Guest guest Posted June 21, 2006 Report Share Posted June 21, 2006 In addition, four other plasma-derived products remain on the market that contain or contained ethyl mercury preservatives. They are as follows: Antivenin (Crotalidae) Polyvalent (Equine); Pit viper snake antivenom, Wyeth Pharmaceuticals Inc Antivenin (Micrurus fulvius); Coral snake antivenom (Equine), Wyeth Pharmaceuticals Inc Crotalidae Polyvalent Immune Fab (Ovine); Pit viper snake antivenom, Protherics Inc Antivenin (Lacrodectus mactans); Black Widow spider antivenom Equine), Merck & Co, Inc Pit Viper [Antivenin (Crotalidae) Polyvalent, licensed 1954] and Coral Snake [Antivenin (Micrurus fulvius), licensed 1967] antivenoms by Wyeth These products are equine antisera. They are in lyophilized form and when reconstituted contain 0.005% thimerosal (50 micrograms per milliliter). The diluent, WFI, contains the preservative phenylmercuric nitrate at 0.001% concentration (10 micrograms per milliliter). A patient bitten by a snake may receive 15 or more vials (doses of 50 vials have been reported) if the envenomization is severe. A 15 vial dose of this antivenom would contain 4.7 milligrams of mercury. Wyeth plans to discontinue these products; however, the current supply will last several years, until each lot reaches its expiration date. Rattlesnake bites are dangerous and can cause serious morbidity or mortality. In the interest of the public health these products need to be available until sufficient ethyl mercury-free product can be provided to the public. Pit Viper antivenom [Crotalidae Polyvalent Immune Fab (Ovine) licensed October 2000, Protherics] Mercury is not added to the final product in the form of a preservative, but thimerosal is used to assure that the chromatography columns used in the manufacturing of this product do not become bacterially contaminated with repeated use. The product was approved but the ethyl mercury content was limited to not more than 104.5 micrograms ethyl mercury per vial, with a recommended maximum dose of 18 vials. A patient receiving this product would receive about 1.88 milligrams of mercury. > > > > > > Actually, I think the pre-1943 there were plenty of artistic > > Indians, just not any autistic Indians. The diagnosticians are > > spelling-challenged! > > > > > > Screws up everything. > Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.