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gluten/appetite (was warrior diet question)

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Heidi,

On the subject of gluten and appetite.. I have a different appetite problem

than most-- very early satiety, meaning I'll be hungry if I wait long

enough but then feel full after a few bites. (So I'm doing the WD by

default, but only the undereating phase!)

A few years ago when I was looking into the mechanism for appetite

regulation, I came across some posts from Ron Hoggan (co-author of

Dangerous Grains) on one of the paleo lists. I don't see this mentioned in

the book, but he had said that the duodenum is the site of the earliest gut

damage in gluten intolerance, and that's where most of the production of

cholecystokinin (CCK) takes place.

Since CCK is involved with fat digestion and signalling satiety, if gluten

compromises CCK production it would make sense that the satiety signalling

would be compromised, leading to overeating. Maybe this is also why

difficulty digesting fats is a typical gluten sensitivity issue.

Estrogen, for one thing, regulates CCK, so that may be another clue.

-

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