Re: Escape hatch for the tyranny of norvir?

[Guest guest]

Not sure if there is actual proof rescriptor boosts lexiva. Didnt

see any studies in pubmed. Rescriptor package insert shows it boosts

area under curve, maximum and minimum concentrations substantially

for saquinavir, crixivan and nelfinavir. Rescriptor is an inhibitor

of CYP3A isoform like norvir so it is a good assumption that it also

boosts lexiva. It boosts a whole bunch of other drugs too, most

likely due to this and other isoform inhibitions.

The adverse reactions sound awful. Viramune has also similar

adverse effects in a small number of people, which can be life

threatening. If interrupted, it needs to be restarted at a lower

dose each time. Taking two drugs with similar, albeit rare side

effects, may very well increase the likelihood of these side

effects. Just like it might increase the liver side effects. I

guess giving up viramune's hdl raising benefit would be the wise

thing to do. But then it is easier to let go since norvir's

deleterious lipid effects will also be gone.

Thanks for walking through with this guys...:-)

> Does your doctor have evidence that rescriptor actually boosts

> lexivia? I'm not aware of it, and lexivia has typically been

> boosted with Norvir.

>

> When I took Rescriptor, it was in phase II testing. About 15

> minutes post dose, under observation, I would get a rash,

hoarseness,

> and mucosal ulcerations, and I would spike a fever. It was

repeated

> several times.

>

> My reaction was pretty bad, and I'm sure that in most this

doesn't

> happen, as the drug got approved.

>

> Because of this experience, and th suspicion it could have

produced

> resistance, I'm very leery of the whole drug class, in my

individual

> case.

>

> I would not re try it, outside of a hospital room with direct

> observation

>

> JB

>