Eplerenone + Biaxin

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www.drugs.com clarithromycin ↔ eplerenoneApplies to: Biaxin (clarithromycin), eplerenone (Major contraindication)CONTRAINDICATED: Coadministration with potent inhibitors of CYP450 3A4 may significantly increase the plasma concentrations of eplerenone, which is primarily metabolized by the isoenzyme. In pharmacokinetic studies, administration of eplerenone (100 mg single dose) with ketoconazole (200 mg twice a day) resulted in a 1.7-fold increase in eplerenone peak plasma concentration (Cmax) and a 5.4-fold increase in systemic exposure (AUC).MANAGEMENT: The use of eplerenone with potent inhibitors of CYP450 3A4 (e.g., itraconazole, ketoconazole, nefazodone, delavirdine, ketolide and certain macrolide antibiotics, most protease inhibitors) is considered contraindicated. This is the interaction checker http://www.drugs.com/interactions-check.php?drug_list=997-0,685-337 Val From: hyperaldosteronism [mailto:hyperaldosteronism ] On Behalf Of Clarence Grim I find this on webMD BUT cannot find the publication? On May 13, 2012, at 16:07, Valarie <val@...> wrote: 20 mg of doxy is not very much and I didn't feel it. It did stop the periodontal progression but didn't improve it. A normal dose is 100 mg x 3/d. My doc just switched me to doxy from Biaxin because of the newly-emerged Biaxin-eplerenone contraindication.