MTHFR Gene Polymorph&Schizophrenia

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Prog Neuropsychopharmacol Biol Psychiatry. 2005 Aug 2; [Epub ahead

of print] Related Articles, Links

Association of the C677T and A1298C polymorphisms of

methylenetetrahydrofolate reductase gene with schizophrenia:

Association is significant in men but not in women.

Sazci A, Ergul E, Kucukali I, Kara I, Kaya G.

Department of Medical Biology and Genetics, Faculty of Medicine,

University of Kocaeli, Derince, 41900, Kocaeli, Turkey.

Schizophrenia is a complex and common psychiatric disorder with a

polygenic inheritance. In our previous report, we showed an

association between the methylenetetrahydrofolate reductase (MTHFR)

gene C677T and A1298C polymorphisms and schizophrenia in patients

from Bakirkoy in Istanbul, Turkey [sazci, A., Ergul, E., Guzelhan,

Y., Kaya, G., Kara, I., 2003. Methylenetetrahydrofolate reductase

gene polymorphisms in patients with schizophrenia. Mol. Brain Res.

117, 104-107]. We wanted also independently to confirm this study in

a gender-specific manner with schizophrenic patients from Erenkoy in

Istanbul, Turkey. To investigate the role of the C677T and A1298C

polymorphisms of methylenetetrahydrofolate reductase gene in

schizophrenia in a gender-specific manner, we analyzed the genotypes

of MTHFR677 and MTHFR1298 of 297 schizophrenic patients and 341

healthy controls, using a polymerase chain reaction restriction

fragment length polymorphism method. The MTHFR 677T allele was

significantly distributed (chi(2)=7.312; P=0.026), between

schizophrenic patients and healthy controls. The T677T genotype was

overrepresented in the total schizophrenic patients (OR=1.938; 95%

CI=1.133-3.315; chi(2)=5.996; P=0.014). Similarly, the T677T/A1298A

compound genotype was the most significant one in the total

schizophrenic patients (OR=2.397; 95% CI=1.327-4.330; chi(2)=8.821;

P=0.003). The C1298C genotype was overrepresented in the total

schizophrenic patients (OR=1.706; 95%CI=1.014-2.870; chi(2)=4.126;

P=0.042). Likewise, the C677C/C1298C compound genotype was

significant in the total schizophrenic patients (OR=1.689; 95%

CI=0.985-2.894; chi(2)=3.695; P=0.055). When schizophrenic patients

and healthy controls were stratified according to gender difference,

the T677T genotype and T677T/A1298A compound genotype were

significantly overrepresented (OR=2.184; 95%CI=1.069-4.462; chi(2)

=4.767; P=0.029; OR=2.748; 95%CI=1.215-6.214; chi(2)=6.301; P=0.012,

respectively) in men schizophrenic patients. However, neither the

MTHFR C677T nor the A1298C polymorphisms are associated with

schizophrenia in women. In conclusion, the MTHFR 677T allele and

T677T, C1298C genotypes, and T677T/A1298A, C677C/C1298C compound

genotypes are genetic risk factors for schizophrenia in men but not

in women in a gender-specific manner.

PMID: 16084002 [PubMed - as supplied by publisher]

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Brain Res Mol Brain Res. 2003 Sep 10;117(1):104-7. Related Articles,

Links

Methylenetetrahydrofolate reductase gene polymorphisms in patients

with schizophrenia.

Sazci A, Ergul E, Guzelhan Y, Kaya G, Kara I.

Department of Medical Biology and Genetics, Faculty of Medicine,

University of Kocaeli, 41900 Derince, Kocaeli, Turkey.

alisazci@...

To investigate the role of methylenetetrahydrofolate reductase gene

polymorphisms in schizophrenia, we analyzed the genotypes of

MTHFR677 and MTHFR1298 of 130 schizophrenic patients and 226

controls, using a polymerase chain reaction restriction fragment

length polymorphism method. The MTHFR T677 allele was significantly

distributed (chi(2)=7.900; P=0.019), between schizophrenic cases and

healthy controls. The T677T genotype was overrepresented in the

schizophrenic patients (OR=2.504; 95% CI=1.276-4.915; chi(2)=7.477;

P=0.006). The T677T/A1298A, and C677T/C1298C compound genotypes were

greater in the schizophrenic patients (OR=3.157; 95% CI=1.522-6.545;

chi(2)=10.336; P=0.001 and OR=1.744; 95% CI=0.108-28.121; chi(2)

=0.158; P=0.691, respectively). The MTHFR T677 allele and T677T and

T677T/A1298A genotypes are genetic risk factors for schizophrenia.

PMID: 14499487 [PubMed - indexed for MEDLINE]