Cracking the Autism Puzzle

[Guest guest]

That's right, the genetics people will not be able to explain autism.

My recommendation- better go speak to an environmental toxicologist.

Cracking the Autism Puzzle

http://www.popsci.com/popsci/medicine/c8dedaef32d05010vgnvcm1000004eecbccdrcrd.html

Cracking the Autism PuzzleA pair of twins is born, and both infants begin to develop normally. By their first birthday, however, the male sibling has begun to diverge from his sister, showing less eye contact and affection. He often wears a spaced-out expression and fixates on certain puzzles and patterns. By age three, his mounting symptoms lead to a diagnosis that has become disturbingly routine in recent years: autism. What causes the disease, which now strikes 1 in every 166 children, and why does it affect four times as many boys as girls? Geneticists at the University of California at Los Angeles are closing in on the answers. This spring they announced that they had pinned down the likely location of an autism gene on chromosome 17. The evidence was found only in families with autistic males, indicating a hereditary basis for the disease’s gender bias. Reporting the discovery in the American Journal of Human Genetics, the scientists will next try to find the actual gene among the 50 or so clustered nearby, a painstaking process that could take another year. “If we’re lucky,” says co-author Rita Cantor, a professor of genetics at the university’s Geffen School of Medicine, “we’ll be able to explain 10 percent of autism.”

To complicate matters, researchers believe that the gene is probably just one of dozens linked to autism, many of which may trigger the disease only if a genetic predisposition is activated by some external factor.

So where does environment come into the picture? Although we have decoded our genome, our “envirome”—everything that influences a person after conception, from parenting to pollution—remains a fragmented riddle. To decipher the envirome’s role in the disease, Eaton, a psychiatrist at the Bloomberg School of Public Health at s Hopkins University, recently helped to conduct a large-scale study involving nearly 700 Danish children. Some intriguing correlations emerged. Scouring for trends among a host of parameters such as birth weight and socioeconomic status, scientists discovered an increased prevalence of autism both in children with a family history of schizophrenia and in those whose births involved complications such as premature or breech delivery.

Casting an even wider net than the Danish survey, researchers at the University of California at are conducting a study called CHARGE (Childhood Autism Risks from Genetics and the Environment) to scrutinize everything from genes to mercury exposure. “The hope is that we’ll find patterns,” says toxicologist Isaac Pessah, who is director of the school’s Center for Children’s Environmental Health. “We’re not looking for the magic bullet that causes autism.”

Churning through reams of data, the study has uncovered its first pattern: that certain proteins, metabolites and immune-system components in blood samples from autistic children differ sharply from normal ones. Announced in May at the International Meeting for Autism Research in Boston, the discovery could lead to the first-ever blood test for autism in newborns, allowing treatment to begin long before outward symptoms typically occur.

If autism is indeed caused by the complex interaction of genetic and external factors, Pessah believes that eliminating the environmental problems would be easier in the short term than the awesome biomolecular challenge of finding and altering the offending DNA. “I don’t think there’s going to be genetic intervention in my lifetime,” he says. There is only one other human disease, Pessah points out, that rivals autism in complexity. It’s called cancer.

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[Guest guest]

I met a mother with twin boys. When they were born, the hospital

mixed up the twins and vaccinated one of the twins twice with HEPB.

The boy they vaccinated twice is the one who is messed up, other boy

is fine.

> >

> >

>

http://www.popsci.com/popsci/medicine/c8dedaef32d05010vgnvcm1000004ee

> cbccdrcrd.html

> >

> > Cracking the Autism Puzzle

> >

> >

> >

> > A pair of twins is born, and both infants begin to develop

> normally. By their first birthday, however, the male sibling has

> begun to diverge from his sister, showing less eye contact and

> affection. He often wears a spaced-out expression and fixates on

> certain puzzles and patterns. By age three, his mounting symptoms

> lead to a diagnosis that has become disturbingly routine in recent

> years: autism. What causes the disease, which now strikes 1 in

> every 166 children, and why does it affect four times as many boys

> as girls? Geneticists at the University of California at Los

Angeles

> are closing in on the answers. This spring they announced that they

> had pinned down the likely location of an autism gene on chromosome

> 17. The evidence was found only in families with autistic males,

> indicating a hereditary basis for the disease's gender bias.

> Reporting the discovery in the American Journal of Human Genetics,

> the scientists will next try to find the actual gene among the 50

or

> so

>

[Guest guest]

And remember what Martha Herbert, MD, PhD, pediatric neurologist and

brain development researcher had to say about it?

" These researchers justify their hunt for autism genes by pointing to

studies of twins: while anywhere from 36 to 96 percent of both

identical twins have autistic features, this is true for only 0 to 33

percent of fraternal twins. The very spread of these figures shows

that claims of full genetic causation are flimsy; and these same

figures can equally be used to argue that environmental factors must

play a role, since the concordance for identical twins is not 100%. "

http://www.gene-watch.org/genewatch/articles/16-2herbert_silverman.html

>

> I met a mother with twin boys. When they were born, the hospital

> mixed up the twins and vaccinated one of the twins twice with HEPB.

> The boy they vaccinated twice is the one who is messed up, other boy

> is fine.

>

>

[Guest guest]

It was a pediatric neuro who said this?

Debi

> > >

> > > I met a mother with twin boys. When they were born, the

> hospital

> > > mixed up the twins and vaccinated one of the twins twice with

> HEPB.

> > > The boy they vaccinated twice is the one who is messed up,

> other boy

> > > is fine.

> > >

> > >

> >

> >

> >

> >

> >

> >

> >

[Guest guest]

yep.

> > > >

> > > > I met a mother with twin boys. When they were born, the

> > hospital

> > > > mixed up the twins and vaccinated one of the twins twice

with

> > HEPB.

> > > > The boy they vaccinated twice is the one who is messed up,

> > other boy

> > > > is fine.

> > > >

> > > >

> > >

> > >

> > >

> > >

> > >

> > >

> > >

[Guest guest]

By way of personal experience, many pediatric neurologists I have spoke to

(actually, all of them) haven't got a clue.

Then its really hard to consider them as real doctors isn't it Henry? Are

they that blind or that closed or that ignorant or perhaps they just don't

want to know. You would think that they think all the increases in chronic

neuroligical disease is being caused from a ray gun from Mars when you hear

they have not a clue.

One thing I am going to add to my MULLTIPLE CAUSES OF AUTISM chapter that I

overlooked in the orginal writing is radiation contamination. The kids today

are getting hit from all sides of the toxic fence.....and the pediatric

neuroligists must think its snowing out side and christmas....

Mark

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[Guest guest]

Yes, you're right.

I misread the piece.

I'm conditioned to the pediatric neurologists being completely daft on this issue.

She's made a go of it.

Re: Cracking the Autism Puzzle

And remember what Martha Herbert, MD, PhD, pediatric neurologist andbrain development researcher had to say about it? "These researchers justify their hunt for autism genes by pointing tostudies of twins: while anywhere from 36 to 96 percent of bothidentical twins have autistic features, this is true for only 0 to 33percent of fraternal twins. The very spread of these figures showsthat claims of full genetic causation are flimsy; and these samefigures can equally be used to argue that environmental factors mustplay a role, since the concordance for identical twins is not 100%." http://www.gene-watch.org/genewatch/articles/16-2herbert_silverman.html

[Guest guest]

And she didn't get knocked in the head????

<g>

Debi

> > > > >

> > > > > I met a mother with twin boys. When they were born, the

> > > hospital

> > > > > mixed up the twins and vaccinated one of the twins twice

> with

> > > HEPB.

> > > > > The boy they vaccinated twice is the one who is messed up,

> > > other boy

> > > > > is fine.

> > > > >

> > > > >

> > > >

> > > >

> > > >

> > > >

> > > >

> > > >

> > > >

[Guest guest]

in my fantasies it is much worse than that.

> > > > > >

> > > > > > I met a mother with twin boys. When they were born, the

> > > > hospital

> > > > > > mixed up the twins and vaccinated one of the twins

twice

> > with

> > > > HEPB.

> > > > > > The boy they vaccinated twice is the one who is messed

up,

> > > > other boy

> > > > > > is fine.

> > > > > >

> > > > > >

> > > > >

> > > > >

> > > > >

> > > > >

> > > > >

> > > > >

> > > > >

[Guest guest]

Regarding this article, here is a paragraph I find the most

interesting:

" Churning through reams of data, the study has uncovered its first

pattern: that certain proteins, metabolites and immune-system

components in blood samples from autistic children differ sharply

from normal ones. Announced in May at the International Meeting for

Autism Research in Boston, the discovery could lead to the first-

ever blood test for autism in newborns, allowing treatment to begin

long before outward symptoms typically occur. "

I find this interesting because:

1) We already know, according to this article and many others, that

autism is a genetic difference.

2) Now we know that " certain proteins, metabolites and immune-system

components in blood samples from autistic children differ sharply

from normal ones. "

3) Yet with every new discovery that autistics are genetically

different -and different in their physiognomy- people are STILL

trying to make autistics " normal " through cognitive therapies,

diets, hyperbaric chambers, etc.m regardless.

My points would be:

1) How can you make someone " normal " when they are obviously so very

dfifferent?

2) How can you expect treatments that work on " normal " people to

work on autistics anyway considering how different autistics are?

Tom

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