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Hear it here at EOHarm first!

Autism Speaks is about to announce that the head of NAAR, psychiatrist

Dr. London, is going to head up their Environmental

Research team. Our analogy? This is like asking a proctologist to run a

brain surgery clinic. Makes sense only if you have your head up your……

And we are thrilled to announce that Dan Olmsted has a

piece on Rescue Post today about the lead in toys controversy.

Dan, as you know, wrote the ground breaking series “The Age of Autism”

for UPI. You can comment to him and see his email address if you care to reach

him, in his Rescue Post piece.

See both articles at www.rescuepost.com.

Kim Stagliano

www.kimstagliano.blogspot.com

http://www.huffingtonpost.com/kim-stagliano/

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PERFECTION! On all accounts!

Thanks. :)

~

>

> Hear it here at EOHarm first!

>

>

>

> Autism Speaks is about to announce that the head of NAAR,

psychiatrist Dr.

> London, is going to head up their Environmental Research

team. Our

> analogy? This is like asking a proctologist to run a brain surgery

clinic.

> Makes sense only if you have your head up your..

>

>

>

> And we are thrilled to announce that Dan Olmsted has a piece on

Rescue Post

> today about the lead in toys controversy. Dan, as you know, wrote

the

> ground breaking series " The Age of Autism " for UPI. You can comment

to him

> and see his email address if you care to reach him, in his Rescue

Post

> piece.

>

>

>

> See both articles at www.rescuepost.com.

>

>

>

> Kim Stagliano

>

> <http://www.kimstagliano.blogspot.com>

www.kimstagliano.blogspot.com

>

> <http://www.huffingtonpost.com/kim-stagliano/>

> http://www.huffingtonpost.com/kim-stagliano/

>

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Lenny, may I transfer this post into the comments section of Rescue

Post, with your name? You make excellent points. This would prove

that Autism Speaks has no intention of changing it's NAAR roots.

We may have more to report soon. Let me know if I can run this as a

comment, on or offlist.

Thanks, KIM

In EOHarm , " schaferatsprynet " <schafer@...> wrote:

>

>

> >

> > Hear it here at EOHarm first!

> >

> > Autism Speaks is about to announce that the head of NAAR,

> psychiatrist Dr.

> > London, is going to head up their Environmental Research

team. Our

> > analogy? This is like asking a proctologist to run a brain surgery

> clinic.

> > Makes sense only if you have your head up your..

>

> Assuming your information is correct, Kim. . .interesting leak. If

> they are probing for early reactions, here's mine:

>

> London has long declared himself opposed to research into

> environmental issues and alternative biomedical treatments. A few

> years back he launched some attacks against Bernard Rimland and the

> ARI, essentially characterizing Rimland as a quack. London's NAAR

was

> also responsible for giving money to one of the fraudulent CDC

Danish

> studies, with the sole purpose of generating alibis for dirty

vaccines.

>

> If true, this announcement should taken as a clear signal that AS is

> not serious about taking the research to where the science leads

them,

> as Alison Singer recently pronounced. (And it should give us no

doubt

> that the NAAR faction is running Autism Speaks.) Environmental

> research is only chance Autism Speaks has for having a relevant

future

> with the autism community. Alternative biomedical treatment is where

> the community is taking their children in growing numbers. Parents

are

> in wholesale numbers abandoning faith in the genetics that AS has

> championed with the bulk of their money. Putting London, with his

> anti-treatment taint in charge of AS's new found interest in

> environmental research is a sober signal for how uncommitted AS is

to

> doing something real for autism. Surely AS can instead come up with

> toxicologist with clean political hands to do the job. Autism

Speaks

> is not part of the solution; it continues to appear to me to be part

> of the cover-up malignancy.

>

> Lenny

>

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Kim,

You are welcome to quote any of my humble comments for your blogs.

(But do leave me out of your funny autism book! Didn't kiss, nothing

to tell. . .)

Lenny

> > >

> > > Hear it here at EOHarm first!

> > >

> > > Autism Speaks is about to announce that the head of NAAR,

> > psychiatrist Dr.

> > > London, is going to head up their Environmental Research

> team. Our

> > > analogy? This is like asking a proctologist to run a brain surgery

> > clinic.

> > > Makes sense only if you have your head up your..

> >

> > Assuming your information is correct, Kim. . .interesting leak. If

> > they are probing for early reactions, here's mine:

> >

> > London has long declared himself opposed to research into

> > environmental issues and alternative biomedical treatments. A few

> > years back he launched some attacks against Bernard Rimland and the

> > ARI, essentially characterizing Rimland as a quack. London's NAAR

> was

> > also responsible for giving money to one of the fraudulent CDC

> Danish

> > studies, with the sole purpose of generating alibis for dirty

> vaccines.

> >

> > If true, this announcement should taken as a clear signal that AS is

> > not serious about taking the research to where the science leads

> them,

> > as Alison Singer recently pronounced. (And it should give us no

> doubt

> > that the NAAR faction is running Autism Speaks.) Environmental

> > research is only chance Autism Speaks has for having a relevant

> future

> > with the autism community. Alternative biomedical treatment is where

> > the community is taking their children in growing numbers. Parents

> are

> > in wholesale numbers abandoning faith in the genetics that AS has

> > championed with the bulk of their money. Putting London, with his

> > anti-treatment taint in charge of AS's new found interest in

> > environmental research is a sober signal for how uncommitted AS is

> to

> > doing something real for autism. Surely AS can instead come up with

> > toxicologist with clean political hands to do the job. Autism

> Speaks

> > is not part of the solution; it continues to appear to me to be part

> > of the cover-up malignancy.

> >

> > Lenny

> >

>

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Thanks. But I write fiction... I get to make stuff up! What's your

pleasure? LOL!

KS

> > > >

> > > > Hear it here at EOHarm first!

> > > >

> > > > Autism Speaks is about to announce that the head of NAAR,

> > > psychiatrist Dr.

> > > > London, is going to head up their Environmental Research

> > team. Our

> > > > analogy? This is like asking a proctologist to run a brain

surgery

> > > clinic.

> > > > Makes sense only if you have your head up your..

> > >

> > > Assuming your information is correct, Kim. . .interesting

leak. If

> > > they are probing for early reactions, here's mine:

> > >

> > > London has long declared himself opposed to research into

> > > environmental issues and alternative biomedical treatments. A

few

> > > years back he launched some attacks against Bernard Rimland and

the

> > > ARI, essentially characterizing Rimland as a quack. London's

NAAR

> > was

> > > also responsible for giving money to one of the fraudulent CDC

> > Danish

> > > studies, with the sole purpose of generating alibis for dirty

> > vaccines.

> > >

> > > If true, this announcement should taken as a clear signal that

AS is

> > > not serious about taking the research to where the science

leads

> > them,

> > > as Alison Singer recently pronounced. (And it should give us

no

> > doubt

> > > that the NAAR faction is running Autism Speaks.) Environmental

> > > research is only chance Autism Speaks has for having a relevant

> > future

> > > with the autism community. Alternative biomedical treatment is

where

> > > the community is taking their children in growing numbers.

Parents

> > are

> > > in wholesale numbers abandoning faith in the genetics that AS

has

> > > championed with the bulk of their money. Putting London, with

his

> > > anti-treatment taint in charge of AS's new found interest in

> > > environmental research is a sober signal for how uncommitted AS

is

> > to

> > > doing something real for autism. Surely AS can instead come up

with

> > > toxicologist with clean political hands to do the job. Autism

> > Speaks

> > > is not part of the solution; it continues to appear to me to be

part

> > > of the cover-up malignancy.

> > >

> > > Lenny

> > >

> >

>

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>

> Thanks. But I write fiction... I get to make stuff up! What's your

> pleasure? LOL!

>

> KS

>

This reminds me very little of an old Monty Python skit that satirizes

the BBC:

SECOND ANNOUNCER:

Good evening. A Book at Bedtime.

Alan Hutchinson reads another extract from a series of bedside books.

ALAN HUTCHINSON:

Number 32. The lady lies with her left leg planted firmly on the

ground and the right hand waiting. The gentleman with the melon

switches on the battery and places his left thigh on the edge of the

swivel table, keeping the neck of the .....

(fades out to music)

Well, I think Monty Python is hilarious, but they seem to have fallen

from their faulty towers.

Lenny

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Kim and others from my reliable sources I am told that there

are no plans for any announcement of a new head of environmental research.

In addition Dr. London is not taking on any new roles. Not sure where

you got the information but it is not accurate.

It seems to me we would all be better off making sure some good

environmental proposals get submitted to AS and then we can really have something

to judge. That to me will be the real test.

Marty

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>> Hear it here at EOHarm first!> > Autism Speaks is about to announce that the head of NAAR, psychiatrist Dr.> London, is going to head up their Environmental Research team. Our> analogy? This is like asking a proctologist to run a brain surgery clinic.> Makes sense only if you have your head up your..I'm having a really hard time understanding how you people think here.If you read something on a blog, do you accept it as fact without question?I decided to do a Medline search on London and it just happens that he published one of the very first peer reviewed articles calling for MORE environmental research into the etiologies of autism--see below. This was published in 2000! Don't any of you question these posts before you demonize another scientist or parent of an autistic child who's just struggling to find an answer that might even help your own children?? Dr. London isn't selling snake oil to unsuspecting parents like many of the practitioners who already claim to "know" the cause of autism. Wake up! I swear, many of you wouldn't know who was your best friend even if he was staring you right in the face.----------------------------------The Environment as an Etiologic Factor in Autism: A New Direction for Research London1,2 and Ruth A. Etzel31The National Alliance for Autism Research, Princeton, New Jersey,USA; 2University of Medicine and Dentistry of New Jersey, NewBrunswick, New Jersey, USA; 3Division of Epidemiology and RiskAssessment, Food Safety and Inspection Service, Washington, D.C., USA * Autism and the Interaction of Genes and Environment * Epidemiology of Autism * The Brick Township Cluster * The Neurobiology of Autism * Autism as a Birth Defect * Retinoid Research * The Case for Environmental Research in Autism AbstractAutism is one of a group of developmental disorders that havedevastating lifelong effects on its victims. Despite the severity ofthe disease and the fact that it is relatively common (15 in 10,000) ,there is still little understanding of its etiology. Although believedto be highly genetic, no abnormal genes have been found. Recentfindings in autism and in related disorders point to the possibilitythat the disease is caused by a gene-environment interaction.Epidemiologic studies indicate that the number of cases of autism isincreasing dramatically each year. It is not clear whether this is dueto a real increase in the disease or whether this is an artifact ofascertainment. A new theory regarding the etiology of autism suggeststhat it may be a disease of very early fetal development(approximately day 20-24 of gestation) . This theory has initiated newlines of investigation into developmental genes. Environmentalexposures during pregnancy could cause or contribute to autism basedon the neurobiology of these genes. Key words: autism, autismepidemiology, autism etiology, children, developmental disorders,retinoids, gene-environment interaction, Hox genes.-- Environ Health Perspect 108(suppl 3) :401-404 (2000) .http://ehpnet1.niehs.nih.gov/docs/2000/suppl-3/401-404london/abstract.htmlThe full article can be downloaded here:http://www.ehponline.org/members/2000/suppl-3/401-404london/london-full.html

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> " You people " ? Please explain, Pamela, how you ascertained that 2000

> people on this list accepted the information without question.

Somehow 1999 people on this list didn't bother to search for articles

published by Dr. London on Medline. Or else they decided to keep the

information to themselves.

Or perhaps 1999 people decided that one of the first peer reviewed

publications drawing attention to possible environmental etiologies of

autism and calling for more environmental research related to autism

was irrelevant to a discussion demonizing Dr. London.

> Money talks, b.s. walks.

And where're you walking to Lenny? ;-)

> London has done virtually nothing since then

> to fund scientists not doing the dirty vaccines alibi research he

> favors. Cite me the relevant environmental studies NAAR has undertaken

> that supports his 2000 assertion.

I'll do a bit more Medlining and see what appears--unless the 1999

others on this list have already done that and turned up zip.

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>

> Money talks, b.s. walks. London has done virtually nothing since then

> to fund scientists not doing the dirty vaccines alibi research he

> favors. Cite me the relevant environmental studies NAAR has undertaken

> that supports his 2000 assertion.

Geesh, Lenny, I hope you have a good pair of walking shoes.

I didn't even have to bother with Medline! From the AS website . . .

http://www.autismspeaks.org/science/programs/2007_grants.php [if you

want more studies, I'm sure you can find them in prior years grant

awards. " You people " just have to look for them.]

Alberto Ascherio, M.D., MPH

Harvard School of Public Health

$120,000 for two years

Maternal Risk Factors for Autism in the Nurses Health Study II – a

Pilot Study

(Co-Sponsor: The Higgins Family Charitable Foundation)

Established in 1989, the Nurses Health Study II has prospectively

evaluated many aspects of women's health in a cohort of over 100,000

women in the United States. The information collected on this group

include medical, obstetrical, and prospectively collected dietary

factors, as well as neurodevelopmental diagnosis of children born to

women in this cohort. This allows for a unique opportunity to

investigate a wide range of environmental factors, including maternal

dietary and reproductive factors, which may be associated with risk of

developing autism spectrum disorders. Diet and medical history of

mothers with a child with autism, as well as those who did not report

a child diagnosed with autism, will be studied using information

gathered prior to pregnancy. These children and their parents will be

screened using the social responsiveness scale (SRS) and then followed

up by the Autism Diagnostic Instrument-Revised (ADI-R). Utility of the

SRS, which measures autism severity using one quantifiable score, as a

diagnostic instrument will also be investigated in this study.

What this means for people with autism: In addition to diet and

obstetrical complications, this study will provide support to evaluate

the feasibility of using this extensive and well-researched project to

study risk factors associated with autism. This project provides a

unique opportunity to use existing data in order to determine the role

of environmental risk factors on neurodevelopment for a better

understanding of the cause and possible preventative measures.

Andre Sourander, M.D.

Turku University, Turku, Finland

$119,075 for two years

Early Developmental Risk Factors for Autism in a National Birth Cohort

This pilot study will establish a new project called the Finnish

Prenatal Study of Autism and Autism Spectrum Disorders (FiPS-A). The

FiPS-A is based on the Finnish Maternity Cohort (FMC), which consists

of virtually all births in Finland (N=1.1 million) from 1987- 2005.

The investigators will use maternal medical and exposure history

collected during pregnancy to examine if infection, hormonal

abnormalities and smoking are related to an increased risk of autism

in their children in a subset of these 1.1 million births. This study

will also be able to identify potential early risk factors including

improper growth and development before the child was diagnosed to

assess whether these parameters can be included in early signs of

autism. In addition to medical data, this project has the ability to

analyze blood samples that were drawn during pregnancy in a random

sample of children who are diagnosed with autism, and a random sample

of children without autism, all of whom were in the national FMC cohort.

What this means for people with autism: This project has the potential

to become one of the largest epidemiological studies to investigate

prenatal and perinatal risk factors in autism, including a large

biomarker repository to isolate possible early prenatal risk factors.

In addition to studying the longitudinal development of children who

later develop autism, multiple environmental factors, including

medical information from the mother and child, will be studied for

further analysis.

Harley Kornblum, M.D., Ph.D.

UCLA School of Medicine

$450,000 for 3 years

Molecular and Environmental Influences on Autism Pathophysiology

Multiple studies have reported abnormal brain growth in people with

autism, reflected by a larger head size early in development. This

feature, called " macrocephaly " is determined in part by the number of

times a cell divides as the brain matures. Using a cell culture

technique, this study will examine genetic mutations of two genes

associated with autism, PTEN and TSC on cell size and number. In

addition to genetic influences, environmental factors could influence

head size and cell division in the developing brain through production

of reactive oxygen species (ROS). At low doses that are not toxic to

neurons, these molecules have been known to produce changes in cell

number. The current study will examine if ROS stimulates cell division

through a similar pathway as PTEN and TSC mutations. The effects of

prenatal exposure to low levels of ROS on cells with and without

mutations of the PTEN gene will be assessed in parallel models to

determine the interaction of the two on both brain size and cell number.

What this means for people with autism: Both genetic susceptibility

and environmental factors have been linked to the cause of autism.

This research will help scientists understand the basic neurobiology

behind enlarged head size in people with autism, as well as isolate a

specific molecular mechanism where environmental influences can

interact with genetic factors to produce macrocephaly.

A. Kimberley McAllister, Ph.D.

University of California,

$450,000 for 3 years

Immune molecules and cortical synaptogenesis: possible implications

for the pathogenesis of autism

(Co-Sponsor: The Higgins Family Charitable Foundation)

Proper formation of connections in the brain during childhood provides

the substrate for adult perception, learning, memory, and cognition.

Tragically, improper formation or function of these connections may

lead to many neurodevelopmental disorders, including autism. Although

there is clearly a strong genetic component to autism, its incidence

also appears to be influenced by a wide range of environmental

factors. Many of these factors have in common the ability to alter

immune function. Since MHCI molecules are proteins that mediate the

immune response and that are also present on neurons, it is possible

that changes in expression of MHCI in the developing brain lead to the

cellular changes that contribute to autism.

Recently, Dr. McAllister's lab has discovered that MHCI molecules

negatively regulate the initial formation of connections in the

developing brain. This result is particularly exciting because it

implies that environmental factors that initiate an immune response

could dramatically affect connectivity in the developing brain and

thereby alter cognition. Since cytokines potently regulate MHCI

expression in the immune system and several cytokines have been found

to be upregulated in the brains of autistic children, it is possible

that these cytokines alter synaptic connectivity in the developing

brain by altering MHCI levels. This project will test this hypothesis.

What this means for people with autism: Results from these experiments

will identify whether alterations in MHCI levels could be involved in

the pathogenesis of autism. Elucidating the mechanisms by which MHCI

molecules act could reveal possible therapeutic targets for preventing

and/or treating autism.

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I said NAAR funded studies, not Autism Speaks. I am aware of the

environmental stuff favored by the CAN faction. As long as AS

specifically avoids looking at vaccines -- since that is the best

hypothesis around for the cause of " autism " -- I remain quite dubious

of such efforts as alibi research.

Lenny

> >

> > Money talks, b.s. walks. London has done virtually nothing since then

> > to fund scientists not doing the dirty vaccines alibi research he

> > favors. Cite me the relevant environmental studies NAAR has undertaken

> > that supports his 2000 assertion.

>

> Geesh, Lenny, I hope you have a good pair of walking shoes.

>

> I didn't even have to bother with Medline! From the AS website . . .

> http://www.autismspeaks.org/science/programs/2007_grants.php [if you

> want more studies, I'm sure you can find them in prior years grant

> awards. " You people " just have to look for them.]

>

>

> Alberto Ascherio, M.D., MPH

> Harvard School of Public Health

> $120,000 for two years

>

> Maternal Risk Factors for Autism in the Nurses Health Study II – a

> Pilot Study

> (Co-Sponsor: The Higgins Family Charitable Foundation)

>

> Established in 1989, the Nurses Health Study II has prospectively

> evaluated many aspects of women's health in a cohort of over 100,000

> women in the United States. The information collected on this group

> include medical, obstetrical, and prospectively collected dietary

> factors, as well as neurodevelopmental diagnosis of children born to

> women in this cohort. This allows for a unique opportunity to

> investigate a wide range of environmental factors, including maternal

> dietary and reproductive factors, which may be associated with risk of

> developing autism spectrum disorders. Diet and medical history of

> mothers with a child with autism, as well as those who did not report

> a child diagnosed with autism, will be studied using information

> gathered prior to pregnancy. These children and their parents will be

> screened using the social responsiveness scale (SRS) and then followed

> up by the Autism Diagnostic Instrument-Revised (ADI-R). Utility of the

> SRS, which measures autism severity using one quantifiable score, as a

> diagnostic instrument will also be investigated in this study.

>

> What this means for people with autism: In addition to diet and

> obstetrical complications, this study will provide support to evaluate

> the feasibility of using this extensive and well-researched project to

> study risk factors associated with autism. This project provides a

> unique opportunity to use existing data in order to determine the role

> of environmental risk factors on neurodevelopment for a better

> understanding of the cause and possible preventative measures.

>

>

> Andre Sourander, M.D.

> Turku University, Turku, Finland

> $119,075 for two years

>

> Early Developmental Risk Factors for Autism in a National Birth Cohort

>

> This pilot study will establish a new project called the Finnish

> Prenatal Study of Autism and Autism Spectrum Disorders (FiPS-A). The

> FiPS-A is based on the Finnish Maternity Cohort (FMC), which consists

> of virtually all births in Finland (N=1.1 million) from 1987- 2005.

> The investigators will use maternal medical and exposure history

> collected during pregnancy to examine if infection, hormonal

> abnormalities and smoking are related to an increased risk of autism

> in their children in a subset of these 1.1 million births. This study

> will also be able to identify potential early risk factors including

> improper growth and development before the child was diagnosed to

> assess whether these parameters can be included in early signs of

> autism. In addition to medical data, this project has the ability to

> analyze blood samples that were drawn during pregnancy in a random

> sample of children who are diagnosed with autism, and a random sample

> of children without autism, all of whom were in the national FMC cohort.

>

> What this means for people with autism: This project has the potential

> to become one of the largest epidemiological studies to investigate

> prenatal and perinatal risk factors in autism, including a large

> biomarker repository to isolate possible early prenatal risk factors.

> In addition to studying the longitudinal development of children who

> later develop autism, multiple environmental factors, including

> medical information from the mother and child, will be studied for

> further analysis.

>

>

> Harley Kornblum, M.D., Ph.D.

> UCLA School of Medicine

> $450,000 for 3 years

>

> Molecular and Environmental Influences on Autism Pathophysiology

>

> Multiple studies have reported abnormal brain growth in people with

> autism, reflected by a larger head size early in development. This

> feature, called " macrocephaly " is determined in part by the number of

> times a cell divides as the brain matures. Using a cell culture

> technique, this study will examine genetic mutations of two genes

> associated with autism, PTEN and TSC on cell size and number. In

> addition to genetic influences, environmental factors could influence

> head size and cell division in the developing brain through production

> of reactive oxygen species (ROS). At low doses that are not toxic to

> neurons, these molecules have been known to produce changes in cell

> number. The current study will examine if ROS stimulates cell division

> through a similar pathway as PTEN and TSC mutations. The effects of

> prenatal exposure to low levels of ROS on cells with and without

> mutations of the PTEN gene will be assessed in parallel models to

> determine the interaction of the two on both brain size and cell number.

>

> What this means for people with autism: Both genetic susceptibility

> and environmental factors have been linked to the cause of autism.

> This research will help scientists understand the basic neurobiology

> behind enlarged head size in people with autism, as well as isolate a

> specific molecular mechanism where environmental influences can

> interact with genetic factors to produce macrocephaly.

>

> A. Kimberley McAllister, Ph.D.

> University of California,

> $450,000 for 3 years

>

> Immune molecules and cortical synaptogenesis: possible implications

> for the pathogenesis of autism

> (Co-Sponsor: The Higgins Family Charitable Foundation)

>

> Proper formation of connections in the brain during childhood provides

> the substrate for adult perception, learning, memory, and cognition.

> Tragically, improper formation or function of these connections may

> lead to many neurodevelopmental disorders, including autism. Although

> there is clearly a strong genetic component to autism, its incidence

> also appears to be influenced by a wide range of environmental

> factors. Many of these factors have in common the ability to alter

> immune function. Since MHCI molecules are proteins that mediate the

> immune response and that are also present on neurons, it is possible

> that changes in expression of MHCI in the developing brain lead to the

> cellular changes that contribute to autism.

>

> Recently, Dr. McAllister's lab has discovered that MHCI molecules

> negatively regulate the initial formation of connections in the

> developing brain. This result is particularly exciting because it

> implies that environmental factors that initiate an immune response

> could dramatically affect connectivity in the developing brain and

> thereby alter cognition. Since cytokines potently regulate MHCI

> expression in the immune system and several cytokines have been found

> to be upregulated in the brains of autistic children, it is possible

> that these cytokines alter synaptic connectivity in the developing

> brain by altering MHCI levels. This project will test this hypothesis.

>

> What this means for people with autism: Results from these experiments

> will identify whether alterations in MHCI levels could be involved in

> the pathogenesis of autism. Elucidating the mechanisms by which MHCI

> molecules act could reveal possible therapeutic targets for preventing

> and/or treating autism.

>

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>

> And where're you walking to Lenny? ;-)

>

Where I go is of little importance. I am only one member of the mob

dragging public health research kicking and screaming to look into the

environmental causes of autism.

If London, and the rest of the expert mercury/vaccine apologists turn

out to be on the wrong path, they will be held accountable for helping

to extend the autism epidemic, causing thousands of more children to

suffer needlessly.

Lenny

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