Medications Effect

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Hello Dr. Grim, Here is a more precise analysis of drug doses and resulting chemistry. · Yellow: medication has statistically significant effect on blood component at left column (p<0.05)· Green: medication has statistically sig favorable effect on blood component at left column (P<0.05)· Red: medication has statistically sig unfavorable effect on blood component at left column (P<0.05)· White: medication has no statistically sig effect on blood component at left column (P<0.05) Examples:· Yellow: fenofibrate has sig effect TRIG (p<0.05)· Green: Crestor has sig effect on CHOL (p<0.05)· Red: Metformin reduces HDL (p<0.05)· White: Crestor has no effect on TRIG (p<0.05), Fenofibrate has no sig effect on CHOL (p<0.05) Parameter EstimatesDependent VariableParameterBStd. ErrortSig.95% Confidence IntervalNoncent. ParameterObserved PoweraLower BoundUpper BoundCHOL: Cholesterol Total, mmol/LIntercept5.2575.12243.221.0005.0185.49743.2211.000rosuvastatin-.0159.004-4.231.000-.023-.0094.231.988fenofibrate-.0014.001-1.750.081-.003.0001.750.415spironolactone-.0061.001-10.744.000-.007-.00510.7441.000ramipril.0069.010.674.501-.013.027.674.103amlodipine-.0232.013-1.842.066-.048.0021.842.451indapamide.1160.0741.564.119-.030.2621.564.345metformin-.0004.000-5.304.000-.001.0005.3041.000cyanocobalamin-.0005.000-4.890.000-.001.0004.890.998domperidone-.0075.004-1.928.055-.015.0001.928.485HDL: Cholesterol HDL (12h fasting), mmol/LIntercept.9683.02342.686.000.9241.01342.6861.000rosuvastatin.0001.001.180.857-.001.002.180.054fenofibrate.0006.0003.987.000.000.0013.987.978spironolactone.0010.0008.994.000.001.0018.9941.000ramipril.0123.0026.463.000.009.0166.4631.000amlodipine.0175.0027.440.000.013.0227.4401.000indapamide.0077.014.559.577-.019.035.559.086metformin-.0003.000-16.970.000.000.00016.9701.000cyanocobalamin-.0001.000-5.075.000.000.0005.075.999domperidone-.0015.001-2.001.046-.003.0002.001.514LDL: Cholesterol LDL (12h fasting), mmol/LIntercept3.0879.11526.862.0002.8623.31426.8621.000rosuvastatin-.0152.004-4.262.000-.022-.0084.262.989fenofibrate-.0012.001-1.476.141-.003.0001.476.313spironolactone-.0066.001-12.261.000-.008-.00612.2611.000ramipril-.0023.010-.238.812-.021.017.238.056amlodipine-.0441.012-3.699.000-.068-.0213.699.958indapamide.2250.0703.210.001.087.3633.210.893metformin-.0002.000-2.921.004.000.0002.921.830cyanocobalamin-.0003.000-3.506.001-.001.0003.506.938domperidone-.0051.004-1.382.168-.012.0021.382.281TRIG: Cholesterol Triglycerides (12h fasting), mmol/LIntercept2.6515.05449.109.0002.5452.75849.1091.000rosuvastatin-.0020.002-1.203.230-.005.0011.203.224fenofibrate-.0020.000-5.487.000-.003-.0015.4871.000spironolactone-.0011.000-4.390.000-.002-.0014.390.992ramipril-.0077.005-1.694.091-.017.0011.694.393amlodipine.0065.0061.167.244-.004.0181.167.214indapamide-.2559.033-7.772.000-.321-.1917.7721.000metformin.0001.0003.214.001.000.0003.214.894cyanocobalamin-.0001.000-3.199.002.000.0003.199.891domperidone-.0022.002-1.261.208-.006.0011.261.242GLUCF: Plasma Glucose, fasting 8h, mmol/L (raw lab results)Intercept5.8997.20628.622.0005.4946.30528.6221.000rosuvastatin-.0039.006-.619.537-.017.009.619.095fenofibrate-.0009.001-.673.502-.004.002.673.103spironolactone-.0033.001-3.395.001-.005-.0013.395.923ramipril-.0086.017-.495.621-.043.025.495.078amlodipine.0628.0212.940.004.021.1052.940.834indapamide.3049.1262.425.016.058.5522.425.677metformin-.0005.000-3.631.000-.001.0003.631.952cyanocobalamin.0004.0002.250.025.000.0012.250.612domperidone.0146.0072.211.028.002.0282.211.597a. Computed using alpha = .05 Now applying these coefficients on doses of my medications I obtain my estimated resulting blood work test results.· Spiro=100 reduces my HDL by -0.7 (p<0.05)· Metformin=1000 reduces my GLUCF by -0.5 (p<0.5)…but increases my TRIG by +0.1 (p<0.05)· Ramipril=5 elevates my HDL by +.1 (p<0.05)· Fenofibrate=67 reduces my TRIG by -0.1 (p<0.05) Estimated TotalInterceptCrestorFenofibrateSpironolactoneRamiprilAmlodipineIndapamideMetforminB12Domperidonedose:20671005102.51000100010CHOL3.75.3-.3.0-.6.0-.2.0-.4-0.50.0HDL1.11.0.0.0.1.1.2.0-.3-0.10.0LDL1.53.1-.3.0-.7.0-.4.0-.2-0.30.0TRIG1.92.7.0-.1-.1.0.0-.6.1-0.10.0GLUCF6.55.9.0.0-.3.0.6.8-.50.40.1 I expect to have Estimated Total values but they differ slightly from Actual Lab values. Differences can be attributed to multitude of other factors like diet,…,exercise, …etc. Estimated TotalActual Lab ReportCHOL3.73.12HDL1.1.96LDL1.51.41TRIG1.91.64GLUCF6.57.1 Conclusion:Metformin is the worst enemy of my HDL L Max.62M HTN (since < c1995, dx 1999) L adenoma by NP59 scan. Aldos=1065…2056 [28-860] pmol/L, Renin=6 [<30] ng/L (dx 2009). med combo #79={Spiro=100, Amlo=2x5mg, Indap=2.5mg, Ramip=2x2.5mg,  Metf=2x500mg, Crestor=20mg, Feno=67mg, K.Cl=6x20mEq, Motilium=10mg, B12=1000µg/m}{K=4.5}{not DASHing but low-salt diet just slightly above salt craving while keeping K/Na ratio high, heat intolerance, insulin resistance, tingling right leg & hand reduced by B12, BMI=30, non-smoker, non-alcoholic, no history of MI}