Metabolic Syndrome and Testosterone

June 23, 2012

I was researching testosterone this morning as I continue to validate my

decision of surgery instead of meds. (With my co-morbid conditions I do have a

slightly elevated risk!) I came across this new study (March 2012) which sheds

light on the issue (MAYBE) and may even be relevant to the Gordon, Stowasser,

etal study I posted earlier.

I ask that you carefully read both with this question in mind: ¡°Is the

medicines being used to treat IHA altering the outcome of the study? And maybe

QOL?¡± In other words, I bet they are using Spironolactone and also hypothesize

the outcome would be different if they used Eplerenone and didn¡¯t antagonize

androgen! Dr. Grim, what do you think? Do you want to ¡°burst their bubble¡± or

should I? (Probably more effective coming from you!) Also, are you ready to join

me in recommending Eplerenone as the first (and only) choice and to hell with

cost!

Ladies: Please note this paragraph: TESTOSTERONE AND METABOLIC SYNDROME -

¡°There are a number of epidemiological studies linking T and MetS. Although

there are a number of publications showing the association of T and MetS in

females,[45¨C56] in this review we will restrict to the association in males.¡±

I did not try to analyze ¡°the fairer sex¡± but the titles look like you could

interpret and apply. (Momma told me a long time ago that I would never figure

out a woman!)

¡¡

¡°We found in our previous study higher occurrence of metabolic disturbances in

patients with idiopathic hyperaldosteronism (IHA) compared to subjects with

aldosterone-producing adenoma (APA).¡±

Testosterone and metabolic syndrome: The link ¡°Serum testosterone (T) has been

shown to be associated with MetS. Several studies have shown a higher prevalence

of MetS in subjects with low testosterone.¡±

Have you had your testosterone checked? I finally convinced my PCP to check

mine in March, 2012, as near as I can tell the first time in 65 years! It was

1.26, range 1.95 - 11.36. I had been off Spironolactone for 3 months but it

sure would be nice to know what it was before I started. Might be worth

checking a few that are on Spiro now and see if we can reduce MetS! Who does

all the surveys?

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