Re: anyone with diarrhea in PA?

[Guest guest]

I'm not sure where the " R " came from, I thought it was a " MCB " . I think the

" action " takes place after the excess aldo is in the system. Here is what I

base that on:

Spironolactone is in a class of medications called aldosterone receptor

antagonists.

Aldosterone receptor antagonists block the effects of aldosterone, therefore

decrease sodium re-absorption and water retention by the kidneys and

consequently lead to a decrease in blood pressure.

If it increases aldosterone it would be defeating the purpose!

> >

> > Are you on Spiro? I had a lot of gastric issues when I was on it if I went

above 25mg bid. In fact, even at 25mg twice a day I had to be careful to dose

pretty much exactly 12 hours apart. Just a thought.

> >

>

[Guest guest]

In most as the salt in the body and BP DECREASE renin and aldo increase. One reason RAAS testing on spiro is a problem. CHANGES are less in PA THAN not PA. May your pressure be low!CE Grim MS, MDSpecializing in DifficultHypertensionOn May 7, 2012, at 15:26, <jclark24p@...> wrote:

I'm not sure where the "R"came from, I thought it was a "MCB". I think the "action" takes place after the excess aldo is in the system. Here is what I base that on:

Spironolactone is in a class of medications called aldosterone receptor antagonists.

Aldosterone receptor antagonists block the effects of aldosterone, therefore decrease sodium re-absorption and water retention by the kidneys and consequently lead to a decrease in blood pressure.

If it increases aldosterone it would be defeating the purpose!

> >

> > Are you on Spiro? I had a lot of gastric issues when I was on it if I went above 25mg bid. In fact, even at 25mg twice a day I had to be careful to dose pretty much exactly 12 hours apart. Just a thought.

> >

>

[Guest guest]

Best way to do that is to try yourself. Say maybe start on RICE fruit diet. If still a problem the stop fruit. If Better on both then start adding back food till u find problem. May your pressure be low!CE Grim MS, MDSpecializing in DifficultHypertensionOn May 7, 2012, at 13:39, lvasiliu@... wrote:

Got it, thank you!

Incidentally I am on the low side of B12 (but not below) but Celiac has been ruled out last year.

Guess I will have to talk to the GI doctor about food intolerances!

>

> Allergies are entirely different than intolerances. I test negative on all blood tests for wheat allergy, yet I have celiac disease which is a reaction to the gluten in wheat.

[Guest guest]

Best way to do that is to try yourself. Say maybe start on RICE fruit diet. If still a problem the stop fruit. If Better on both then start adding back food till u find problem. May your pressure be low!CE Grim MS, MDSpecializing in DifficultHypertensionOn May 7, 2012, at 13:39, lvasiliu@... wrote:

Got it, thank you!

Incidentally I am on the low side of B12 (but not below) but Celiac has been ruled out last year.

Guess I will have to talk to the GI doctor about food intolerances!

>

> Allergies are entirely different than intolerances. I test negative on all blood tests for wheat allergy, yet I have celiac disease which is a reaction to the gluten in wheat.

[Guest guest]

Best way to do that is to try yourself. Say maybe start on RICE fruit diet. If still a problem the stop fruit. If Better on both then start adding back food till u find problem. May your pressure be low!CE Grim MS, MDSpecializing in DifficultHypertensionOn May 7, 2012, at 13:39, lvasiliu@... wrote:

Got it, thank you!

Incidentally I am on the low side of B12 (but not below) but Celiac has been ruled out last year.

Guess I will have to talk to the GI doctor about food intolerances!

>

> Allergies are entirely different than intolerances. I test negative on all blood tests for wheat allergy, yet I have celiac disease which is a reaction to the gluten in wheat.

[Guest guest]

Dr. Grim is spot-on with this one: I've found GI docs to be pretty much useless

when it comes to dealing with food intolerances. My original diagnosis was made

by an internist, first by elimination diet, then by hydrogen testing (something

that was incredibly unpleasant and really, I wouldn't suggest doing if the

elimination diet works).

> > >

> > > Allergies are entirely different than intolerances. I test negative on all

blood tests for wheat allergy, yet I have celiac disease which is a reaction to

the gluten in wheat.

> >

> >

>

[Guest guest]

Oh, and if I remember correctly, my elimination diet started with rice and

chicken, which are two of the most-tolerated and least-allergenic foods. Then

added in potatoes, then added in other proteins, then added in veggies, etc.

> > >

> > > Allergies are entirely different than intolerances. I test negative on all

blood tests for wheat allergy, yet I have celiac disease which is a reaction to

the gluten in wheat.

> >

> >

>

[Guest guest]

Oh, and if I remember correctly, my elimination diet started with rice and

chicken, which are two of the most-tolerated and least-allergenic foods. Then

added in potatoes, then added in other proteins, then added in veggies, etc.

> > >

> > > Allergies are entirely different than intolerances. I test negative on all

blood tests for wheat allergy, yet I have celiac disease which is a reaction to

the gluten in wheat.

> >

> >

>

[Guest guest]

Oh, and if I remember correctly, my elimination diet started with rice and

chicken, which are two of the most-tolerated and least-allergenic foods. Then

added in potatoes, then added in other proteins, then added in veggies, etc.

> > >

> > > Allergies are entirely different than intolerances. I test negative on all

blood tests for wheat allergy, yet I have celiac disease which is a reaction to

the gluten in wheat.

> >

> >

>

[Guest guest]

You have early PA with a very low renin and not a low aldo and a high A/R ratio. Ever been on spiro?Start elimination diet now I assume you have had a stool for ova and parasites done.CE Grim MDOn May 7, 2012, at 3:17 PM, lvasiliu@... wrote: Nope, none of those problems that I am aware. I am actually gaining weight (only on Verapamil ER). Maybe not an aldo problem "per se" but something derived from it. My aldo is normal yet my renin is very low so my ARR=41. Could it be another symptom of low K? Diarrhea induced by electrolyte imbalance maybe? Ar maybe water retention diarrhea? Thank you. tiu > > Not likely an aldo problem. > > Losing weight? > > Any Hx of pancreas problems? EtOH,cirrhosis?

[Guest guest]

Okay Dr. Grim, and what happens if you occasionally eat a lot of sodium, even if you are Dashing most of the time? Natalia Kamneva 68 Russian F with 2 cm left adrenal adenoma, recently diagnosed with PA; diabetic; on 100 mg eplerenone, 80 mg Micardis, 2000 mg metformin, 60 mg Dexilant and 2 mg Lorazepam; Dashing; still have some occasional problems with BP, K and Na; on private consultation with Dr Grim. From: Clarence Grim <lowerbp2@...> hyperaldosteronism Cc: Clarence Grim <lowerbp2@...> Sent: Monday, May 7, 2012 2:49 PM Subject: Re: Re: anyone with diarrhea in PA?

Hmm. usually the aldo does not go up much over the long haul. If you DASH you block most of the aldo effects even without the spiro. Or at least come can.. On May 7, 2012, at 2:07 PM, lvasiliu@... wrote: , I am ONLY on Verapamil ER (not Spiro). As MS suggested I will try some OTC enzymes. The point is that Spiro being an MCRB, will block Aldo receptors and likely your body will end up producing MORE Aldo (in the short term). I can almost certainly say from my experience that excess Aldo will wreak havoc into one's digestive system, regardless of Spiro. > > Are you on Spiro? I had a lot of gastric issues when I was on it if I went above 25mg bid. In fact, even at 25mg twice a day I had to be careful to dose pretty much exactly 12 hours apart. Just a thought. >

[Guest guest]

Some will get quick jump in BP others may take a few days off the wagon. Need to test yourself to see suspect. CE Grim MDOn May 10, 2012, at 3:11 PM, Natalia Kamneva wrote: Okay Dr. Grim, and what happens if you occasionally eat a lot of sodium, even if you are Dashing most of the time? Natalia Kamneva 68 Russian F with 2 cm left adrenal adenoma, recently diagnosed with PA; diabetic; on 100 mg eplerenone, 80 mg Micardis, 2000 mg metformin, 60 mg Dexilant and 2 mg Lorazepam; Dashing; still have some occasional problems with BP, K and Na; on private consultation with Dr Grim. From: Clarence Grim <lowerbp2@...> hyperaldosteronism Cc: Clarence Grim <lowerbp2@...> Sent: Monday, May 7, 2012 2:49 PM Subject: Re: Re: anyone with diarrhea in PA? Hmm. usually the aldo does not go up much over the long haul. If you DASH you block most of the aldo effects even without the spiro. Or at least come can.. On May 7, 2012, at 2:07 PM, lvasiliu@... wrote: , I am ONLY on Verapamil ER (not Spiro). As MS suggested I will try some OTC enzymes. The point is that Spiro being an MCRB, will block Aldo receptors and likely your body will end up producing MORE Aldo (in the short term). I can almost certainly say from my experience that excess Aldo will wreak havoc into one's digestive system, regardless of Spiro. > > Are you on Spiro? I had a lot of gastric issues when I was on it if I went above 25mg bid. In fact, even at 25mg twice a day I had to be careful to dose pretty much exactly 12 hours apart. Just a thought. >

[Guest guest]

I see the jump within hours of going over 1400-1500. Can come down pretty quick, but I notice it physically too. Or one big salty meal - pasta is the big one for me - seems to do it.

, I am ONLY on Verapamil ER (not Spiro).As MS suggested I will try some OTC enzymes.The point is that Spiro being an MCRB, will block Aldo receptors and likely your body will end up producing MORE Aldo (in the short term).I can almost certainly say from my experience that excess Aldo will wreak havoc into one's digestive system, regardless of Spiro.>> Are you on Spiro? I had a lot of gastric issues when I was on it if I went above 25mg bid. In fact, even at 25mg twice a day I had to be careful to dose pretty much exactly 12 hours apart. Just a

thought.>