huge amounts of vit c??? TO me, that seems crazy,, I cannot think of any time a dose of 5 grams a day would be beneficial? People just need to be realistic and take moderate amounts of anything,, everything,, just makes sense to me,,

good article tho, especially those of us with hep c need to be careful, ESPECIALLY if they have too much iron!elizabethnv1 <elizabethnv1@...> wrote:

Known harmful effectsA primary concern is people with unusual or unaddressed iron overload conditions, including hemochromatosis. Vitamin C enhances iron absorption. If sufferers of iron overload conditions take gram sized doses of Vitamin C, they may worsen the iron overload due to enhanced iron absorption. Vitamin C causes diarrhea in everyone if taken in quantities beyond a limit which is variable to the individual. Cathcart[3] has called this limit the Bowel Tolerance Limit and observed that it is higher in people with serious illness than those in good health. It ranges from 5 grams per day in the healthy to 300 grams per day in the seriously ill, such as those with AIDS and cancer. The diarrhea will cease as soon as the dose is reduced, and without harmful effect. Inadequate Glucose-6-phosphate dehydrogenase enzyme (G6PD) levels, a genetic condition, may predispose some individuals to hemolytic anemia after intake of specific oxidizing substances present in some food and drugs. This includes repeated, very large intravenous or oral dosages of vitamin C. There is a test available for G6PD deficiency [13]. High dose Vitamin E has been proposed as a potential protective factor. [edit]Other reports of harmful effectsReports of harmful effects of vitamin C tend to receive great prominence in the world's media. As such, these reports tend to generate much debate and more research into Vitamin C. Some of the harmful effects described below have been proven to be unfounded in later studies, while other effects are still undergoing further analysis.In April 1998 the journal Nature reported alleged carcinogenic and teratogenic effects of excessive doses of vitamin C. The effects were noted in test tube experiments and on only two of the 20 markers of free radical damage to DNA. They have not been supported by further evidence from living organisms. [14] In April 2000, University of Southern California researchers reported a thickening of the arteries of the neck in persons taking high vitamin C doses. It was later pointed out by vitamin C advocates that this can be explained by vitamin C's collagen synthesising role leading to thicker and stronger artery walls. (ref.6 para 10) In June 2004, Duke University researchers reported an increased susceptibility to osteo-arthritis in guinea pigs fed a diet high in vitamin C. However, a 2003 study at Umeå University in Sweden, found that "the plasma levels of vitamin C, retinol and uric acid were inversely correlated to variables related to rheumatoid arthritis disease activity." A speculated increased risk of kidney stones may be a side effect of taking Vitamin C in larger than normal amounts. The potential mechanism of action is through the metabolism of Vitamin C (ascorbic acid) to dehydroascorbic acid, which is then metabolized to oxalic acid, a known constituent of kidney stones. However, this issue is still controversial, with evidence being presented for [15] and against [16] the possibility of this side effect. Vitamin B6 may mitigate this risk by decreasing oxalate production [17]. Additionally, thiamine may inhibit oxalate formation. Furthermore, correcting any magnesium deficiency [7] may decrease the risk of kidney stones by decreasing oxalate crystallization. Increasing one's fluid intake also helps to preventing oxalate crystallization in the kidney. "Rebound scurvy" is a theoretical, never observed, condition that could occur when daily intake of Vitamin C is rapidly reduced from a very large amount to a relatively low amount. Advocates suggest this an exaggeration of the rebound effect which occurs because ascorbate-dependent enzyme reactions continue for 24-48 hours after intake is lowered, and use up vitamin C which is not being replenished. The effect is to lower one's serum vitamin C blood concentration to less than normal for a short amount of time. During this period of time there is a slight risk of cold or flu infection through reduced resistance. Within a couple of days the enzyme reactions shut down and blood serum returns to the normal level of someone not taking large supplements. This is not scurvy, which takes weeks of zero vitamin C consumption to produce symptoms. It is something people who take large vitamin C supplements need to be aware of in order to manage phased rather than sudden changes to the amount taken. (ref.6 para 4) This is a theoretical risk for those taking supplements - e.g. if they find themselves severely ill, and in a hospital without the supplements, at a time when they need normal or better levels of vitamin C to fight the disease (ref.[3] and search for "The major problem"). Some writers [8] have identified a theoretical risk of poor Copper absorption from high doses of Vitamin C, although little experimental evidence supports this. However, ceruloplasmin levels seem specifically lowered by high vitamin C intake. In one study, 600 milligrams of Vitamin C daily did not decrease copper absorption or overall body copper status in young men, but led to lower ceruloplasmin levels similar to those caused by copper deficiency [9]. In another, ceruloplasmin levels were significantly reduced [10]. There are stories circulating among some folk remedy proponants that doses of around 12 grams per day of Vitamin C can induce an abortion in women under 4 weeks of pregnancy. [11] This is not supported by scientific reseach however. [12] [edit]Sourcesing, Linus (1986) How to Live Longer and Feel Better W. H. Freeman and Company, ISBN 0-380-70289-4 Levy (September 2002) Vitamin C, Infectious Diseases, and Toxins, Xlibris Corporation (Paperback). ISBN 1401069630 (Note: Xlibris is a print on demand self-publishing house.) Hickey, Steve; , (May, 2004) Ascorbate: The Science of Vitamin C, Lulu Press, Inc. ISBN 1411607244 (Note: Lulu is a print on demand self-publishing house.) [edit]References & #8593; ish Crop Research Institute -Development of a Yeast-Based Single-Step Process for the Manufacture of L-Ascorbic Acid (vitamin C) & #8593; British pharmacology professors debate with the US National Institutes of Health over the optimum vitamin c dose (from PR Newswire - 6th July 2004) [1] & #8593; a b c d e f F. Cathcart III M.D., Vitamin C, Titrating To Bowel Tolerance, Anascorbemia, and Acute Induced Scurvey, Allergy, Environmental, and Orthomolecular Medicine & #8593; Combs GF. The Vitamins, Fundamental Aspects in Nutrition and Health. 2nd ed. San Diego, CA: Academic Press, 2001:245-272 & #8593; Qi Chen and others. Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues. Proceedings of the National Academy of Sciences of the United States of America (PNAS) | September 20, 2005 | vol. 102 | no. 38 | 13604-13609 & #8593; Hickey, Steve & , ; (March, 2005), Ridiculous Dietary Allowance, Lulu Press, Inc. ISBN 1411622219.(Note: Lulu is a print on demand self-publishing house.) & #8593; NCBI & #8593; acu-cell & #8593; NCBI & #8593; NCBI & #8593; Home Abortion Remedy - Vitamin C, 8 March 2006 & #8593; Vitamins C and E in spontaneous abortion Int J Vitam Nutr Res. 1976;46(3):291-6. Jackie Jackie

March 25, 2006

I know you are right,, but why?? lol, I KNOW that the RDA is just enough to prevent someone from getting scurvy from having a vit c deficiency,, but the RDA is not enough to increase health,, so there has to be a happy medium,, somewhere,, elizabethnv1 <elizabethnv1@...> wrote: Believe it or not alot of doc's that prescribe vit c for patients titrate the dosage according to the amount they can take before getting diarrhea ..lol Re: Known harmful effects of vitamin c Hi Liz I wonder WHY anyone would take such huge amounts

of vit c??? TO me, that seems crazy,, I cannot think of any time a dose of 5 grams a day would be beneficial? People just need to be realistic and take moderate amounts of anything,, everything,, just makes sense to me,, good article tho, especially those of us with hep c need to be careful, ESPECIALLY if they have too much iron!elizabethnv1 <elizabethnv1@...> wrote: Known harmful effectsA primary concern is people with unusual or unaddressed iron overload conditions, including hemochromatosis. Vitamin C enhances iron absorption. If sufferers of iron overload conditions take gram sized doses of Vitamin C, they may worsen the iron overload due to enhanced iron absorption. Vitamin C causes diarrhea in everyone if taken in quantities beyond a limit which is variable to the individual.

Cathcart[3] has called this limit the Bowel Tolerance Limit and observed that it is higher in people with serious illness than those in good health. It ranges from 5 grams per day in the healthy to 300 grams per day in the seriously ill, such as those with AIDS and cancer. The diarrhea will cease as soon as the dose is reduced, and without harmful effect. Inadequate Glucose-6-phosphate dehydrogenase enzyme (G6PD) levels, a genetic condition, may predispose some individuals to hemolytic anemia after intake of specific oxidizing substances present in some food and drugs. This includes repeated, very large intravenous or oral dosages of vitamin C. There is a test available for G6PD deficiency [13]. High dose Vitamin E has been proposed as a potential protective factor. [edit]Other reports of harmful effectsReports of harmful effects of vitamin C tend to receive great prominence in the world's media. As such, these reports

tend to generate much debate and more research into Vitamin C. Some of the harmful effects described below have been proven to be unfounded in later studies, while other effects are still undergoing further analysis.In April 1998 the journal Nature reported alleged carcinogenic and teratogenic effects of excessive doses of vitamin C. The effects were noted in test tube experiments and on only two of the 20 markers of free radical damage to DNA. They have not been supported by further evidence from living organisms. [14] In April 2000, University of Southern California researchers reported a thickening of the arteries of the neck in persons taking high vitamin C doses. It was later pointed out by vitamin C advocates that this can be explained by vitamin C's collagen synthesising role leading to thicker and stronger artery walls. (ref.6 para 10) In June 2004, Duke University researchers reported an increased

susceptibility to osteo-arthritis in guinea pigs fed a diet high in vitamin C. However, a 2003 study at Umeå University in Sweden, found that "the plasma levels of vitamin C, retinol and uric acid were inversely correlated to variables related to rheumatoid arthritis disease activity." A speculated increased risk of kidney stones may be a side effect of taking Vitamin C in larger than normal amounts. The potential mechanism of action is through the metabolism of Vitamin C (ascorbic acid) to dehydroascorbic acid, which is then metabolized to oxalic acid, a known constituent of kidney stones. However, this issue is still controversial, with evidence being presented for [15] and against [16] the possibility of this side effect. Vitamin B6 may mitigate this risk by decreasing oxalate production [17]. Additionally, thiamine may inhibit oxalate formation. Furthermore, correcting any magnesium deficiency [7] may decrease the risk

of kidney stones by decreasing oxalate crystallization. Increasing one's fluid intake also helps to preventing oxalate crystallization in the kidney. "Rebound scurvy" is a theoretical, never observed, condition that could occur when daily intake of Vitamin C is rapidly reduced from a very large amount to a relatively low amount. Advocates suggest this an exaggeration of the rebound effect which occurs because ascorbate-dependent enzyme reactions continue for 24-48 hours after intake is lowered, and use up vitamin C which is not being replenished. The effect is to lower one's serum vitamin C blood concentration to less than normal for a short amount of time. During this period of time there is a slight risk of cold or flu infection through reduced resistance. Within a couple of days the enzyme reactions shut down and blood serum returns to the normal level of someone not taking large supplements. This is not scurvy, which

takes weeks of zero vitamin C consumption to produce symptoms. It is something people who take large vitamin C supplements need to be aware of in order to manage phased rather than sudden changes to the amount taken. (ref.6 para 4) This is a theoretical risk for those taking supplements - e.g. if they find themselves severely ill, and in a hospital without the supplements, at a time when they need normal or better levels of vitamin C to fight the disease (ref.[3] and search for "The major problem"). Some writers [8] have identified a theoretical risk of poor Copper absorption from high doses of Vitamin C, although little experimental evidence supports this. However, ceruloplasmin levels seem specifically lowered by high vitamin C intake. In one study, 600 milligrams of Vitamin C daily did not decrease copper absorption or overall body copper status in young men, but led to lower ceruloplasmin levels similar to those caused

by copper deficiency [9]. In another, ceruloplasmin levels were significantly reduced [10]. There are stories circulating among some folk remedy proponants that doses of around 12 grams per day of Vitamin C can induce an abortion in women under 4 weeks of pregnancy. [11] This is not supported by scientific reseach however. [12] [edit]Sourcesing, Linus (1986) How to Live Longer and Feel Better W. H. Freeman and Company, ISBN 0-380-70289-4 Levy (September 2002) Vitamin C, Infectious Diseases, and Toxins, Xlibris Corporation (Paperback). ISBN 1401069630 (Note: Xlibris is a print on demand self-publishing house.) Hickey, Steve; , (May, 2004) Ascorbate: The Science of Vitamin C, Lulu Press, Inc. ISBN 1411607244 (Note: Lulu is a print on demand self-publishing house.) [edit]References & #8593; ish Crop Research Institute -Development of a Yeast-Based Single-Step Process for the

Manufacture of L-Ascorbic Acid (vitamin C) & #8593; British pharmacology professors debate with the US National Institutes of Health over the optimum vitamin c dose (from PR Newswire - 6th July 2004) [1] & #8593; a b c d e f F. Cathcart III M.D., Vitamin C, Titrating To Bowel Tolerance, Anascorbemia, and Acute Induced Scurvey, Allergy, Environmental, and Orthomolecular Medicine & #8593; Combs GF. The Vitamins, Fundamental Aspects in Nutrition and Health. 2nd ed. San Diego, CA: Academic Press, 2001:245-272 & #8593; Qi Chen and others. Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues. Proceedings of the National Academy of Sciences of the United States of America (PNAS) | September 20, 2005 | vol. 102 | no. 38 | 13604-13609 & #8593; Hickey, Steve & , ; (March, 2005), Ridiculous Dietary Allowance,

Lulu Press, Inc. ISBN 1411622219.(Note: Lulu is a print on demand self-publishing house.) & #8593; NCBI & #8593; acu-cell & #8593; NCBI & #8593; NCBI & #8593; Home Abortion Remedy - Vitamin C, 8 March 2006 & #8593; Vitamins C and E in spontaneous abortion Int J Vitam Nutr Res. 1976;46(3):291-6. Jackie Jackie Jackie

March 26, 2006

I figure if a person is eating a well balanced diet they will get all the stuff they need . So I personaly avoid any extra meds ,LOL

Re: Known harmful effects of vitamin c

Hi Liz

I wonder WHY anyone would take such huge amounts of vit c??? TO me, that seems crazy,, I cannot think of any time a dose of 5 grams a day would be beneficial? People just need to be realistic and take moderate amounts of anything,, everything,, just makes sense to me,,

good article tho, especially those of us with hep c need to be careful, ESPECIALLY if they have too much iron!elizabethnv1 <elizabethnv1@...> wrote:

Known harmful effectsA primary concern is people with unusual or unaddressed iron overload conditions, including hemochromatosis. Vitamin C enhances iron absorption. If sufferers of iron overload conditions take gram sized doses of Vitamin C, they may worsen the iron overload due to enhanced iron absorption. Vitamin C causes diarrhea in everyone if taken in quantities beyond a limit which is variable to the individual. Cathcart[3] has called this limit the Bowel Tolerance Limit and observed that it is higher in people with serious illness than those in good health. It ranges from 5 grams per day in the healthy to 300 grams per day in the seriously ill, such as those with AIDS and cancer. The diarrhea will cease as soon as the dose is reduced, and without harmful effect. Inadequate Glucose-6-phosphate dehydrogenase enzyme (G6PD) levels, a genetic condition, may predispose some individuals to hemolytic anemia after intake of specific oxidizing substances present in some food and drugs. This includes repeated, very large intravenous or oral dosages of vitamin C. There is a test available for G6PD deficiency [13]. High dose Vitamin E has been proposed as a potential protective factor. [edit]Other reports of harmful effectsReports of harmful effects of vitamin C tend to receive great prominence in the world's media. As such, these reports tend to generate much debate and more research into Vitamin C. Some of the harmful effects described below have been proven to be unfounded in later studies, while other effects are still undergoing further analysis.In April 1998 the journal Nature reported alleged carcinogenic and teratogenic effects of excessive doses of vitamin C. The effects were noted in test tube experiments and on only two of the 20 markers of free radical damage to DNA. They have not been supported by further evidence from living organisms. [14] In April 2000, University of Southern California researchers reported a thickening of the arteries of the neck in persons taking high vitamin C doses. It was later pointed out by vitamin C advocates that this can be explained by vitamin C's collagen synthesising role leading to thicker and stronger artery walls. (ref.6 para 10) In June 2004, Duke University researchers reported an increased susceptibility to osteo-arthritis in guinea pigs fed a diet high in vitamin C. However, a 2003 study at Umeå University in Sweden, found that "the plasma levels of vitamin C, retinol and uric acid were inversely correlated to variables related to rheumatoid arthritis disease activity." A speculated increased risk of kidney stones may be a side effect of taking Vitamin C in larger than normal amounts. The potential mechanism of action is through the metabolism of Vitamin C (ascorbic acid) to dehydroascorbic acid, which is then metabolized to oxalic acid, a known constituent of kidney stones. However, this issue is still controversial, with evidence being presented for [15] and against [16] the possibility of this side effect. Vitamin B6 may mitigate this risk by decreasing oxalate production [17]. Additionally, thiamine may inhibit oxalate formation. Furthermore, correcting any magnesium deficiency [7] may decrease the risk of kidney stones by decreasing oxalate crystallization. Increasing one's fluid intake also helps to preventing oxalate crystallization in the kidney. "Rebound scurvy" is a theoretical, never observed, condition that could occur when daily intake of Vitamin C is rapidly reduced from a very large amount to a relatively low amount. Advocates suggest this an exaggeration of the rebound effect which occurs because ascorbate-dependent enzyme reactions continue for 24-48 hours after intake is lowered, and use up vitamin C which is not being replenished. The effect is to lower one's serum vitamin C blood concentration to less than normal for a short amount of time. During this period of time there is a slight risk of cold or flu infection through reduced resistance. Within a couple of days the enzyme reactions shut down and blood serum returns to the normal level of someone not taking large supplements. This is not scurvy, which takes weeks of zero vitamin C consumption to produce symptoms. It is something people who take large vitamin C supplements need to be aware of in order to manage phased rather than sudden changes to the amount taken. (ref.6 para 4) This is a theoretical risk for those taking supplements - e.g. if they find themselves severely ill, and in a hospital without the supplements, at a time when they need normal or better levels of vitamin C to fight the disease (ref.[3] and search for "The major problem"). Some writers [8] have identified a theoretical risk of poor Copper absorption from high doses of Vitamin C, although little experimental evidence supports this. However, ceruloplasmin levels seem specifically lowered by high vitamin C intake. In one study, 600 milligrams of Vitamin C daily did not decrease copper absorption or overall body copper status in young men, but led to lower ceruloplasmin levels similar to those caused by copper deficiency [9]. In another, ceruloplasmin levels were significantly reduced [10]. There are stories circulating among some folk remedy proponants that doses of around 12 grams per day of Vitamin C can induce an abortion in women under 4 weeks of pregnancy. [11] This is not supported by scientific reseach however. [12] [edit]Sourcesing, Linus (1986) How to Live Longer and Feel Better W. H. Freeman and Company, ISBN 0-380-70289-4 Levy (September 2002) Vitamin C, Infectious Diseases, and Toxins, Xlibris Corporation (Paperback). ISBN 1401069630 (Note: Xlibris is a print on demand self-publishing house.) Hickey, Steve; , (May, 2004) Ascorbate: The Science of Vitamin C, Lulu Press, Inc. ISBN 1411607244 (Note: Lulu is a print on demand self-publishing house.) [edit]References & #8593; ish Crop Research Institute -Development of a Yeast-Based Single-Step Process for the Manufacture of L-Ascorbic Acid (vitamin C) & #8593; British pharmacology professors debate with the US National Institutes of Health over the optimum vitamin c dose (from PR Newswire - 6th July 2004) [1] & #8593; a b c d e f F. Cathcart III M.D., Vitamin C, Titrating To Bowel Tolerance, Anascorbemia, and Acute Induced Scurvey, Allergy, Environmental, and Orthomolecular Medicine & #8593; Combs GF. The Vitamins, Fundamental Aspects in Nutrition and Health. 2nd ed. San Diego, CA: Academic Press, 2001:245-272 & #8593; Qi Chen and others. Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues. Proceedings of the National Academy of Sciences of the United States of America (PNAS) | September 20, 2005 | vol. 102 | no. 38 | 13604-13609 & #8593; Hickey, Steve & , ; (March, 2005), Ridiculous Dietary Allowance, Lulu Press, Inc. ISBN 1411622219.(Note: Lulu is a print on demand self-publishing house.) & #8593; NCBI & #8593; acu-cell & #8593; NCBI & #8593; NCBI & #8593; Home Abortion Remedy - Vitamin C, 8 March 2006 & #8593; Vitamins C and E in spontaneous abortion Int J Vitam Nutr Res. 1976;46(3):291-6. Jackie Jackie Jackie

March 26, 2006

thats a good thing to do hon,, elizabethnv1 <elizabethnv1@...> wrote: I figure if a person is eating a well balanced diet they will get all the stuff they need . So I personaly avoid any extra meds ,LOL Re: Known harmful effects of vitamin c Hi Liz I wonder WHY anyone would take such huge amounts of vit c??? TO me, that seems crazy,, I cannot think of any time a dose of 5 grams a day would be beneficial? People just need to be realistic and take moderate amounts of anything,, everything,, just makes sense to me,, good article tho, especially those of us with hep c need to be careful, ESPECIALLY if they have too much iron!elizabethnv1 <elizabethnv1@...> wrote: Known harmful effectsA primary concern is people with unusual or unaddressed iron overload conditions, including hemochromatosis. Vitamin C enhances iron absorption. If

sufferers of iron overload conditions take gram sized doses of Vitamin C, they may worsen the iron overload due to enhanced iron absorption. Vitamin C causes diarrhea in everyone if taken in quantities beyond a limit which is variable to the individual. Cathcart[3] has called this limit the Bowel Tolerance Limit and observed that it is higher in people with serious illness than those in good health. It ranges from 5 grams per day in the healthy to 300 grams per day in the seriously ill, such as those with AIDS and cancer. The diarrhea will cease as soon as the dose is reduced, and without harmful effect. Inadequate Glucose-6-phosphate dehydrogenase enzyme (G6PD) levels, a genetic condition, may predispose some individuals to hemolytic anemia after intake of specific oxidizing substances present in some food and drugs. This includes repeated, very large intravenous or oral dosages of vitamin C. There is a test available for G6PD

deficiency [13]. High dose Vitamin E has been proposed as a potential protective factor. [edit]Other reports of harmful effectsReports of harmful effects of vitamin C tend to receive great prominence in the world's media. As such, these reports tend to generate much debate and more research into Vitamin C. Some of the harmful effects described below have been proven to be unfounded in later studies, while other effects are still undergoing further analysis.In April 1998 the journal Nature reported alleged carcinogenic and teratogenic effects of excessive doses of vitamin C. The effects were noted in test tube experiments and on only two of the 20 markers of free radical damage to DNA. They have not been supported by further evidence from living organisms. [14] In April 2000, University of Southern California researchers reported a thickening of the arteries of the neck in persons taking high vitamin C doses.

It was later pointed out by vitamin C advocates that this can be explained by vitamin C's collagen synthesising role leading to thicker and stronger artery walls. (ref.6 para 10) In June 2004, Duke University researchers reported an increased susceptibility to osteo-arthritis in guinea pigs fed a diet high in vitamin C. However, a 2003 study at Umeå University in Sweden, found that "the plasma levels of vitamin C, retinol and uric acid were inversely correlated to variables related to rheumatoid arthritis disease activity." A speculated increased risk of kidney stones may be a side effect of taking Vitamin C in larger than normal amounts. The potential mechanism of action is through the metabolism of Vitamin C (ascorbic acid) to dehydroascorbic acid, which is then metabolized to oxalic acid, a known constituent of kidney stones. However, this issue is still controversial, with evidence being presented for [15] and against

[16] the possibility of this side effect. Vitamin B6 may mitigate this risk by decreasing oxalate production [17]. Additionally, thiamine may inhibit oxalate formation. Furthermore, correcting any magnesium deficiency [7] may decrease the risk of kidney stones by decreasing oxalate crystallization. Increasing one's fluid intake also helps to preventing oxalate crystallization in the kidney. "Rebound scurvy" is a theoretical, never observed, condition that could occur when daily intake of Vitamin C is rapidly reduced from a very large amount to a relatively low amount. Advocates suggest this an exaggeration of the rebound effect which occurs because ascorbate-dependent enzyme reactions continue for 24-48 hours after intake is lowered, and use up vitamin C which is not being replenished. The effect is to lower one's serum vitamin C blood concentration to less than normal for a short amount of time. During this period of time

there is a slight risk of cold or flu infection through reduced resistance. Within a couple of days the enzyme reactions shut down and blood serum returns to the normal level of someone not taking large supplements. This is not scurvy, which takes weeks of zero vitamin C consumption to produce symptoms. It is something people who take large vitamin C supplements need to be aware of in order to manage phased rather than sudden changes to the amount taken. (ref.6 para 4) This is a theoretical risk for those taking supplements - e.g. if they find themselves severely ill, and in a hospital without the supplements, at a time when they need normal or better levels of vitamin C to fight the disease (ref.[3] and search for "The major problem"). Some writers [8] have identified a theoretical risk of poor Copper absorption from high doses of Vitamin C, although little experimental evidence supports this. However, ceruloplasmin levels

seem specifically lowered by high vitamin C intake. In one study, 600 milligrams of Vitamin C daily did not decrease copper absorption or overall body copper status in young men, but led to lower ceruloplasmin levels similar to those caused by copper deficiency [9]. In another, ceruloplasmin levels were significantly reduced [10]. There are stories circulating among some folk remedy proponants that doses of around 12 grams per day of Vitamin C can induce an abortion in women under 4 weeks of pregnancy. [11] This is not supported by scientific reseach however. [12] [edit]Sourcesing, Linus (1986) How to Live Longer and Feel Better W. H. Freeman and Company, ISBN 0-380-70289-4 Levy (September 2002) Vitamin C, Infectious Diseases, and Toxins, Xlibris Corporation (Paperback). ISBN 1401069630 (Note: Xlibris is a print on demand self-publishing house.) Hickey, Steve; , (May, 2004) Ascorbate:

The Science of Vitamin C, Lulu Press, Inc. ISBN 1411607244 (Note: Lulu is a print on demand self-publishing house.) [edit]References & #8593; ish Crop Research Institute -Development of a Yeast-Based Single-Step Process for the Manufacture of L-Ascorbic Acid (vitamin C) & #8593; British pharmacology professors debate with the US National Institutes of Health over the optimum vitamin c dose (from PR Newswire - 6th July 2004) [1] & #8593; a b c d e f F. Cathcart III M.D., Vitamin C, Titrating To Bowel Tolerance, Anascorbemia, and Acute Induced Scurvey, Allergy, Environmental, and Orthomolecular Medicine & #8593; Combs GF. The Vitamins, Fundamental Aspects in Nutrition and Health. 2nd ed. San Diego, CA: Academic Press, 2001:245-272 & #8593; Qi Chen and others. Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to

tissues. Proceedings of the National Academy of Sciences of the United States of America (PNAS) | September 20, 2005 | vol. 102 | no. 38 | 13604-13609 & #8593; Hickey, Steve & , ; (March, 2005), Ridiculous Dietary Allowance, Lulu Press, Inc. ISBN 1411622219.(Note: Lulu is a print on demand self-publishing house.) & #8593; NCBI & #8593; acu-cell & #8593; NCBI & #8593; NCBI & #8593; Home Abortion Remedy - Vitamin C, 8 March 2006 & #8593; Vitamins C and E in spontaneous abortion Int J Vitam Nutr Res. 1976;46(3):291-6. Jackie Jackie Jackie Jackie

March 26, 2006

Well heck , I feel like a walking pharmacy already why take more if I can avoid it by eating good ....lol

Re: Known harmful effects of vitamin c

Hi Liz

I wonder WHY anyone would take such huge amounts of vit c??? TO me, that seems crazy,, I cannot think of any time a dose of 5 grams a day would be beneficial? People just need to be realistic and take moderate amounts of anything,, everything,, just makes sense to me,,

good article tho, especially those of us with hep c need to be careful, ESPECIALLY if they have too much iron!elizabethnv1 <elizabethnv1@...> wrote:

Known harmful effectsA primary concern is people with unusual or unaddressed iron overload conditions, including hemochromatosis. Vitamin C enhances iron absorption. If sufferers of iron overload conditions take gram sized doses of Vitamin C, they may worsen the iron overload due to enhanced iron absorption. Vitamin C causes diarrhea in everyone if taken in quantities beyond a limit which is variable to the individual. Cathcart[3] has called this limit the Bowel Tolerance Limit and observed that it is higher in people with serious illness than those in good health. It ranges from 5 grams per day in the healthy to 300 grams per day in the seriously ill, such as those with AIDS and cancer. The diarrhea will cease as soon as the dose is reduced, and without harmful effect. Inadequate Glucose-6-phosphate dehydrogenase enzyme (G6PD) levels, a genetic condition, may predispose some individuals to hemolytic anemia after intake of specific oxidizing substances present in some food and drugs. This includes repeated, very large intravenous or oral dosages of vitamin C. There is a test available for G6PD deficiency [13]. High dose Vitamin E has been proposed as a potential protective factor. [edit]Other reports of harmful effectsReports of harmful effects of vitamin C tend to receive great prominence in the world's media. As such, these reports tend to generate much debate and more research into Vitamin C. Some of the harmful effects described below have been proven to be unfounded in later studies, while other effects are still undergoing further analysis.In April 1998 the journal Nature reported alleged carcinogenic and teratogenic effects of excessive doses of vitamin C. The effects were noted in test tube experiments and on only two of the 20 markers of free radical damage to DNA. They have not been supported by further evidence from living organisms. [14] In April 2000, University of Southern California researchers reported a thickening of the arteries of the neck in persons taking high vitamin C doses. It was later pointed out by vitamin C advocates that this can be explained by vitamin C's collagen synthesising role leading to thicker and stronger artery walls. (ref.6 para 10) In June 2004, Duke University researchers reported an increased susceptibility to osteo-arthritis in guinea pigs fed a diet high in vitamin C. However, a 2003 study at Umeå University in Sweden, found that "the plasma levels of vitamin C, retinol and uric acid were inversely correlated to variables related to rheumatoid arthritis disease activity." A speculated increased risk of kidney stones may be a side effect of taking Vitamin C in larger than normal amounts. The potential mechanism of action is through the metabolism of Vitamin C (ascorbic acid) to dehydroascorbic acid, which is then metabolized to oxalic acid, a known constituent of kidney stones. However, this issue is still controversial, with evidence being presented for [15] and against [16] the possibility of this side effect. Vitamin B6 may mitigate this risk by decreasing oxalate production [17]. Additionally, thiamine may inhibit oxalate formation. Furthermore, correcting any magnesium deficiency [7] may decrease the risk of kidney stones by decreasing oxalate crystallization. Increasing one's fluid intake also helps to preventing oxalate crystallization in the kidney. "Rebound scurvy" is a theoretical, never observed, condition that could occur when daily intake of Vitamin C is rapidly reduced from a very large amount to a relatively low amount. Advocates suggest this an exaggeration of the rebound effect which occurs because ascorbate-dependent enzyme reactions continue for 24-48 hours after intake is lowered, and use up vitamin C which is not being replenished. The effect is to lower one's serum vitamin C blood concentration to less than normal for a short amount of time. During this period of time there is a slight risk of cold or flu infection through reduced resistance. Within a couple of days the enzyme reactions shut down and blood serum returns to the normal level of someone not taking large supplements. This is not scurvy, which takes weeks of zero vitamin C consumption to produce symptoms. It is something people who take large vitamin C supplements need to be aware of in order to manage phased rather than sudden changes to the amount taken. (ref.6 para 4) This is a theoretical risk for those taking supplements - e.g. if they find themselves severely ill, and in a hospital without the supplements, at a time when they need normal or better levels of vitamin C to fight the disease (ref.[3] and search for "The major problem"). Some writers [8] have identified a theoretical risk of poor Copper absorption from high doses of Vitamin C, although little experimental evidence supports this. However, ceruloplasmin levels seem specifically lowered by high vitamin C intake. In one study, 600 milligrams of Vitamin C daily did not decrease copper absorption or overall body copper status in young men, but led to lower ceruloplasmin levels similar to those caused by copper deficiency [9]. In another, ceruloplasmin levels were significantly reduced [10]. There are stories circulating among some folk remedy proponants that doses of around 12 grams per day of Vitamin C can induce an abortion in women under 4 weeks of pregnancy. [11] This is not supported by scientific reseach however. [12] [edit]Sourcesing, Linus (1986) How to Live Longer and Feel Better W. H. Freeman and Company, ISBN 0-380-70289-4 Levy (September 2002) Vitamin C, Infectious Diseases, and Toxins, Xlibris Corporation (Paperback). ISBN 1401069630 (Note: Xlibris is a print on demand self-publishing house.) Hickey, Steve; , (May, 2004) Ascorbate: The Science of Vitamin C, Lulu Press, Inc. ISBN 1411607244 (Note: Lulu is a print on demand self-publishing house.) [edit]References & #8593; ish Crop Research Institute -Development of a Yeast-Based Single-Step Process for the Manufacture of L-Ascorbic Acid (vitamin C) & #8593; British pharmacology professors debate with the US National Institutes of Health over the optimum vitamin c dose (from PR Newswire - 6th July 2004) [1] & #8593; a b c d e f F. Cathcart III M.D., Vitamin C, Titrating To Bowel Tolerance, Anascorbemia, and Acute Induced Scurvey, Allergy, Environmental, and Orthomolecular Medicine & #8593; Combs GF. The Vitamins, Fundamental Aspects in Nutrition and Health. 2nd ed. San Diego, CA: Academic Press, 2001:245-272 & #8593; Qi Chen and others. Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues. Proceedings of the National Academy of Sciences of the United States of America (PNAS) | September 20, 2005 | vol. 102 | no. 38 | 13604-13609 & #8593; Hickey, Steve & , ; (March, 2005), Ridiculous Dietary Allowance, Lulu Press, Inc. ISBN 1411622219.(Note: Lulu is a print on demand self-publishing house.) & #8593; NCBI & #8593; acu-cell & #8593; NCBI & #8593; NCBI & #8593; Home Abortion Remedy - Vitamin C, 8 March 2006 & #8593; Vitamins C and E in spontaneous abortion Int J Vitam Nutr Res. 1976;46(3):291-6. Jackie Jackie Jackie Jackie

March 26, 2006

good hon,, eat healthily,, stay away from white sugar, white flour ,, white is yukky,, elizabethnv1 <elizabethnv1@...> wrote: Well heck , I feel like a walking pharmacy already why take more if I can avoid it by eating good ....lol Re: Known harmful effects of vitamin c Hi Liz I wonder WHY anyone would take such huge amounts of vit c??? TO me, that seems crazy,, I cannot think of any time a dose of 5 grams a day would be beneficial? People just need to be realistic and take moderate amounts of anything,, everything,, just makes sense to me,, good article tho, especially those of us with hep c need to be careful, ESPECIALLY if they have too much iron!elizabethnv1

<elizabethnv1@...> wrote: Known harmful effectsA primary concern is people with unusual or unaddressed iron overload conditions, including hemochromatosis. Vitamin C enhances iron absorption. If sufferers of iron overload conditions take gram sized doses of Vitamin C, they may worsen the iron overload due to enhanced iron absorption. Vitamin C causes diarrhea in everyone if taken in quantities beyond a limit which is variable to the individual. Cathcart[3] has called this limit the Bowel Tolerance Limit and observed that it is higher in people with serious illness than those in good health. It ranges from 5 grams per day in the healthy to 300 grams per day in the seriously ill, such as those with AIDS and cancer. The diarrhea will cease as soon as the dose is reduced, and without harmful

effect. Inadequate Glucose-6-phosphate dehydrogenase enzyme (G6PD) levels, a genetic condition, may predispose some individuals to hemolytic anemia after intake of specific oxidizing substances present in some food and drugs. This includes repeated, very large intravenous or oral dosages of vitamin C. There is a test available for G6PD deficiency [13]. High dose Vitamin E has been proposed as a potential protective factor. [edit]Other reports of harmful effectsReports of harmful effects of vitamin C tend to receive great prominence in the world's media. As such, these reports tend to generate much debate and more research into Vitamin C. Some of the harmful effects described below have been proven to be unfounded in later studies, while other effects are still undergoing further analysis.In April 1998 the journal Nature reported alleged carcinogenic and teratogenic effects of excessive doses of vitamin C. The

effects were noted in test tube experiments and on only two of the 20 markers of free radical damage to DNA. They have not been supported by further evidence from living organisms. [14] In April 2000, University of Southern California researchers reported a thickening of the arteries of the neck in persons taking high vitamin C doses. It was later pointed out by vitamin C advocates that this can be explained by vitamin C's collagen synthesising role leading to thicker and stronger artery walls. (ref.6 para 10) In June 2004, Duke University researchers reported an increased susceptibility to osteo-arthritis in guinea pigs fed a diet high in vitamin C. However, a 2003 study at Umeå University in Sweden, found that "the plasma levels of vitamin C, retinol and uric acid were inversely correlated to variables related to rheumatoid arthritis disease activity." A speculated increased risk of kidney stones may be a side effect of

taking Vitamin C in larger than normal amounts. The potential mechanism of action is through the metabolism of Vitamin C (ascorbic acid) to dehydroascorbic acid, which is then metabolized to oxalic acid, a known constituent of kidney stones. However, this issue is still controversial, with evidence being presented for [15] and against [16] the possibility of this side effect. Vitamin B6 may mitigate this risk by decreasing oxalate production [17]. Additionally, thiamine may inhibit oxalate formation. Furthermore, correcting any magnesium deficiency [7] may decrease the risk of kidney stones by decreasing oxalate crystallization. Increasing one's fluid intake also helps to preventing oxalate crystallization in the kidney. "Rebound scurvy" is a theoretical, never observed, condition that could occur when daily intake of Vitamin C is rapidly reduced from a very large amount to a relatively low amount. Advocates suggest this

an exaggeration of the rebound effect which occurs because ascorbate-dependent enzyme reactions continue for 24-48 hours after intake is lowered, and use up vitamin C which is not being replenished. The effect is to lower one's serum vitamin C blood concentration to less than normal for a short amount of time. During this period of time there is a slight risk of cold or flu infection through reduced resistance. Within a couple of days the enzyme reactions shut down and blood serum returns to the normal level of someone not taking large supplements. This is not scurvy, which takes weeks of zero vitamin C consumption to produce symptoms. It is something people who take large vitamin C supplements need to be aware of in order to manage phased rather than sudden changes to the amount taken. (ref.6 para 4) This is a theoretical risk for those taking supplements - e.g. if they find themselves severely ill, and in a hospital without

the supplements, at a time when they need normal or better levels of vitamin C to fight the disease (ref.[3] and search for "The major problem"). Some writers [8] have identified a theoretical risk of poor Copper absorption from high doses of Vitamin C, although little experimental evidence supports this. However, ceruloplasmin levels seem specifically lowered by high vitamin C intake. In one study, 600 milligrams of Vitamin C daily did not decrease copper absorption or overall body copper status in young men, but led to lower ceruloplasmin levels similar to those caused by copper deficiency [9]. In another, ceruloplasmin levels were significantly reduced [10]. There are stories circulating among some folk remedy proponants that doses of around 12 grams per day of Vitamin C can induce an abortion in women under 4 weeks of pregnancy. [11] This is not supported by scientific reseach however. [12]

[edit]Sourcesing, Linus (1986) How to Live Longer and Feel Better W. H. Freeman and Company, ISBN 0-380-70289-4 Levy (September 2002) Vitamin C, Infectious Diseases, and Toxins, Xlibris Corporation (Paperback). ISBN 1401069630 (Note: Xlibris is a print on demand self-publishing house.) Hickey, Steve; , (May, 2004) Ascorbate: The Science of Vitamin C, Lulu Press, Inc. ISBN 1411607244 (Note: Lulu is a print on demand self-publishing house.) [edit]References & #8593; ish Crop Research Institute -Development of a Yeast-Based Single-Step Process for the Manufacture of L-Ascorbic Acid (vitamin C) & #8593; British pharmacology professors debate with the US National Institutes of Health over the optimum vitamin c dose (from PR Newswire - 6th July 2004) [1] & #8593; a b c d e f F. Cathcart III M.D., Vitamin C, Titrating To Bowel Tolerance, Anascorbemia, and Acute

Induced Scurvey, Allergy, Environmental, and Orthomolecular Medicine & #8593; Combs GF. The Vitamins, Fundamental Aspects in Nutrition and Health. 2nd ed. San Diego, CA: Academic Press, 2001:245-272 & #8593; Qi Chen and others. Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues. Proceedings of the National Academy of Sciences of the United States of America (PNAS) | September 20, 2005 | vol. 102 | no. 38 | 13604-13609 & #8593; Hickey, Steve & , ; (March, 2005), Ridiculous Dietary Allowance, Lulu Press, Inc. ISBN 1411622219.(Note: Lulu is a print on demand self-publishing house.) & #8593; NCBI & #8593; acu-cell & #8593; NCBI & #8593; NCBI & #8593; Home Abortion Remedy - Vitamin C, 8 March 2006 & #8593; Vitamins C and E in spontaneous abortion Int J Vitam Nutr Res. 1976;46(3):291-6.

Jackie Jackie Jackie Jackie Jackie

March 26, 2006

I avoid sugar , and breads to be honest . I have even taken to avoiding meats . Now I eat yogurt , fruits and veggies .

Re: Known harmful effects of vitamin c

Hi Liz

I wonder WHY anyone would take such huge amounts of vit c??? TO me, that seems crazy,, I cannot think of any time a dose of 5 grams a day would be beneficial? People just need to be realistic and take moderate amounts of anything,, everything,, just makes sense to me,,

good article tho, especially those of us with hep c need to be careful, ESPECIALLY if they have too much iron!elizabethnv1 <elizabethnv1@...> wrote:

Known harmful effectsA primary concern is people with unusual or unaddressed iron overload conditions, including hemochromatosis. Vitamin C enhances iron absorption. If sufferers of iron overload conditions take gram sized doses of Vitamin C, they may worsen the iron overload due to enhanced iron absorption. Vitamin C causes diarrhea in everyone if taken in quantities beyond a limit which is variable to the individual. Cathcart[3] has called this limit the Bowel Tolerance Limit and observed that it is higher in people with serious illness than those in good health. It ranges from 5 grams per day in the healthy to 300 grams per day in the seriously ill, such as those with AIDS and cancer. The diarrhea will cease as soon as the dose is reduced, and without harmful effect. Inadequate Glucose-6-phosphate dehydrogenase enzyme (G6PD) levels, a genetic condition, may predispose some individuals to hemolytic anemia after intake of specific oxidizing substances present in some food and drugs. This includes repeated, very large intravenous or oral dosages of vitamin C. There is a test available for G6PD deficiency [13]. High dose Vitamin E has been proposed as a potential protective factor. [edit]Other reports of harmful effectsReports of harmful effects of vitamin C tend to receive great prominence in the world's media. As such, these reports tend to generate much debate and more research into Vitamin C. Some of the harmful effects described below have been proven to be unfounded in later studies, while other effects are still undergoing further analysis.In April 1998 the journal Nature reported alleged carcinogenic and teratogenic effects of excessive doses of vitamin C. The effects were noted in test tube experiments and on only two of the 20 markers of free radical damage to DNA. They have not been supported by further evidence from living organisms. [14] In April 2000, University of Southern California researchers reported a thickening of the arteries of the neck in persons taking high vitamin C doses. It was later pointed out by vitamin C advocates that this can be explained by vitamin C's collagen synthesising role leading to thicker and stronger artery walls. (ref.6 para 10) In June 2004, Duke University researchers reported an increased susceptibility to osteo-arthritis in guinea pigs fed a diet high in vitamin C. However, a 2003 study at Umeå University in Sweden, found that "the plasma levels of vitamin C, retinol and uric acid were inversely correlated to variables related to rheumatoid arthritis disease activity." A speculated increased risk of kidney stones may be a side effect of taking Vitamin C in larger than normal amounts. The potential mechanism of action is through the metabolism of Vitamin C (ascorbic acid) to dehydroascorbic acid, which is then metabolized to oxalic acid, a known constituent of kidney stones. However, this issue is still controversial, with evidence being presented for [15] and against [16] the possibility of this side effect. Vitamin B6 may mitigate this risk by decreasing oxalate production [17]. Additionally, thiamine may inhibit oxalate formation. Furthermore, correcting any magnesium deficiency [7] may decrease the risk of kidney stones by decreasing oxalate crystallization. Increasing one's fluid intake also helps to preventing oxalate crystallization in the kidney. "Rebound scurvy" is a theoretical, never observed, condition that could occur when daily intake of Vitamin C is rapidly reduced from a very large amount to a relatively low amount. Advocates suggest this an exaggeration of the rebound effect which occurs because ascorbate-dependent enzyme reactions continue for 24-48 hours after intake is lowered, and use up vitamin C which is not being replenished. The effect is to lower one's serum vitamin C blood concentration to less than normal for a short amount of time. During this period of time there is a slight risk of cold or flu infection through reduced resistance. Within a couple of days the enzyme reactions shut down and blood serum returns to the normal level of someone not taking large supplements. This is not scurvy, which takes weeks of zero vitamin C consumption to produce symptoms. It is something people who take large vitamin C supplements need to be aware of in order to manage phased rather than sudden changes to the amount taken. (ref.6 para 4) This is a theoretical risk for those taking supplements - e.g. if they find themselves severely ill, and in a hospital without the supplements, at a time when they need normal or better levels of vitamin C to fight the disease (ref.[3] and search for "The major problem"). Some writers [8] have identified a theoretical risk of poor Copper absorption from high doses of Vitamin C, although little experimental evidence supports this. However, ceruloplasmin levels seem specifically lowered by high vitamin C intake. In one study, 600 milligrams of Vitamin C daily did not decrease copper absorption or overall body copper status in young men, but led to lower ceruloplasmin levels similar to those caused by copper deficiency [9]. In another, ceruloplasmin levels were significantly reduced [10]. There are stories circulating among some folk remedy proponants that doses of around 12 grams per day of Vitamin C can induce an abortion in women under 4 weeks of pregnancy. [11] This is not supported by scientific reseach however. [12] [edit]Sourcesing, Linus (1986) How to Live Longer and Feel Better W. H. Freeman and Company, ISBN 0-380-70289-4 Levy (September 2002) Vitamin C, Infectious Diseases, and Toxins, Xlibris Corporation (Paperback). ISBN 1401069630 (Note: Xlibris is a print on demand self-publishing house.) Hickey, Steve; , (May, 2004) Ascorbate: The Science of Vitamin C, Lulu Press, Inc. ISBN 1411607244 (Note: Lulu is a print on demand self-publishing house.) [edit]References & #8593; ish Crop Research Institute -Development of a Yeast-Based Single-Step Process for the Manufacture of L-Ascorbic Acid (vitamin C) & #8593; British pharmacology professors debate with the US National Institutes of Health over the optimum vitamin c dose (from PR Newswire - 6th July 2004) [1] & #8593; a b c d e f F. Cathcart III M.D., Vitamin C, Titrating To Bowel Tolerance, Anascorbemia, and Acute Induced Scurvey, Allergy, Environmental, and Orthomolecular Medicine & #8593; Combs GF. The Vitamins, Fundamental Aspects in Nutrition and Health. 2nd ed. San Diego, CA: Academic Press, 2001:245-272 & #8593; Qi Chen and others. Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues. Proceedings of the National Academy of Sciences of the United States of America (PNAS) | September 20, 2005 | vol. 102 | no. 38 | 13604-13609 & #8593; Hickey, Steve & , ; (March, 2005), Ridiculous Dietary Allowance, Lulu Press, Inc. ISBN 1411622219.(Note: Lulu is a print on demand self-publishing house.) & #8593; NCBI & #8593; acu-cell & #8593; NCBI & #8593; NCBI & #8593; Home Abortion Remedy - Vitamin C, 8 March 2006 & #8593; Vitamins C and E in spontaneous abortion Int J Vitam Nutr Res. 1976;46(3):291-6. Jackie Jackie Jackie Jackie Jackie

March 26, 2006

well make sure you get "some" protein in some fashion,, your liver still needs some,, tho not nearly as much as we'd like to believe,, only 3-6 ounces a day will suffice,, elizabethnv1 <elizabethnv1@...> wrote: I avoid sugar , and breads to be honest . I have even taken to avoiding meats . Now I eat yogurt , fruits and veggies . Re: Known harmful effects of vitamin c Hi Liz I wonder WHY anyone would take such huge amounts