Vaccine-induced immune responses reduce SIVmac239 concentrations

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http://www.therapeuticsdaily.com/news/article.cfm?contentvalue=1026049 & contenttype=sentryarticle & channelID=31 Vaccine-induced immune responses reduce SIVmac239 concentrations Vaccine Weekly - Aug. 02, 2006 & lt;a & gt; & lt;img & gt; & lt;/a & gt; 2006 AUG 2 - (NewsRx.com) -- Vaccine-induced cellular immune responses reduce plasma viral concentrations after repeated low-dose challenge with pathogenic simian immunodeficiency virus SIVmac239. "The goal of an AIDS vaccine regimen designed to induce cellular immune responses should be to reduce the viral set point and preserve memory CD4 lymphocytes. Here we investigated whether vaccine-induced cellular immunity in the absence of any Env-specific antibodies can control viral replication following multiple low-dose challenges with the highly pathogenic SIVmac239 isolate," investigators in the United States report. "Eight Mamu-A*01-positive Indian rhesus macaques were vaccinated with simian immunodeficiency virus (SIV) gag, tat, rev, and nef using a DNA prime-adenovirus boost strategy," said A. at the University of Wisconsin-Madison and collaborators. Peak viremia (p=0.007) and the chronic phase set point (p=0.0192) were significantly decreased in the vaccinated cohort, out to one year post-infection. Loss of CD4+ memory populations was also ameliorated in vaccinated animals. "Interestingly, only one of the eight vaccinees developed Env-specific neutralizing antibodies after infection. The control observed was significantly improved over that observed in animals vaccinated with SIV gag only," the authors noted. They concluded, "Vaccine-induced cellular immune responses can, therefore, exert a measure of control over replication of the AIDS virus in the complete absence of neutralizing antibody and give us hope that a vaccine designed to induce cellular immune responses might control viral replication." and her coauthors published their study in the

Journal of Virology (Vaccine-induced cellular immune responses reduce plasma viral concentrations after repeated low-dose challenge with pathogenic simian immunodeficiency virus SIVmac239. J Virol, 2006;80(12):5875-5885). For additional information, contact I. Watkins, Wisconsin National Primate Research Center, University of Wisconsin-Madison, 555 Science Drive, Madison, WI 53711, USA. E-mail: watkins@.... The publisher of the Journal of Virology can be contacted at: American Society for Microbiology, 1752 N Street NW, Washington, DC 20036-2904, USA. Keywords: Madison, Wisconsin, United States, AIDS and HIV Vaccine, Vaccine Development, Vaccine Efficacy, Immunology, Immunotherapy, Human Immunodeficiency Virus, Virology.

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