Re: Melatonin - Help!

[Guest guest]

Sheela-my son FLIPPED OUT on .3 mg time release melatonin. I hsave an idea

why. E-mail me:)

[ ] Melatonin - Help!

>

>Hi!

>Did any of you see ANY negative side effects to Melatonin? My son has been

a

>good sleeper. Now we are chelating. I thought that 1 mg of Melatonin

(Source

>Naturals) would help him heal. Well, he becomes VERY irritable and

>destructive the next day. We tried it twice and the same behavior returned.

>What is it that I am doing wrong? Oh, he is 60 pounds/eight years old.

>

>Thanks in advance.

>Love and Prayers,

>Sheela.

>

>

>

[Guest guest]

Jean

My 9 year old ASD son also has a horrible time with melatonin. I've tried it

on him several times over the years with always the same results of unhappy,

aggressive behavior the next day. What specific kind of testing did you do

to determine that there was problems with the tryptophan pathway? Thanks so

much for any insight because I do feel this is a major problem for my son and

a key to finding some answers for him.

Janet

In a message dated 11/21/00 9:57:51 AM Pacific Standard Time,

finders@... writes:

<< It's just that tested high for a toxic byproduct of serotonin

metabolism, and handles NOTHING that goes through the tryptophan

pathway.poppy seeds, melatonin, purple grape skins, st johns

wart...everything that he reacts to is an indole in some form. If you over

metabolize serotonin, you produce indoles that are neurotoxic, and they can

cause colon cancer. they're the thing you're supposed to avoid by not

blackening meat over a metal surface. I think the melatonin is probably

good for most of the kids, the mutant being the exception, not the

rule. the problems Mike has with melatonin are identical tothe symptoms

produced by milk, or too much protein. Most likely the mutant germs making

poisons that the leaky gut lets through. I am ordering a homeopathic that

helps your body excrete indoles. I will let you know what happens:) >>

[Guest guest]

could you please post your theory to the list?

If there is some reason that you feel it would be

inappropriate, then please post your response to me as

well. We just started our kids on 1 mg Melatonin last

night and I'd like to know what to look for if there

is a problem.

Thanks

tali

--- Curtin <finders@...> wrote:

> Sheela-my son FLIPPED OUT on .3 mg time release

> melatonin. I hsave an idea

> why. E-mail me:)

> [ ] Melatonin - Help!

>

>

> >

> >Hi!

> >Did any of you see ANY negative side effects to

> Melatonin? My son has been

> a

> >good sleeper. Now we are chelating. I thought that

> 1 mg of Melatonin

> (Source

> >Naturals) would help him heal. Well, he becomes

> VERY irritable and

> >destructive the next day. We tried it twice and the

> same behavior returned.

> >What is it that I am doing wrong? Oh, he is 60

> pounds/eight years old.

> >

> >Thanks in advance.

> >Love and Prayers,

> >Sheela.

> >

> >

> >

[Guest guest]

It's just that tested high for a toxic byproduct of serotonin

metabolism, and handles NOTHING that goes through the tryptophan

pathway.poppy seeds, melatonin, purple grape skins, st johns

wart...everything that he reacts to is an indole in some form. If you over

metabolize serotonin, you produce indoles that are neurotoxic, and they can

cause colon cancer. they're the thing you're supposed to avoid by not

blackening meat over a metal surface. I think the melatonin is probably

good for most of the kids, the mutant being the exception, not the

rule. the problems Mike has with melatonin are identical tothe symptoms

produced by milk, or too much protein. Most likely the mutant germs making

poisons that the leaky gut lets through. I am ordering a homeopathic that

helps your body excrete indoles. I will let you know what happens:)

[ ] Melatonin - Help!

>>

>>

>> >

>> >Hi!

>> >Did any of you see ANY negative side effects to

>> Melatonin? My son has been

>> a

>> >good sleeper. Now we are chelating. I thought that

>> 1 mg of Melatonin

>> (Source

>> >Naturals) would help him heal. Well, he becomes

>> VERY irritable and

>> >destructive the next day. We tried it twice and the

>> same behavior returned.

>> >What is it that I am doing wrong? Oh, he is 60

>> pounds/eight years old.

>> >

>> >Thanks in advance.

>> >Love and Prayers,

>> >Sheela.

>> >

>> >

>> >

[Guest guest]

Hi Janet. Dr Shaw's organic acid test panel showed 5HAII, a toxic metabolite

of tryptophan, in his pee. Last I knew, Dr Shaw was the only one testing for

this.Dr. Shaw says those metabolites will disappear if you give colostrum

gold from KIrkman, but Micahel cannot handle colostrum, it produces violent

outbursts-the very thing we are trying to avoid LOL. There's another

indole he tests for that alot of kids show, but Mike was normal on that

(IAG)

Re: [ ] Melatonin - Help!

>Jean

>My 9 year old ASD son also has a horrible time with melatonin. I've tried

it

>on him several times over the years with always the same results of

unhappy,

>aggressive behavior the next day. What specific kind of testing did you do

>to determine that there was problems with the tryptophan pathway? Thanks

so

>much for any insight because I do feel this is a major problem for my son

and

>a key to finding some answers for him.

>Janet

>

>In a message dated 11/21/00 9:57:51 AM Pacific Standard Time,

>finders@... writes:

>

><< It's just that tested high for a toxic byproduct of serotonin

> metabolism, and handles NOTHING that goes through the tryptophan

> pathway.poppy seeds, melatonin, purple grape skins, st johns

> wart...everything that he reacts to is an indole in some form. If you

over

> metabolize serotonin, you produce indoles that are neurotoxic, and they

can

> cause colon cancer. they're the thing you're supposed to avoid by not

> blackening meat over a metal surface. I think the melatonin is probably

> good for most of the kids, the mutant being the exception, not the

> rule. the problems Mike has with melatonin are identical tothe symptoms

> produced by milk, or too much protein. Most likely the mutant germs

making

> poisons that the leaky gut lets through. I am ordering a homeopathic that

> helps your body excrete indoles. I will let you know what happens:) >>

>

>

>

[Guest guest]

PLease post your reason for all to see. Tahnks KenG

--- In egroups, " Curtin " <finders@r...>

wrote:

> Sheela-my son FLIPPED OUT on .3 mg time release melatonin. I hsave

an idea

> why. E-mail me:)

> [ ] Melatonin - Help!

>

>

> >

> >Hi!

> >Did any of you see ANY negative side effects to Melatonin? My son

has been

> a

> >good sleeper. Now we are chelating. I thought that 1 mg of

Melatonin

> (Source

> >Naturals) would help him heal. Well, he becomes VERY irritable and

> >destructive the next day. We tried it twice and the same behavior

returned.

> >What is it that I am doing wrong? Oh, he is 60 pounds/eight years

old.

> >

> >Thanks in advance.

> >Love and Prayers,

> >Sheela.

> >

> >

> >

[Guest guest]

Melatonin was a disaster for Kenny too. Same sort of results you saw.

(Cary, NC)persistentC@...

[ ] Melatonin - Help!

Hi!Did any of you see ANY negative side effects to Melatonin? My son has been a good sleeper. Now we are chelating. I thought that 1 mg of Melatonin (Source Naturals) would help him heal. Well, he becomes VERY irritable and destructive the next day. We tried it twice and the same behavior returned. What is it that I am doing wrong? Oh, he is 60 pounds/eight years old.Thanks in advance.Love and Prayers,Sheela.

[Guest guest]

Hi

Was this part of the smokies detox test? If not what test was it?

Thanks

Barry

> It's just that tested high for a toxic byproduct of

serotonin

> metabolism, and handles NOTHING that goes through the tryptophan

> pathway.poppy seeds, melatonin, purple grape skins, st johns

> wart...

[Guest guest]

In a message dated 11/23/00 9:58:12 AM, snickol@... writes:

<< Hi. Our son is 6 years and we are about to start round 4

of chelation this fri. We did first 3 rounds of DMSA 75mg and are

increasing it to 200mg. Anyway, we think the chelation is helping him

but are having a bad time with melatonin. He sleeps well on all nights

except when we give him melatonin he is up for the rest of the night at

1:00 or 2:00am! I want to find out if we can eliminate this part of the

protocol or do it during the day instead of pm. Do you know? >>

I've had the same problem with DJ. DJ always slept through the night 8-9

hours. He's 11 years old. Since starting the melatonin, he's been getting

up at 2-3 in the morning and staying up without showing signs of fatigue.

When I stopped it this weekend, he has slept well the past three nights. I

will speak to his doctor tomorrow. Doesn't make sense.

[Guest guest]

Do you think the time release Melatonin would make a difference for these

kids who wake up in the middle of the night?

Just a thought...

Prayers,

Sheela.

In a message dated 11/26/00 2:55:17 PM Central Standard Time,

DenNeg01@... writes:

> In a message dated 11/23/00 9:58:12 AM, snickol@... writes:

>

> << Hi. Our son is 6 years and we are about to start round 4

> of chelation this fri. We did first 3 rounds of DMSA 75mg and are

> increasing it to 200mg. Anyway, we think the chelation is helping him

> but are having a bad time with melatonin. He sleeps well on all nights

> except when we give him melatonin he is up for the rest of the night at

> 1:00 or 2:00am! I want to find out if we can eliminate this part of the

> protocol or do it during the day instead of pm. Do you know? >>

>

> I've had the same problem with DJ. DJ always slept through the night 8-9

> hours. He's 11 years old. Since starting the melatonin, he's been

getting

> up at 2-3 in the morning and staying up without showing signs of fatigue.

> When I stopped it this weekend, he has slept well the past three nights.

I

> will speak to his doctor tomorrow. Doesn't make sense.

>

[Guest guest]

:

What brand of timed-release did you try? Where did you get it? I will

probably have to try it.

Thanks

Tina

[Guest guest]

We tried time release melatonin, and it didn't help :-(

(Cary, NC)persistentC@...

Do you think the time release Melatonin would make a difference for these kids who wake up in the middle of the night? Just a thought...Prayers,Sheela.In a message dated 11/26/00 2:55:17 PM Central Standard Time, DenNeg01@... writes:> In a message dated 11/23/00 9:58:12 AM, snickol@... writes:> > << Hi. Our son is 6 years and we are about to start round 4> of chelation this fri. We did first 3 rounds of DMSA 75mg and are> increasing it to 200mg. Anyway, we think the chelation is helping him> but are having a bad time with melatonin. He sleeps well on all nights> except when we give him melatonin he is up for the rest of the night at> 1:00 or 2:00am! I want to find out if we can eliminate this part of the> protocol or do it during the day instead of pm. Do you know? >>> > I've had the same problem with DJ. DJ always slept through the night 8-9 > hours. He's 11 years old. Since starting the melatonin, he's been getting > up at 2-3 in the morning and staying up without showing signs of fatigue. > When I stopped it this weekend, he has slept well the past three nights. I > will speak to his doctor tomorrow. Doesn't make sense.>

[Guest guest]

Is there some way to test beforehand whether a child is a good candidate for melatonin, or not? Do some of our kids have a deficiency in it and others not? My daughter has done beautifully with melatonin and I have to wonder why it wasn't recommended to us years ago because we've had many years of having difficulty settling her to sleep (sometimes up until 1 or 2 a.m., or more!). If a child reacts badly, then perhaps he/she already has the body's tolerance level and any more will cause a disturbance? Like I said, any way to test for this that isn't too invasive?

Re: [ ] Melatonin - Help!

We tried time release melatonin, and it didn't help :-(

(Cary, NC)persistentC@...

Do you think the time release Melatonin would make a difference for these kids who wake up in the middle of the night? Just a thought...Prayers,Sheela.In a message dated 11/26/00 2:55:17 PM Central Standard Time, DenNeg01@... writes:> In a message dated 11/23/00 9:58:12 AM, snickol@... writes:> > << Hi. Our son is 6 years and we are about to start round 4> of chelation this fri. We did first 3 rounds of DMSA 75mg and are> increasing it to 200mg. Anyway, we think the chelation is helping him> but are having a bad time with melatonin. He sleeps well on all nights> except when we give him melatonin he is up for the rest of the night at> 1:00 or 2:00am! I want to find out if we can eliminate this part of the> protocol or do it during the day instead of pm. Do you know? >>> > I've had the same problem with DJ. DJ always slept through the night 8-9 > hours. He's 11 years old. Since starting the melatonin, he's been getting > up at 2-3 in the morning and staying up without showing signs of fatigue. > When I stopped it this weekend, he has slept well the past three nights. I > will speak to his doctor tomorrow. Doesn't make sense.>

[Guest guest]

Was that 75 mg every 4 hours or 8 hours? 200 mg seems awfully high!

I would consider increasing much more slowly whether 4 or 8 hours.

Even the insert for chemet says 10 mg/kg every 8 hours (or 350 mg max

for adult) which is about 4 times higher than Dr. Amy seems to

suggest. Sorry don't have weight of oyur son but please go slowly

otherwise the negatives will start to override the positives. Good

luck, KenG

--- In egroups, stephanie nickolson <snickol@J...>

wrote:

> Hi. Our son is 6 years and we are about to start round 4

> of chelation this fri. We did first 3 rounds of DMSA 75mg and are

> increasing it to 200mg. Anyway, we think the chelation is helping

him

> but are having a bad time with melatonin. He sleeps well on all

nights

> except when we give him melatonin he is up for the rest of the

night at

> 1:00 or 2:00am! I want to find out if we can eliminate this part of

the

> protocol or do it during the day instead of pm. Do you know?

> ________________________________________________________________

> GET INTERNET ACCESS FROM JUNO!

> Juno offers FREE or PREMIUM Internet access for less!

> Join Juno today! For your FREE software, visit:

> http://dl.www.juno.com/get/tagj.

[Guest guest]

Hi ! I hope you don't give up on melatonin completely or

forever! It may just be that he couldn't handle it due to the stage

of toxicity of his body at the time and his detox or processing

pathways. All of these bad reactions that some people have (eg ALA,

melatonin, etc) should not necessarily be discounted completely or

scare off everyone else otherwise no-one will get better. Rememeber,

each kid is different and each kid is different at different times!

Just go slow and observe and revisit certain challenges again later.

Good luck and I love oyur input. Kenny is a lucky kid! KenG

--- In egroups, " s " <persistentC@b...>

wrote:

> Melatonin was a disaster for Kenny too. Same sort of results you

saw.

> (Cary, NC)

> persistentC@b...

>

> [ ] Melatonin - Help!

>

>

>

> Hi!

> Did any of you see ANY negative side effects to Melatonin? My son

has been a

> good sleeper. Now we are chelating. I thought that 1 mg of

Melatonin (Source

> Naturals) would help him heal. Well, he becomes VERY irritable

and

> destructive the next day. We tried it twice and the same behavior

returned.

> What is it that I am doing wrong? Oh, he is 60 pounds/eight years

old.

>

> Thanks in advance.

> Love and Prayers,

> Sheela.

>

> eGroups Sponsor

>

>

>

[Guest guest]

We've tried it several times actually. I guess he's not ready for it yet.

One can always hope....

We've been having a terrible time with him waking in the middle of the night and having a BM wherever he happens to be. Usually that's on the carpet in the hall, or his therapy room. But a couple of days ago it was on top of the dining room table and 3 chairs.

The night waking is MUCH worse than it's ever been. I sure hope we get through this! We are pretty worried about Kenny endangering himself, and are at our wits end to figure out how to stop this. We've locked every door we possibly can, but there is no way to close off the living room/dining room area. My husband even suggested that we should get a motion detector to wake us up when he went downstairs. (Maybe it would only need to go off once ....!)

(Cary, NC)persistentC@...

[ ] Melatonin - Help!> > > > Hi!> Did any of you see ANY negative side effects to Melatonin? My son has been a > good sleeper. Now we are chelating. I thought that 1 mg of Melatonin (Source > Naturals) would help him heal. Well, he becomes VERY irritable and > destructive the next day. We tried it twice and the same behavior returned. > What is it that I am doing wrong? Oh, he is 60 pounds/eight years old.> > Thanks in advance.> Love and Prayers,> Sheela.> > eGroups Sponsor > > >

[Guest guest]

and family:

My heart goes out to you! I certainly did not mean to imply that you

haven't tried enough or done enough. I just mean that as our kids

bodies heal, some of their bodies processes may change such that they

can handle a product they never could in the past and that product

may eventually become beneficial to them.

I am hoping that is the case with Dr. Amy's son Mike - with mercury

out of the way, wheat may actually be nutritional to him!!!! HArd

to believe but, if the mercury and other toxins used to inhibit his

gut and gluten processing ability are now gone, it makes sense that

gluten containing products could now be nutritious for him. Nice

thought?! :-) Maybe so with melatonin after a longer while?

Good luck, KenG

> > Melatonin was a disaster for Kenny too. Same sort of results

you

> saw.

> > (Cary, NC)

> > persistentC@b...

> >

> > [ ] Melatonin - Help!

> >

> >

> >

> > Hi!

> > Did any of you see ANY negative side effects to Melatonin? My

son

> has been a

> > good sleeper. Now we are chelating. I thought that 1 mg of

> Melatonin (Source

> > Naturals) would help him heal. Well, he becomes VERY

irritable

> and

> > destructive the next day. We tried it twice and the same

behavior

> returned.

> > What is it that I am doing wrong? Oh, he is 60 pounds/eight

years

> old.

> >

> > Thanks in advance.

> > Love and Prayers,

> > Sheela.

> >

> > eGroups Sponsor

> >

> >

> >

[Guest guest]

Here are some good things about Melatonin from Comprehensive guide to managing autism by Willis Langford:

Many find solution to sleep problem with a supplement of melatonin (1/2 to 3

mg, 20 minutes before bedtime). There are, potentially, several benefits to

taking supplemental doses of melatonin other than improved sleep; for

example, it promotes absorption of zinc, stimulates the thyroid, and as

tests show, protects against brain damage from mercury poisoning reducing

potential for Alzheimer’s (without it glutathione was reduced 30%, and other

damage occurred). It is a powerful antioxidant, able to enter every cell of

the body. Dr. Reiter found melatonin to be 5.9 times more effective than

glutathione and 11.3 times more effective than mannitol in fighting

dangerous, hydroxyl radicals.

A 24-hour exposure to 50 µg/L mercury induced significant cell cytotoxicity

in neuroblastoma cells. Treatment of cells with melatonin before

administration of mercury greatly reduced the mercury-induced cytotoxicity.

Mercury treatment of cells produced another as yet undocumented phenomenon,

that of inducing oxidative stress, as measured by the loss of reduced

glutathione (GSH) from cells. This was a rapid process, requiring only 30

minutes of exposure to mercury. Similarly, pretreating the cells with

melatonin...before administration protected cells from the mercury-induced

oxidative stress. Melatonin’s mechanism of action is at present unclear;

however, melatonin is known to bind heavy metals (Limson et al., 1998REF15)

and to increase intracellular GSH levels through an up-regulation of

GSH-synthesizing enzymes (Todoroki et al., 1998REF3). It is thus possible to

speculate on two mechanisms for melatonin’s antioxidant action, namely, (a)

melatonin as a chelating agent binding mercury, thus eliminating its

cytotoxic properties, or ( melatonin causing production of increased

levels of intracellular antioxidants such as (Todoroki et al., 1998REF30).

It is further not excluded that both these mechanisms could be operating

simultaneously.

The release of both Aß 1-40 and Aß 1-42 into the culture medium was

increased by exposure of SHSY5Y cells to mercury. Melatonin preincubation

resulted in a significant decrease in Aß release....Mercury has previously

been shown to be a potent inhibitor of enzymes, especially those containing

sulfhydryl groups (Edstrom and Mattsson, 1976REF9). Protein kinase C

activity in vitro and in brain tissue is markedly reduced in a

concentration-dependent manner by mercury (Rajanna et al.,

1995REF21).....Mercury induces both Aß production and oxidative stress;

thus, the chelation of mercury by melatonin could shift the APP metabolism

back toward the secretase pathway, reducing Aß production and the

concomitant oxidative stress-inducing effects of mercury and Aß.

Aß-Fibrillogenesis is also inhibited by melatonin, thereby potentially

reducing the toxic buildup of Aß 1-40 and Aß 1-42 fibrils (Pappolla et al.,

1998REF20). Furthermore, melatonin has been shown to reduce the release of

soluble APP from cells in culture and to reduce the levels of APP mRNA and

other housekeeping protein mRNAs (Song and Lahiri, 1997REF24). These data

suggest that melatonin may be involved in metabolic mechanisms regulating

APP and other essential cellular protein production, over and above its

antioxidant capacity.

Another abstract with no title credits says in part: Recent data indicate

that melatonin inhibits brain glutamate receptors and nitric oxide

production thus suggesting that it may exert a neuroprotective and

antiexcitotoxic effect. Melatonin has been seen to prevent seizures in

several animal models, and to decrease epileptic manifestations in

humans....The results suggest that melatonin may have a useful role in

mechanisms of neuroprotection, and they also indicate its use in other cases

of untreatable epilepsy. Another study is of interest: Children’s Memorial

Hospital, Chicago, in a report published by Lancet, found that, though their

sleep problem was benefited, children with severe nervous–system damage,

using a dosage of five mg, experienced an increased incidence of seizures

that returned to previous levels on discontinuance.

One can increase acetylcholine production and enhance muscle

tone by supplementing one or more of these: Bethanecol, melatonin,

N-acetylcarnitine, SAMe, DMAE, TMG, manganese, Coenzyme A, lecithin granules

(choline), phosphatidylcholine.

[Guest guest]

DJ (11 years old, 90 pounds, autistic) has always slept pretty well, before

chelation and melatonin about 8-9 hours. Every now and then, he would get up

around 2 or 3am and stay up but it would catch up with him in the afternoon

and he would have to take a nap. We started melatonin (1 mg) a month before

chelation. He started getting up at 2 or 3 am more often. I told the doctor

and he told me to increase it to 3mg. Same problem.

At our appointment last week, he asked me to give him 100mg glutathione with

the melatonin. DJ was sleeping only about 4-5 hours and then be up for the

day without any sign of fatigue. He would not nap during the day either.

Per doctor, we discontinued and DJ has been sleeping about 9-10 hours since

we stopped 6 days ago.

Does anyone think that perhaps children that do not have a sleep problem

would not benefit from melatonin and glutathoine? But it concerns me that

the melatonin helps protect the brain from mercury. This is all so confusing.

In a message dated 11/29/00 3:09:26 PM, Mycoltjoe@... writes:

<< Here are some good things about Melatonin from Comprehensive guide to

managing autism by Willis Langford:

Many find solution to sleep problem with a supplement of melatonin (1/2 to 3

mg, 20 minutes before bedtime). There are, potentially, several benefits to

taking supplemental doses of melatonin other than improved sleep; for

example, it promotes absorption of zinc, stimulates the thyroid, and as

tests show, protects against brain damage from mercury poisoning reducing

potential for Alzheimer’s (without it glutathione was reduced 30%, and other

damage occurred). It is a powerful antioxidant, able to enter every cell of

the body. Dr. Reiter found melatonin to be 5.9 times more effective than

glutathione and 11.3 times more effective than mannitol in fighting

dangerous, hydroxyl radicals.

A 24-hour exposure to 50 µg/L mercury induced significant cell cytotoxicity

in neuroblastoma cells. Treatment of cells with melatonin before

administration of mercury greatly reduced the mercury-induced cytotoxicity.

Mercury treatment of cells produced another as yet undocumented phenomenon,

that of inducing oxidative stress, as measured by the loss of reduced

glutathione (GSH) from cells. This was a rapid process, requiring only 30

minutes of exposure to mercury. Similarly, pretreating the cells with

melatonin...before administration protected cells from the mercury-induced

oxidative stress. Melatonin’s mechanism of action is at present unclear;

however, melatonin is known to bind heavy metals (Limson et al., 1998REF15)

and to increase intracellular GSH levels through an up-regulation of

GSH-synthesizing enzymes (Todoroki et al., 1998REF3). It is thus possible to

speculate on two mechanisms for melatonin’s antioxidant action, namely, (a)

melatonin as a chelating agent binding mercury, thus eliminating its

cytotoxic properties, or ( melatonin causing production of increased

levels of intracellular antioxidants such as (Todoroki et al., 1998REF30).

It is further not excluded that both these mechanisms could be operating

simultaneously.

The release of both Aß 1-40 and Aß 1-42 into the culture medium was

increased by exposure of SHSY5Y cells to mercury. Melatonin preincubation

resulted in a significant decrease in Aß release....Mercury has previously

been shown to be a potent inhibitor of enzymes, especially those containing

sulfhydryl groups (Edstrom and Mattsson, 1976REF9). Protein kinase C

activity in vitro and in brain tissue is markedly reduced in a

concentration-dependent manner by mercury (Rajanna et al.,

1995REF21).....Mercury induces both Aß production and oxidative stress;

thus, the chelation of mercury by melatonin could shift the APP metabolism

back toward the secretase pathway, reducing Aß production and the

concomitant oxidative stress-inducing effects of mercury and Aß.

Aß-Fibrillogenesis is also inhibited by melatonin, thereby potentially

reducing the toxic buildup of Aß 1-40 and Aß 1-42 fibrils (Pappolla et al.,

1998REF20). Furthermore, melatonin has been shown to reduce the release of

soluble APP from cells in culture and to reduce the levels of APP mRNA and

other housekeeping protein mRNAs (Song and Lahiri, 1997REF24). These data

suggest that melatonin may be involved in metabolic mechanisms regulating

APP and other essential cellular protein production, over and above its

antioxidant capacity.

Another abstract with no title credits says in part: Recent data indicate

that melatonin inhibits brain glutamate receptors and nitric oxide

production thus suggesting that it may exert a neuroprotective and

antiexcitotoxic effect. Melatonin has been seen to prevent seizures in

several animal models, and to decrease epileptic manifestations in

humans....The results suggest that melatonin may have a useful role in

mechanisms of neuroprotection, and they also indicate its use in other cases

of untreatable epilepsy. Another study is of interest: Children’s Memorial

Hospital, Chicago, in a report published by Lancet, found that, though their

sleep problem was benefited, children with severe nervous–system damage,

using a dosage of five mg, experienced an increased incidence of seizures

that returned to previous levels on discontinuance.

One can increase acetylcholine production and enhance muscle

tone by supplementing one or more of these: Bethanecol, melatonin,

N-acetylcarnitine, SAMe, DMAE, TMG, manganese, Coenzyme A, lecithin granules

(choline), phosphatidylcholine. >>

[Guest guest]

Maybe your son would tolerate a lower dose? My daughter takes only 1/2 mg

and sleeps fine.

Re: [ ] Re: Melatonin - Help!

DJ (11 years old, 90 pounds, autistic) has always slept pretty well, before

chelation and melatonin about 8-9 hours. Every now and then, he would get

up

around 2 or 3am and stay up but it would catch up with him in the afternoon

and he would have to take a nap. We started melatonin (1 mg) a month before

chelation. He started getting up at 2 or 3 am more often. I told the

doctor

and he told me to increase it to 3mg. Same problem.

At our appointment last week, he asked me to give him 100mg glutathione with

the melatonin. DJ was sleeping only about 4-5 hours and then be up for the

day without any sign of fatigue. He would not nap during the day either.

Per doctor, we discontinued and DJ has been sleeping about 9-10 hours since

we stopped 6 days ago.

Does anyone think that perhaps children that do not have a sleep problem

would not benefit from melatonin and glutathoine? But it concerns me that

the melatonin helps protect the brain from mercury. This is all so

confusing.

In a message dated 11/29/00 3:09:26 PM, Mycoltjoe@... writes:

<< Here are some good things about Melatonin from Comprehensive guide to

managing autism by Willis Langford:

Many find solution to sleep problem with a supplement of melatonin (1/2 to 3

mg, 20 minutes before bedtime). There are, potentially, several benefits to

taking supplemental doses of melatonin other than improved sleep; for

example, it promotes absorption of zinc, stimulates the thyroid, and as

tests show, protects against brain damage from mercury poisoning reducing

potential for Alzheimer’s (without it glutathione was reduced 30%, and other

damage occurred). It is a powerful antioxidant, able to enter every cell of

the body. Dr. Reiter found melatonin to be 5.9 times more effective than

glutathione and 11.3 times more effective than mannitol in fighting

dangerous, hydroxyl radicals.

A 24-hour exposure to 50 µg/L mercury induced significant cell cytotoxicity

in neuroblastoma cells. Treatment of cells with melatonin before

administration of mercury greatly reduced the mercury-induced cytotoxicity.

Mercury treatment of cells produced another as yet undocumented phenomenon,

that of inducing oxidative stress, as measured by the loss of reduced

glutathione (GSH) from cells. This was a rapid process, requiring only 30

minutes of exposure to mercury. Similarly, pretreating the cells with

melatonin...before administration protected cells from the mercury-induced

oxidative stress. Melatonin’s mechanism of action is at present unclear;

however, melatonin is known to bind heavy metals (Limson et al., 1998REF15)

and to increase intracellular GSH levels through an up-regulation of

GSH-synthesizing enzymes (Todoroki et al., 1998REF3). It is thus possible to

speculate on two mechanisms for melatonin’s antioxidant action, namely, (a)

melatonin as a chelating agent binding mercury, thus eliminating its

cytotoxic properties, or ( melatonin causing production of increased

levels of intracellular antioxidants such as (Todoroki et al., 1998REF30).

It is further not excluded that both these mechanisms could be operating

simultaneously.

The release of both Aß 1-40 and Aß 1-42 into the culture medium was

increased by exposure of SHSY5Y cells to mercury. Melatonin preincubation

resulted in a significant decrease in Aß release....Mercury has previously

been shown to be a potent inhibitor of enzymes, especially those containing

sulfhydryl groups (Edstrom and Mattsson, 1976REF9). Protein kinase C

activity in vitro and in brain tissue is markedly reduced in a

concentration-dependent manner by mercury (Rajanna et al.,

1995REF21).....Mercury induces both Aß production and oxidative stress;

thus, the chelation of mercury by melatonin could shift the APP metabolism

back toward the secretase pathway, reducing Aß production and the

concomitant oxidative stress-inducing effects of mercury and Aß.

Aß-Fibrillogenesis is also inhibited by melatonin, thereby potentially

reducing the toxic buildup of Aß 1-40 and Aß 1-42 fibrils (Pappolla et al.,

1998REF20). Furthermore, melatonin has been shown to reduce the release of

soluble APP from cells in culture and to reduce the levels of APP mRNA and

other housekeeping protein mRNAs (Song and Lahiri, 1997REF24). These data

suggest that melatonin may be involved in metabolic mechanisms regulating

APP and other essential cellular protein production, over and above its

antioxidant capacity.

Another abstract with no title credits says in part: Recent data indicate

that melatonin inhibits brain glutamate receptors and nitric oxide

production thus suggesting that it may exert a neuroprotective and

antiexcitotoxic effect. Melatonin has been seen to prevent seizures in

several animal models, and to decrease epileptic manifestations in

humans....The results suggest that melatonin may have a useful role in

mechanisms of neuroprotection, and they also indicate its use in other cases

of untreatable epilepsy. Another study is of interest: Children’s Memorial

Hospital, Chicago, in a report published by Lancet, found that, though their

sleep problem was benefited, children with severe nervous–system damage,

using a dosage of five mg, experienced an increased incidence of seizures

that returned to previous levels on discontinuance.

One can increase acetylcholine production and enhance muscle

tone by supplementing one or more of these: Bethanecol, melatonin,

N-acetylcarnitine, SAMe, DMAE, TMG, manganese, Coenzyme A, lecithin granules

(choline), phosphatidylcholine. >>

[Guest guest]

I was just given a prescription for DMSA 200mg w/alpha lipoic acid

compounded together. This is for my 63 lb son. I've been instructed

to give it every 8 hours for 3 days and off for 4 days. I will not start this

until after I have all the metal taken out of his mouth, which will be on

Dec. 12th. I personally am feeling like this is very high to start off with

but according to the paper I was given this is the new dosage per AH.

I am just very eager to get this going my son's mercury level is 12, normal

being 0-3. Please respond if you are using DMSA and what dose is work=

ing for you. Thanks and God Bless You All in the Autism World!

Also, has anyone used MSM with there child?

[Guest guest]

<I am hoping that is the case with Dr. Amy's son Mike - with mercury

out of the way, wheat may actually be nutritional to him!!!! HArd

to believe but, if the mercury and other toxins used to inhibit his

gut and gluten processing ability are now gone, it makes sense that

gluten containing products could now be nutritious for him.>

Was it just the mercury, or did her son also then require clearing of

candida before he could tolerate wheat? I understood that the leaky gut

often is because of candida in the hyphae stage eating holes in the gut, and

the partially-digested wheat (gliadorphins) and milk (casomorphins) then

leaked through these holes. I'd sure like to know, because I would LOVE to

be free of this gfcf diet. I have enough M.D./Ph.D.'s from the Med School

of Hard Knocks already, and would love to be able to forget all about gluten

and all it's hiding places in our food supply!!

G

[Guest guest]

Hi ,

Yes, We tried MSM on our son, but he became all irritable when he was on it.

So now, when starting on DMSA the doctor started him on a VERY low dosage -

like half mg/pound three times a day three days on and four days off. He is

planning to ramp up the dose as we go... He DOES NOT have any metal in his

mouth.

Good Luck.

Love and Prayers,

Sheela.

In a message dated 11/29/00 10:21:25 PM Central Standard Time,

jcanna1111@... writes:

> I was just given a prescription for DMSA 200mg w/alpha lipoic acid

> compounded together. This is for my 63 lb son. I've been instructed

> to give it every 8 hours for 3 days and off for 4 days. I will not start

> this

> until after I have all the metal taken out of his mouth, which will be on

> Dec. 12th. I personally am feeling like this is very high to start off

with

> but according to the paper I was given this is the new dosage per AH.

> I am just very eager to get this going my son's mercury level is 12, normal

> being 0-3. Please respond if you are using DMSA and what dose is work=

> ing for you. Thanks and God Bless You All in the Autism World!

> Also, has anyone used MSM with there child?

[Guest guest]

What kind of metal does your son have in his mouth?

Thanks.

Cheryl

In a message dated 11/29/00 11:21:47 PM Eastern Standard Time,

jcanna1111@... writes:

<< was just given a prescription for DMSA 200mg w/alpha lipoic acid

compounded together. This is for my 63 lb son. I've been instructed

to give it every 8 hours for 3 days and off for 4 days. I will not start

this

until after I have all the metal taken out of his mouth, which will be on

Dec. 12th. I personally am feeling like this is very high to start off with

but according to the paper I was given this is the new dosage per AH.

I am just very eager to get this going my son's mercury level is 12, normal

being 0-3. Please respond if you are using DMSA and what dose is work=

ing for you. Thanks and God Bless You All in the Autism World!

Also, has anyone used MSM with there child?

>>

[Guest guest]

My children do not have sleep problems and we started

giving both of them 1 mg melatonin nightly about a

week ago. (7 1/2 year old daughter with autism and 6

year old son (not NT, but not classically autistic,

possibly Asperger's, possibly hyperlexia, possibly

ADHD, definately mild sensory dysfunction and some

language processing problems)

We've had no sleep disturbance with it and are

continuing use at that dosage. Both kids have been in

great moods (per teachers) for past couple weeks

(started chelation with 50 mg DMSA every eight hours

three days on, four days off starting 11/17/00 and

started use of melatonin around the same time).

Tali

--- DenNeg01@... wrote:

> DJ (11 years old, 90 pounds, autistic) has always

> slept pretty well, before

> chelation and melatonin about 8-9 hours. Every now

> and then, he would get up

> around 2 or 3am and stay up but it would catch up

> with him in the afternoon

> and he would have to take a nap. We started

> melatonin (1 mg) a month before

> chelation. He started getting up at 2 or 3 am more

> often. I told the doctor

> and he told me to increase it to 3mg. Same problem.

>

>

> At our appointment last week, he asked me to give

> him 100mg glutathione with

> the melatonin. DJ was sleeping only about 4-5 hours

> and then be up for the

> day without any sign of fatigue. He would not nap

> during the day either.

> Per doctor, we discontinued and DJ has been sleeping

> about 9-10 hours since

> we stopped 6 days ago.

>

> Does anyone think that perhaps children that do not

> have a sleep problem

> would not benefit from melatonin and glutathoine?

> But it concerns me that

> the melatonin helps protect the brain from mercury.

> This is all so confusing.

>

> In a message dated 11/29/00 3:09:26 PM,

> Mycoltjoe@... writes:

>

> << Here are some good things about Melatonin from

> Comprehensive guide to

>

> managing autism by Willis Langford:

>

>

> Many find solution to sleep problem with a

> supplement of melatonin (1/2 to 3

>

> mg, 20 minutes before bedtime). There are,

> potentially, several benefits to

>

> taking supplemental doses of melatonin other than

> improved sleep; for

>

> example, it promotes absorption of zinc, stimulates

> the thyroid, and as

>

> tests show, protects against brain damage from

> mercury poisoning reducing

>

> potential for Alzheimer’s (without it glutathione

> was reduced 30%, and other

>

> damage occurred). It is a powerful antioxidant, able

> to enter every cell of

>

> the body. Dr. Reiter found melatonin to be 5.9 times

> more effective than

>

> glutathione and 11.3 times more effective than

> mannitol in fighting

>

> dangerous, hydroxyl radicals.

>

>

>

> A 24-hour exposure to 50 µg/L mercury induced

> significant cell cytotoxicity

>

> in neuroblastoma cells. Treatment of cells with

> melatonin before

>

> administration of mercury greatly reduced the

> mercury-induced cytotoxicity.

>

> Mercury treatment of cells produced another as yet

> undocumented phenomenon,

>

> that of inducing oxidative stress, as measured by

> the loss of reduced

>

> glutathione (GSH) from cells. This was a rapid

> process, requiring only 30

>

> minutes of exposure to mercury. Similarly,

> pretreating the cells with

>

> melatonin...before administration protected cells

> from the mercury-induced

>

> oxidative stress. Melatonin’s mechanism of action

> is at present unclear;

>

> however, melatonin is known to bind heavy metals

> (Limson et al., 1998REF15)

>

> and to increase intracellular GSH levels through an

> up-regulation of

>

> GSH-synthesizing enzymes (Todoroki et al.,

> 1998REF3). It is thus possible to

>

> speculate on two mechanisms for melatonin’s

> antioxidant action, namely, (a)

>

> melatonin as a chelating agent binding mercury, thus

> eliminating its

>

> cytotoxic properties, or ( melatonin causing

> production of increased

>

> levels of intracellular antioxidants such as

> (Todoroki et al., 1998REF30).

>

> It is further not excluded that both these

> mechanisms could be operating

>

> simultaneously.

>

> The release of both Aß 1-40 and Aß 1-42 into the

> culture medium was

>

> increased by exposure of SHSY5Y cells to mercury.

> Melatonin preincubation

>

> resulted in a significant decrease in Aß

> release....Mercury has previously

>

> been shown to be a potent inhibitor of enzymes,

> especially those containing

>

> sulfhydryl groups (Edstrom and Mattsson, 1976REF9).

> Protein kinase C

>

> activity in vitro and in brain tissue is markedly

> reduced in a

>

> concentration-dependent manner by mercury (Rajanna

> et al.,

>

> 1995REF21).....Mercury induces both Aß production

> and oxidative stress;

>

> thus, the chelation of mercury by melatonin could

> shift the APP metabolism

>

> back toward the secretase pathway, reducing Aß

> production and the

>

> concomitant oxidative stress-inducing effects of

> mercury and Aß.

>

> Aß-Fibrillogenesis is also inhibited by melatonin,

> thereby potentially

>

> reducing the toxic buildup of Aß 1-40 and Aß 1-42

> fibrils (Pappolla et al.,

>

> 1998REF20). Furthermore, melatonin has been shown to

> reduce the release of

>

> soluble APP from cells in culture and to reduce the

> levels of APP mRNA and

>

> other housekeeping protein mRNAs (Song and Lahiri,

> 1997REF24). These data

>

> suggest that melatonin may be involved in metabolic

> mechanisms regulating

>

> APP and other essential cellular protein production,

> over and above its

>

> antioxidant capacity.

>

>

> Another abstract with no title credits says in part:

> Recent data indicate

>

> that melatonin inhibits brain glutamate receptors

> and nitric oxide

>

> production thus suggesting that it may exert a

> neuroprotective and

>

> antiexcitotoxic effect. Melatonin has been seen to

> prevent seizures in

>

> several animal models, and to decrease epileptic

> manifestations in

>

> humans....The results suggest that melatonin may

> have a useful role in

>

> mechanisms of neuroprotection, and they also

> indicate its use in other cases

>

>

=== message truncated ===

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