Guest guest Posted April 4, 2007 Report Share Posted April 4, 2007 Anal warts are caused by different strains of HPV than the strains that causes dysplasia and cancer. However, anyone with anal warts should still get checked for dysplasia, because it is likely that they are also infected with the strains that cause dysplasia and cancer. Where there is smoke, there is probably fire. Bill Gaul <wgaul1@...> wrote: Anal warts are NOT associated with the HPV that causes cancer? Where did Imiss this before?Reading the link below, I get conflicting recommendations. Maybe this quote sums it up?"It is common, especially in people who are immune-compromised, to have ongoing HPV and to develop HSIL within a few years of developing LSIL or warts."This is really news to me!BG Re: Get your butt checked> >> >> > For those close to Indianapolis, Dr. R Barry Melbert, M.D. Phone:> > (317) 889-7906 has the proper equipment and training to do High> > Resolution Anoscopy and the appropriate treatment for abnormal> findings> > due to HPV.> >> > He is very knowledgable about the disease from HPV and gay friendly. I> > highly recommend him.> >> > J Sherlock, M.D.> >> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 4, 2007 Report Share Posted April 4, 2007 You're correct, this statement is not true. "Anal warts are NOT associated with the HPV that causes cancer?" NO, this is not correct. The HPV strains which cause cancer also cause genital warts. There are more than 60 different strains of HPV virus. The Gardasil vaccine protects against 4 strains of HPV (types 6, 11, 16 and 18) which are believed to be responsible for most HPV related cancers and most genital warts. This article may provide additional clarification. http://www.medicalnewstoday.com/medicalnews.php?newsid=22620 Merck HPV Vaccine Effective in Preventing Infection With Four Strains Linked to Genital Warts, Cervical Cancer, Study Says Article Date: 11 Apr 2005 - 0:00 PDTMerck's experimental vaccine targeting the four strains of the sexually transmitted disease human papillomavirus that are most likely to cause cervical cancer or genital warts was 89% effective in preventing infection with the viral strains and 100% effective in preventing cervical cancer, precancerous lesions or genital warts, according to a study published in the April issue of the journal Lancet Oncology, Reuters Health reports. a Villa, a biologist at the Ludwig Institute for Cancer Research in Sao o, Brazil, and colleagues conducted the Phase II trial of the vaccine among 552 women ages 16 to 23 in the United States, Europe and Brazil. None of the participants were pregnant, had a history of abnormal Pap tests or had more than four sexual partners (Reuters Health, 4/7). Participants who had tested positive for HPV antibodies in the past were not excluded from the study. Of the 552 study participants, 277 received three shots of the vaccine -- known as Gardasil -- and 275 women received placebo injections over a six-month period (Rubin, USA Today, 4/6). Over three years, study participants underwent routine pelvic exams, Pap testing, serum testing for HPV antibodies and cervicovaginal sampling for HPV DNA (Villa et al., Lancet Oncology, 4/1). > > >> > > Is there treatment for abnormal findings (dysplasia)? I was told that> > > there's not much to be done in the rectum until there's an actual> > growth to> > > deal with, as compared to the cervix, where a layer of cells can be> > scraped.> > > So we continue to monitor it. (I don't show low grade dysplasia> > anymore> > > after an initial positive pap smear a few years back)> > >> > > BG> > >> > >> > > Re: Get your butt checked> > >> > >> > > For those close to Indianapolis, Dr. R Barry Melbert, M.D. Phone:> > > (317) 889-7906 has the proper equipment and training to do High> > > Resolution Anoscopy and the appropriate treatment for abnormal> > findings> > > due to HPV.> > >> > > He is very knowledgable about the disease from HPV and gay friendly. I> > > highly recommend him.> > >> > > J Sherlock, M.D.> > >> >> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 4, 2007 Report Share Posted April 4, 2007 You're correct, this statement is not true. "Anal warts are NOT associated with the HPV that causes cancer?" NO, this is not correct. The HPV strains which cause cancer also cause genital warts. There are more than 60 different strains of HPV virus. The Gardasil vaccine protects against 4 strains of HPV (types 6, 11, 16 and 18) which are believed to be responsible for most HPV related cancers and most genital warts. This article may provide additional clarification. http://www.medicalnewstoday.com/medicalnews.php?newsid=22620 Merck HPV Vaccine Effective in Preventing Infection With Four Strains Linked to Genital Warts, Cervical Cancer, Study Says Article Date: 11 Apr 2005 - 0:00 PDTMerck's experimental vaccine targeting the four strains of the sexually transmitted disease human papillomavirus that are most likely to cause cervical cancer or genital warts was 89% effective in preventing infection with the viral strains and 100% effective in preventing cervical cancer, precancerous lesions or genital warts, according to a study published in the April issue of the journal Lancet Oncology, Reuters Health reports. a Villa, a biologist at the Ludwig Institute for Cancer Research in Sao o, Brazil, and colleagues conducted the Phase II trial of the vaccine among 552 women ages 16 to 23 in the United States, Europe and Brazil. None of the participants were pregnant, had a history of abnormal Pap tests or had more than four sexual partners (Reuters Health, 4/7). Participants who had tested positive for HPV antibodies in the past were not excluded from the study. Of the 552 study participants, 277 received three shots of the vaccine -- known as Gardasil -- and 275 women received placebo injections over a six-month period (Rubin, USA Today, 4/6). Over three years, study participants underwent routine pelvic exams, Pap testing, serum testing for HPV antibodies and cervicovaginal sampling for HPV DNA (Villa et al., Lancet Oncology, 4/1). > > >> > > Is there treatment for abnormal findings (dysplasia)? I was told that> > > there's not much to be done in the rectum until there's an actual> > growth to> > > deal with, as compared to the cervix, where a layer of cells can be> > scraped.> > > So we continue to monitor it. (I don't show low grade dysplasia> > anymore> > > after an initial positive pap smear a few years back)> > >> > > BG> > >> > >> > > Re: Get your butt checked> > >> > >> > > For those close to Indianapolis, Dr. R Barry Melbert, M.D. Phone:> > > (317) 889-7906 has the proper equipment and training to do High> > > Resolution Anoscopy and the appropriate treatment for abnormal> > findings> > > due to HPV.> > >> > > He is very knowledgable about the disease from HPV and gay friendly. I> > > highly recommend him.> > >> > > J Sherlock, M.D.> > >> >> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 4, 2007 Report Share Posted April 4, 2007 In any event, I still know better than to end my vigilance. Still getting checked regularly for any abnormalities. They also think that as many as 100% of people who have had anal receptive sex are infected. That's an epidemic waiting to happen. BG Re: Re: Get your butt checked Anal warts are caused by different strains of HPV than the strains that causes dysplasia and cancer. However, anyone with anal warts should still get checked for dysplasia, because it is likely that they are also infected with the strains that cause dysplasia and cancer. Where there is smoke, there is probably fire. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 4, 2007 Report Share Posted April 4, 2007 In any event, I still know better than to end my vigilance. Still getting checked regularly for any abnormalities. They also think that as many as 100% of people who have had anal receptive sex are infected. That's an epidemic waiting to happen. BG Re: Re: Get your butt checked Anal warts are caused by different strains of HPV than the strains that causes dysplasia and cancer. However, anyone with anal warts should still get checked for dysplasia, because it is likely that they are also infected with the strains that cause dysplasia and cancer. Where there is smoke, there is probably fire. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 4, 2007 Report Share Posted April 4, 2007 I just learned something new. This June 2005 vaccine review may clarify this issue regarding HPV and the Gardasil vaccine (and the soon to be approved Cervarix vaccine, which is of less interest). It appears that the strains (6 and 11) which cause most genital warts may not cause cancer, but I wouldn't count on that. Worse still, the strains which cause cancer (16 and 18) may not cause warts or any noticeable symptom prior to causing the dysplasia and cancer. Molecular tests have revealed that all these cancers are due to persistent infection with the carcinogenic strains of HPV. Over 90% of persons clear HPV within 6 to 24 months, and any existing lesions or warts disappear. Persistent infection with the cancer-causing strains can lead to serious trouble in a small proportion of cases. Men and women infected anally run the risk of anal cancer as much as women with cervical infections risk cervical cancer. Glaxo's Cervarix includes only HPV strains 16 and 18, which are responsible for 70% of cervical malignancies. It plans to market the vaccine exclusively to women, as a cancer prevention agent. The company claims it would not be cost-effective to also vaccinate men and has conducted no studies with males or on anal cancer. Merck's version, Gardasil, includes HPV 6 and 11 in addition to 16 and 18. HPV strains 6 and 11 are implicated in 90% of genital warts. http://www.champnetwork.org/media/JuneHHSWatch.doc Which explains the results . . . Merck's Gardasil vaccine targeting the four strains of the sexually transmitted disease human papillomavirus that are most likely to cause cervical cancer or genital warts. Gardasil was 89% effective in preventing infection with the viral strains Gardasil was 100% effective in preventing cervical cancer, precancerous lesions or genital warts http://www.medicalnewstoday.com/medicalnews.php?newsid=22620 > > >> > > Is there treatment for abnormal findings (dysplasia)? I was told that> > > there's not much to be done in the rectum until there's an actual> > growth to> > > deal with, as compared to the cervix, where a layer of cells can be> > scraped.> > > So we continue to monitor it. (I don't show low grade dysplasia> > anymore> > > after an initial positive pap smear a few years back)> > >> > > BG> > >> > >> > > Re: Get your butt checked> > >> > >> > > For those close to Indianapolis, Dr. R Barry Melbert, M.D. Phone:> > > (317) 889-7906 has the proper equipment and training to do High> > > Resolution Anoscopy and the appropriate treatment for abnormal> > findings> > > due to HPV.> > >> > > He is very knowledgable about the disease from HPV and gay friendly. I> > > highly recommend him.> > >> > > J Sherlock, M.D.> > >> >> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 4, 2007 Report Share Posted April 4, 2007 I just learned something new. This June 2005 vaccine review may clarify this issue regarding HPV and the Gardasil vaccine (and the soon to be approved Cervarix vaccine, which is of less interest). It appears that the strains (6 and 11) which cause most genital warts may not cause cancer, but I wouldn't count on that. Worse still, the strains which cause cancer (16 and 18) may not cause warts or any noticeable symptom prior to causing the dysplasia and cancer. Molecular tests have revealed that all these cancers are due to persistent infection with the carcinogenic strains of HPV. Over 90% of persons clear HPV within 6 to 24 months, and any existing lesions or warts disappear. Persistent infection with the cancer-causing strains can lead to serious trouble in a small proportion of cases. Men and women infected anally run the risk of anal cancer as much as women with cervical infections risk cervical cancer. Glaxo's Cervarix includes only HPV strains 16 and 18, which are responsible for 70% of cervical malignancies. It plans to market the vaccine exclusively to women, as a cancer prevention agent. The company claims it would not be cost-effective to also vaccinate men and has conducted no studies with males or on anal cancer. Merck's version, Gardasil, includes HPV 6 and 11 in addition to 16 and 18. HPV strains 6 and 11 are implicated in 90% of genital warts. http://www.champnetwork.org/media/JuneHHSWatch.doc Which explains the results . . . Merck's Gardasil vaccine targeting the four strains of the sexually transmitted disease human papillomavirus that are most likely to cause cervical cancer or genital warts. Gardasil was 89% effective in preventing infection with the viral strains Gardasil was 100% effective in preventing cervical cancer, precancerous lesions or genital warts http://www.medicalnewstoday.com/medicalnews.php?newsid=22620 > > >> > > Is there treatment for abnormal findings (dysplasia)? I was told that> > > there's not much to be done in the rectum until there's an actual> > growth to> > > deal with, as compared to the cervix, where a layer of cells can be> > scraped.> > > So we continue to monitor it. (I don't show low grade dysplasia> > anymore> > > after an initial positive pap smear a few years back)> > >> > > BG> > >> > >> > > Re: Get your butt checked> > >> > >> > > For those close to Indianapolis, Dr. R Barry Melbert, M.D. Phone:> > > (317) 889-7906 has the proper equipment and training to do High> > > Resolution Anoscopy and the appropriate treatment for abnormal> > findings> > > due to HPV.> > >> > > He is very knowledgable about the disease from HPV and gay friendly. I> > > highly recommend him.> > >> > > J Sherlock, M.D.> > >> >> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 5, 2007 Report Share Posted April 5, 2007 While all of the comments about different sub types, etc., are interesting, for practical purposes I think ALL HIV positive men should assume they are colonized by HPV. You may have several strains, as with that virus, infection with several strains, "superinfection" is not theory, but reality.If in one biopsy, a "bad" strain is found, who knows what's around, elsewhere.Also, "tops" are infected anally, too. The virus is shed from skin cells, which travel back to the crack via friction, and they love to settle in back there, even without penetration.Just assume this is a problem you need to follow with "routine maintenance." Barrowpozbod@... Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 5, 2007 Report Share Posted April 5, 2007 While all of the comments about different sub types, etc., are interesting, for practical purposes I think ALL HIV positive men should assume they are colonized by HPV. You may have several strains, as with that virus, infection with several strains, "superinfection" is not theory, but reality.If in one biopsy, a "bad" strain is found, who knows what's around, elsewhere.Also, "tops" are infected anally, too. The virus is shed from skin cells, which travel back to the crack via friction, and they love to settle in back there, even without penetration.Just assume this is a problem you need to follow with "routine maintenance." Barrowpozbod@... Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 5, 2007 Report Share Posted April 5, 2007 I don't know enough about the terminology to be sure, but I'm getting the impression that warts are actually a form of dysplasia (low or medium grade). That's why you don't see "wart" or "condyloma" that often in the literature. Is this accurate? I have tested positive for low grade dysplasia after warts years before that, and that's why I've been on top of it for about 10 years looking for the less obvious signs. With what I'm learning now, I'd be checked for dysplasia regularly even with no sign at all of HPV. I think it's the "herpes" of the decade - but much more dangerous. BG Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 5, 2007 Report Share Posted April 5, 2007 I don't know enough about the terminology to be sure, but I'm getting the impression that warts are actually a form of dysplasia (low or medium grade). That's why you don't see "wart" or "condyloma" that often in the literature. Is this accurate? I have tested positive for low grade dysplasia after warts years before that, and that's why I've been on top of it for about 10 years looking for the less obvious signs. With what I'm learning now, I'd be checked for dysplasia regularly even with no sign at all of HPV. I think it's the "herpes" of the decade - but much more dangerous. BG Quote Link to comment Share on other sites More sharing options...
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