Re: Fran - cimetidine questions

[Guest guest]

Hi Hannah

Yes... the cimetidine can cause and inflammation of the liver and cause the

enzymes to elevate... so if you start the treatment you would check the enzymes

every 3-4 months.... if ok continue... if they elevate you stop the medication

and the liver will reduce to normal and enzymes back down to normal levels.

This happens with numerous medications.... God Bless

Fran

Fran Bulone RN

Mom to ph 7yr CIAS1 mutation 11/05; Dyspraxia 11/06

Waxhaw NC

/

[Guest guest]

From: [mailto: ] On Behalf Of Fran

Bulone

Sent: Friday, January 12, 2007 9:10 AM

Subject: Re: Fran - cimetidine questions

Hi Hannah

Yes... the cimetidine can cause and inflammation of the liver and cause the

enzymes to elevate... so if you start the treatment you would check the

enzymes every 3-4 months.... if ok continue... if they elevate you stop the

medication and the liver will reduce to normal and enzymes back down to

normal levels.

This happens with numerous medications.... God Bless

Fran

Fran Bulone RN

Mom to ph 7yr CIAS1 mutation 11/05; Dyspraxia 11/06

Waxhaw NC

/

[Guest guest]

How come my Pediatrician and the infectious disease docs at Vanderbilt all said

this was unnecessary?

Re: Fran - cimetidine questions

Hi Hannah

Yes... the cimetidine can cause and inflammation of the liver and cause the

enzymes to elevate... so if you start the treatment you would check the

enzymes every 3-4 months.... if ok continue... if they elevate you stop the

medication and the liver will reduce to normal and enzymes back down to

normal levels.

This happens with numerous medications.... God Bless

Fran

Fran Bulone RN

Mom to ph 7yr CIAS1 mutation 11/05; Dyspraxia 11/06

Waxhaw NC

/

[Guest guest]

Hi,

Not sure why the docs you see say this is not needed....

Fran

Fran Bulone RN

Mom to ph 7yr CIAS1 mutation 11/05; Dyspraxia 11/06

Waxhaw NC

/

[Guest guest]

http://213.4.18.135:8080/26.pdf

This is one article describing a study with cimetidine and similar drugs causing

elevated liver enzymes. The docs not ordering a simple blood test are not the

norm.

Fran

Fran Bulone RN

Mom to ph 7yr CIAS1 mutation 11/05; Dyspraxia 11/06

Waxhaw NC

/

[Guest guest]

They say it takes a VERY high dose on a daily basis for the liver enzymes to

rise or liver damage. I will talk to them again when I go in.

Re: Fran - cimetidine questions

Hi,

Not sure why the docs you see say this is not needed....

Fran

Fran Bulone RN

Mom to ph 7yr CIAS1 mutation 11/05; Dyspraxia 11/06

Waxhaw NC

/

[Guest guest]

Hi again

It is quite rare to see a chemical hepititis with Cimetidine however it is given

at the highest dose for PFS and we have seen it here at least a dozen times...

SO I would definitely want to check it... Maybe some of the parents are still on

board here and can post about it...

I remember one of the parents really upset and fearful.... but the baby's

enzymes returned to normal within a couple of weeks of coming off the

Cimetidine.

God Bless

Fran

Fran Bulone RN

Mom to ph 7yr CIAS1 mutation 11/05; Dyspraxia 11/06

Waxhaw NC

/

[Guest guest]

Hi

I just took Kianna in to get tested, I will get the results back on Monday,

I will keep you posted. She is on 800 milligrams a day. I think that's

pretty high.

Azzie mom to Kianna 9 yrs

From: [mailto: ] On Behalf Of Fran

Bulone

Sent: Saturday, January 27, 2007 1:02 PM

Subject: Re: Fran - cimetidine questions

Hi again

It is quite rare to see a chemical hepititis with Cimetidine however it is

given at the highest dose for PFS and we have seen it here at least a dozen

times... SO I would definitely want to check it... Maybe some of the parents

are still on board here and can post about it...

I remember one of the parents really upset and fearful.... but the baby's

enzymes returned to normal within a couple of weeks of coming off the

Cimetidine.

God Bless

Fran

Fran Bulone RN

Mom to ph 7yr CIAS1 mutation 11/05; Dyspraxia 11/06

Waxhaw NC

/