Re: Ped Med: The biological factor in autism

[Guest guest]

There can't be any arguement about outside factors affecting gene

expression. If you have the genes to grow tall and there is a food

shortage in your environment, your height will be reduced.

Sally

natasa778 wrote:

Huh, unfortunately it looks like the calcium issue is MUCH more

complex

than just glutamate toxicity... glutamate opens NMDA receptors and

allows extra calcium into the cell, but NMDA-glutamate pathway is just

one of the many ways calcium can enter the cell, and this extra

glutamate is most probably downstream conseqence of another problem in

calcium homeostasis = dysregulated VOLTAGE gated calcium channels, the

ones that get open by depolarisation, and that can be messed up badly,

directly and indirectly, by various agents such as VIRUSES (including

HIV proteins), metals, solvents, hypoxia, ishemia, maternal IgGs,

pesticides.. . take your pick.... hard to sum it up, it is going to take

me some 40 pages plus to really illustrate this issue and various

consequences it can have... Just to pick the one I was most stunned by

was uncovering that this particular calcium signalling pathway has A

DIRECT WAY TO GENETIC TRANSCRIPTION, something called CREB (look it up

on wikipedia), in other words this is the direct link to EPIGENETICS

that has been talked about a lot lately.

So there you have it, a huge up-yours to all those

"autism-is-all- genetic" bull***t theories, as this shows how external

agents have a very direct say on how our genes are

transcribed/ expressed. .. so no matter what you have in your

chromosomal

DNA it is only goint to come to surface (or not come to surface)

depending on what external things are going on in your life... if you go

back read that link on epigentics a few posts back, this is what I am

talking about.

And yes, calcium channel blockers and NMDA antagonists could be an

option, maybe, probably, possibly in some of the cases... hope someone

else will be able to answer this one day.

Natasa

> > > > >

> > > > > Thanks for posting this. The longer I go the

more convinced

I

> > > am that

> > > > our babies's immune systems are what go haywire.

Along with

> > > chelation (I

> > > > think chelation agents also offer some kind of

immune

> > > regulation, dmsa

> > > > is thought to be an antiretroviral and dmps has

been used to

> > > combat

> > > > AIDS) shoring up the child's immune system is very

important.

> > > > >

> > > > > I don't follow a lot of what Dr. McCandless

does or says but

> > > one thing

> > > > she was spot on about was her observation that she

never saw

an

> > > ASD

> > > > child with a fully functioning immune system.

> > > > >

> > > > > We have been unable to use any antiviral

product either rx

or

> > > otc due

> > > > to stomach or allergic rash issues, but shoring up

her immune

> > > system

> > > > with products like Transfer Factor and Neutrophil

Plus, in

> > > addition to

> > > > chelation are what I credit for her complete

recovery.

> > > > >

> > > > > You have to do both; chelation to remove the

heavy metals

and

> > > regulate

> > > > the immune system and at the same time, prop up the

immune

> > > system in

> > > > whatever way you can.

> > > > >

> > > > >

> > > > > Ped Med:

The biological

> > > factor

> > > > in autism

> > > > >

> > > > >

> > > > >

> > > > > Ped Med: The biological factor in autism

> > > > > By LIDIA WASOWICZ

> > > > > UPI Senior Science Writer

> > > > > SAN FRANCISCO, Nov. 28 (UPI) -- Scientists

trying to dig up

> > > the roots

> > > > of autism are unearthing mounting evidence of the

immune

> > > system's

> > > > involvement in the intractable disorder.

> > > > >

> > > > > Scientific hints that the body's

disease-fighting mechanisms

> > > play a

> > > > role in autism first surfaced in 1986, researchers

said.

> > > > >

> > > > > However, for the most part, these studies were

small and the

> > > results

> > > > inconclusive so that what now appears a logical

concept didn't

> > > catch on

> > > > until more recently, said Amaral, professor of

psychiatry

> > > and

> > > > behavioral sciences at the University of

California, ,

> > > School of

> > > > Medicine and Medical Center and M.I.N.D. research

director.

> > > > >

> > > > > "You cannot have a normal neurodevelopment

without having a

> > > normal

> > > > immune system," said Judy Van de Water, an

immunology

specialist

> > > at the

> > > > UC Center for Children's Environmental Health.

> > > > >

> > > > > "We know when these kids are faced with

particular

> > > environmental

> > > > agents, such as certain bacteria, they don't

respond as

> > > rigorously as

> > > > the control kids do."

> > > > >

> > > > > Among other projects, she's looking into

whether children

with

> > > autism

> > > > show signs of autoimmunity, a phenomenon in which

the body's

> > > protective

> > > > system goes haywire, turning on the very tissues

and organs

it's

> > > > supposed to safeguard from attack.

> > > > >

> > > > > "This is important because a lot of

investigators have

> > > suggested that

> > > > patients with autism have auto-antibodies, so we're

looking at

> > > whether

> > > > these kids have auto-antibodies to brain tissue,"

she told an

> > > > international meeting on autism research in Boston.

> > > > >

> > > > > Indeed, when Van de Water probed the brain's

> > > disease-deflecting armor

> > > > in 30 autistic children ages 2 to 5 and 26 without

the

disorder,

> > > she

> > > > detected a variation in the way specialized

messenger

molecules

> > > called

> > > > cytokines react to bacteria and other health

threats in the

two

> > > groups.

> > > > >

> > > > > These immune proteins, which normally get into

gear when a

> > > response is

> > > > needed to injury or irritation, instead appear to be

constantly

> > > > "switched on," or inflamed, in individuals with

autism,

reported

> > > another

> > > > team, which veered off the beaten path to study the

issue.

> > > > >

> > > > > Rather than taking the more common approach of

looking at

the

> > > > immensely complex immune system as a whole, the

investigators

> > > from s

> > > > Hopkins University School of Medicine in Baltimore

and the

> > > University of

> > > > Milan in Italy decided to narrow their field of

inquiry to

just

> > > a few

> > > > components within the relatively restricted

environment of the

> > > central

> > > > nervous apparatus.

> > > > >

> > > > > They confined their search to the

cell-coordinating

cytokines,

> > > > measuring their levels in brain tissue samples

taken from 11

> > > children

> > > > and adults ages 5 to 44 who had died by accident,

illness or

> > > injury.

> > > > >

> > > > > They observed the abnormal patterns of

inflammation,

> > > reinforcing the

> > > > view that immune activation in the brain is

involved in

autism.

> > > However,

> > > > the authors noted, it is not yet clear whether the

irregularity

> > > is

> > > > destructive or beneficial, or perhaps both, to the

developing

> > > brain.

> > > > >

> > > > > Wanting to see if their findings would hold

up, the

> > > investigators

> > > > followed up with an analysis of cerebrospinal fluid

from six

> > > children

> > > > with autism ages 5 to 12.

> > > > >

> > > > > As in the previous studies, they once again

detected

elevated

> > > cytokine

> > > > levels, raising the possibility that ultimately

doctors might

be

> > > able to

> > > > use these anomalies to diagnose autism or even that

they might

> > > be able

> > > > to treat the inflammation, thereby preventing or

reversing the

> > > disorder.

> > > > >

> > > > > But that's a long time and many studies away.

> > > > >

> > > > > First, they must deal with such challenges as

figuring out

the

> > > > chicken-and- egg quandary that can sabotage

attempts to

> > > definitively get

> > > > at the source of an ailment.

> > > > >

> > > > > In the case at hand, the scientists were

uncertain whether

the

> > > > abnormality they observed is a cause or consequence

of the

> > > disorder.

> > > > >

> > > > > Just as the body's first-aid response to a

skinned knee is

to

> > > > protectively wall off the injury and ward off the

agent of

harm

> > > with

> > > > heat, redness and swelling, so, too, it may be that

the

> > > inflammation

> > > > detected by the researchers may represent the

brain's efforts

to

> > > combat

> > > > some other cell-damaging process.

> > > > >

> > > > > The finding "backs up what we're seeing in the

peripheral

> > > blood, that

> > > > perhaps there is a change in these kids and the

cytokine

> > > production in

> > > > the brain is altered," said Van de Water, who plans

to conduct

> > > her own

> > > > investigation into what those changes mean, whether

they

affect

> > > brain

> > > > function and how they might be related to some of

the classic

> > > symptoms

> > > > of autism.

> > > > >

> > > > > For example, cytokines are known to affect

slumber, and

sleep

> > > > disorders are a common complaint of individuals

with autism.

> > > > >

> > > > > Among the next steps, scientists are looking

into what role

> > > heredity

> > > > may play in the development of immune abnormalities

in the

brain

> > > that

> > > > may stir up a susceptibility to autism.

> > > > >

> > > > > To get a clue, Van de Water and other

researchers are

looking

> > > back,

> > > > sifting through tens of thousands of medical

histories for any

> > > patterns

> > > > in the rates of earaches, colds and other

infections in

autistic

> > > > youngsters.

> > > > >

> > > > > Although still preliminary, results of one

study -- of

88,000

> > > babies

> > > > born between 1995 and 1999 in Northern California

-- hint at

an

> > > > increased risk of autism in the offspring of

mothers with

> > > psoriasis, a

> > > > chronic condition that runs in families.

> > > > >

> > > > > Some 3 million American women of child-bearing

age have the

> > > disorder

> > > > marked by itchy, scaly, inflamed skin on the

elbows, knees,

back

> > > and/or

> > > > scalp, according to the patient advocacy group

Psoriasis Cure

> > > Now!

> > > > >

> > > > > The early findings also indicate expectant

mothers suffering

> > > from

> > > > asthma and allergies -- particularly during the

second

trimester

> > > -- may

> > > > face double the typical risk of giving birth to a

child with

> > > autism.

> > > > >

> > > > > However, the presence during pregnancy of 45

other

autoimmune

> > > diseases

> > > > that turn the body against itself -- including

rheumatoid

> > > arthritis,

> > > > type 1 diabetes, rheumatic fever, certain heart

complications,

> > > lupus and

> > > > multiple sclerosis -- appear to have no bearing on

the baby's

> > > autism

> > > > status, the study authors reported.

> > > > >

> > > > > These maladies are under scrutiny because they

affect

> > > primarily women

> > > > -- who account for 78 percent of all cases -- and

because

> > > chemicals

> > > > produced in response to their presence often are

found at high

> > > levels in

> > > > the bloodstream of autistic children.

> > > > >

> > > > > That would suggest a possible link between

autism and

> > > pre-birth

> > > > exposure to an autoimmune ailment, scientists said.

> > > > >

> > > > > The authors speculate a common genetic cause

may underlie

such

> > > > conditions as asthma and autism. Or, because the

mother's

> > > illness was

> > > > frequently diagnosed in the second trimester of

pregnancy, the

> > > flare-up

> > > > may have triggered her immune system to produce more

> > > inflammatory

> > > > cytokines, which, in turn, might have disrupted

brain

> > > development in the

> > > > fetus, the researchers proposed.

> > > > >

> > > > > (Note: In this multi-part installment, based

on dozens of

> > > reports,

> > > > conferences and interviews, Ped Med is keeping on

eye on

autism,

> > > taking

> > > > a backward glance at its history and surrounding

controversies,

> > > facing

> > > > facts revealed by research and looking forward to

treatment

> > > enhancements

> > > > and expansions. Wasowicz is the author of the

forthcoming

book,

> > > "Suffer

> > > > the Child: How the American Healthcare System Is

Failing Our

> > > Future," to

> > > > be published by Capital Books.)

> > > > >

> > > > > Next: Some autism study results point in

genetic directions

> > > > >

> > > >

> > > >

> > > >

> > > >

> > > > --

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> > > > Version: 7.1.409 / Virus Database: 268.14.19/556 -

Release

Date:

> > > 28/11/2006

> > > >

> > > >

> > > >

> > > >

> > > > --

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> > > > Checked by AVG Free Edition.

> > > > Version: 7.1.409 / Virus Database: 268.14.19/556 -

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Date:

> > > 28/11/2006

> > > >

> > >

> >

>

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Checked by AVG Free Edition.

Version: 7.1.409 / Virus Database: 268.15.2/559 - Release Date: 30/11/2006

[Guest guest]

Well

the metals , Hg worst , makes impact on the immune system (together with or done through gluten opioid peptides), so there is a " immune shift " from cellular immunoreactivity (that issues cancer and viruses) to humoral immunoreactivity that makes more autoimmunity and allergies.

Here is the combined effects..

LDN should have the impact of partly restoring this effect.

Geir Flatabø

On 11/30/06, JULIE GRIFFITHS <moppett1@...> wrote:

Geir,

Thanks for pointing this out. Think we have made a lot of headway today....thank-you for the power of the internet!!!!

Still think though it has a heavy metal origin.

Who wants to sleep over this....

----- Original Message -----

[Guest guest]

Geir,

If LDN is partly effective on the 'immume shift', then also the success of

enzyme supplementation is due to blocking gluten opioid peptides. Would LDN and

enzyme supplementation then be masking the underlying problem?

Bridget

>

> From: " Geir Flatabø " <geirf@...>

> Date: 2006/12/01 Fri AM 08:30:14 GMT

> Autism Treatment

> Subject: Re: Re: Ped Med: The biological factor in

autism

>

> Well

> the metals , Hg worst , makes impact on the immune system (together with or

> done through gluten opioid peptides), so there is a " immune shift " from

> cellular immunoreactivity (that issues cancer and viruses) to humoral

> immunoreactivity that makes more autoimmunity and allergies.

> Here is the combined effects..

> LDN should have the impact of partly restoring this effect.

>

> Geir Flatabø

>

> On 11/30/06, JULIE GRIFFITHS <moppett1@...> wrote:

>

> > Geir,

> >

> > Thanks for pointing this out. Think we have made a lot of headway

> > today....thank-you for the power of the internet!!!!

> >

> > Still think though it has a heavy metal origin.

> >

> >

> > Who wants to sleep over this....

> >

> >

> > ----- Original Message -----

> >

> >

>

>

[Guest guest]

If the underlying problem is Mercury or other metal toxicity

the answer is yes,

but common way of thinking is that you anyway do a good thing, because

that kind of treatment is in a way an antidote to parts of the Mercury

toxicity.

If the underlying cause is a viral disease and a inborn - heredity -

cause making immunity problem , or malfunctioning peptidases,

then enzyme supplementation - or LDN rather would be the treatment of choice...

the right treatment..?

Geir Flatabø

On 12/2/06, mummysboy@... <mummysboy@...> wrote:

> Geir,

> If LDN is partly effective on the 'immume shift', then also the success of

enzyme supplementation is due to blocking gluten opioid peptides. Would LDN and

enzyme supplementation then be masking the underlying problem?

>

> Bridget

>

> >

> > From: " Geir Flatabø " <geirf@...>

> > Date: 2006/12/01 Fri AM 08:30:14 GMT

> > Autism Treatment

> > Subject: Re: Re: Ped Med: The biological factor

in autism

> >

> > Well

> > the metals , Hg worst , makes impact on the immune system (together with or

> > done through gluten opioid peptides), so there is a " immune shift " from

> > cellular immunoreactivity (that issues cancer and viruses) to humoral

> > immunoreactivity that makes more autoimmunity and allergies.

> > Here is the combined effects..

> > LDN should have the impact of partly restoring this effect.

> >

> > Geir Flatabø

> >

> > On 11/30/06, JULIE GRIFFITHS <moppett1@...> wrote:

> >

> > > Geir,

> > >

> > > Thanks for pointing this out. Think we have made a lot of headway

> > > today....thank-you for the power of the internet!!!!

> > >

> > > Still think though it has a heavy metal origin.

> > >

> > >

> > > Who wants to sleep over this....

> > >

> > >

> > > ----- Original Message -----

> > >

> > >

> >

> >

>

>

>

> DISCLAIMER

> No information contained in this post is to be construed as medical advice. If

you need medical advice, please seek it from a suitably qualified practitioner.

>

>