Re: Autism, A Little Understood Disorder May Have Genetic Roots

[Guest guest]

This article and the papers published by these researchers are very

misleading.

As Mark Blaxill illustrated so well with many examples in his science

presentation at Autism One this research on the P-ten gene is an

example of bullshit - let us call it what it is. The research on the

P-ten gene, rather than showing that autism is genetic proves the exact

opposite. Deleting the P-ten gene acts on the P13-kinase enzyme, the

same pathway that is affected by thimerosal and other toxins, as shown

in the work of Dr. Deth. P-ten deletion is fine as a research

technique but this kind of mutation is a rare occurrence in nature.

P-ten deletion is not a common occurrence in humans, but " activation "

of P13 kinase pathway can occur in anyone who is mercury toxic.

THere is no evidence that P-ten mutations are common in autism. The

conclusions suggested by the authors are completely misleading. Their

work helps confirm the thimerosal/vaccine/environmental hypothesis. I

would go so far as to say that, in my opinion, either the suggestions

made by the authors verge on being fraudulent (not saying that they

committed fraud) and are intended to procure more funding, or the

researchers are " blinded by genetics. " Most genetic research has this

characteristic - every metabolic pathway has a genetic root and can be

manipulated genetically. That has little relationship to showing that

autism has a genetic basis. Every disease, and life itself is genetic.

This genetic research is interesting and suggestive, but does little or

nothing to show genetic etiology for autism.

See abstract below of their paper:

Pten Regulates Neuronal Arborization and Social Interaction in Mice.

Kwon CH, Luikart BW, CM, Zhou J, Matheny SA, Zhang W, Li Y,

Baker SJ, Parada LF.

Center for Developmental Biology and Kent Waldrep Foundation Center for

Basic Neuroscience Research on Nerve Growth and Regeneration,

University of Texas Southwestern Medical Center, Dallas, Texas 75390;

Department of Developmental Neurobiology, St. Jude Children's Research

Hospital, Memphis, Tennessee 38105.

CNS deletion of Pten in the mouse has revealed its roles in controlling

cell size and number, thus providing compelling etiology for

macrocephaly and Lhermitte-Duclos disease. PTEN mutations in

individuals with autism spectrum disorders (ASD) have also been

reported, although a causal link between PTEN and ASD remains unclear.

In the present study, we deleted Pten in limited differentiated

neuronal populations in the cerebral cortex and hippocampus of mice.

Resulting mutant mice showed abnormal social interaction and

exaggerated responses to sensory stimuli. We observed macrocephaly and

neuronal hypertrophy, including hypertrophic and ectopic dendrites and

axonal tracts with increased synapses. This abnormal morphology was

associated with activation of the Akt/mTor/S6k pathway and inactivation

of Gsk3beta. Thus, our data suggest that abnormal activation of the

PI3K/AKT pathway in specific neuronal populations can underlie

macrocephaly and behavioral abnormalities reminiscent of certain

features of human ASD.

PMID: 16675393 [PubMed - as supplied by publisher]

On May 29, 2006, at 12:56 PM, Chap 'n Ali wrote:

>

>  

>  

> http://www.voanews.com/english/2006-05-29-voa16.cfm

>  

> Autism, A Little Understood Disorder May Have Genetic Roots

> By Carol Pearson

> Washington, DC

> 29 May 2006

>  

>

> watch Autism Gene report / Real broadband - download   <unknown.gif>

> watch Autism Gene report / Real broadband  <unknown.gif>

> watch Autism Gene report / Real dialup - download   <unknown.gif>

> watch Autism Gene report / Real dialup  <unknown.gif>

>

> Researchers at the University of Texas Southwestern have been able to

> genetically change mice so their behavior is similar to some people

> with autism.  The researchers hope their discovery will eventually

> lead to treatment for people with autism spectrum disorder.

>

> Mice are genetically similar to people which is why geneticists such

> as Lander study them. " We might think of ourselves as different

> than a mouse because we're so much bigger and we think we're so much

> smarter, but look inside, the organs are all the same. "

> <unknown.jpg>Professor Parada

>

> Including the brain.  Researchers led by Professor Parada at the

> University of Texas Southwestern have found that by deleting a gene

> called P-ten in certain parts of the mouse brain, they created mice

> that act like people with autism spectrum disorder, a range of

> disorders in which people have trouble with communication and social

> interaction:  they may not even look at people they are with.  They

> may also exhibit other strange behaviors: walking on their toes, and

> flapping their arms.

>

> Professor Parada directs the university's Center of

> Developmental Biology.  He says by genetically altering the mice, he

> got some of the same behavior as people who have autism. " The abnormal

> behaviors are based on the fact that mice are extremely social

> animals. "

> <unknown.jpg>

> Mice are generally interested in other mice, but not mice whose P-ten

> gene has been deleted. Professor Parada says the genetically altered

> mice have other social deficits. " If one gives mice in a box cotton

> material, they will quickly shred it and transform it into a

> three-dimensional nest and go and burrow under it.  When the mutant

> mice are given this nesting material they completely ignore it. "

>

> The genetically altered females also ignore their offspring.

>

> " The P-ten mice they wouldn't let you pick them up. They're just

> really skittish just like autistic children are.  They don't like to

> be picked up. "

>

> Autism affects about one in every 250 people, yet little is known

> about this disorder or how to treat it which is why the genetic

> research with mice is so important.

>

> “It gives us at least a first clue as to where the mutations in the

> brain could result in deficits in social interaction. " Professor

> Parada says the next step is to treat the genetically altered mice

> with drugs to see if it is possible to reverse the condition. The

> research might lead someday to a cure for autism spectrum disorder and

> similar genetic abnormalities in people.

>  

>  

>  

>  

>

[Guest guest]



This is the type of genetic research which is being conducted and funded by the various governmental agencies in order to discredit the fact that the government mandated and institutionalized a huge mercury toxicology test known as the mandatory vaccine program on the nation's children during the 1990's.

Re: Autism, A Little Understood Disorder May Have Genetic Roots

This article and the papers published by these researchers are very misleading.As Mark Blaxill illustrated so well with many examples in his science presentation at Autism One this research on the P-ten gene is an example of bullshit - let us call it what it is. The research on the P-ten gene, rather than showing that autism is genetic proves the exact opposite. Deleting the P-ten gene acts on the P13-kinase enzyme, the same pathway that is affected by thimerosal and other toxins, as shown in the work of Dr. Deth. P-ten deletion is fine as a research technique but this kind of mutation is a rare occurrence in nature. P-ten deletion is not a common occurrence in humans, but "activation" of P13 kinase pathway can occur in anyone who is mercury toxic.THere is no evidence that P-ten mutations are common in autism. The conclusions suggested by the authors are completely misleading. Their work helps confirm the thimerosal/vaccine/environmental hypothesis. I would go so far as to say that, in my opinion, either the suggestions made by the authors verge on being fraudulent (not saying that they committed fraud) and are intended to procure more funding, or the researchers are "blinded by genetics." Most genetic research has this characteristic - every metabolic pathway has a genetic root and can be manipulated genetically. That has little relationship to showing that autism has a genetic basis. Every disease, and life itself is genetic. This genetic research is interesting and suggestive, but does little or nothing to show genetic etiology for autism.See abstract below of their paper:Pten Regulates Neuronal Arborization and Social Interaction in Mice.Kwon CH, Luikart BW, CM, Zhou J, Matheny SA, Zhang W, Li Y, Baker SJ, Parada LF.Center for Developmental Biology and Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, Texas 75390; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105.CNS deletion of Pten in the mouse has revealed its roles in controlling cell size and number, thus providing compelling etiology for macrocephaly and Lhermitte-Duclos disease. PTEN mutations in individuals with autism spectrum disorders (ASD) have also been reported, although a causal link between PTEN and ASD remains unclear. In the present study, we deleted Pten in limited differentiated neuronal populations in the cerebral cortex and hippocampus of mice. Resulting mutant mice showed abnormal social interaction and exaggerated responses to sensory stimuli. We observed macrocephaly and neuronal hypertrophy, including hypertrophic and ectopic dendrites and axonal tracts with increased synapses. This abnormal morphology was associated with activation of the Akt/mTor/S6k pathway and inactivation of Gsk3beta. Thus, our data suggest that abnormal activation of the PI3K/AKT pathway in specific neuronal populations can underlie macrocephaly and behavioral abnormalities reminiscent of certain features of human ASD.PMID: 16675393 [PubMed - as supplied by publisher]On May 29, 2006, at 12:56 PM, Chap 'n Ali wrote:

http://www.voanews.com/english/2006-05-29-voa16.cfm Autism, A Little Understood Disorder May Have Genetic RootsBy Carol Pearson Washington, DC29 May 2006 watch Autism Gene report / Real broadband - download <unknown.gif>watch Autism Gene report / Real broadband <unknown.gif>watch Autism Gene report / Real dialup - download <unknown.gif>watch Autism Gene report / Real dialup <unknown.gif>Researchers at the University of Texas Southwestern have been able to genetically change mice so their behavior is similar to some people with autism. The researchers hope their discovery will eventually lead to treatment for people with autism spectrum disorder.Mice are genetically similar to people which is why geneticists such as Lander study them. "We might think of ourselves as different than a mouse because we're so much bigger and we think we're so much smarter, but look inside, the organs are all the same."<unknown.jpg>Professor ParadaIncluding the brain. Researchers led by Professor Parada at the University of Texas Southwestern have found that by deleting a gene called P-ten in certain parts of the mouse brain, they created mice that act like people with autism spectrum disorder, a range of disorders in which people have trouble with communication and social interaction: they may not even look at people they are with. They may also exhibit other strange behaviors: walking on their toes, and flapping their arms.Professor Parada directs the university's Center of Developmental Biology. He says by genetically altering the mice, he got some of the same behavior as people who have autism. "The abnormal behaviors are based on the fact that mice are extremely social animals."<unknown.jpg>Mice are generally interested in other mice, but not mice whose P-ten gene has been deleted. Professor Parada says the genetically altered mice have other social deficits. "If one gives mice in a box cotton material, they will quickly shred it and transform it into a three-dimensional nest and go and burrow under it. When the mutant mice are given this nesting material they completely ignore it."The genetically altered females also ignore their offspring."The P-ten mice they wouldn't let you pick them up. They're just really skittish just like autistic children are. They don't like to be picked up."Autism affects about one in every 250 people, yet little is known about this disorder or how to treat it which is why the genetic research with mice is so important.“It gives us at least a first clue as to where the mutations in the brain could result in deficits in social interaction." Professor Parada says the next step is to treat the genetically altered mice with drugs to see if it is possible to reverse the condition. The research might lead someday to a cure for autism spectrum disorder and similar genetic abnormalities in people.

[Guest guest]

Thank you , I only posted it to get

it discredited. You did that very well. -

From: EOHarm [mailto:EOHarm ] On Behalf Of J. Krakow

Sent: Monday, May 29, 2006 3:20 PM

EOHarm

Subject: Re: Autism, A

Little Understood Disorder May Have Genetic Roots

This article and the

papers published by these researchers are very misleading.

As Mark Blaxill illustrated so well with many examples in his science

presentation at Autism One this research on the P-ten gene is an example of

bullshit - let us call it what it is. The research on the P-ten gene, rather

than showing that autism is genetic proves the exact opposite. Deleting the

P-ten gene acts on the P13-kinase enzyme, the same pathway that is affected by

thimerosal and other toxins, as shown in the work of Dr. Deth. P-ten

deletion is fine as a research technique but this kind of mutation is a rare

occurrence in nature. P-ten deletion is not a common occurrence in humans, but

" activation " of P13 kinase pathway can occur in anyone who is mercury

toxic.

THere is no evidence that P-ten mutations are common in autism. The conclusions

suggested by the authors are completely misleading. Their work helps confirm

the thimerosal/vaccine/environmental hypothesis. I would go so far as to say

that, in my opinion, either the suggestions made by the authors verge on being

fraudulent (not saying that they committed fraud) and are intended to procure

more funding, or the researchers are " blinded by genetics. " Most

genetic research has this characteristic - every metabolic pathway has a

genetic root and can be manipulated genetically. That has little relationship

to showing that autism has a genetic basis. Every disease, and life itself is

genetic. This genetic research is interesting and suggestive, but does little or

nothing to show genetic etiology for autism.

See abstract below of their paper:

Pten Regulates Neuronal Arborization and Social

Interaction in Mice.

Kwon CH,

Luikart BW,

CM,

Zhou J,

Matheny SA,

Zhang W,

Li Y,

Baker SJ,

Parada LF.

Center for Developmental Biology and Kent Waldrep Foundation Center for Basic

Neuroscience Research on Nerve Growth and Regeneration, University of Texas

Southwestern Medical Center, Dallas, Texas 75390; Department of Developmental

Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105.

CNS deletion of Pten in the mouse has revealed its roles in controlling cell

size and number, thus providing compelling etiology for macrocephaly and

Lhermitte-Duclos disease. PTEN mutations in individuals with autism spectrum

disorders (ASD) have also been reported, although a causal link between PTEN

and ASD remains unclear. In the present study, we deleted Pten in limited

differentiated neuronal populations in the cerebral cortex and hippocampus of mice.

Resulting mutant mice showed abnormal social interaction and exaggerated

responses to sensory stimuli. We observed macrocephaly and neuronal

hypertrophy, including hypertrophic and ectopic dendrites and axonal tracts

with increased synapses. This abnormal morphology was associated with

activation of the Akt/mTor/S6k pathway and inactivation of Gsk3beta. Thus, our

data suggest that abnormal

activation of the PI3K/AKT pathway

in specific neuronal populations can underlie macrocephaly and behavioral abnormalities

reminiscent of certain features of human ASD.

PMID: 16675393 [PubMed - as supplied by publisher]

On May 29, 2006, at 12:56 PM, Chap 'n Ali wrote:

http://www.voanews.com/english/2006-05-29-voa16.cfm

Autism, A Little Understood Disorder May Have Genetic

Roots

By Carol Pearson

Washington,

DC

29 May 2006

watch Autism Gene report / Real broadband - download

<unknown.gif>

watch Autism Gene report / Real broadband <unknown.gif>

watch Autism Gene report / Real dialup - download

<unknown.gif>

watch Autism Gene report / Real dialup <unknown.gif>

Researchers

at the University

of Texas Southwestern

have been able to genetically change mice so their behavior is similar to some

people with autism. The researchers hope their discovery will eventually

lead to treatment for people with autism spectrum disorder.

Mice are genetically similar to

people which is why geneticists such as Lander study them. " We might

think of ourselves as different than a mouse because we're so much bigger and

we think we're so much smarter, but look inside, the organs are all the same. "

<unknown.jpg>Professor Parada

Including the brain.

Researchers led by Professor Parada at the University of Texas Southwestern

have found that by deleting a gene called P-ten in certain parts of the mouse

brain, they created mice that act like people with autism spectrum disorder, a

range of disorders in which people have trouble with communication and social

interaction: they may not even look at people they are with. They

may also exhibit other strange behaviors: walking on their toes, and flapping

their arms.

Professor Parada directs the

university's Center

of Developmental Biology.

He says by genetically altering the mice, he got some of the same behavior as

people who have autism. " The abnormal behaviors are based on the fact that

mice are extremely social animals. "

<unknown.jpg>

Mice are generally interested in

other mice, but not mice whose P-ten gene has been deleted. Professor Parada

says the genetically altered mice have other social deficits. " If one

gives mice in a box cotton material, they will quickly shred it and transform

it into a three-dimensional nest and go and burrow under it. When the

mutant mice are given this nesting material they completely ignore it. "

The genetically altered females

also ignore their offspring.

" The P-ten mice they

wouldn't let you pick them up. They're just really skittish just like autistic

children are. They don't like to be picked up. "

Autism affects about one in every

250 people, yet little is known about this disorder or how to treat it which is

why the genetic research with mice is so important.

“It gives us at least a first

clue as to where the mutations in the brain could result in deficits in social

interaction. " Professor Parada says the next step is to treat the

genetically altered mice with drugs to see if it is possible to reverse the

condition. The research might lead someday to a cure for autism spectrum disorder

and similar genetic abnormalities in people.

------------------------

[Guest guest]

, I understand and appreciate why you posted it. I did not for a

second believe that you posted the article to promote its content.

Thank you for posting it - we will see more use in the future of the

P-ten work to promote misleading conclusions about the role of genetics

in autism. Thank you.

On May 29, 2006, at 7:06 PM, Chap 'n Ali wrote:

>

> Thank you , I only posted it to get it discredited.  You did

> that very well.  -

>  

>

> From: EOHarm [mailto:EOHarm ] On Behalf

> Of J. Krakow

> Sent: Monday, May 29, 2006 3:20 PM

> EOHarm

> Subject: Re: Autism, A Little Understood Disorder May Have

> Genetic Roots

>  

>

> This article and the papers published by these researchers are very

> misleading.

>

> As Mark Blaxill illustrated so well with many examples in his science

> presentation at Autism One this research on the P-ten gene is an

> example of bullshit - let us call it what it is. The research on the

> P-ten gene, rather than showing that autism is genetic proves the

> exact opposite. Deleting the P-ten gene acts on the P13-kinase enzyme,

> the same pathway that is affected by thimerosal and other toxins, as

> shown in the work of Dr. Deth. P-ten deletion is fine as a

> research technique but this kind of mutation is a rare occurrence in

> nature. P-ten deletion is not a common occurrence in humans, but

> " activation " of P13 kinase pathway can occur in anyone who is mercury

> toxic.

>

> THere is no evidence that P-ten mutations are common in autism. The

> conclusions suggested by the authors are completely misleading. Their

> work helps confirm the thimerosal/vaccine/environmental hypothesis. I

> would go so far as to say that, in my opinion, either the suggestions

> made by the authors verge on being fraudulent (not saying that they

> committed fraud) and are intended to procure more funding, or the

> researchers are " blinded by genetics. " Most genetic research has this

> characteristic - every metabolic pathway has a genetic root and can be

> manipulated genetically. That has little relationship to showing that

> autism has a genetic basis. Every disease, and life itself is genetic.

> This genetic research is interesting and suggestive, but does little

> or nothing to show genetic etiology for autism.

>

> See abstract below of their paper:

> Pten Regulates Neuronal Arborization and Social Interaction in Mice.

>

> Kwon CH, Luikart BW, CM, Zhou J, Matheny SA, Zhang W, Li Y,

> Baker SJ, Parada LF.

>

> Center for Developmental Biology and Kent Waldrep Foundation Center

> for Basic Neuroscience Research on Nerve Growth and Regeneration,

> University of Texas Southwestern Medical Center, Dallas, Texas 75390;

> Department of Developmental Neurobiology, St. Jude Children's Research

> Hospital, Memphis, Tennessee 38105.

>

> CNS deletion of Pten in the mouse has revealed its roles in

> controlling cell size and number, thus providing compelling etiology

> for macrocephaly and Lhermitte-Duclos disease. PTEN mutations in

> individuals with autism spectrum disorders (ASD) have also been

> reported, although a causal link between PTEN and ASD remains unclear.

> In the present study, we deleted Pten in limited differentiated

> neuronal populations in the cerebral cortex and hippocampus of mice.

> Resulting mutant mice showed abnormal social interaction and

> exaggerated responses to sensory stimuli. We observed macrocephaly and

> neuronal hypertrophy, including hypertrophic and ectopic dendrites and

> axonal tracts with increased synapses. This abnormal morphology was

> associated with activation of the Akt/mTor/S6k pathway and

> inactivation of Gsk3beta. Thus, our data suggest that abnormal

> activation of the PI3K/AKT pathway in specific neuronal populations

> can underlie macrocephaly and behavioral abnormalities reminiscent of

> certain features of human ASD.

>

> PMID: 16675393 [PubMed - as supplied by publisher]

>

>

> On May 29, 2006, at 12:56 PM, Chap 'n Ali wrote:

>

>

>  

>  

> http://www.voanews.com/english/2006-05-29-voa16.cfm

>  

> Autism, A Little Understood Disorder May Have Genetic Roots

> By Carol Pearson

> Washington, DC

> 29 May 2006

>  

>

> watch Autism Gene report / Real broadband - download  <unknown.gif>

> watch Autism Gene report / Real broadband  <unknown.gif>

> watch Autism Gene report / Real dialup - download  <unknown.gif>

> watch Autism Gene report / Real dialup  <unknown.gif>

>

> Researchers at the University of Texas Southwestern have been able to

> genetically change mice so their behavior is similar to some people

> with autism.  The researchers hope their discovery will eventually

> lead to treatment for people with autism spectrum disorder.

>

> Mice are genetically similar to people which is why geneticists such

> as Lander study them. " We might think of ourselves as different

> than a mouse because we're so much bigger and we think we're so much

> smarter, but look inside, the organs are all the same. "

> <unknown.jpg>Professor Parada

>

> Including the brain.  Researchers led by Professor Parada at the

> University of Texas Southwesternhave found that by deleting a gene

> called P-ten in certain parts of the mouse brain, they created mice

> that act like people with autism spectrum disorder, a range of

> disorders in which people have trouble with communication and social

> interaction:  they may not even look at people they are with.  They

> may also exhibit other strange behaviors: walking on their toes, and

> flapping their arms.

>

> Professor Parada directs the university's Center of

> Developmental Biology.  He says by genetically altering the mice, he

> got some of the same behavior as people who have autism. " The abnormal

> behaviors are based on the fact that mice are extremely social

> animals. "

> <unknown.jpg>

> Mice are generally interested in other mice, but not mice whose P-ten

> gene has been deleted. Professor Parada says the genetically altered

> mice have other social deficits. " If one gives mice in a box cotton

> material, they will quickly shred it and transform it into a

> three-dimensional nest and go and burrow under it.  When the mutant

> mice are given this nesting material they completely ignore it. "

>

> The genetically altered females also ignore their offspring.

>

> " The P-ten mice they wouldn't let you pick them up. They're just

> really skittish just like autistic children are.  They don't like to

> be picked up. "

>

> Autism affects about one in every 250 people, yet little is known

> about this disorder or how to treat it which is why the genetic

> research with mice is so important.

>

> “It gives us at least a first clue as to where the mutations in the

> brain could result in deficits in social interaction. " Professor

> Parada says the next step is to treat the genetically altered mice

> with drugs to see if it is possible to reverse the condition. The

> research might lead someday to a cure for autism spectrum disorder and

> similar genetic abnormalities in people.

>  

>  

>  

>  

>

[Guest guest]

One more thing - it is troubling that Voice of America picked this up.

Clearly the P-ten research is being used as a propaganda and

disinformation tool. At the end the report refers to curing " autism

spectrum and other genetic disorders " as if it is now definitively

shown that autism is genetic. What a crock of bs.

On May 29, 2006, at 8:25 PM, J. Krakow wrote:

> , I understand and appreciate why you posted it. I did not for

> a second believe that you posted the article to promote its content.

> Thank you for posting it - we will see more use in the future of the

> P-ten work to promote misleading conclusions about the role of

> genetics in autism. Thank you.

>

> On May 29, 2006, at 7:06 PM, Chap 'n Ali wrote:

>

>>

>> Thank you , I only posted it to get it discredited.  You did

>> that very well.  -

>>  

>>

>> From: EOHarm [mailto:EOHarm ] On

>> Behalf Of J. Krakow

>> Sent: Monday, May 29, 2006 3:20 PM

>> EOHarm

>> Subject: Re: Autism, A Little Understood Disorder May Have

>> Genetic Roots

>>  

>>

>> This article and the papers published by these researchers are very

>> misleading.

>>

>> As Mark Blaxill illustrated so well with many examples in his

>> science presentation at Autism One this research on the P-ten gene is

>> an example of bullshit - let us call it what it is. The research on

>> the P-ten gene, rather than showing that autism is genetic proves the

>> exact opposite. Deleting the P-ten gene acts on the P13-kinase

>> enzyme, the same pathway that is affected by thimerosal and other

>> toxins, as shown in the work of Dr. Deth. P-ten deletion is

>> fine as a research technique but this kind of mutation is a rare

>> occurrence in nature. P-ten deletion is not a common occurrence in

>> humans, but " activation " of P13 kinase pathway can occur in anyone

>> who is mercury toxic.

>>

>> THere is no evidence that P-ten mutations are common in autism. The

>> conclusions suggested by the authors are completely misleading. Their

>> work helps confirm the thimerosal/vaccine/environmental hypothesis. I

>> would go so far as to say that, in my opinion, either the suggestions

>> made by the authors verge on being fraudulent (not saying that they

>> committed fraud) and are intended to procure more funding, or the

>> researchers are " blinded by genetics. " Most genetic research has this

>> characteristic - every metabolic pathway has a genetic root and can

>> be manipulated genetically. That has little relationship to showing

>> that autism has a genetic basis. Every disease, and life itself is

>> genetic. This genetic research is interesting and suggestive, but

>> does little or nothing to show genetic etiology for autism.

>>

>> See abstract below of their paper:

>> Pten Regulates Neuronal Arborization and Social Interaction in Mice.

>>

>> Kwon CH, Luikart BW, CM, Zhou J, Matheny SA, Zhang W, Li Y,

>> Baker SJ, Parada LF.

>>

>> Center for Developmental Biology and Kent Waldrep Foundation Center

>> for Basic Neuroscience Research on Nerve Growth and Regeneration,

>> University of Texas Southwestern Medical Center, Dallas, Texas 75390;

>> Department of Developmental Neurobiology, St. Jude Children's

>> Research Hospital, Memphis, Tennessee 38105.

>>

>> CNS deletion of Pten in the mouse has revealed its roles in

>> controlling cell size and number, thus providing compelling etiology

>> for macrocephaly and Lhermitte-Duclos disease. PTEN mutations in

>> individuals with autism spectrum disorders (ASD) have also been

>> reported, although a causal link between PTEN and ASD remains

>> unclear. In the present study, we deleted Pten in limited

>> differentiated neuronal populations in the cerebral cortex and

>> hippocampus of mice. Resulting mutant mice showed abnormal social

>> interaction and exaggerated responses to sensory stimuli. We observed

>> macrocephaly and neuronal hypertrophy, including hypertrophic and

>> ectopic dendrites and axonal tracts with increased synapses. This

>> abnormal morphology was associated with activation of the

>> Akt/mTor/S6k pathway and inactivation of Gsk3beta. Thus, our data

>> suggest that abnormal activation of the PI3K/AKT pathway in specific

>> neuronal populations can underlie macrocephaly and behavioral

>> abnormalities reminiscent of certain features of human ASD.

>>

>> PMID: 16675393 [PubMed - as supplied by publisher]

>>

>>

>> On May 29, 2006, at 12:56 PM, Chap 'n Ali wrote:

>>

>>

>>  

>>  

>> http://www.voanews.com/english/2006-05-29-voa16.cfm

>>  

>> Autism, A Little Understood Disorder May Have Genetic Roots

>> By Carol Pearson

>> Washington, DC

>> 29 May 2006

>>  

>>

>> watch Autism Gene report / Real broadband - download  <unknown.gif>

>> watch Autism Gene report / Real broadband  <unknown.gif>

>> watch Autism Gene report / Real dialup - download  <unknown.gif>

>> watch Autism Gene report / Real dialup  <unknown.gif>

>>

>> Researchers at the University of Texas Southwestern have been able to

>> genetically change mice so their behavior is similar to some people

>> with autism.  The researchers hope their discovery will eventually

>> lead to treatment for people with autism spectrum disorder.

>>

>> Mice are genetically similar to people which is why geneticists such

>> as Lander study them. " We might think of ourselves as different

>> than a mouse because we're so much bigger and we think we're so much

>> smarter, but look inside, the organs are all the same. "

>> <unknown.jpg>Professor Parada

>>

>> Including the brain.  Researchers led by Professor Parada at

>> the University of Texas Southwesternhave found that by deleting a

>> gene called P-ten in certain parts of the mouse brain, they created

>> mice that act like people with autism spectrum disorder, a range of

>> disorders in which people have trouble with communication and social

>> interaction:  they may not even look at people they are with.  They

>> may also exhibit other strange behaviors: walking on their toes, and

>> flapping their arms.

>>

>> Professor Parada directs the university's Center of

>> Developmental Biology.  He says by genetically altering the mice, he

>> got some of the same behavior as people who have autism. " The

>> abnormal behaviors are based on the fact that mice are extremely

>> social animals. "

>> <unknown.jpg>

>> Mice are generally interested in other mice, but not mice whose

>> P-ten gene has been deleted. Professor Parada says the genetically

>> altered mice have other social deficits. " If one gives mice in a box

>> cotton material, they will quickly shred it and transform it into a

>> three-dimensional nest and go and burrow under it.  When the mutant

>> mice are given this nesting material they completely ignore it. "

>>

>> The genetically altered females also ignore their offspring.

>>

>> " The P-ten mice they wouldn't let you pick them up. They're just

>> really skittish just like autistic children are.  They don't like to

>> be picked up. "

>>

>> Autism affects about one in every 250 people, yet little is known

>> about this disorder or how to treat it which is why the genetic

>> research with mice is so important.

>>

>> “It gives us at least a first clue as to where the mutations in the

>> brain could result in deficits in social interaction. " Professor

>> Parada says the next step is to treat the genetically altered mice

>> with drugs to see if it is possible to reverse the condition. The

>> research might lead someday to a cure for autism spectrum disorder

>> and similar genetic abnormalities in people.

>>  

>>  

>>

[Guest guest]



What exactly isn't being used as a propaganda and disinformation tool? How many billion dollars will the U.S. government invest in tail-chasing genetics research in order to exonerate ethylmercury's featured role in autimercurialpoisonism. They can spend a few G in order to once and for all establish a federal safe exposure level for ethylmercury and have that done in a few months.

You know what? Based on Burbacher's study, they can't do it. They know they can't do it. Which is exactly why Maggie Fox and Dr. Polly Sager were flapping around the blood work from the study even before the study was published about a year later.

http://www.autismcanada.org/News/ProbeintovaccinesFeb2004.htm

Dr. Polly Sager of the National Institute of Allergy and Infectious Disease will also speak to the panel. She reviewed several studies that show babies eliminate the mercury found in thimerosal within days.

"The fact that it is excreted in stool really is pretty exciting," she said in a telephone interview. "It is a simple concept -- if a kid is pooping out mercury, it is not in their body, it is not getting to theirbrain, it can't do damage."

Re: Autism, A Little Understood Disorder May Have Genetic Roots

One more thing - it is troubling that Voice of America picked this up. Clearly the P-ten research is being used as a propaganda and disinformation tool. At the end the report refers to curing "autism spectrum and other genetic disorders" as if it is now definitively shown that autism is genetic. What a crock of bs.On May 29, 2006, at 8:25 PM, J. Krakow wrote:

, I understand and appreciate why you posted it. I did not for a second believe that you posted the article to promote its content. Thank you for posting it - we will see more use in the future of the P-ten work to promote misleading conclusions about the role of genetics in autism. Thank you.On May 29, 2006, at 7:06 PM, Chap 'n Ali wrote:

Thank you , I only posted it to get it discredited. You did that very well. - From: EOHarm [mailto:EOHarm ] On Behalf Of J. KrakowSent: Monday, May 29, 2006 3:20 PMEOHarm Subject: Re: Autism, A Little Understood Disorder May Have Genetic Roots This article and the papers published by these researchers are very misleading.As Mark Blaxill illustrated so well with many examples in his science presentation at Autism One this research on the P-ten gene is an example of bullshit - let us call it what it is. The research on the P-ten gene, rather than showing that autism is genetic proves the exact opposite. Deleting the P-ten gene acts on the P13-kinase enzyme, the same pathway that is affected by thimerosal and other toxins, as shown in the work of Dr. Deth. P-ten deletion is fine as a research technique but this kind of mutation is a rare occurrence in nature. P-ten deletion is not a common occurrence in humans, but "activation" of P13 kinase pathway can occur in anyone who is mercury toxic.THere is no evidence that P-ten mutations are common in autism. The conclusions suggested by the authors are completely misleading. Their work helps confirm the thimerosal/vaccine/environmental hypothesis. I would go so far as to say that, in my opinion, either the suggestions made by the authors verge on being fraudulent (not saying that they committed fraud) and are intended to procure more funding, or the researchers are "blinded by genetics." Most genetic research has this characteristic - every metabolic pathway has a genetic root and can be manipulated genetically. That has little relationship to showing that autism has a genetic basis. Every disease, and life itself is genetic. This genetic research is interesting and suggestive, but does little or nothing to show genetic etiology for autism.See abstract below of their paper:Pten Regulates Neuronal Arborization and Social Interaction in Mice.Kwon CH, Luikart BW, CM, Zhou J, Matheny SA, Zhang W, Li Y, Baker SJ, Parada LF.Center for Developmental Biology and Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, Texas 75390; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105.CNS deletion of Pten in the mouse has revealed its roles in controlling cell size and number, thus providing compelling etiology for macrocephaly and Lhermitte-Duclos disease. PTEN mutations in individuals with autism spectrum disorders (ASD) have also been reported, although a causal link between PTEN and ASD remains unclear. In the present study, we deleted Pten in limited differentiated neuronal populations in the cerebral cortex and hippocampus of mice. Resulting mutant mice showed abnormal social interaction and exaggerated responses to sensory stimuli. We observed macrocephaly and neuronal hypertrophy, including hypertrophic and ectopic dendrites and axonal tracts with increased synapses. This abnormal morphology was associated with activation of the Akt/mTor/S6k pathway and inactivation of Gsk3beta. Thus, our data suggest that abnormal activation of the PI3K/AKT pathway in specific neuronal populations can underlie macrocephaly and behavioral abnormalities reminiscent of certain features of human ASD.PMID: 16675393 [PubMed - as supplied by publisher]On May 29, 2006, at 12:56 PM, Chap 'n Ali wrote: http://www.voanews.com/english/2006-05-29-voa16.cfm Autism, A Little Understood Disorder May Have Genetic RootsBy Carol Pearson Washington, DC29 May 2006 watch Autism Gene report / Real broadband - download <unknown.gif>watch Autism Gene report / Real broadband <unknown.gif>watch Autism Gene report / Real dialup - download <unknown.gif>watch Autism Gene report / Real dialup <unknown.gif>Researchers at the University of Texas Southwestern have been able to genetically change mice so their behavior is similar to some people with autism. The researchers hope their discovery will eventually lead to treatment for people with autism spectrum disorder.Mice are genetically similar to people which is why geneticists such as Lander study them. "We might think of ourselves as different than a mouse because we're so much bigger and we think we're so much smarter, but look inside, the organs are all the same."<unknown.jpg>Professor ParadaIncluding the brain. Researchers led by Professor Parada at the University of Texas Southwesternhave found that by deleting a gene called P-ten in certain parts of the mouse brain, they created mice that act like people with autism spectrum disorder, a range of disorders in which people have trouble with communication and social interaction: they may not even look at people they are with. They may also exhibit other strange behaviors: walking on their toes, and flapping their arms.Professor Parada directs the university's Center of Developmental Biology. He says by genetically altering the mice, he got some of the same behavior as people who have autism. "The abnormal behaviors are based on the fact that mice are extremely social animals."<unknown.jpg>Mice are generally interested in other mice, but not mice whose P-ten gene has been deleted. Professor Parada says the genetically altered mice have other social deficits. "If one gives mice in a box cotton material, they will quickly shred it and transform it into a three-dimensional nest and go and burrow under it. When the mutant mice are given this nesting material they completely ignore it."The genetically altered females also ignore their offspring."The P-ten mice they wouldn't let you pick them up. They're just really skittish just like autistic children are. They don't like to be picked up."Autism affects about one in every 250 people, yet little is known about this disorder or how to treat it which is why the genetic research with mice is so important.“It gives us at least a first clue as to where the mutations in the brain could result in deficits in social interaction." Professor Parada says the next step is to treat the genetically altered mice with drugs to see if it is possible to reverse the condition. The research might lead someday to a cure for autism spectrum disorder and similar genetic abnormalities in people.

[Guest guest]

Another thing...epigenetic effects upon P-ten are not well understood. I wonder what effect various sources of mercury may have upon P-ten. Aasa" J. Krakow" <rkrakow@...> wrote: One more thing - it is troubling that Voice of America picked this up. Clearly the P-ten research is being used as a propaganda and disinformation tool. At the end the report refers to curing "autism spectrum and other genetic disorders" as if it is now definitively shown that autism is genetic. What a crock of bs.On May 29, 2006, at 8:25 PM, J. Krakow wrote:> , I understand and appreciate why you posted it. I did not for > a second believe that you posted the article to promote its content. > Thank you for posting it - we will see more use in the future of the > P-ten work to

promote misleading conclusions about the role of > genetics in autism. Thank you.>> On May 29, 2006, at 7:06 PM, Chap 'n Ali wrote:>>>>> Thank you , I only posted it to get it discredited. You did >> that very well. ->>  >>>> From: EOHarm [mailto:EOHarm ] On >> Behalf Of J. Krakow>> Sent: Monday, May 29, 2006 3:20 PM>> EOHarm >> Subject: Re: Autism, A Little Understood Disorder May Have >> Genetic Roots>>  >>>> This article and the papers published by these researchers are very >> misleading.>>>> As Mark Blaxill illustrated so well with many examples in his >> science presentation at Autism One this research on the P-ten gene is >> an example of bullshit -

let us call it what it is. The research on >> the P-ten gene, rather than showing that autism is genetic proves the >> exact opposite. Deleting the P-ten gene acts on the P13-kinase >> enzyme, the same pathway that is affected by thimerosal and other >> toxins, as shown in the work of Dr. Deth. P-ten deletion is >> fine as a research technique but this kind of mutation is a rare >> occurrence in nature. P-ten deletion is not a common occurrence in >> humans, but "activation" of P13 kinase pathway can occur in anyone >> who is mercury toxic.>>>> THere is no evidence that P-ten mutations are common in autism. The >> conclusions suggested by the authors are completely misleading. Their >> work helps confirm the thimerosal/vaccine/environmental hypothesis. I >> would go so far as to say that, in my opinion, either the suggestions

>> made by the authors verge on being fraudulent (not saying that they >> committed fraud) and are intended to procure more funding, or the >> researchers are "blinded by genetics." Most genetic research has this >> characteristic - every metabolic pathway has a genetic root and can >> be manipulated genetically. That has little relationship to showing >> that autism has a genetic basis. Every disease, and life itself is >> genetic. This genetic research is interesting and suggestive, but >> does little or nothing to show genetic etiology for autism.>>>> See abstract below of their paper:>> Pten Regulates Neuronal Arborization and Social Interaction in Mice.>>>> Kwon CH, Luikart BW, CM, Zhou J, Matheny SA, Zhang W, Li Y, >> Baker SJ, Parada LF.>>>> Center for Developmental Biology and Kent Waldrep Foundation

Center >> for Basic Neuroscience Research on Nerve Growth and Regeneration, >> University of Texas Southwestern Medical Center, Dallas, Texas 75390; >> Department of Developmental Neurobiology, St. Jude Children's >> Research Hospital, Memphis, Tennessee 38105.>>>> CNS deletion of Pten in the mouse has revealed its roles in >> controlling cell size and number, thus providing compelling etiology >> for macrocephaly and Lhermitte-Duclos disease. PTEN mutations in >> individuals with autism spectrum disorders (ASD) have also been >> reported, although a causal link between PTEN and ASD remains >> unclear. In the present study, we deleted Pten in limited >> differentiated neuronal populations in the cerebral cortex and >> hippocampus of mice. Resulting mutant mice showed abnormal social >> interaction and exaggerated responses to sensory

stimuli. We observed >> macrocephaly and neuronal hypertrophy, including hypertrophic and >> ectopic dendrites and axonal tracts with increased synapses. This >> abnormal morphology was associated with activation of the >> Akt/mTor/S6k pathway and inactivation of Gsk3beta. Thus, our data >> suggest that abnormal activation of the PI3K/AKT pathway in specific >> neuronal populations can underlie macrocephaly and behavioral >> abnormalities reminiscent of certain features of human ASD.>>>> PMID: 16675393 [PubMed - as supplied by publisher]>>>>>> On May 29, 2006, at 12:56 PM, Chap 'n Ali wrote:>>>>>> Â >> Â >> http://www.voanews.com/english/2006-05-29-voa16.cfm>> Â >> Autism, A Little Understood Disorder May Have Genetic Roots>> By Carol Pearson>>

Washington, DC>> 29 May 2006>>  >>>> watch Autism Gene report / Real broadband - download >> watch Autism Gene report / Real broadband  >> watch Autism Gene report / Real dialup - download >> watch Autism Gene report / Real dialup  >>>> Researchers at the University of Texas Southwestern have been able to >> genetically change mice so their behavior is similar to some people >> with autism. The researchers hope their discovery will eventually >> lead to treatment for people with autism spectrum disorder.>>>> Mice are genetically similar to people which is why geneticists such >> as Lander study them. "We might think of ourselves as different >> than a mouse because we're so much bigger and we think we're so much

>> smarter, but look inside, the organs are all the same.">> Professor Parada>>>> Including the brain. Researchers led by Professor Parada at >> the University of Texas Southwesternhave found that by deleting a >> gene called P-ten in certain parts of the mouse brain, they created >> mice that act like people with autism spectrum disorder, a range of >> disorders in which people have trouble with communication and social >> interaction: they may not even look at people they are with. They >> may also exhibit other strange behaviors: walking on their toes, and >> flapping their arms.>>>> Professor Parada directs the university's Center of >> Developmental Biology. He says by genetically altering the mice, he >> got some of the same behavior as people who have autism. "The

>> abnormal behaviors are based on the fact that mice are extremely >> social animals.">> >> Mice are generally interested in other mice, but not mice whose >> P-ten gene has been deleted. Professor Parada says the genetically >> altered mice have other social deficits. "If one gives mice in a box >> cotton material, they will quickly shred it and transform it into a >> three-dimensional nest and go and burrow under it. When the mutant >> mice are given this nesting material they completely ignore it.">>>> The genetically altered females also ignore their offspring.>>>> "The P-ten mice they wouldn't let you pick them up. They're just >> really skittish just like autistic children are. They don't like to >> be picked up.">>>> Autism affects about one in every 250 people, yet

little is known >> about this disorder or how to treat it which is why the genetic >> research with mice is so important.>>>> “It gives us at least a first clue as to where the mutations in the >> brain could result in deficits in social interaction." Professor >> Parada says the next step is to treat the genetically altered mice >> with drugs to see if it is possible to reverse the condition. The >> research might lead someday to a cure for autism spectrum disorder >> and similar genetic abnormalities in people.>>  >>  >>

[Guest guest]

Another thing...epigenetic effects upon P-ten are not well understood. I wonder what effect various sources of mercury may have upon P-ten. Aasa" J. Krakow" <rkrakow@...> wrote: One more thing - it is troubling that Voice of America picked this up. Clearly the P-ten research is being used as a propaganda and disinformation tool. At the end the report refers to curing "autism spectrum and other genetic disorders" as if it is now definitively shown that autism is genetic. What a crock of bs.On May 29, 2006, at 8:25 PM, J. Krakow wrote:> , I understand and appreciate why you posted it. I did not for > a second believe that you posted the article to promote its content. > Thank you for posting it - we will see more use in the future of the > P-ten work to

promote misleading conclusions about the role of > genetics in autism. Thank you.>> On May 29, 2006, at 7:06 PM, Chap 'n Ali wrote:>>>>> Thank you , I only posted it to get it discredited. You did >> that very well. ->>  >>>> From: EOHarm [mailto:EOHarm ] On >> Behalf Of J. Krakow>> Sent: Monday, May 29, 2006 3:20 PM>> EOHarm >> Subject: Re: Autism, A Little Understood Disorder May Have >> Genetic Roots>>  >>>> This article and the papers published by these researchers are very >> misleading.>>>> As Mark Blaxill illustrated so well with many examples in his >> science presentation at Autism One this research on the P-ten gene is >> an example of bullshit -

let us call it what it is. The research on >> the P-ten gene, rather than showing that autism is genetic proves the >> exact opposite. Deleting the P-ten gene acts on the P13-kinase >> enzyme, the same pathway that is affected by thimerosal and other >> toxins, as shown in the work of Dr. Deth. P-ten deletion is >> fine as a research technique but this kind of mutation is a rare >> occurrence in nature. P-ten deletion is not a common occurrence in >> humans, but "activation" of P13 kinase pathway can occur in anyone >> who is mercury toxic.>>>> THere is no evidence that P-ten mutations are common in autism. The >> conclusions suggested by the authors are completely misleading. Their >> work helps confirm the thimerosal/vaccine/environmental hypothesis. I >> would go so far as to say that, in my opinion, either the suggestions

>> made by the authors verge on being fraudulent (not saying that they >> committed fraud) and are intended to procure more funding, or the >> researchers are "blinded by genetics." Most genetic research has this >> characteristic - every metabolic pathway has a genetic root and can >> be manipulated genetically. That has little relationship to showing >> that autism has a genetic basis. Every disease, and life itself is >> genetic. This genetic research is interesting and suggestive, but >> does little or nothing to show genetic etiology for autism.>>>> See abstract below of their paper:>> Pten Regulates Neuronal Arborization and Social Interaction in Mice.>>>> Kwon CH, Luikart BW, CM, Zhou J, Matheny SA, Zhang W, Li Y, >> Baker SJ, Parada LF.>>>> Center for Developmental Biology and Kent Waldrep Foundation

Center >> for Basic Neuroscience Research on Nerve Growth and Regeneration, >> University of Texas Southwestern Medical Center, Dallas, Texas 75390; >> Department of Developmental Neurobiology, St. Jude Children's >> Research Hospital, Memphis, Tennessee 38105.>>>> CNS deletion of Pten in the mouse has revealed its roles in >> controlling cell size and number, thus providing compelling etiology >> for macrocephaly and Lhermitte-Duclos disease. PTEN mutations in >> individuals with autism spectrum disorders (ASD) have also been >> reported, although a causal link between PTEN and ASD remains >> unclear. In the present study, we deleted Pten in limited >> differentiated neuronal populations in the cerebral cortex and >> hippocampus of mice. Resulting mutant mice showed abnormal social >> interaction and exaggerated responses to sensory

stimuli. We observed >> macrocephaly and neuronal hypertrophy, including hypertrophic and >> ectopic dendrites and axonal tracts with increased synapses. This >> abnormal morphology was associated with activation of the >> Akt/mTor/S6k pathway and inactivation of Gsk3beta. Thus, our data >> suggest that abnormal activation of the PI3K/AKT pathway in specific >> neuronal populations can underlie macrocephaly and behavioral >> abnormalities reminiscent of certain features of human ASD.>>>> PMID: 16675393 [PubMed - as supplied by publisher]>>>>>> On May 29, 2006, at 12:56 PM, Chap 'n Ali wrote:>>>>>> Â >> Â >> http://www.voanews.com/english/2006-05-29-voa16.cfm>> Â >> Autism, A Little Understood Disorder May Have Genetic Roots>> By Carol Pearson>>

Washington, DC>> 29 May 2006>>  >>>> watch Autism Gene report / Real broadband - download >> watch Autism Gene report / Real broadband  >> watch Autism Gene report / Real dialup - download >> watch Autism Gene report / Real dialup  >>>> Researchers at the University of Texas Southwestern have been able to >> genetically change mice so their behavior is similar to some people >> with autism. The researchers hope their discovery will eventually >> lead to treatment for people with autism spectrum disorder.>>>> Mice are genetically similar to people which is why geneticists such >> as Lander study them. "We might think of ourselves as different >> than a mouse because we're so much bigger and we think we're so much

>> smarter, but look inside, the organs are all the same.">> Professor Parada>>>> Including the brain. Researchers led by Professor Parada at >> the University of Texas Southwesternhave found that by deleting a >> gene called P-ten in certain parts of the mouse brain, they created >> mice that act like people with autism spectrum disorder, a range of >> disorders in which people have trouble with communication and social >> interaction: they may not even look at people they are with. They >> may also exhibit other strange behaviors: walking on their toes, and >> flapping their arms.>>>> Professor Parada directs the university's Center of >> Developmental Biology. He says by genetically altering the mice, he >> got some of the same behavior as people who have autism. "The

>> abnormal behaviors are based on the fact that mice are extremely >> social animals.">> >> Mice are generally interested in other mice, but not mice whose >> P-ten gene has been deleted. Professor Parada says the genetically >> altered mice have other social deficits. "If one gives mice in a box >> cotton material, they will quickly shred it and transform it into a >> three-dimensional nest and go and burrow under it. When the mutant >> mice are given this nesting material they completely ignore it.">>>> The genetically altered females also ignore their offspring.>>>> "The P-ten mice they wouldn't let you pick them up. They're just >> really skittish just like autistic children are. They don't like to >> be picked up.">>>> Autism affects about one in every 250 people, yet

little is known >> about this disorder or how to treat it which is why the genetic >> research with mice is so important.>>>> “It gives us at least a first clue as to where the mutations in the >> brain could result in deficits in social interaction." Professor >> Parada says the next step is to treat the genetically altered mice >> with drugs to see if it is possible to reverse the condition. The >> research might lead someday to a cure for autism spectrum disorder >> and similar genetic abnormalities in people.>>  >>  >>

[Guest guest]

Good point. Precisely. Thimerosal effects on methionine synthase or

other pathways may effect DNA methylation of P-ten, effectively

knocking it out. Not a mutation but an environmental effect.

On May 30, 2006, at 12:21 AM, Aasa wrote:

> Another thing...epigenetic effects upon P-ten are not well

> understood. I wonder what effect various sources of mercury may have

> upon P-ten.  Aasa

>

> " J. Krakow " <rkrakow@...> wrote:One more thing - it

> is troubling that Voice of America picked this up.

>> Clearly the P-ten research is being used as a propaganda and

>> disinformation tool. At the end the report refers to curing " autism

>> spectrum and other genetic disorders " as if it is now definitively

>> shown that autism is genetic. What a crock of bs.

>>

>> On May 29, 2006, at 8:25 PM, J. Krakow wrote:

>>

>> > , I understand and appreciate why you posted it. I did not

>> for

>> > a second believe that you posted the article to promote its content.

>> > Thank you for posting it - we will see more use in the future of the

>> > P-ten work to promote misleading conclusions about the role of

>> > genetics in autism. Thank you.

>> >

>> > On May 29, 2006, at 7:06 PM, Chap 'n Ali wrote:

>> >

>> >>

>> >> Thank you , I only posted it to get it discredited.  You did

>> >> that very well.  -

>> >>  

>> >>

>> >> From: EOHarm [mailto:EOHarm ] On

>> >> Behalf Of J. Krakow

>> >> Sent: Monday, May 29, 2006 3:20 PM

>> >> EOHarm

>> >> Subject: Re: Autism, A Little Understood Disorder May Have

>> >> Genetic Roots

>> >>  

>> >>

>> >> This article and the papers published by these researchers are very

>> >> misleading.

>> >>

>> >> As Mark Blaxill illustrated so well with many examples in his

>> >> science presentation at Autism One this research on the P-ten gene

>> is

>> >> an example of bullshit - let us call it what it is. The research on

>> >> the P-ten gene, rather than showing that autism is genetic proves

>> the

>> >> exact opposite. Deleting the P-ten gene acts on the P13-kinase

>> >> enzyme, the same pathway that is affected by thimerosal and other

>> >> toxins, as shown in the work of Dr. Deth. P-ten deletion is

>> >> fine as a research technique but this kind of mutation is a rare

>> >> occurrence in nature. P-ten deletion is not a common occurrence in

>> >> humans, but " activation " of P13 kinase pathway can occur in anyone

>> >> who is mercury toxic.

>> >>

>> >> THere is no evidence that P-ten mutations are common in autism. The

>> >> conclusions suggested by the authors are completely misleading.

>> Their

>> >> work helps confirm the thimerosal/vaccine/environmental

>> hypothesis. I

>> >> would go so far as to say that, in my opinion, either the

>> suggestions

>> >> made by the authors verge on being fraudulent (not saying that they

>> >> committed fraud) and are intended to procure more funding, or the

>> >> researchers are " blinded by genetics. " Most genetic research has

>> this

>> >> characteristic - every metabolic pathway has a genetic root and can

>> >> be manipulated genetically. That has little relationship to showing

>> >> that autism has a genetic basis. Every disease, and life itself is

>> >> genetic. This genetic research is interesting and suggestive, but

>> >> does little or nothing to show genetic etiology for autism.

>> >>

>> >> See abstract below of their paper:

>> >> Pten Regulates Neuronal Arborization and Social Interaction in

>> Mice.

>> >>

>> >> Kwon CH, Luikart BW, CM, Zhou J, Matheny SA, Zhang W, Li Y,

>> >> Baker SJ, Parada LF.

>> >>

>> >> Center for Developmental Biology and Kent Waldrep Foundation Center

>> >> for Basic Neuroscience Research on Nerve Growth and Regeneration,

>> >> University of Texas Southwestern Medical Center, Dallas, Texas

>> 75390;

>> >> Department of Developmental Neurobiology, St. Jude Children's

>> >> Research Hospital, Memphis, Tennessee 38105.

>> >>

>> >> CNS deletion of Pten in the mouse has revealed its roles in

>> >> controlling cell size and number, thus providing compelling

>> etiology

>> >> for macrocephaly and Lhermitte-Duclos disease. PTEN mutations in

>> >> individuals with autism spectrum disorders (ASD) have also been

>> >> reported, although a causal link between PTEN and ASD remains

>> >> unclear. In the present study, we deleted Pten in limited

>> >> differentiated neuronal populations in the cerebral cortex and

>> >> hippocampus of mice. Resulting mutant mice showed abnormal social

>> >> interaction and exaggerated responses to sensory stimuli. We

>> observed

>> >> macrocephaly and neuronal hypertrophy, including hypertrophic and

>> >> ectopic dendrites and axonal tracts with increased synapses. This

>> >> abnormal morphology was associated with activation of the

>> >> Akt/mTor/S6k pathway and inactivation of Gsk3beta. Thus, our data

>> >> suggest that abnormal activation of the PI3K/AKT pathway in

>> specific

>> >> neuronal populations can underlie macrocephaly and behavioral

>> >> abnormalities reminiscent of certain features of human ASD.

>> >>

>> >> PMID: 16675393 [PubMed - as supplied by publisher]

>> >>

>> >>

>> >> On May 29, 2006, at 12:56 PM, Chap 'n Ali wrote:

>> >>

>> >>

>> >>  

>> >>  

>> >> http://www.voanews.com/english/2006-05-29-voa16.cfm

>> >>  

>> >> Autism, A Little Understood Disorder May Have Genetic Roots

>> >> By Carol Pearson

>> >> Washington, DC

>> >> 29 May 2006

>> >>  

>> >>

>> >> watch Autism Gene report / Real broadband - download 

>> >> watch Autism Gene report / Real broadband  

>> >> watch Autism Gene report / Real dialup - download 

>> >> watch Autism Gene report / Real dialup  

>> >>

>> >> Researchers at the University of Texas Southwestern have been able

>> to

>> >> genetically change mice so their behavior is similar to some people

>> >> with autism.  The researchers hope their discovery will eventually

>> >> lead to treatment for people with autism spectrum disorder.

>> >>

>> >> Mice are genetically similar to people which is why geneticists

>> such

>> >> as Lander study them. " We might think of ourselves as

>> different

>> >> than a mouse because we're so much bigger and we think we're so

>> much

>> >> smarter, but look inside, the organs are all the same. "

>> >> Professor Parada

>> >>

>> >> Including the brain.  Researchers led by Professor Parada at

>> >> the University of Texas Southwesternhave found that by deleting a

>> >> gene called P-ten in certain parts of the mouse brain, they created

>> >> mice that act like people with autism spectrum disorder, a range of

>> >> disorders in which people have trouble with communication and

>> social

>> >> interaction:  they may not even look at people they are with. 

>> They

>> >> may also exhibit other strange behaviors: walking on their toes,

>> and

>> >> flapping their arms.

>> >>

>> >> Professor Parada directs the university's Center of

>> >> Developmental Biology.  He says by genetically altering the mice,

>> he

>> >> got some of the same behavior as people who have autism. " The

>> >> abnormal behaviors are based on the fact that mice are extremely

>> >> social animals. "

>> >>

>> >> Mice are generally interested in other mice, but not mice whose

>> >> P-ten gene has been deleted. Professor Parada says the genetically

>> >> altered mice have other social deficits. " If one gives mice in a

>> box

>> >> cotton material, they will quickly shred it and transform it into a

>> >> three-dimensional nest and go and burrow under it.  When the

>> mutant

>> >> mice are given this nesting material they completely ignore it. "

>> >>

>> >> The genetically altered females also ignore their offspring.

>> >>

>> >> " The P-ten mice they wouldn't let you pick them up. They're just

>> >> really skittish just like autistic children are.  They don't like

>> to

>> >> be picked up. "

>> >>

>> >> Autism affects about one in every 250 people, yet little is known

>> >> about this disorder or how to treat it which is why the genetic

>> >> research with mice is so important.

>> >>

>> >> “It gives us at least a first clue as to where the mutations in

>> the

>> >> brain could result in deficits in social interaction. " Professor

>> >> Parada says the next step is to treat the genetically altered mice

>> >> with drugs to see if it is possible to reverse the condition. The

>> >> research might lead someday to a cure for autism spectrum disorder

>> >> and similar genetic abnormalities in people.

>> >>  

>> >>  

>> >>

[Guest guest]



Flapping around? Are you saying they are mercury toxic and don't even know it.

They really are oxymoronic!

Re: Autism, A Little Understood Disorder May Have Genetic Roots

One more thing - it is troubling that Voice of America picked this up. Clearly the P-ten research is being used as a propaganda and disinformation tool. At the end the report refers to curing "autism spectrum and other genetic disorders" as if it is now definitively shown that autism is genetic. What a crock of bs.On May 29, 2006, at 8:25 PM, J. Krakow wrote:

, I understand and appreciate why you posted it. I did not for a second believe that you posted the article to promote its content. Thank you for posting it - we will see more use in the future of the P-ten work to promote misleading conclusions about the role of genetics in autism. Thank you.On May 29, 2006, at 7:06 PM, Chap 'n Ali wrote:

Thank you , I only posted it to get it discredited. You did that very well. - From: EOHarm [mailto:EOHarm ] On Behalf Of J. KrakowSent: Monday, May 29, 2006 3:20 PMEOHarm Subject: Re: Autism, A Little Understood Disorder May Have Genetic Roots This article and the papers published by these researchers are very misleading.As Mark Blaxill illustrated so well with many examples in his science presentation at Autism One this research on the P-ten gene is an example of bullshit - let us call it what it is. The research on the P-ten gene, rather than showing that autism is genetic proves the exact opposite. Deleting the P-ten gene acts on the P13-kinase enzyme, the same pathway that is affected by thimerosal and other toxins, as shown in the work of Dr. Deth. P-ten deletion is fine as a research technique but this kind of mutation is a rare occurrence in nature. P-ten deletion is not a common occurrence in humans, but "activation" of P13 kinase pathway can occur in anyone who is mercury toxic.THere is no evidence that P-ten mutations are common in autism. The conclusions suggested by the authors are completely misleading. Their work helps confirm the thimerosal/vaccine/environmental hypothesis. I would go so far as to say that, in my opinion, either the suggestions made by the authors verge on being fraudulent (not saying that they committed fraud) and are intended to procure more funding, or the researchers are "blinded by genetics." Most genetic research has this characteristic - every metabolic pathway has a genetic root and can be manipulated genetically. That has little relationship to showing that autism has a genetic basis. Every disease, and life itself is genetic. This genetic research is interesting and suggestive, but does little or nothing to show genetic etiology for autism.See abstract below of their paper:Pten Regulates Neuronal Arborization and Social Interaction in Mice.Kwon CH, Luikart BW, CM, Zhou J, Matheny SA, Zhang W, Li Y, Baker SJ, Parada LF.Center for Developmental Biology and Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, Texas 75390; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105.CNS deletion of Pten in the mouse has revealed its roles in controlling cell size and number, thus providing compelling etiology for macrocephaly and Lhermitte-Duclos disease. PTEN mutations in individuals with autism spectrum disorders (ASD) have also been reported, although a causal link between PTEN and ASD remains unclear. In the present study, we deleted Pten in limited differentiated neuronal populations in the cerebral cortex and hippocampus of mice. Resulting mutant mice showed abnormal social interaction and exaggerated responses to sensory stimuli. We observed macrocephaly and neuronal hypertrophy, including hypertrophic and ectopic dendrites and axonal tracts with increased synapses. This abnormal morphology was associated with activation of the Akt/mTor/S6k pathway and inactivation of Gsk3beta. Thus, our data suggest that abnormal activation of the PI3K/AKT pathway in specific neuronal populations can underlie macrocephaly and behavioral abnormalities reminiscent of certain features of human ASD.PMID: 16675393 [PubMed - as supplied by publisher]On May 29, 2006, at 12:56 PM, Chap 'n Ali wrote: http://www.voanews.com/english/2006-05-29-voa16.cfm Autism, A Little Understood Disorder May Have Genetic RootsBy Carol Pearson Washington, DC29 May 2006 watch Autism Gene report / Real broadband - download <unknown.gif>watch Autism Gene report / Real broadband <unknown.gif>watch Autism Gene report / Real dialup - download <unknown.gif>watch Autism Gene report / Real dialup <unknown.gif>Researchers at the University of Texas Southwestern have been able to genetically change mice so their behavior is similar to some people with autism. The researchers hope their discovery will eventually lead to treatment for people with autism spectrum disorder.Mice are genetically similar to people which is why geneticists such as Lander study them. "We might think of ourselves as different than a mouse because we're so much bigger and we think we're so much smarter, but look inside, the organs are all the same."<unknown.jpg>Professor ParadaIncluding the brain. Researchers led by Professor Parada at the University of Texas Southwesternhave found that by deleting a gene called P-ten in certain parts of the mouse brain, they created mice that act like people with autism spectrum disorder, a range of disorders in which people have trouble with communication and social interaction: they may not even look at people they are with. They may also exhibit other strange behaviors: walking on their toes, and flapping their arms.Professor Parada directs the university's Center of Developmental Biology. He says by genetically altering the mice, he got some of the same behavior as people who have autism. "The abnormal behaviors are based on the fact that mice are extremely social animals."<unknown.jpg>Mice are generally interested in other mice, but not mice whose P-ten gene has been deleted. Professor Parada says the genetically altered mice have other social deficits. "If one gives mice in a box cotton material, they will quickly shred it and transform it into a three-dimensional nest and go and burrow under it. When the mutant mice are given this nesting material they completely ignore it."The genetically altered females also ignore their offspring."The P-ten mice they wouldn't let you pick them up. They're just really skittish just like autistic children are. They don't like to be picked up."Autism affects about one in every 250 people, yet little is known about this disorder or how to treat it which is why the genetic research with mice is so important.“It gives us at least a first clue as to where the mutations in the brain could result in deficits in social interaction." Professor Parada says the next step is to treat the genetically altered mice with drugs to see if it is possible to reverse the condition. The research might lead someday to a cure for autism spectrum disorder and similar genetic abnormalities in people.

[Guest guest]

I agree. The hep B at birth had mercury plus stated it changed the

signalling pathways of the host recipients body,had recombinant dna,

genetically modified yeast base,yadda,yadda,yadda. It doesnt take a

harvard education to see the dna mutations can be caused by the

vaccines. R

> >> >>

> >> >>

> >> >>  

> >> >>  

> >> >> http://www.voanews.com/english/2006-05-29-voa16.cfm

> >> >>  

> >> >> Autism, A Little Understood Disorder May Have Genetic Roots

> >> >> By Carol Pearson

> >> >> Washington, DC

> >> >> 29 May 2006

> >> >>  

> >> >>

> >> >> watch Autism Gene report / Real broadband - download 

> >> >> watch Autism Gene report / Real broadband  

> >> >> watch Autism Gene report / Real dialup - download 

> >> >> watch Autism Gene report / Real dialup  

> >> >>

> >> >> Researchers at the University of Texas Southwestern have

been able

> >> to

> >> >> genetically change mice so their behavior is similar to some

people

> >> >> with autism.  The researchers hope their discovery will

eventually

> >> >> lead to treatment for people with autism spectrum disorder.

> >> >>

> >> >> Mice are genetically similar to people which is why

geneticists

> >> such

> >> >> as Lander study them. " We might think of ourselves as

> >> different

> >> >> than a mouse because we're so much bigger and we think we're

so

> >> much

> >> >> smarter, but look inside, the organs are all the same. "

> >> >> Professor Parada

> >> >>

> >> >> Including the brain.  Researchers led by Professor

Parada at

> >> >> the University of Texas Southwesternhave found that by

deleting a

> >> >> gene called P-ten in certain parts of the mouse brain, they

created

> >> >> mice that act like people with autism spectrum disorder, a

range of

> >> >> disorders in which people have trouble with communication

and

> >> social

> >> >> interaction:  they may not even look at people they are

with. 

> >> They

> >> >> may also exhibit other strange behaviors: walking on their

toes,

> >> and

> >> >> flapping their arms.

> >> >>

> >> >> Professor Parada directs the university's Center of

> >> >> Developmental Biology.  He says by genetically altering

the mice,

> >> he

> >> >> got some of the same behavior as people who have autism. " The

> >> >> abnormal behaviors are based on the fact that mice are

extremely

> >> >> social animals. "

> >> >>

> >> >> Mice are generally interested in other mice, but not mice

whose

> >> >> P-ten gene has been deleted. Professor Parada says the

genetically

> >> >> altered mice have other social deficits. " If one gives mice

in a

> >> box

> >> >> cotton material, they will quickly shred it and transform it

into a

> >> >> three-dimensional nest and go and burrow under it.  When

the

> >> mutant

> >> >> mice are given this nesting material they completely ignore

it. "

> >> >>

> >> >> The genetically altered females also ignore their offspring.

> >> >>

> >> >> " The P-ten mice they wouldn't let you pick them up. They're

just

> >> >> really skittish just like autistic children are.  They

don't like

> >> to

> >> >> be picked up. "

> >> >>

> >> >> Autism affects about one in every 250 people, yet little is

known

> >> >> about this disorder or how to treat it which is why the

genetic

> >> >> research with mice is so important.

> >> >>

> >> >>  " It gives us at least a first clue as to where the

mutations in

> >> the

> >> >> brain could result in deficits in social interaction. "

Professor

> >> >> Parada says the next step is to treat the genetically

altered mice

> >> >> with drugs to see if it is possible to reverse the

condition. The

> >> >> research might lead someday to a cure for autism spectrum

disorder

> >> >> and similar genetic abnormalities in people.

> >> >>  

> >> >>  

> >> >>

[Guest guest]

Hep. B vaccine increases the risk of various neurologic disorders-onset 7 hours to 7 Days after receiving it-- 4 to 22 fold.

Internat. J. Clin. Invest. 13, pp 1-4,Dec. 2005

H. H.Fudenberg, M.D.,DDG.IOM

Inman, SC 29349

(864) 592 8076

Website nitrf.org

From: "maria rawlings" <jamaraw@...>Reply-EOHarm To: EOHarm Subject: Re: Autism, A Little Understood Disorder May Have Genetic RootsDate: Wed, 31 May 2006 03:53:55 -0000I agree. The hep B at birth had mercury plus stated it changed the signalling pathways of the host recipients body,had recombinant dna, genetically modified yeast base,yadda,yadda,yadda. It doesnt take a harvard education to see the dna mutations can be caused by the vaccines. R> >> >>> >> >>> >> >>  > >> >>  > >> >> http://www.voanews.com/english/2006-05-29-voa16.cfm> >> >>  > >> >> Autism, A Little Understood Disorder May Have Genetic Roots> >> >> By Carol Pearson> >> >> Washington, DC> >> >> 29 May 2006> >> >>  > >> >>> >> >> watch Autism Gene report / Real broadband - download > >> >> watch Autism Gene report / Real broadband  > >> >> watch Autism Gene report / Real dialup - download > >> >> watch Autism Gene report / Real dialup  > >> >>> >> >> Researchers at the University of Texas Southwestern have been able > >> to> >> >> genetically change mice so their behavior is similar to some people> >> >> with autism. The researchers hope their discovery will eventually> >> >> lead to treatment for people with autism spectrum disorder.> >> >>> >> >> Mice are genetically similar to people which is why geneticists > >> such> >> >> as Lander study them. "We might think of ourselves as > >> different> >> >> than a mouse because we're so much bigger and we think we're so > >> much> >> >> smarter, but look inside, the organs are all the same."> >> >> Professor Parada> >> >>> >> >> Including the brain. Researchers led by Professor Parada at> >> >> the University of Texas Southwesternhave found that by deleting a> >> >> gene called P-ten in certain parts of the mouse brain, they created> >> >> mice that act like people with autism spectrum disorder, a range of> >> >> disorders in which people have trouble with communication and > >> social> >> >> interaction: they may not even look at people they are with. > >> They> >> >> may also exhibit other strange behaviors: walking on their toes, > >> and> >> >> flapping their arms.> >> >>> >> >> Professor Parada directs the university's Center of> >> >> Developmental Biology. He says by genetically altering the mice, > >> he> >> >> got some of the same behavior as people who have autism. "The> >> >> abnormal behaviors are based on the fact that mice are extremely> >> >> social animals."> >> >>> >> >> Mice are generally interested in other mice, but not mice whose> >> >> P-ten gene has been deleted. Professor Parada says the genetically> >> >> altered mice have other social deficits. "If one gives mice in a > >> box> >> >> cotton material, they will quickly shred it and transform it into a> >> >> three-dimensional nest and go and burrow under it. When the > >> mutant> >> >> mice are given this nesting material they completely ignore it."> >> >>> >> >> The genetically altered females also ignore their offspring.> >> >>> >> >> "The P-ten mice they wouldn't let you pick them up. They're just> >> >> really skittish just like autistic children are. They don't like > >> to> >> >> be picked up."> >> >>> >> >> Autism affects about one in every 250 people, yet little is known> >> >> about this disorder or how to treat it which is why the genetic> >> >> research with mice is so important.> >> >>> >> >> â€Å"It gives us at least a first clue as to where the mutations in > >> the> >> >> brain could result in deficits in social interaction." Professor> >> >> Parada says the next step is to treat the genetically altered mice> >> >> with drugs to see if it is possible to reverse the condition. The> >> >> research might lead someday to a cure for autism spectrum disorder> >> >> and similar genetic abnormalities in people.> >> >>  > >> >>  > >> >>