Guest guest Posted July 26, 2012 Report Share Posted July 26, 2012 I came across the following tonight and although it doesn't apply to all I thought it would be interesting to many. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132764/pdf/gbq094.pdf Associations Between Cognitive Function and Naturally Occurring Daily Cortisol During Middle Adulthood: Timing Is Everything It will certainly give me something to talk about at my appointment next week! Maybe I can educate her too! Dr. Grim, this raises a bunch of questions. I'm not sure how the Pituitary decides how much Cortisol to request. Is it possible that the excess being produced by the adenoma is taken into consideration so the " normal process " is lessened during the day? (This might explain why 24h tests come in normal.) I guess another question might be with the AVS. As I understand it the overactive adrenal causes the other adrenal to " shut down " so you have to allow time for it to " awaken " sometimes. Is that true for Cortisol also? Would that explain excess Cortisol from that side also? I have also come up with theory why sub clinical Cortisol shows up on the late night tests: The pituitary does its job and shuts down Cortisol but the adenoma doesn't get the message (or is so damn independent) that it just keeps pumping it out! Plenty of questions, observations/answers appreciated! …. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 27, 2012 Report Share Posted July 27, 2012 Maybe it you look at the cause for cushion's syndrome it will give you more information. > > I came across the following tonight and although it doesn't apply to all I thought it would be interesting to many. > > http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132764/pdf/gbq094.pdf > Associations Between Cognitive Function and Naturally Occurring Daily Cortisol During Middle Adulthood: Timing Is Everything > > It will certainly give me something to talk about at my appointment next week! Maybe I can educate her too! > > Dr. Grim, this raises a bunch of questions. I'm not sure how the Pituitary decides how much Cortisol to request. Is it possible that the excess being produced by the adenoma is taken into consideration so the " normal process " is lessened during the day? (This might explain why 24h tests come in normal.) I guess another question might be with the AVS. As I understand it the overactive adrenal causes the other adrenal to " shut down " so you have to allow time for it to " awaken " sometimes. Is that true for Cortisol also? Would that explain excess Cortisol from that side also? > > I have also come up with theory why sub clinical Cortisol shows up on the late night tests: The pituitary does its job and shuts down Cortisol but the adenoma doesn't get the message (or is so damn independent) that it just keeps pumping it out! > > Plenty of questions, observations/answers appreciated! > > …. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 27, 2012 Report Share Posted July 27, 2012 Can look at this link http://en.wikipedia.org/wiki/Cushing's_syndrome > > > > I came across the following tonight and although it doesn't apply to all I thought it would be interesting to many. > > > > http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132764/pdf/gbq094.pdf > > Associations Between Cognitive Function and Naturally Occurring Daily Cortisol During Middle Adulthood: Timing Is Everything > > > > It will certainly give me something to talk about at my appointment next week! Maybe I can educate her too! > > > > Dr. Grim, this raises a bunch of questions. I'm not sure how the Pituitary decides how much Cortisol to request. Is it possible that the excess being produced by the adenoma is taken into consideration so the " normal process " is lessened during the day? (This might explain why 24h tests come in normal.) I guess another question might be with the AVS. As I understand it the overactive adrenal causes the other adrenal to " shut down " so you have to allow time for it to " awaken " sometimes. Is that true for Cortisol also? Would that explain excess Cortisol from that side also? > > > > I have also come up with theory why sub clinical Cortisol shows up on the late night tests: The pituitary does its job and shuts down Cortisol but the adenoma doesn't get the message (or is so damn independent) that it just keeps pumping it out! > > > > Plenty of questions, observations/answers appreciated! > > > > …. > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 27, 2012 Report Share Posted July 27, 2012 First, as I have stated before I have very low trust of Wikipedia unless an expert like Dr. Grim refers me there. Trust me, I can make it say pretty much anything I want! As for more info as to what is causing it, in my case I think I have a pretty good handle on it. It is caused by an adrenal adenoma that is producing excess cortisol. I'm not sure that the excess cortisol is causing as much problem as the timing of it. There are many good researchers looking at it currently and maggiekat7 and I are validating their research! > > > > > > I came across the following tonight and although it doesn't apply to all I thought it would be interesting to many. > > > > > > http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132764/pdf/gbq094.pdf > > > Associations Between Cognitive Function and Naturally Occurring Daily Cortisol During Middle Adulthood: Timing Is Everything > > > > > > It will certainly give me something to talk about at my appointment next week! Maybe I can educate her too! > > > > > > Dr. Grim, this raises a bunch of questions. I'm not sure how the Pituitary decides how much Cortisol to request. Is it possible that the excess being produced by the adenoma is taken into consideration so the " normal process " is lessened during the day? (This might explain why 24h tests come in normal.) I guess another question might be with the AVS. As I understand it the overactive adrenal causes the other adrenal to " shut down " so you have to allow time for it to " awaken " sometimes. Is that true for Cortisol also? Would that explain excess Cortisol from that side also? > > > > > > I have also come up with theory why sub clinical Cortisol shows up on the late night tests: The pituitary does its job and shuts down Cortisol but the adenoma doesn't get the message (or is so damn independent) that it just keeps pumping it out! > > > > > > Plenty of questions, observations/answers appreciated! > > > > > > …. > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 27, 2012 Report Share Posted July 27, 2012 In general if a tumor produces cortisol it usually does it all the time thus losing the diurnal variation. At least once the tumor produces more cortisol than your normal 24 hr production. Similar to concept of early PA. ONCE cortisol production from tumor exceeds your usual production then DV IS LOST. IF tumor is driven by ACTH THEN cortisol may fluctuate as ACTH DOES. Again this will cycle early on. ACTH. IF ACTH is coming from say a lung tumor then less likely to fluctuate also. May your pressure be low!CE Grim MS, MDSpecializing in DifficultHypertensionOn Jul 27, 2012, at 10:05, <jclark24p@...> wrote: First, as I have stated before I have very low trust of Wikipedia unless an expert like Dr. Grim refers me there. Trust me, I can make it say pretty much anything I want! As for more info as to what is causing it, in my case I think I have a pretty good handle on it. It is caused by an adrenal adenoma that is producing excess cortisol. I'm not sure that the excess cortisol is causing as much problem as the timing of it. There are many good researchers looking at it currently and maggiekat7 and I are validating their research! > > > > > > I came across the following tonight and although it doesn't apply to all I thought it would be interesting to many. > > > > > > http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132764/pdf/gbq094.pdf > > > Associations Between Cognitive Function and Naturally Occurring Daily Cortisol During Middle Adulthood: Timing Is Everything > > > > > > It will certainly give me something to talk about at my appointment next week! Maybe I can educate her too! > > > > > > Dr. Grim, this raises a bunch of questions. I'm not sure how the Pituitary decides how much Cortisol to request. Is it possible that the excess being produced by the adenoma is taken into consideration so the "normal process" is lessened during the day? (This might explain why 24h tests come in normal.) I guess another question might be with the AVS. As I understand it the overactive adrenal causes the other adrenal to "shut down" so you have to allow time for it to "awaken" sometimes. Is that true for Cortisol also? Would that explain excess Cortisol from that side also? > > > > > > I have also come up with theory why sub clinical Cortisol shows up on the late night tests: The pituitary does its job and shuts down Cortisol but the adenoma doesn't get the message (or is so damn independent) that it just keeps pumping it out! > > > > > > Plenty of questions, observations/answers appreciated! > > > > > > …. > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 27, 2012 Report Share Posted July 27, 2012 That is exactly why I thought the midnight durinal cortisol test picks it up. I spent half an hour on the phone with the PTN Advocate yesterday and expect I will be getting more info from Dr. Stratakis. She thought she should hire me as a consultant! (Reminded me in business when we had consultants come in and they introduced themselves. " Hi, I've got 3 years experience, I've got 7 years, etc.) I'm sitting there with 29 years and nobody even asked me! One interviewed me and wanted to know if I could produce a list of people who and the number of voice messages each had. When I asked her what she was going to do with the info she said the people that had messages were being ineffecient. I took her to the tele. room and offered to shut the system down and that would make everyone effecient! (Of course they would have to rehire ~50 secretaries and assistants!) God I love consultants! I could tell more but I got frustrated enough that I took early retirement! They had consulted at the largest hospital in Vermont before they came to us. They did a lot of " cost cutting " there and then had a rough 2-4 years restaffing, it's called " brain drain " ! Rant over! > > > > > > > > > > I came across the following tonight and although it doesn't apply to all I thought it would be interesting to many. > > > > > > > > > > http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132764/pdf/gbq094.pdf > > > > > Associations Between Cognitive Function and Naturally Occurring Daily Cortisol During Middle Adulthood: Timing Is Everything > > > > > > > > > > It will certainly give me something to talk about at my appointment next week! Maybe I can educate her too! > > > > > > > > > > Dr. Grim, this raises a bunch of questions. I'm not sure how the Pituitary decides how much Cortisol to request. Is it possible that the excess being produced by the adenoma is taken into consideration so the " normal process " is lessened during the day? (This might explain why 24h tests come in normal.) I guess another question might be with the AVS. As I understand it the overactive adrenal causes the other adrenal to " shut down " so you have to allow time for it to " awaken " sometimes. Is that true for Cortisol also? Would that explain excess Cortisol from that side also? > > > > > > > > > > I have also come up with theory why sub clinical Cortisol shows up on the late night tests: The pituitary does its job and shuts down Cortisol but the adenoma doesn't get the message (or is so damn independent) that it just keeps pumping it out! > > > > > > > > > > Plenty of questions, observations/answers appreciated! > > > > > > > > > > …. > > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 27, 2012 Report Share Posted July 27, 2012 Picks it up earlier. May your pressure be low!CE Grim MS, MDSpecializing in DifficultHypertensionOn Jul 27, 2012, at 11:09, <jclark24p@...> wrote: That is exactly why I thought the midnight durinal cortisol test picks it up. I spent half an hour on the phone with the PTN Advocate yesterday and expect I will be getting more info from Dr. Stratakis. She thought she should hire me as a consultant! (Reminded me in business when we had consultants come in and they introduced themselves. "Hi, I've got 3 years experience, I've got 7 years, etc.) I'm sitting there with 29 years and nobody even asked me! One interviewed me and wanted to know if I could produce a list of people who and the number of voice messages each had. When I asked her what she was going to do with the info she said the people that had messages were being ineffecient. I took her to the tele. room and offered to shut the system down and that would make everyone effecient! (Of course they would have to rehire ~50 secretaries and assistants!) God I love consultants! I could tell more but I got frustrated enough that I took early retirement! They had consulted at the largest hospital in Vermont before they came to us. They did a lot of "cost cutting" there and then had a rough 2-4 years restaffing, it's called "brain drain"! Rant over! > > > > > > > > > > I came across the following tonight and although it doesn't apply to all I thought it would be interesting to many. > > > > > > > > > > http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132764/pdf/gbq094.pdf > > > > > Associations Between Cognitive Function and Naturally Occurring Daily Cortisol During Middle Adulthood: Timing Is Everything > > > > > > > > > > It will certainly give me something to talk about at my appointment next week! Maybe I can educate her too! > > > > > > > > > > Dr. Grim, this raises a bunch of questions. I'm not sure how the Pituitary decides how much Cortisol to request. Is it possible that the excess being produced by the adenoma is taken into consideration so the "normal process" is lessened during the day? (This might explain why 24h tests come in normal.) I guess another question might be with the AVS. As I understand it the overactive adrenal causes the other adrenal to "shut down" so you have to allow time for it to "awaken" sometimes. Is that true for Cortisol also? Would that explain excess Cortisol from that side also? > > > > > > > > > > I have also come up with theory why sub clinical Cortisol shows up on the late night tests: The pituitary does its job and shuts down Cortisol but the adenoma doesn't get the message (or is so damn independent) that it just keeps pumping it out! > > > > > > > > > > Plenty of questions, observations/answers appreciated! > > > > > > > > > > …. > > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 27, 2012 Report Share Posted July 27, 2012 Can start with what is on Wikipedia and then see if there information is right by checking other sources. > > > > > > > > I came across the following tonight and although it doesn't apply to all I thought it would be interesting to many. > > > > > > > > http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132764/pdf/gbq094.pdf > > > > Associations Between Cognitive Function and Naturally Occurring Daily Cortisol During Middle Adulthood: Timing Is Everything > > > > > > > > It will certainly give me something to talk about at my appointment next week! Maybe I can educate her too! > > > > > > > > Dr. Grim, this raises a bunch of questions. I'm not sure how the Pituitary decides how much Cortisol to request. Is it possible that the excess being produced by the adenoma is taken into consideration so the " normal process " is lessened during the day? (This might explain why 24h tests come in normal.) I guess another question might be with the AVS. As I understand it the overactive adrenal causes the other adrenal to " shut down " so you have to allow time for it to " awaken " sometimes. Is that true for Cortisol also? Would that explain excess Cortisol from that side also? > > > > > > > > I have also come up with theory why sub clinical Cortisol shows up on the late night tests: The pituitary does its job and shuts down Cortisol but the adenoma doesn't get the message (or is so damn independent) that it just keeps pumping it out! > > > > > > > > Plenty of questions, observations/answers appreciated! > > > > > > > > …. > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 27, 2012 Report Share Posted July 27, 2012 Can COPD increase cortisol? > > > > > > > > > > I came across the following tonight and although it doesn't apply to all I thought it would be interesting to many. > > > > > > > > > > http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132764/pdf/gbq094.pdf > > > > > Associations Between Cognitive Function and Naturally Occurring Daily Cortisol During Middle Adulthood: Timing Is Everything > > > > > > > > > > It will certainly give me something to talk about at my appointment next week! Maybe I can educate her too! > > > > > > > > > > Dr. Grim, this raises a bunch of questions. I'm not sure how the Pituitary decides how much Cortisol to request. Is it possible that the excess being produced by the adenoma is taken into consideration so the " normal process " is lessened during the day? (This might explain why 24h tests come in normal.) I guess another question might be with the AVS. As I understand it the overactive adrenal causes the other adrenal to " shut down " so you have to allow time for it to " awaken " sometimes. Is that true for Cortisol also? Would that explain excess Cortisol from that side also? > > > > > > > > > > I have also come up with theory why sub clinical Cortisol shows up on the late night tests: The pituitary does its job and shuts down Cortisol but the adenoma doesn't get the message (or is so damn independent) that it just keeps pumping it out! > > > > > > > > > > Plenty of questions, observations/answers appreciated! > > > > > > > > > > …. > > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 27, 2012 Report Share Posted July 27, 2012 Hmmm. JC I though you would say go to HTN PRIMER. May your pressure be low!CE Grim MS, MDSpecializing in DifficultHypertensionOn Jul 27, 2012, at 14:58, Francis Bill SUSPECTED PA <georgewbill@...> wrote: Can start with what is on Wikipedia and then see if there information is right by checking other sources. > > > > > > > > I came across the following tonight and although it doesn't apply to all I thought it would be interesting to many. > > > > > > > > http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132764/pdf/gbq094.pdf > > > > Associations Between Cognitive Function and Naturally Occurring Daily Cortisol During Middle Adulthood: Timing Is Everything > > > > > > > > It will certainly give me something to talk about at my appointment next week! Maybe I can educate her too! > > > > > > > > Dr. Grim, this raises a bunch of questions. I'm not sure how the Pituitary decides how much Cortisol to request. Is it possible that the excess being produced by the adenoma is taken into consideration so the "normal process" is lessened during the day? (This might explain why 24h tests come in normal.) I guess another question might be with the AVS. As I understand it the overactive adrenal causes the other adrenal to "shut down" so you have to allow time for it to "awaken" sometimes. Is that true for Cortisol also? Would that explain excess Cortisol from that side also? > > > > > > > > I have also come up with theory why sub clinical Cortisol shows up on the late night tests: The pituitary does its job and shuts down Cortisol but the adenoma doesn't get the message (or is so damn independent) that it just keeps pumping it out! > > > > > > > > Plenty of questions, observations/answers appreciated! > > > > > > > > …. > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 27, 2012 Report Share Posted July 27, 2012 YesMay your pressure be low!CE Grim MS, MDSpecializing in DifficultHypertensionOn Jul 27, 2012, at 15:00, Francis Bill SUSPECTED PA <georgewbill@...> wrote: Can COPD increase cortisol? > > > > > > > > > > I came across the following tonight and although it doesn't apply to all I thought it would be interesting to many. > > > > > > > > > > http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132764/pdf/gbq094.pdf > > > > > Associations Between Cognitive Function and Naturally Occurring Daily Cortisol During Middle Adulthood: Timing Is Everything > > > > > > > > > > It will certainly give me something to talk about at my appointment next week! Maybe I can educate her too! > > > > > > > > > > Dr. Grim, this raises a bunch of questions. I'm not sure how the Pituitary decides how much Cortisol to request. Is it possible that the excess being produced by the adenoma is taken into consideration so the "normal process" is lessened during the day? (This might explain why 24h tests come in normal.) I guess another question might be with the AVS. As I understand it the overactive adrenal causes the other adrenal to "shut down" so you have to allow time for it to "awaken" sometimes. Is that true for Cortisol also? Would that explain excess Cortisol from that side also? > > > > > > > > > > I have also come up with theory why sub clinical Cortisol shows up on the late night tests: The pituitary does its job and shuts down Cortisol but the adenoma doesn't get the message (or is so damn independent) that it just keeps pumping it out! > > > > > > > > > > Plenty of questions, observations/answers appreciated! > > > > > > > > > > …. > > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 27, 2012 Report Share Posted July 27, 2012 I could also start at the local bar! I usually have something I want to know about and I find Pubmed is a good resource and am successful some of the time. That method works for me and I'm sure others have their methods. > > > > > > > > > > I came across the following tonight and although it doesn't apply to all I thought it would be interesting to many. > > > > > > > > > > http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132764/pdf/gbq094.pdf > > > > > Associations Between Cognitive Function and Naturally Occurring Daily Cortisol During Middle Adulthood: Timing Is Everything > > > > > > > > > > It will certainly give me something to talk about at my appointment next week! Maybe I can educate her too! > > > > > > > > > > Dr. Grim, this raises a bunch of questions. I'm not sure how the Pituitary decides how much Cortisol to request. Is it possible that the excess being produced by the adenoma is taken into consideration so the " normal process " is lessened during the day? (This might explain why 24h tests come in normal.) I guess another question might be with the AVS. As I understand it the overactive adrenal causes the other adrenal to " shut down " so you have to allow time for it to " awaken " sometimes. Is that true for Cortisol also? Would that explain excess Cortisol from that side also? > > > > > > > > > > I have also come up with theory why sub clinical Cortisol shows up on the late night tests: The pituitary does its job and shuts down Cortisol but the adenoma doesn't get the message (or is so damn independent) that it just keeps pumping it out! > > > > > > > > > > Plenty of questions, observations/answers appreciated! > > > > > > > > > > …. > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 27, 2012 Report Share Posted July 27, 2012 I do use HTN primer to look up how to treat something but I am beyond that point for most of what I'm looking up. It is also more difficult and time consuming because it is paper. Also may be a little dated because a lot of the info around subclinical cortisol is just being developed and published. I also sometimes follow the references in an article. ie, Two of the authors of the article I just referenced today were from Brandeis University, a research university in Waltham, MA. That website led me to a Master's Thesis which helped me understand how things work together. The advantage with this is that since it is a PDF file I can search for key words like " cortisol " ! Every researcher has their own methodology and the rel trich is to seperate fact from fiction! > > > > > > > > > > > > I came across the following tonight and although it doesn't apply to all I thought it would be interesting to many. > > > > > > > > > > > > http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132764/pdf/gbq094.pdf > > > > > > Associations Between Cognitive Function and Naturally Occurring Daily Cortisol During Middle Adulthood: Timing Is Everything > > > > > > > > > > > > It will certainly give me something to talk about at my appointment next week! Maybe I can educate her too! > > > > > > > > > > > > Dr. Grim, this raises a bunch of questions. I'm not sure how the Pituitary decides how much Cortisol to request. Is it possible that the excess being produced by the adenoma is taken into consideration so the " normal process " is lessened during the day? (This might explain why 24h tests come in normal.) I guess another question might be with the AVS. As I understand it the overactive adrenal causes the other adrenal to " shut down " so you have to allow time for it to " awaken " sometimes. Is that true for Cortisol also? Would that explain excess Cortisol from that side also? > > > > > > > > > > > > I have also come up with theory why sub clinical Cortisol shows up on the late night tests: The pituitary does its job and shuts down Cortisol but the adenoma doesn't get the message (or is so damn independent) that it just keeps pumping it out! > > > > > > > > > > > > Plenty of questions, observations/answers appreciated! > > > > > > > > > > > > …. > > > > > > > > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 27, 2012 Report Share Posted July 27, 2012 So if has COPD then this could be his cause of over prodction of cortisol. In that case removing just one adrenal gland would not help cushing's. > > > > > > > > > > > > > > I came across the following tonight and although it doesn't apply to all I thought it would be interesting to many. > > > > > > > > > > > > > > http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132764/pdf/gbq094.pdf > > > > > > > Associations Between Cognitive Function and Naturally Occurring Daily Cortisol During Middle Adulthood: Timing Is Everything > > > > > > > > > > > > > > It will certainly give me something to talk about at my appointment next week! Maybe I can educate her too! > > > > > > > > > > > > > > Dr. Grim, this raises a bunch of questions. I'm not sure how the Pituitary decides how much Cortisol to request. Is it possible that the excess being produced by the adenoma is taken into consideration so the " normal process " is lessened during the day? (This might explain why 24h tests come in normal.) I guess another question might be with the AVS. As I understand it the overactive adrenal causes the other adrenal to " shut down " so you have to allow time for it to " awaken " sometimes. Is that true for Cortisol also? Would that explain excess Cortisol from that side also? > > > > > > > > > > > > > > I have also come up with theory why sub clinical Cortisol shows up on the late night tests: The pituitary does its job and shuts down Cortisol but the adenoma doesn't get the message (or is so damn independent) that it just keeps pumping it out! > > > > > > > > > > > > > > Plenty of questions, observations/answers appreciated! > > > > > > > > > > > > > > …. > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 27, 2012 Report Share Posted July 27, 2012 Francis, don't practice medicine w/o a license. My COPD is so minimal, I missed the cutoff by 5%, that I am sure it is not much of a factor if any. In fact I never would have gotten that DX if LVH had not caused me to need suppl. oxygen. > > > > > > > > > > > > > > > > I came across the following tonight and although it doesn't apply to all I thought it would be interesting to many. > > > > > > > > > > > > > > > > http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132764/pdf/gbq094.pdf > > > > > > > > Associations Between Cognitive Function and Naturally Occurring Daily Cortisol During Middle Adulthood: Timing Is Everything > > > > > > > > > > > > > > > > It will certainly give me something to talk about at my appointment next week! Maybe I can educate her too! > > > > > > > > > > > > > > > > Dr. Grim, this raises a bunch of questions. I'm not sure how the Pituitary decides how much Cortisol to request. Is it possible that the excess being produced by the adenoma is taken into consideration so the " normal process " is lessened during the day? (This might explain why 24h tests come in normal.) I guess another question might be with the AVS. As I understand it the overactive adrenal causes the other adrenal to " shut down " so you have to allow time for it to " awaken " sometimes. Is that true for Cortisol also? Would that explain excess Cortisol from that side also? > > > > > > > > > > > > > > > > I have also come up with theory why sub clinical Cortisol shows up on the late night tests: The pituitary does its job and shuts down Cortisol but the adenoma doesn't get the message (or is so damn independent) that it just keeps pumping it out! > > > > > > > > > > > > > > > > Plenty of questions, observations/answers appreciated! > > > > > > > > > > > > > > > > …. > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
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