Re: Metabolic Syndrome and Testosterone

[Guest guest]

ne of the things constantly being overlooked, and not mentioned in the commercials on TV for "Low T" etc, is that people on, or who have a history of chronic opiate pain med use, from oxycontin, to hydrocodone, to methadone, often get overlooked as a cause of low T. Opiates drive down testosterone. Yet in our society the use of opiates, chronically and even illegal use, has jumped so much that hydrocodone is now the most prescribed med in the United States. The use of them is epidemice, and ironically so is low T now in men, but we do not always see that as a factor, nor are patients who have a low T willing to often to address their use of opiates.

Not wanting to start any debate, but it is my opinion again that the reason they are number one is that too many have found them as the treatment for their depression and anxiety, and pain is only the medium that got them there. Of course getting a patient to admit to that is impossible because they will even feign pain once they are addicted or dependant on them and since pain is so subjective one can't prove or disprove someone elses pain.

Here's the issue I think we have forthcoming though - we have so many addicted and dependant and we have too many men with low T - which we know, though we fail to acknowledge, is a HUGE factor in stress and depression - and anger and mood swings, not just sex drive, but were also getting to a point where the prescribing of the opiates is going to be so regulated or no more(now that opiate related deaths has surpassed car wrecks as the leading accidental death) , that many a doc I fear will not do it anymore, and we're going to have all these men (and women as it messes up their T and E also) angry, edgy, due to low T and then were also going to cut off their opiate addictions for those that are addicted -

.........I see this as a perfect storm for trouble on the horizon.

http://www.webmd.com/news/20110420/the-10-most-prescribed-drugs

From: <jclark24p@...>Subject: Metabolic Syndrome and Testosteronehyperaldosteronism Date: Saturday, June 23, 2012, 1:11 PM

I was researching testosterone this morning as I continue to validate my decision of surgery instead of meds. (With my co-morbid conditions I do have a slightly elevated risk!) I came across this new study (March 2012) which sheds light on the issue (MAYBE) and may even be relevant to the Gordon, Stowasser, etal study I posted earlier.

I ask that you carefully read both with this question in mind: ¡°Is the medicines being used to treat IHA altering the outcome of the study? And maybe QOL?¡± In other words, I bet they are using Spironolactone and also hypothesize the outcome would be different if they used Eplerenone and didn¡¯t antagonize androgen! Dr. Grim, what do you think? Do you want to ¡°burst their bubble¡± or should I? (Probably more effective coming from you!) Also, are you ready to join me in recommending Eplerenone as the first (and only) choice and to hell with cost!

Ladies: Please note this paragraph: TESTOSTERONE AND METABOLIC SYNDROME -

¡°There are a number of epidemiological studies linking T and MetS. Although there are a number of publications showing the association of T and MetS in females,[45¨C56] in this review we will restrict to the association in males.¡± I did not try to analyze ¡°the fairer sex¡± but the titles look like you could interpret and apply. (Momma told me a long time ago that I would never figure out a woman!)

¡¡

¡°We found in our previous study higher occurrence of metabolic disturbances in patients with idiopathic hyperaldosteronism (IHA) compared to subjects with aldosterone-producing adenoma (APA).¡±

http://www.biomed.cas.cz/physiolres/pdf/prepress/932335.pdf

Testosterone and metabolic syndrome: The link ¡°Serum testosterone (T) has been shown to be associated with MetS. Several studies have shown a higher prevalence of MetS in subjects with low testosterone.¡±

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354945/?report=printable

Have you had your testosterone checked? I finally convinced my PCP to check mine in March, 2012, as near as I can tell the first time in 65 years! It was 1.26, range 1.95 - 11.36. I had been off Spironolactone for 3 months but it sure would be nice to know what it was before I started. Might be worth checking a few that are on Spiro now and see if we can reduce MetS! Who does all the surveys?

[Guest guest]

, are you sick, when did you not want to start a debate?

You may have actually uncovered my issue since I was on methadone 10mg bid and oxycodone 5mg bid. And I thought it was just my age and fat! (I had been off the drugs for over a year when the test was done.)

Should I try Medical Marijuana this time? (I don't have any experience with it but many in Vietnam thought it reduced stress and pain! )

> > > From: jclark24p@...> Subject: Metabolic Syndrome and Testosterone> hyperaldosteronism > Date: Saturday, June 23, 2012, 1:11 PM> > > >  > > > > > I was researching testosterone this morning as I continue to validate my decision of surgery instead of meds. (With my co-morbid conditions I do have a slightly elevated risk!) I came across this new study (March 2012) which sheds light on the issue (MAYBE) and may even be relevant to the Gordon, Stowasser, etal study I posted earlier.> I ask that you carefully read both with this question in mind: ¡°Is the medicines being used to treat IHA altering the outcome of the study? And maybe QOL?¡± In other words, I bet they are using Spironolactone and also hypothesize the outcome would be different if they used Eplerenone and didn¡¯t antagonize androgen! Dr. Grim, what do you think? Do you want to ¡°burst their bubble¡± or should I? (Probably more effective coming from you!) Also, are you ready to join me in recommending Eplerenone as the first (and only) choice and to hell with cost! > Ladies: Please note this paragraph: TESTOSTERONE AND METABOLIC SYNDROME -> ¡°There are a number of epidemiological studies linking T and MetS. Although there are a number of publications showing the association of T and MetS in females,[45¨C56] in this review we will restrict to the association in males.¡± I did not try to analyze ¡°the fairer sex¡± but the titles look like you could interpret and apply. (Momma told me a long time ago that I would never figure out a woman!)> ¡¡> ¡°We found in our previous study higher occurrence of metabolic disturbances in patients with idiopathic hyperaldosteronism (IHA) compared to subjects with aldosterone-producing adenoma (APA).¡±> http://www.biomed.cas.cz/physiolres/pdf/prepress/932335.pdf> Testosterone and metabolic syndrome: The link ¡°Serum testosterone (T) has been shown to be associated with MetS. Several studies have shown a higher prevalence of MetS in subjects with low testosterone.¡±> http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354945/?report=printable> Have you had your testosterone checked? I finally convinced my PCP to check mine in March, 2012, as near as I can tell the first time in 65 years! It was 1.26, range 1.95 - 11.36. I had been off Spironolactone for 3 months but it sure would be nice to know what it was before I started.  Might be worth checking a few that are on Spiro now and see if we can reduce MetS! Who does all the surveys?>

[Guest guest]

I know vicodin had driven mine down, but I haven't taken anything for 2 + years, then it was the spiro, but I am not on that now. I worry what they are going to do when the day comes they control prescribing much tighter.

From: <jclark24p@...>Subject: Re: Metabolic Syndrome and Testosteronehyperaldosteronism Date: Saturday, June 23, 2012, 7:58 PM

, are you sick, when did you not want to start a debate?

You may have actually uncovered my issue since I was on methadone 10mg bid and oxycodone 5mg bid. And I thought it was just my age and fat! (I had been off the drugs for over a year when the test was done.)

Should I try Medical Marijuana this time? (I don't have any experience with it but many in Vietnam thought it reduced stress and pain! )

> > > From: jclark24p@...> Subject: Metabolic Syndrome and Testosterone> hyperaldosteronism > Date: Saturday, June 23, 2012, 1:11 PM> > > > Â > > > > > I was researching testosterone this morning as I continue to validate my decision of surgery instead of meds. (With my co-morbid conditions I do have a slightly elevated risk!) I came across this new study (March 2012) which sheds light on the issue (MAYBE) and may even be relevant to the

Gordon, Stowasser, etal study I posted earlier.> I ask that you carefully read both with this question in mind: ¡°Is the medicines being used to treat IHA altering the outcome of the study? And maybe QOL?¡± In other words, I bet they are using Spironolactone and also hypothesize the outcome would be different if they used Eplerenone and didn¡¯t antagonize androgen! Dr. Grim, what do you think? Do you want to ¡°burst their bubble¡± or should I? (Probably more effective coming from you!) Also, are you ready to join me in recommending Eplerenone as the first (and only) choice and to hell with cost! > Ladies: Please note this paragraph: TESTOSTERONE AND METABOLIC SYNDROME -> ¡°There are a number of epidemiological studies linking T and MetS. Although there are a number of publications showing the association of T and MetS in females,[45¨C56] in this review we will restrict to the

association in males.¡± I did not try to analyze ¡°the fairer sex¡± but the titles look like you could interpret and apply. (Momma told me a long time ago that I would never figure out a woman!)> ¡¡> ¡°We found in our previous study higher occurrence of metabolic disturbances in patients with idiopathic hyperaldosteronism (IHA) compared to subjects with aldosterone-producing adenoma (APA).¡±> http://www.biomed.cas.cz/physiolres/pdf/prepress/932335.pdf> Testosterone and metabolic syndrome: The link ¡°Serum testosterone (T) has been shown to be associated with MetS. Several studies have shown a higher prevalence of MetS in subjects with low testosterone.¡±> http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354945/?report=printable> Have you had your testosterone checked? I finally convinced my PCP to check mine in March, 2012, as near as I can tell the first time

in 65 years! It was 1.26, range 1.95 - 11.36. I had been off Spironolactone for 3 months but it sure would be nice to know what it was before I started.  Might be worth checking a few that are on Spiro now and see if we can reduce MetS! Who does all the surveys?>

[Guest guest]

If testosterone is low then other testing should be done to find the cause.

> >

> >

> > From: jclark24p@

> > Subject: Metabolic Syndrome and Testosterone

> > hyperaldosteronism

> > Date: Saturday, June 23, 2012, 1:11 PM

> >

> >

> >

> >  

> >

> >

> >

> >

> > I was researching testosterone this morning as I continue to validate my

decision of surgery instead of meds. (With my co-morbid conditions I do have a

slightly elevated risk!) I came across this new study (March 2012) which sheds

light on the issue (MAYBE) and may even be relevant to the Gordon, Stowasser,

etal study I posted earlier.

> > I ask that you carefully read both with this question in mind: ¡°Is

the medicines being used to treat IHA altering the outcome of the study? And

maybe QOL?¡± In other words, I bet they are using Spironolactone and also

hypothesize the outcome would be different if they used Eplerenone and

didn¡¯t antagonize androgen! Dr. Grim, what do you think? Do you want to

¡°burst their bubble¡± or should I? (Probably more effective coming

from you!) Also, are you ready to join me in recommending Eplerenone as the

first (and only) choice and to hell with cost! 

> > Ladies: Please note this paragraph: TESTOSTERONE AND METABOLIC SYNDROME -

> > ¡°There are a number of epidemiological studies linking T and MetS.

Although there are a number of publications showing the association of T and

MetS in females,[45¨C56] in this review we will restrict to the association

in males.¡± I did not try to analyze ¡°the fairer sex¡± but

the titles look like you could interpret and apply. (Momma told me a long time

ago that I would never figure out a woman!)

> > ¡¡

> > ¡°We found in our previous study higher occurrence of metabolic

disturbances in patients with idiopathic hyperaldosteronism (IHA) compared to

subjects with aldosterone-producing adenoma (APA).¡±

> > http://www.biomed.cas.cz/physiolres/pdf/prepress/932335.pdf

> > Testosterone and metabolic syndrome: The link ¡°Serum testosterone (T)

has been shown to be associated with MetS. Several studies have shown a higher

prevalence of MetS in subjects with low testosterone.¡±

> > http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354945/?report=printable

> > Have you had your testosterone checked?  I finally convinced my PCP to

check mine in March, 2012, as near as I can tell the first time in 65 years! 

It was 1.26, range 1.95 - 11.36.  I had been off Spironolactone for 3 months

but it sure would be nice to know what it was before I started.   Might be

worth checking a few that are on Spiro now and see if we can reduce MetS! 

Who does all the surveys?

> >

>

[Guest guest]

Still on the road but will be able to read in detail by Wed I hope. May your pressure be low!CE Grim MS, MDSpecializing in DifficultHypertensionOn Jun 23, 2012, at 12:11, <jclark24p@...> wrote:

I was researching testosterone this morning as I continue to validate my decision of surgery instead of meds. (With my co-morbid conditions I do have a slightly elevated risk!) I came across this new study (March 2012) which sheds light on the issue (MAYBE) and may even be relevant to the Gordon, Stowasser, etal study I posted earlier.

I ask that you carefully read both with this question in mind: ¡°Is the medicines being used to treat IHA altering the outcome of the study? And maybe QOL?¡± In other words, I bet they are using Spironolactone and also hypothesize the outcome would be different if they used Eplerenone and didn¡¯t antagonize androgen! Dr. Grim, what do you think? Do you want to ¡°burst their bubble¡± or should I? (Probably more effective coming from you!) Also, are you ready to join me in recommending Eplerenone as the first (and only) choice and to hell with cost!

Ladies: Please note this paragraph: TESTOSTERONE AND METABOLIC SYNDROME -

¡°There are a number of epidemiological studies linking T and MetS. Although there are a number of publications showing the association of T and MetS in females,[45¨C56] in this review we will restrict to the association in males.¡± I did not try to analyze ¡°the fairer sex¡± but the titles look like you could interpret and apply. (Momma told me a long time ago that I would never figure out a woman!)

¡¡

¡°We found in our previous study higher occurrence of metabolic disturbances in patients with idiopathic hyperaldosteronism (IHA) compared to subjects with aldosterone-producing adenoma (APA).¡±

http://www.biomed.cas.cz/physiolres/pdf/prepress/932335.pdf

Testosterone and metabolic syndrome: The link ¡°Serum testosterone (T) has been shown to be associated with MetS. Several studies have shown a higher prevalence of MetS in subjects with low testosterone.¡±

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354945/?report=printable

Have you had your testosterone checked? I finally convinced my PCP to check mine in March, 2012, as near as I can tell the first time in 65 years! It was 1.26, range 1.95 - 11.36. I had been off Spironolactone for 3 months but it sure would be nice to know what it was before I started. Might be worth checking a few that are on Spiro now and see if we can reduce MetS! Who does all the surveys?

[Guest guest]

Still on the road but will be able to read in detail by Wed I hope. May your pressure be low!CE Grim MS, MDSpecializing in DifficultHypertensionOn Jun 23, 2012, at 12:11, <jclark24p@...> wrote:

I was researching testosterone this morning as I continue to validate my decision of surgery instead of meds. (With my co-morbid conditions I do have a slightly elevated risk!) I came across this new study (March 2012) which sheds light on the issue (MAYBE) and may even be relevant to the Gordon, Stowasser, etal study I posted earlier.

I ask that you carefully read both with this question in mind: ¡°Is the medicines being used to treat IHA altering the outcome of the study? And maybe QOL?¡± In other words, I bet they are using Spironolactone and also hypothesize the outcome would be different if they used Eplerenone and didn¡¯t antagonize androgen! Dr. Grim, what do you think? Do you want to ¡°burst their bubble¡± or should I? (Probably more effective coming from you!) Also, are you ready to join me in recommending Eplerenone as the first (and only) choice and to hell with cost!

Ladies: Please note this paragraph: TESTOSTERONE AND METABOLIC SYNDROME -

¡°There are a number of epidemiological studies linking T and MetS. Although there are a number of publications showing the association of T and MetS in females,[45¨C56] in this review we will restrict to the association in males.¡± I did not try to analyze ¡°the fairer sex¡± but the titles look like you could interpret and apply. (Momma told me a long time ago that I would never figure out a woman!)

¡¡

¡°We found in our previous study higher occurrence of metabolic disturbances in patients with idiopathic hyperaldosteronism (IHA) compared to subjects with aldosterone-producing adenoma (APA).¡±

http://www.biomed.cas.cz/physiolres/pdf/prepress/932335.pdf

Testosterone and metabolic syndrome: The link ¡°Serum testosterone (T) has been shown to be associated with MetS. Several studies have shown a higher prevalence of MetS in subjects with low testosterone.¡±

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354945/?report=printable

Have you had your testosterone checked? I finally convinced my PCP to check mine in March, 2012, as near as I can tell the first time in 65 years! It was 1.26, range 1.95 - 11.36. I had been off Spironolactone for 3 months but it sure would be nice to know what it was before I started. Might be worth checking a few that are on Spiro now and see if we can reduce MetS! Who does all the surveys?

[Guest guest]

And how is your level?

> > >

> > >

> > > From: jclark24p@

> > > Subject: Metabolic Syndrome and Testosterone

> > > hyperaldosteronism

> > > Date: Saturday, June 23, 2012, 1:11 PM

> > >

> > >

> > >

> > >  

> > >

> > >

> > >

> > >

> > > I was researching testosterone this morning as I continue to validate my

decision of surgery instead of meds. (With my co-morbid conditions I do have a

slightly elevated risk!) I came across this new study (March 2012) which sheds

light on the issue (MAYBE) and may even be relevant to the Gordon, Stowasser,

etal study I posted earlier.

> > > I ask that you carefully read both with this question in mind: ¡°Is

the medicines being used to treat IHA altering the outcome of the study? And

maybe QOL?¡± In other words, I bet they are using Spironolactone and also

hypothesize the outcome would be different if they used Eplerenone and

didn¡¯t antagonize androgen! Dr. Grim, what do you think? Do you want to

¡°burst their bubble¡± or should I? (Probably more effective coming

from you!) Also, are you ready to join me in recommending Eplerenone as the

first (and only) choice and to hell with cost! 

> > > Ladies: Please note this paragraph: TESTOSTERONE AND METABOLIC SYNDROME -

> > > ¡°There are a number of epidemiological studies linking T and MetS.

Although there are a number of publications showing the association of T and

MetS in females,[45¨C56] in this review we will restrict to the association

in males.¡± I did not try to analyze ¡°the fairer sex¡± but

the titles look like you could interpret and apply. (Momma told me a long time

ago that I would never figure out a woman!)

> > > ¡¡

> > > ¡°We found in our previous study higher occurrence of metabolic

disturbances in patients with idiopathic hyperaldosteronism (IHA) compared to

subjects with aldosterone-producing adenoma (APA).¡±

> > > http://www.biomed.cas.cz/physiolres/pdf/prepress/932335.pdf

> > > Testosterone and metabolic syndrome: The link ¡°Serum testosterone

(T) has been shown to be associated with MetS. Several studies have shown a

higher prevalence of MetS in subjects with low testosterone.¡±

> > > http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354945/?report=printable

> > > Have you had your testosterone checked?  I finally convinced my PCP to

check mine in March, 2012, as near as I can tell the first time in 65 years! 

It was 1.26, range 1.95 - 11.36.  I had been off Spironolactone for 3 months

but it sure would be nice to know what it was before I started.   Might be

worth checking a few that are on Spiro now and see if we can reduce MetS! 

Who does all the surveys?

> > >

> >

>

[Guest guest]

And how is your level?

> > >

> > >

> > > From: jclark24p@

> > > Subject: Metabolic Syndrome and Testosterone

> > > hyperaldosteronism

> > > Date: Saturday, June 23, 2012, 1:11 PM

> > >

> > >

> > >

> > >  

> > >

> > >

> > >

> > >

> > > I was researching testosterone this morning as I continue to validate my

decision of surgery instead of meds. (With my co-morbid conditions I do have a

slightly elevated risk!) I came across this new study (March 2012) which sheds

light on the issue (MAYBE) and may even be relevant to the Gordon, Stowasser,

etal study I posted earlier.

> > > I ask that you carefully read both with this question in mind: ¡°Is

the medicines being used to treat IHA altering the outcome of the study? And

maybe QOL?¡± In other words, I bet they are using Spironolactone and also

hypothesize the outcome would be different if they used Eplerenone and

didn¡¯t antagonize androgen! Dr. Grim, what do you think? Do you want to

¡°burst their bubble¡± or should I? (Probably more effective coming

from you!) Also, are you ready to join me in recommending Eplerenone as the

first (and only) choice and to hell with cost! 

> > > Ladies: Please note this paragraph: TESTOSTERONE AND METABOLIC SYNDROME -

> > > ¡°There are a number of epidemiological studies linking T and MetS.

Although there are a number of publications showing the association of T and

MetS in females,[45¨C56] in this review we will restrict to the association

in males.¡± I did not try to analyze ¡°the fairer sex¡± but

the titles look like you could interpret and apply. (Momma told me a long time

ago that I would never figure out a woman!)

> > > ¡¡

> > > ¡°We found in our previous study higher occurrence of metabolic

disturbances in patients with idiopathic hyperaldosteronism (IHA) compared to

subjects with aldosterone-producing adenoma (APA).¡±

> > > http://www.biomed.cas.cz/physiolres/pdf/prepress/932335.pdf

> > > Testosterone and metabolic syndrome: The link ¡°Serum testosterone

(T) has been shown to be associated with MetS. Several studies have shown a

higher prevalence of MetS in subjects with low testosterone.¡±

> > > http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354945/?report=printable

> > > Have you had your testosterone checked?  I finally convinced my PCP to

check mine in March, 2012, as near as I can tell the first time in 65 years! 

It was 1.26, range 1.95 - 11.36.  I had been off Spironolactone for 3 months

but it sure would be nice to know what it was before I started.   Might be

worth checking a few that are on Spiro now and see if we can reduce MetS! 

Who does all the surveys?

> > >

> >

>

[Guest guest]

04 Aug 2006 TESTOSTERONE 2.41 ng/mL (1.75-7.81) Testosterone Bioavailable SEX

HORMONE 29.5 nmol/L (13-71) Follicle Stimulating Hormone FOLLITROPIN 2.2

mIUnits/mL (1-19) Luteinizing Hormone LUTROPIN 1.0 mIUnits/mL (1-9)

11 Mar 2006 TESTOSTERONE 1.79 ng/mL (1.75-7.81) Testosterone Bioavailable 32.6

nmol/L (13-71) Follicle Stimulating Hormone FOLLITROPIN 2.3 mIUnits/mL (1-19)

Luteinizing Hormone LUTROPIN 0.6 Low mIUnits/mL (1-9)

> > > >

> > > >

> > > > From: jclark24p@

> > > > Subject: Metabolic Syndrome and Testosterone

> > > > hyperaldosteronism

> > > > Date: Saturday, June 23, 2012, 1:11 PM

> > > >

> > > >

> > > >

> > > >  

> > > >

> > > >

> > > >

> > > >

> > > > I was researching testosterone this morning as I continue to validate my

decision of surgery instead of meds. (With my co-morbid conditions I do have a

slightly elevated risk!) I came across this new study (March 2012) which sheds

light on the issue (MAYBE) and may even be relevant to the Gordon, Stowasser,

etal study I posted earlier.

> > > > I ask that you carefully read both with this question in mind:

¡°Is the medicines being used to treat IHA altering the outcome of the

study? And maybe QOL?¡± In other words, I bet they are using

Spironolactone and also hypothesize the outcome would be different if they used

Eplerenone and didn¡¯t antagonize androgen! Dr. Grim, what do you think?

Do you want to ¡°burst their bubble¡± or should I? (Probably more

effective coming from you!) Also, are you ready to join me in recommending

Eplerenone as the first (and only) choice and to hell with cost! 

> > > > Ladies: Please note this paragraph: TESTOSTERONE AND METABOLIC SYNDROME

-

> > > > ¡°There are a number of epidemiological studies linking T and

MetS. Although there are a number of publications showing the association of T

and MetS in females,[45¨C56] in this review we will restrict to the

association in males.¡± I did not try to analyze ¡°the fairer

sex¡± but the titles look like you could interpret and apply. (Momma told

me a long time ago that I would never figure out a woman!)

> > > > ¡¡

> > > > ¡°We found in our previous study higher occurrence of metabolic

disturbances in patients with idiopathic hyperaldosteronism (IHA) compared to

subjects with aldosterone-producing adenoma (APA).¡±

> > > > http://www.biomed.cas.cz/physiolres/pdf/prepress/932335.pdf

> > > > Testosterone and metabolic syndrome: The link ¡°Serum testosterone

(T) has been shown to be associated with MetS. Several studies have shown a

higher prevalence of MetS in subjects with low testosterone.¡±

> > > > http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354945/?report=printable

> > > > Have you had your testosterone checked?  I finally convinced my PCP

to check mine in March, 2012, as near as I can tell the first time in 65

years!  It was 1.26, range 1.95 - 11.36.  I had been off Spironolactone

for 3 months but it sure would be nice to know what it was before I

started.   Might be worth checking a few that are on Spiro now and see if

we can reduce MetS!  Who does all the surveys?

> > > >

> > >

> >

>

[Guest guest]

So back when you were a young man it was slightly above the minimum! Actually if it is "normally" in the range on 11 March you might experience some of the same side effects as I did if you were to start Soironolactone.

I really am quite impressed that you had any numbers. Even when I started growing boobs and loosing body hair nobody thought to check! (Of course we were playing "Musical Neper" at the time, not that that should matter.)

> > > > > > > > > > > > > > > From: jclark24p@> > > > > Subject: Metabolic Syndrome and Testosterone> > > > > hyperaldosteronism > > > > > Date: Saturday, June 23, 2012, 1:11 PM> > > > > > > > > > > > > > > > > > > >  > > > > > > > > > > > > > > > > > > > > > > > > > I was researching testosterone this morning as I continue to validate my decision of surgery instead of meds. (With my co-morbid conditions I do have a slightly elevated risk!) I came across this new study (March 2012) which sheds light on the issue (MAYBE) and may even be relevant to the Gordon, Stowasser, etal study I posted earlier.> > > > > I ask that you carefully read both with this question in mind: ¡°Is the medicines being used to treat IHA altering the outcome of the study? And maybe QOL?¡± In other words, I bet they are using Spironolactone and also hypothesize the outcome would be different if they used Eplerenone and didn¡¯t antagonize androgen! Dr. Grim, what do you think? Do you want to ¡°burst their bubble¡± or should I? (Probably more effective coming from you!) Also, are you ready to join me in recommending Eplerenone as the first (and only) choice and to hell with cost! > > > > > Ladies: Please note this paragraph: TESTOSTERONE AND METABOLIC SYNDROME -> > > > > ¡°There are a number of epidemiological studies linking T and MetS. Although there are a number of publications showing the association of T and MetS in females,[45¨C56] in this review we will restrict to the association in males.¡± I did not try to analyze ¡°the fairer sex¡± but the titles look like you could interpret and apply. (Momma told me a long time ago that I would never figure out a woman!)> > > > > ¡¡> > > > > ¡°We found in our previous study higher occurrence of metabolic disturbances in patients with idiopathic hyperaldosteronism (IHA) compared to subjects with aldosterone-producing adenoma (APA).¡±> > > > > http://www.biomed.cas.cz/physiolres/pdf/prepress/932335.pdf> > > > > Testosterone and metabolic syndrome: The link ¡°Serum testosterone (T) has been shown to be associated with MetS. Several studies have shown a higher prevalence of MetS in subjects with low testosterone.¡±> > > > > http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354945/?report=printable> > > > > Have you had your testosterone checked? I finally convinced my PCP to check mine in March, 2012, as near as I can tell the first time in 65 years! It was 1.26, range 1.95 - 11.36. I had been off Spironolactone for 3 months but it sure would be nice to know what it was before I started.  Might be worth checking a few that are on Spiro now and see if we can reduce MetS! Who does all the surveys?> > > > >> > > >> > >> >>

[Guest guest]

They tested it to see if it was cause of my fatigue.

> > > > > >

> > > > > >

> > > > > > From: jclark24p@

> > > > > > Subject: Metabolic Syndrome and

> Testosterone

> > > > > > hyperaldosteronism

> > > > > > Date: Saturday, June 23, 2012, 1:11 PM

> > > > > >

> > > > > >

> > > > > >

> > > > > > ÂÂ

> > > > > >

> > > > > >

> > > > > >

> > > > > >

> > > > > > I was researching testosterone this morning as I continue to

> validate my decision of surgery instead of meds. (With my co-morbid

> conditions I do have a slightly elevated risk!) I came across this new

> study (March 2012) which sheds light on the issue (MAYBE) and may even

> be relevant to the Gordon, Stowasser, etal study I posted earlier.

> > > > > > I ask that you carefully read both with this question in mind:

> ¡°Is the medicines being used to treat IHA altering the

> outcome of the study? And maybe QOL?¡± In other words, I bet

> they are using Spironolactone and also hypothesize the outcome would be

> different if they used Eplerenone and didn¡¯t antagonize

> androgen! Dr. Grim, what do you think? Do you want to ¡°burst

> their bubble¡± or should I? (Probably more effective coming

> from you!) Also, are you ready to join me in recommending Eplerenone as

> the first (and only) choice and to hell with cost!ÂÂ

> > > > > > Ladies: Please note this paragraph: TESTOSTERONE AND METABOLIC

> SYNDROME -

> > > > > > ¡°There are a number of epidemiological studies

> linking T and MetS. Although there are a number of publications showing

> the association of T and MetS in females,[45¨C56] in this review

> we will restrict to the association in males.¡± I did not try

> to analyze ¡°the fairer sex¡± but the titles look

> like you could interpret and apply. (Momma told me a long time ago that

> I would never figure out a woman!)

> > > > > > ¡¡

> > > > > > ¡°We found in our previous study higher occurrence

> of metabolic disturbances in patients with idiopathic hyperaldosteronism

> (IHA) compared to subjects with aldosterone-producing adenoma

> (APA).¡±

> > > > > > http://www.biomed.cas.cz/physiolres/pdf/prepress/932335.pdf

> > > > > > Testosterone and metabolic syndrome: The link

> ¡°Serum testosterone (T) has been shown to be associated with

> MetS. Several studies have shown a higher prevalence of MetS in subjects

> with low testosterone.¡±

> > > > > >

> http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354945/?report=printable

> > > > > > Have you had your testosterone checked? I finally

> convinced my PCP to check mine in March, 2012, as near as I can tell the

> first time in 65 years! It was 1.26, range 1.95 - 11.36.ÂÂ

> I had been off Spironolactone for 3 months but it sure would be nice to

> know what it was before I started.  Might be worth

> checking a few that are on Spiro now and see if we can reduce

> MetS! Who does all the surveys?

> > > > > >

> > > > >

> > > >

> > >

> >

>