A review of salt and HTN that focuses on the brain and adrenal. Long and detailed. I have not ever read it in in great detail Good to see one of my former students is on it VanHysse.

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Understand the confidentiality issues. But keep us posted on what you can.CE Grim MDOn May 6, 2012, at 12:24 PM, wrote: It will be interesting if Dr. Stratakis can help you. I signed many psges of confidentially pages. (Their promises to me, not me to them!) Also, his current research appears to be in a very specific area but he may be into something else or know someone who is. > > > Dr. Grim, I am going to explain this one last time so read the whole > > post. > > > > Spironolactone antagonizes androgen causing a reduction (or > > elimination, I'm not sure) at the CYP11B2 gene. This process allows > > cortisol, which is CYP11B1, the gene next door to increase. This is > > all happening on channel 8. > > > > If you are producing excess cortisol for whtever reason you already > > have excess cortisol (CYP11B1). If you then apply the effects of > > spironolactone and antagonize androgen (CYP11B2) you increase > > cortisol (CYP11B1) even more (I call it a "double whammy"!) > > > > This is why NIH thought Spironolactone was the wrong medicine for > > me. This is why I would suggest Spironolactone is poor choice for > > anyone showing signs of excess cortisol. (Actually this is why I > > advocate proper testing and treating appropriately!) > > > > If anyone doesn't know what cortisol does, think "fight or flight" > > and depression compounds the problem. > > > > .... > > > > >