[Fwd: [abmd] Fish oil-fed mice have impaired resistance to influenza infection]

[Guest guest]

Maybe this is the right time to run out of CLO -- see attached

Sally

Fish oil-fed mice have impaired resistance to influenza infection.

Schwerbrock NM, Karlsson EA, Shi Q, Sheridan PA, Beck MA.

J Nutr. 2009 Aug;139(8):1588-94. Epub 2009 Jun 23.

http://jn.nutrition.org/cgi/content/full/139/8/1588

Dietary

fish oils, rich in (n-3) PUFA, including eicosapentaenoic acid and

docosahexaenoic acid, have been shown to have antiinflammatory

properties. Although the antiinflammatory properties of fish oil may be

beneficial during a chronic inflammatory illness, the same

antiinflammatory properties can suppress the inflammatory responses

necessary to combat acute viral infection. Given that (n-3) fatty

acid-rich fish oil supplementation is on the rise and with the

increasing threat of an influenza pandemic, we tested the effect of

fish oil feeding for 2 wk on the immune response to influenza virus

infection. Male C57BL/6 mice fed either a menhaden fish oil/corn oil

diet (4 g fish oil:1 g corn oil, wt:wt at 5 g/100 g diet) or a control

corn oil diet were infected with influenza A/PuertoRico/8/34 and

analyzed for lung pathology and immune function. Although fish oil-fed

mice had lower lung inflammation compared with controls, fish oil

feeding also resulted in a 40% higher mortality rate, a 70% higher lung

viral load at d 7 post infection, and a prolonged recovery period

following infection. Although splenic natural killer (NK) cell activity

was suppressed in fish oil-fed mice, lung NK activity was not affected.

Additionally, lungs of infected fish oil-fed mice had significantly

fewer CD8+ T cells and decreased mRNA expression of macrophage

inflammatory protein-1-alpha, tumor necrosis factor-alpha, and

interleukin-6. These results suggest that the antiinflammatory

properties of fish oil feeding can alter the immune response to

influenza infection, resulting in increased morbidity and mortality.

PMID: 19549756

No virus found in this incoming message.

Checked by AVG - www.avg.com

Version: 8.5.423 / Virus Database: 270.14.39/2468 - Release Date: 10/29/09

19:49:00

[Guest guest]

Sally, Maybe not, though.

In the 1919 epidemic the young died: it is thought that perhaps the strength of

their own immune response overwhelmed them. Those who mounted a weaker

infammatory response mayy have been more likely to survive.

CLO - if you buy a good one - will have the high levels of natural vitamins A

and D which should help resistance to infectious agents.

Margaret

>

> Maybe this is the right time to run out of CLO -- see attached

> Sally

>

>

> Fish oil-fed mice have impaired resistance to influenza infection.

>

>

> Schwerbrock NM, Karlsson EA, Shi Q, Sheridan PA, Beck MA.

> J Nutr. 2009 Aug;139(8):1588-94. Epub 2009 Jun 23.

> http://jn.nutrition.org/cgi/content/full/139/8/1588

>

<http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051 & itool=Abstract-def\

& uid=19549756 & nlmid=0404243 & db=pubmed & url=http://jn.nutrition.org/cgi/pmidlookup\

?view=long & pmid=19549756>

>

>

> Dietary fish oils, rich in (n-3) PUFA, including eicosapentaenoic acid

> and docosahexaenoic acid, have been shown to have antiinflammatory

> properties. Although the antiinflammatory properties of fish oil may be

> beneficial during a chronic inflammatory illness, the same

> antiinflammatory properties can suppress the inflammatory responses

> necessary to combat acute viral infection. Given that (n-3) fatty

> acid-rich fish oil supplementation is on the rise and with the

> increasing threat of an influenza pandemic, we tested the effect of fish

> oil feeding for 2 wk on the immune response to influenza virus

> infection. Male C57BL/6 mice fed either a menhaden fish oil/corn oil

> diet (4 g fish oil:1 g corn oil, wt:wt at 5 g/100 g diet) or a control

> corn oil diet were infected with influenza A/PuertoRico/8/34 and

> analyzed for lung pathology and immune function. Although fish oil-fed

> mice had lower lung inflammation compared with controls, fish oil

> feeding also resulted in a 40% higher mortality rate, a 70% higher lung

> viral load at d 7 post infection, and a prolonged recovery period

> following infection. Although splenic natural killer (NK) cell activity

> was suppressed in fish oil-fed mice, lung NK activity was not affected.

> Additionally, lungs of infected fish oil-fed mice had significantly

> fewer CD8+ T cells and decreased mRNA expression of macrophage

> inflammatory protein-1-alpha, tumor necrosis factor-alpha, and

> interleukin-6. These results suggest that the antiinflammatory

> properties of fish oil feeding can alter the immune response to

> influenza infection, resulting in increased morbidity and mortality.

>

> PMID: 19549756

>

>

>

>

>

> No virus found in this incoming message.

> Checked by AVG - www.avg.com

> Version: 8.5.423 / Virus Database: 270.14.39/2468 - Release Date: 10/29/09

19:49:00

>