Re: autism and food link found

[Guest guest]

> Hi Sally, yes, interestingly b12..

Metabolism

The metabolism of propionic acid begins with its conversion to

propionyl coenzyme A (propionyl-CoA), the usual first step in the

metabolism of carboxylic acids.

Since propionic acid has three carbons, propionyl-CoA can enter

neither beta oxidation nor the citric acid cycle

In most vertebrates propionyl-CoA is carboxylated to D-methylmalonyl-

CoA, isomerised to L-methylmalonyl-CoA, and rearranged to yield

succinyl-CoA via a vitamin B12-dependent enzyme. Succinyl-CoA is an

intermediate of the citric acid cycle and can be readily incorporated

there.

> From elsewhere the 'B12-dependent enzyme' seems to

> be adenosylcobalamin not methylcobalamin. So keep supplementing

> both I assume.

> Need someone clever to confirm the above though! Mark

>

> Does this suggest any treatment to anyone?

> Sally

>

>

>

> Autism

>

> By _JENNIFER O'BRIEN_ (mailto:obrien@) , FREE PRESS REPORTER

>

> _http://lfpress.ca/newsstand/News/Local/2006/10/18/pf-2058851.html_

> (http://lfpress.ca/newsstand/News/Local/2006/10/18/pf-2058851.html)

>

> London researchers have found a link between food and autism, a

> discovery

> that's creating a buzz in the world of medical research.

> Their study is giving clout to a long-held claim by many parents who

> say they

> can alter their children's behaviour -- and lessen autistic

symptoms

> -- by

> altering their diets.

> " What parents are telling us about the digestive system complaints

of

> these

> children has a great deal of merit, " research director Dr. Derrick

> MacFabe

> said yesterday from Atlanta.

> " But I want to show that there is some hope. This study allows us to

> examine

> things which have the potential to reduce the risk of the disease

and

> possibly treat it.

> " There is something common to diet, digestive system, immune system,

> behaviours and to brain function of autistic children. "

> The neuroscientist is director of the Kilee Patchell- Autism

> Research

> Group at the University of Western Ontario.

> Named after the 10-year-old autistic daughter of Patchell-

,

> the

> team was established three years ago to search for causes of the

disease

> affecting one in 166 children.

> Autism is a mental condition characterized by failure to

communicate,

> difficulty in learning and self-stimulating or aggressive behaviour.

> " I'm excited because for a long time, parents have said that what

> their kid

> eats makes a difference, " said Patchell-, the chief executive

of

> GoodLife

> Fitness who established the research team with a sizable donation.

> " Now we've moved from gossip to science and when you stop gossiping

> and move

> to a scientific foundation . . . then you can start some real

> progression

> because the medical community needs a scientifically rigorous

study. "

> Like many parents of autistic children, Patchell- took his

> daughter off

> wheat and dairy about a year after she was diagnosed on the basis of

> anecdotal evidence that it could help.

> The difference, he said, was " night and day. She learns better, she

pays

> better attention, her hyperactivity decreases, her sociability

> increases . . .

> and she sleeps through the night. "

> The research team began looking into a possible link between autism

> and diet

> after hearing many accounts from parents claiming their children had

> digestive problems.

> Patchell-' findings were similar to those of thousands of

> parents, said

> MacFabe, who studied whether digestive upsets could worsen autistic

> symptoms

> such as repetitive behaviours, social isolation and poor impulse

> control.

> The team focused on a compound called propionic acid, present in

some

> foods

> such as refined wheat and dairy products.

> The acid is also produced by many types of digestive bacteria,

> particularly

> those associated with antibiotic-associated diarrhea, MacFabe said.

> Scientists put the compound into the brains of lab rats, which

became

> hyperactive and repetitive, showing signs of social impairment that

> resembles that

> in autistic patients.

> Repeated exposure showed worsening behavioural effects, said

MacFabe,

> and

> brain changes that resemble seizures that often co-exist with

autism.

> Then analysing the brains of these animals, researchers showed an

> inflammatory response closely resembling those found in a recent

> Hopkins study on

> autistic brain material.

> The UWO research team includes MacFabe, psychology chair Dr. Klaus-

> Ossenkopp, Dr. Cain, Dr. Kavaliers, Dr.

> Hampson and Dr.

> Fred Possmayer.

> MacFabe and other team members are in Atlanta to present their study

> at a

> major neuroscience conference.

> Soon to appear in the prestigious biomedical journal Behavioral

Brain

> Research, the study is garnering international attention for the

team.

> Some of the team's work has already been well received at a Montreal

> conference, the International Meeting of Autism Researchers.

> The paper has also attracted the attention of the Brain Development

and

> Disorders Project at the Massachusetts Institute of Technology

(MIT).

> " We need this kind of integrative research to understand what is

going

> on in

> autism and how the gut-brain axis is involved, " said project

director Dr.

> Martha Herbert, who will be collaborating with MacFabe to further

> examine this

> in human patients.

> The next step for the UWO group is to work with Queen's

University's Dr.

> Jeanette Holden, director of the Canadian-American Autism Research

> Consortium.

>

> --- End forwarded message ---

>

>

>

>

>

> --

> No virus found in this incoming message.

> Checked by AVG Free Edition.

> Version: 7.1.408 / Virus Database: 268.13.4/480 - Release Date:

17/10/2006

>

[Guest guest]

thank you. I looked up B12 and the science seemed to suggest that no one

who eats meat could be deficient. Is there some reason to believe that

autistic people can't metabolize B12. I don't supplement with B12 on the

assumption that my daughter eats lots of meat (she used to eat nothing

else really).

Sally

Mark Land wrote:

>

> > Hi Sally, yes, interestingly b12..

>

> Metabolism

> The metabolism of propionic acid begins with its conversion to

> propionyl coenzyme A (propionyl-CoA) , the usual first step in the

> metabolism of carboxylic acids.

>

> Since propionic acid has three carbons, propionyl-CoA can enter

> neither beta oxidation nor the citric acid cycle

>

> In most vertebrates propionyl-CoA is carboxylated to D-methylmalonyl-

> CoA, isomerised to L-methylmalonyl- CoA, and rearranged to yield

> succinyl-CoA via a vitamin B12-dependent enzyme. Succinyl-CoA is an

> intermediate of the citric acid cycle and can be readily incorporated

> there.

>

> > From elsewhere the 'B12-dependent enzyme' seems to

> > be adenosylcobalamin not methylcobalamin. So keep supplementing

> > both I assume.

> > Need someone clever to confirm the above though! Mark

>

>

> >

> > Does this suggest any treatment to anyone?

> > Sally

> >

> >

> >

> > Autism

> >

> > By _JENNIFER O'BRIEN_ (mailto:obrien@ ) , FREE PRESS REPORTER

> >

> > _http://lfpress. ca/newsstand/ News/Local/ 2006/10/18/ pf-2058851.

> html_ <http://lfpress.ca/newsstand/News/Local/2006/10/18/pf-2058851.html_>

> > (http://lfpress. ca/newsstand/ News/Local/ 2006/10/18/ pf-2058851.

> html <http://lfpress.ca/newsstand/News/Local/2006/10/18/pf-2058851.html>)

> >

> > London researchers have found a link between food and autism, a

> > discovery

> > that's creating a buzz in the world of medical research.

> > Their study is giving clout to a long-held claim by many parents who

> > say they

> > can alter their children's behaviour -- and lessen autistic

> symptoms

> > -- by

> > altering their diets.

> > " What parents are telling us about the digestive system complaints

> of

> > these

> > children has a great deal of merit, " research director Dr. Derrick

> > MacFabe

> > said yesterday from Atlanta.

> > " But I want to show that there is some hope. This study allows us to

> > examine

> > things which have the potential to reduce the risk of the disease

> and

> > possibly treat it.

> > " There is something common to diet, digestive system, immune system,

> > behaviours and to brain function of autistic children. "

> > The neuroscientist is director of the Kilee Patchell- Autism

> > Research

> > Group at the University of Western Ontario.

> > Named after the 10-year-old autistic daughter of Patchell-

> ,

> > the

> > team was established three years ago to search for causes of the

> disease

> > affecting one in 166 children.

> > Autism is a mental condition characterized by failure to

> communicate,

> > difficulty in learning and self-stimulating or aggressive behaviour.

> > " I'm excited because for a long time, parents have said that what

> > their kid

> > eats makes a difference, " said Patchell-, the chief executive

> of

> > GoodLife

> > Fitness who established the research team with a sizable donation.

> > " Now we've moved from gossip to science and when you stop gossiping

> > and move

> > to a scientific foundation . . . then you can start some real

> > progression

> > because the medical community needs a scientifically rigorous

> study. "

> > Like many parents of autistic children, Patchell- took his

> > daughter off

> > wheat and dairy about a year after she was diagnosed on the basis of

> > anecdotal evidence that it could help.

> > The difference, he said, was " night and day. She learns better, she

> pays

> > better attention, her hyperactivity decreases, her sociability

> > increases . . .

> > and she sleeps through the night. "

> > The research team began looking into a possible link between autism

> > and diet

> > after hearing many accounts from parents claiming their children had

> > digestive problems.

> > Patchell-' findings were similar to those of thousands of

> > parents, said

> > MacFabe, who studied whether digestive upsets could worsen autistic

> > symptoms

> > such as repetitive behaviours, social isolation and poor impulse

> > control.

> > The team focused on a compound called propionic acid, present in

> some

> > foods

> > such as refined wheat and dairy products.

> > The acid is also produced by many types of digestive bacteria,

> > particularly

> > those associated with antibiotic-associat ed diarrhea, MacFabe said.

> > Scientists put the compound into the brains of lab rats, which

> became

> > hyperactive and repetitive, showing signs of social impairment that

> > resembles that

> > in autistic patients.

> > Repeated exposure showed worsening behavioural effects, said

> MacFabe,

> > and

> > brain changes that resemble seizures that often co-exist with

> autism.

> > Then analysing the brains of these animals, researchers showed an

> > inflammatory response closely resembling those found in a recent

>

> > Hopkins study on

> > autistic brain material.

> > The UWO research team includes MacFabe, psychology chair Dr. Klaus-

>

> > Ossenkopp, Dr. Cain, Dr. Kavaliers, Dr.

> > Hampson and Dr.

> > Fred Possmayer.

> > MacFabe and other team members are in Atlanta to present their study

> > at a

> > major neuroscience conference.

> > Soon to appear in the prestigious biomedical journal Behavioral

> Brain

> > Research, the study is garnering international attention for the

> team.

> > Some of the team's work has already been well received at a Montreal

> > conference, the International Meeting of Autism Researchers.

> > The paper has also attracted the attention of the Brain Development

> and

> > Disorders Project at the Massachusetts Institute of Technology

> (MIT).

> > " We need this kind of integrative research to understand what is

> going

> > on in

> > autism and how the gut-brain axis is involved, " said project

> director Dr.

> > Martha Herbert, who will be collaborating with MacFabe to further

> > examine this

> > in human patients.

> > The next step for the UWO group is to work with Queen's

> University's Dr.

> > Jeanette Holden, director of the Canadian-American Autism Research

> > Consortium.

> >

> > --- End forwarded message ---

> >

> >

> >

> >

> >

> > --

> > No virus found in this incoming message.

> > Checked by AVG Free Edition.

> > Version: 7.1.408 / Virus Database: 268.13.4/480 - Release Date:

> 17/10/2006

> >

>

>

> ------------------------------------------------------------------------

>

> No virus found in this incoming message.

> Checked by AVG Free Edition.

> Version: 7.1.408 / Virus Database: 268.13.5/484 - Release Date: 19/10/2006

>

[Guest guest]

Hey Sally,

I think there's more to it than getting enough of a vitamin or

nutrient in your diet. Here are some possibilities I can think of

for B12 specifically (sorry if they're too sciency - I'm often

accused of that, so please forgive me!):

1. B12 must be absorbed by the body in order to be utilized.

Absorption of nutrients in the intestines can be compromised by gut

pathogens, bad flora, leaky gut, poor gut pH, not enough calcium or

too much calcium and magnesium (interferes with intrinsic factor

binding to B12), inadequate digestion due to pancreatic insuffiency

(rubella specifically targets the pancreas, for instance). Here's

what the Linus ing Institute has to say about B12

absorption: " Absorption of vitamin B12 from food requires normal

function of the stomach, pancreas, and small intestine. Stomach acid

and enzymes free vitamin B12 from food, allowing it to bind to other

proteins, known as R proteins (2). In the alkaline environment of

the small intestine, R proteins are degraded by pancreatic enzymes,

freeing vitamin B12 to bind to intrinsic factor (IF), a protein

secreted by specialized cells in the stomach. Receptors on the

surface of the small intestine take up the IF-B12 complex only in

the presence of calcium, which is also supplied by the pancreas (4).

Vitamin B12 can also be absorbed by passive diffusion, but this

process is very inefficient, allowing only about 1% absorption of a

vitamin B12 dose. "

http://lpi.oregonstate.edu/infocenter/vitamins/vitaminB12/ We

always give oral B12 with intrinsic factor to our daughter.

2. Once it is absorbed, your body must metabolize it correctly in

order to use it. However, heavy metals such as antimony, mercury,

aluminum and others interfere with the enzymes that are responsible

for metabolizing B12 in its various forms, and genetic

polymorphsims, which are small single nucleotide mutations, result

in enzymes that don't function as well as they should. There is an

amazing article by Bruce Ames that Dr. Usman has quoted in several

of her talks which talks about how many polymorphisms that are very

prevalent in populations mean that the enzyme is not able to easily

bind to its " co-factor " (the vitamin or nutrient that it uses to do

its job). For people with these kinds of polymorphisms,

the " nnormal " intake of nutrients is probably not enough -- you need

more. Here is a quote from the beginning of that article " : " As many

as one-third of mutations in a gene result in the corresponding

enzyme having an increased is constant, or Km, (decreased

binding affinity) for a coenzyme, resulting in a lower rate of

reaction. About 50 human genetic diseases due to defective enzymes

can be remedied or ameliorated by the administration of high doses

of the vitamin component of the corresponding coenzyme, which at

least partially restores enzymatic activity. Several single-

nucleotide polymorphisms, in which the variant amino acid reduces

coenzyme binding and thus enzymatic activity, are likely to be

remediable by raising cellular concentrations of the cofactor

through high-dose vitamin therapy. " So you see how some of us will

need higher doses of the vitamin inn order to utilize it.

http://ehscenter.berkeley.edu/publications/02_ames_1.pdf

3. Drs. Deth and Neubander have both addressed this in their talks --

if the MB12 is there in the blood stream, sitting outside the

cells, but enzymes necessary for MB12 utilization are blocked due to

metals or mutations, then the methylcobalamin (methyl-B12) will

oxidize and will not able to be used by the body. Here's a rather

complex quote from one of Deth's papers that suggests that if you

don't have enough of a specific form of folate in the body - 5MTHF --

then methylcobalamin will oxidize and not be usable: " During the

catalytic cycle, folate and homocysteine domains alternatively

interact with the cobalt ion in cobalamin, which alternates between

Cob(I) and methylated Cob(III) states. Cob(I) is, however, extremely

unstable, and occasionally it oxidizes to the Cob(II) state,

interrupting folate-dependent HCY methylation. Oxidation is

especially likely when levels of methylfolate are low and the Cob(I)

state has to wait too long to receive a methyl group. "

http://www.drneubrander.com/Files/Deth%20Testimony.pdf

So -- if your child has gut problems, if your child has any

polyrmorphisms that relate to folate or B12, if your child has a

heavy metal burden, if your child has excessive oxidative stress or

a lack of this specific type of folate (5MTHF) due to heavy metals

or polymorphisms or other factors, then they may not have enough B12

to help things work properly.

Sorry for being long-winded! It's one of my many shortcomings....

Many hugs,

Theresa

> > >

> > > Does this suggest any treatment to anyone?

> > > Sally

> > >

> > >

> > >

> > > Autism

> > >

> > > By _JENNIFER O'BRIEN_ (mailto:obrien@ ) , FREE PRESS REPORTER

> > >

> > > _http://lfpress. ca/newsstand/ News/Local/ 2006/10/18/ pf-

2058851.

> > html_ <http://lfpress.ca/newsstand/News/Local/2006/10/18/pf-

2058851.html_>

> > > (http://lfpress. ca/newsstand/ News/Local/ 2006/10/18/ pf-

2058851.

> > html <http://lfpress.ca/newsstand/News/Local/2006/10/18/pf-

2058851.html>)

> > >

> > > London researchers have found a link between food and autism, a

> > > discovery

> > > that's creating a buzz in the world of medical research.

> > > Their study is giving clout to a long-held claim by many

parents who

> > > say they

> > > can alter their children's behaviour -- and lessen autistic

> > symptoms

> > > -- by

> > > altering their diets.

> > > " What parents are telling us about the digestive system

complaints

> > of

> > > these

> > > children has a great deal of merit, " research director Dr.

Derrick

> > > MacFabe

> > > said yesterday from Atlanta.

> > > " But I want to show that there is some hope. This study allows

us to

> > > examine

> > > things which have the potential to reduce the risk of the

disease

> > and

> > > possibly treat it.

> > > " There is something common to diet, digestive system, immune

system,

> > > behaviours and to brain function of autistic children. "

> > > The neuroscientist is director of the Kilee Patchell-

Autism

> > > Research

> > > Group at the University of Western Ontario.

> > > Named after the 10-year-old autistic daughter of

Patchell-

> > ,

> > > the

> > > team was established three years ago to search for causes of

the

> > disease

> > > affecting one in 166 children.

> > > Autism is a mental condition characterized by failure to

> > communicate,

> > > difficulty in learning and self-stimulating or aggressive

behaviour.

> > > " I'm excited because for a long time, parents have said that

what

> > > their kid

> > > eats makes a difference, " said Patchell-, the chief

executive

> > of

> > > GoodLife

> > > Fitness who established the research team with a sizable

donation.

> > > " Now we've moved from gossip to science and when you stop

gossiping

> > > and move

> > > to a scientific foundation . . . then you can start some real

> > > progression

> > > because the medical community needs a scientifically rigorous

> > study. "

> > > Like many parents of autistic children, Patchell- took his

> > > daughter off

> > > wheat and dairy about a year after she was diagnosed on the

basis of

> > > anecdotal evidence that it could help.

> > > The difference, he said, was " night and day. She learns

better, she

> > pays

> > > better attention, her hyperactivity decreases, her sociability

> > > increases . . .

> > > and she sleeps through the night. "

> > > The research team began looking into a possible link between

autism

> > > and diet

> > > after hearing many accounts from parents claiming their

children had

> > > digestive problems.

> > > Patchell-' findings were similar to those of thousands of

> > > parents, said

> > > MacFabe, who studied whether digestive upsets could worsen

autistic

> > > symptoms

> > > such as repetitive behaviours, social isolation and poor

impulse

> > > control.

> > > The team focused on a compound called propionic acid, present

in

> > some

> > > foods

> > > such as refined wheat and dairy products.

> > > The acid is also produced by many types of digestive bacteria,

> > > particularly

> > > those associated with antibiotic-associat ed diarrhea, MacFabe

said.

> > > Scientists put the compound into the brains of lab rats, which

> > became

> > > hyperactive and repetitive, showing signs of social impairment

that

> > > resembles that

> > > in autistic patients.

> > > Repeated exposure showed worsening behavioural effects, said

> > MacFabe,

> > > and

> > > brain changes that resemble seizures that often co-exist with

> > autism.

> > > Then analysing the brains of these animals, researchers showed

an

> > > inflammatory response closely resembling those found in a

recent

> >

> > > Hopkins study on

> > > autistic brain material.

> > > The UWO research team includes MacFabe, psychology chair Dr.

Klaus-

> >

> > > Ossenkopp, Dr. Cain, Dr. Kavaliers, Dr.

> > > Hampson and Dr.

> > > Fred Possmayer.

> > > MacFabe and other team members are in Atlanta to present their

study

> > > at a

> > > major neuroscience conference.

> > > Soon to appear in the prestigious biomedical journal Behavioral

> > Brain

> > > Research, the study is garnering international attention for

the

> > team.

> > > Some of the team's work has already been well received at a

Montreal

> > > conference, the International Meeting of Autism Researchers.

> > > The paper has also attracted the attention of the Brain

Development

> > and

> > > Disorders Project at the Massachusetts Institute of Technology

> > (MIT).

> > > " We need this kind of integrative research to understand what

is

> > going

> > > on in

> > > autism and how the gut-brain axis is involved, " said project

> > director Dr.

> > > Martha Herbert, who will be collaborating with MacFabe to

further

> > > examine this

> > > in human patients.

> > > The next step for the UWO group is to work with Queen's

> > University's Dr.

> > > Jeanette Holden, director of the Canadian-American Autism

Research

> > > Consortium.

> > >

> > > --- End forwarded message ---

> > >

> > >

> > >

> > >

> > >

> > > --

> > > No virus found in this incoming message.

> > > Checked by AVG Free Edition.

> > > Version: 7.1.408 / Virus Database: 268.13.4/480 - Release Date:

> > 17/10/2006

> > >

> >

> >

> > -----------------------------------------------------------------

-------

> >

> > No virus found in this incoming message.

> > Checked by AVG Free Edition.

> > Version: 7.1.408 / Virus Database: 268.13.5/484 - Release Date:

19/10/2006

> >

>

[Guest guest]

Well I don't do science, I don't do anything academic, but I had a great time not doing them lol.

Anyway, is a huge meat eater, NHS tests have him as deficient in B12, supplementing with MB12 was one of our more obvious improvments, at least in the beginning when we were definitely using the correct dosage, so presumably he wasn't absorbing from his food, but then in the early days he was barely absorbing enough of anything!

Vicky

[Guest guest]

In fact eating a lot of meat might be an attempt to get B12? Mark Land

suggested that the co-enzyme needed might be the adenosylcobalamin form

not the methylcobalamin. Does this seem right? Would MB 12 be OK to take

transdermally? and how would one get hold of the adenoylcobalamin form?

I understand science stuff as long as the abstracts stick to words. Once

they turn into formulae I'm lost

Thanks

Sally

tltbaku wrote:

>

> Hey Sally,

>

> I think there's more to it than getting enough of a vitamin or

> nutrient in your diet. Here are some possibilities I can think of

> for B12 specifically (sorry if they're too sciency - I'm often

> accused of that, so please forgive me!):

>

> 1. B12 must be absorbed by the body in order to be utilized.

> Absorption of nutrients in the intestines can be compromised by gut

> pathogens, bad flora, leaky gut, poor gut pH, not enough calcium or

> too much calcium and magnesium (interferes with intrinsic factor

> binding to B12), inadequate digestion due to pancreatic insuffiency

> (rubella specifically targets the pancreas, for instance). Here's

> what the Linus ing Institute has to say about B12

> absorption: " Absorption of vitamin B12 from food requires normal

> function of the stomach, pancreas, and small intestine. Stomach acid

> and enzymes free vitamin B12 from food, allowing it to bind to other

> proteins, known as R proteins (2). In the alkaline environment of

> the small intestine, R proteins are degraded by pancreatic enzymes,

> freeing vitamin B12 to bind to intrinsic factor (IF), a protein

> secreted by specialized cells in the stomach. Receptors on the

> surface of the small intestine take up the IF-B12 complex only in

> the presence of calcium, which is also supplied by the pancreas (4).

> Vitamin B12 can also be absorbed by passive diffusion, but this

> process is very inefficient, allowing only about 1% absorption of a

> vitamin B12 dose. "

> http://lpi.oregonst ate.edu/infocent er/vitamins/ vitaminB12/

> <http://lpi.oregonstate.edu/infocenter/vitamins/vitaminB12/> We

> always give oral B12 with intrinsic factor to our daughter.

>

> 2. Once it is absorbed, your body must metabolize it correctly in

> order to use it. However, heavy metals such as antimony, mercury,

> aluminum and others interfere with the enzymes that are responsible

> for metabolizing B12 in its various forms, and genetic

> polymorphsims, which are small single nucleotide mutations, result

> in enzymes that don't function as well as they should. There is an

> amazing article by Bruce Ames that Dr. Usman has quoted in several

> of her talks which talks about how many polymorphisms that are very

> prevalent in populations mean that the enzyme is not able to easily

> bind to its " co-factor " (the vitamin or nutrient that it uses to do

> its job). For people with these kinds of polymorphisms,

> the " nnormal " intake of nutrients is probably not enough -- you need

> more. Here is a quote from the beginning of that article " : " As many

> as one-third of mutations in a gene result in the corresponding

> enzyme having an increased is constant, or Km, (decreased

> binding affinity) for a coenzyme, resulting in a lower rate of

> reaction. About 50 human genetic diseases due to defective enzymes

> can be remedied or ameliorated by the administration of high doses

> of the vitamin component of the corresponding coenzyme, which at

> least partially restores enzymatic activity. Several single-

> nucleotide polymorphisms, in which the variant amino acid reduces

> coenzyme binding and thus enzymatic activity, are likely to be

> remediable by raising cellular concentrations of the cofactor

> through high-dose vitamin therapy. " So you see how some of us will

> need higher doses of the vitamin inn order to utilize it.

> http://ehscenter. berkeley. edu/publications /02_ames_ 1.pdf

> <http://ehscenter.berkeley.edu/publications/02_ames_1.pdf>

>

> 3. Drs. Deth and Neubander have both addressed this in their talks --

> if the MB12 is there in the blood stream, sitting outside the

> cells, but enzymes necessary for MB12 utilization are blocked due to

> metals or mutations, then the methylcobalamin (methyl-B12) will

> oxidize and will not able to be used by the body. Here's a rather

> complex quote from one of Deth's papers that suggests that if you

> don't have enough of a specific form of folate in the body - 5MTHF --

> then methylcobalamin will oxidize and not be usable: " During the

> catalytic cycle, folate and homocysteine domains alternatively

> interact with the cobalt ion in cobalamin, which alternates between

> Cob(I) and methylated Cob(III) states. Cob(I) is, however, extremely

> unstable, and occasionally it oxidizes to the Cob(II) state,

> interrupting folate-dependent HCY methylation. Oxidation is

> especially likely when levels of methylfolate are low and the Cob(I)

> state has to wait too long to receive a methyl group. "

> http://www.drneubra nder.com/ Files/Deth% 20Testimony. pdf

> <http://www.drneubrander.com/Files/Deth%20Testimony.pdf>

>

> So -- if your child has gut problems, if your child has any

> polyrmorphisms that relate to folate or B12, if your child has a

> heavy metal burden, if your child has excessive oxidative stress or

> a lack of this specific type of folate (5MTHF) due to heavy metals

> or polymorphisms or other factors, then they may not have enough B12

> to help things work properly.

>

> Sorry for being long-winded! It's one of my many shortcomings. ...

>

> Many hugs,

> Theresa

>

>

> > > >

> > > > Does this suggest any treatment to anyone?

> > > > Sally

> > > >

> > > >

> > > >

> > > > Autism

> > > >

> > > > By _JENNIFER O'BRIEN_ (mailto:obrien@ ) , FREE PRESS REPORTER

> > > >

> > > > _http://lfpress. ca/newsstand/ News/Local/ 2006/10/18/ pf-

> 2058851.

> > > html_ <http://lfpress. ca/newsstand/ News/Local/ 2006/10/18/ pf-

> <http://lfpress.ca/newsstand/News/Local/2006/10/18/pf->

> 2058851.html_ >

> > > > (http://lfpress. ca/newsstand/ News/Local/ 2006/10/18/ pf-

> 2058851.

> > > html <http://lfpress. ca/newsstand/ News/Local/ 2006/10/18/ pf-

> <http://lfpress.ca/newsstand/News/Local/2006/10/18/pf->

> 2058851.html> )

> > > >

> > > > London researchers have found a link between food and autism, a

> > > > discovery

> > > > that's creating a buzz in the world of medical research.

> > > > Their study is giving clout to a long-held claim by many

> parents who

> > > > say they

> > > > can alter their children's behaviour -- and lessen autistic

> > > symptoms

> > > > -- by

> > > > altering their diets.

> > > > " What parents are telling us about the digestive system

> complaints

> > > of

> > > > these

> > > > children has a great deal of merit, " research director Dr.

> Derrick

> > > > MacFabe

> > > > said yesterday from Atlanta.

> > > > " But I want to show that there is some hope. This study allows

> us to

> > > > examine

> > > > things which have the potential to reduce the risk of the

> disease

> > > and

> > > > possibly treat it.

> > > > " There is something common to diet, digestive system, immune

> system,

> > > > behaviours and to brain function of autistic children. "

> > > > The neuroscientist is director of the Kilee Patchell-

> Autism

> > > > Research

> > > > Group at the University of Western Ontario.

> > > > Named after the 10-year-old autistic daughter of

> Patchell-

> > > ,

> > > > the

> > > > team was established three years ago to search for causes of

> the

> > > disease

> > > > affecting one in 166 children.

> > > > Autism is a mental condition characterized by failure to

> > > communicate,

> > > > difficulty in learning and self-stimulating or aggressive

> behaviour.

> > > > " I'm excited because for a long time, parents have said that

> what

> > > > their kid

> > > > eats makes a difference, " said Patchell-, the chief

> executive

> > > of

> > > > GoodLife

> > > > Fitness who established the research team with a sizable

> donation.

> > > > " Now we've moved from gossip to science and when you stop

> gossiping

> > > > and move

> > > > to a scientific foundation . . . then you can start some real

> > > > progression

> > > > because the medical community needs a scientifically rigorous

> > > study. "

> > > > Like many parents of autistic children, Patchell- took his

> > > > daughter off

> > > > wheat and dairy about a year after she was diagnosed on the

> basis of

> > > > anecdotal evidence that it could help.

> > > > The difference, he said, was " night and day. She learns

> better, she

> > > pays

> > > > better attention, her hyperactivity decreases, her sociability

> > > > increases . . .

> > > > and she sleeps through the night. "

> > > > The research team began looking into a possible link between

> autism

> > > > and diet

> > > > after hearing many accounts from parents claiming their

> children had

> > > > digestive problems.

> > > > Patchell-' findings were similar to those of thousands of

> > > > parents, said

> > > > MacFabe, who studied whether digestive upsets could worsen

> autistic

> > > > symptoms

> > > > such as repetitive behaviours, social isolation and poor

> impulse

> > > > control.

> > > > The team focused on a compound called propionic acid, present

> in

> > > some

> > > > foods

> > > > such as refined wheat and dairy products.

> > > > The acid is also produced by many types of digestive bacteria,

> > > > particularly

> > > > those associated with antibiotic-associat ed diarrhea, MacFabe

> said.

> > > > Scientists put the compound into the brains of lab rats, which

> > > became

> > > > hyperactive and repetitive, showing signs of social impairment

> that

> > > > resembles that

> > > > in autistic patients.

> > > > Repeated exposure showed worsening behavioural effects, said

> > > MacFabe,

> > > > and

> > > > brain changes that resemble seizures that often co-exist with

> > > autism.

> > > > Then analysing the brains of these animals, researchers showed

> an

> > > > inflammatory response closely resembling those found in a

> recent

> > >

> > > > Hopkins study on

> > > > autistic brain material.

> > > > The UWO research team includes MacFabe, psychology chair Dr.

> Klaus-

> > >

> > > > Ossenkopp, Dr. Cain, Dr. Kavaliers, Dr.

> > > > Hampson and Dr.

> > > > Fred Possmayer.

> > > > MacFabe and other team members are in Atlanta to present their

> study

> > > > at a

> > > > major neuroscience conference.

> > > > Soon to appear in the prestigious biomedical journal Behavioral

> > > Brain

> > > > Research, the study is garnering international attention for

> the

> > > team.

> > > > Some of the team's work has already been well received at a

> Montreal

> > > > conference, the International Meeting of Autism Researchers.

> > > > The paper has also attracted the attention of the Brain

> Development

> > > and

> > > > Disorders Project at the Massachusetts Institute of Technology

> > > (MIT).

> > > > " We need this kind of integrative research to understand what

> is

> > > going

> > > > on in

> > > > autism and how the gut-brain axis is involved, " said project

> > > director Dr.

> > > > Martha Herbert, who will be collaborating with MacFabe to

> further

> > > > examine this

> > > > in human patients.

> > > > The next step for the UWO group is to work with Queen's

> > > University's Dr.

> > > > Jeanette Holden, director of the Canadian-American Autism

> Research

> > > > Consortium.

> > > >

> > > > --- End forwarded message ---

> > > >

> > > >

> > > >

> > > >

> > > >

> > > > --

> > > > No virus found in this incoming message.

> > > > Checked by AVG Free Edition.

> > > > Version: 7.1.408 / Virus Database: 268.13.4/480 - Release Date:

> > > 17/10/2006

> > > >

> > >

> > >

> > > ------------ --------- --------- --------- --------- --------- -

> -------

> > >

> > > No virus found in this incoming message.

> > > Checked by AVG Free Edition.

> > > Version: 7.1.408 / Virus Database: 268.13.5/484 - Release Date:

> 19/10/2006

> > >

> >

>

>

> ------------------------------------------------------------------------

>

> No virus found in this incoming message.

> Checked by AVG Free Edition.

> Version: 7.1.408 / Virus Database: 268.13.10/491 - Release Date: 23/10/2006

>

>

[Guest guest]

Dr Yasko recommends cyano-, hydroxy- and methylcobalamin, depending

on genetics. Yes, if you can tolerate lots of methyl donors and

don't have any problems with too many lipid donors, the MB12

transdermally can be great. Also nasally and injectible forms if the

need is great and/or there are biomarkers of need for B12 (such as

elevated MMA on an OAT). That's my udnerstanding...

Hugs,

Theresa

> > > > >

> > > > > Does this suggest any treatment to anyone?

> > > > > Sally

> > > > >

> > > > >

> > > > >

> > > > > Autism

> > > > >

> > > > > By _JENNIFER O'BRIEN_ (mailto:obrien@ ) , FREE PRESS

REPORTER

> > > > >

> > > > > _http://lfpress. ca/newsstand/ News/Local/ 2006/10/18/ pf-

> > 2058851.

> > > > html_ <http://lfpress. ca/newsstand/ News/Local/ 2006/10/18/

pf-

> > <http://lfpress.ca/newsstand/News/Local/2006/10/18/pf->

> > 2058851.html_ >

> > > > > (http://lfpress. ca/newsstand/ News/Local/ 2006/10/18/ pf-

> > 2058851.

> > > > html <http://lfpress. ca/newsstand/ News/Local/ 2006/10/18/

pf-

> > <http://lfpress.ca/newsstand/News/Local/2006/10/18/pf->

> > 2058851.html> )

> > > > >

> > > > > London researchers have found a link between food and

autism, a

> > > > > discovery

> > > > > that's creating a buzz in the world of medical research.

> > > > > Their study is giving clout to a long-held claim by many

> > parents who

> > > > > say they

> > > > > can alter their children's behaviour -- and lessen autistic

> > > > symptoms

> > > > > -- by

> > > > > altering their diets.

> > > > > " What parents are telling us about the digestive system

> > complaints

> > > > of

> > > > > these

> > > > > children has a great deal of merit, " research director Dr.

> > Derrick

> > > > > MacFabe

> > > > > said yesterday from Atlanta.

> > > > > " But I want to show that there is some hope. This study

allows

> > us to

> > > > > examine

> > > > > things which have the potential to reduce the risk of the

> > disease

> > > > and

> > > > > possibly treat it.

> > > > > " There is something common to diet, digestive system,

immune

> > system,

> > > > > behaviours and to brain function of autistic children. "

> > > > > The neuroscientist is director of the Kilee Patchell-

> > Autism

> > > > > Research

> > > > > Group at the University of Western Ontario.

> > > > > Named after the 10-year-old autistic daughter of

> > Patchell-

> > > > ,

> > > > > the

> > > > > team was established three years ago to search for causes

of

> > the

> > > > disease

> > > > > affecting one in 166 children.

> > > > > Autism is a mental condition characterized by failure to

> > > > communicate,

> > > > > difficulty in learning and self-stimulating or aggressive

> > behaviour.

> > > > > " I'm excited because for a long time, parents have said

that

> > what

> > > > > their kid

> > > > > eats makes a difference, " said Patchell-, the chief

> > executive

> > > > of

> > > > > GoodLife

> > > > > Fitness who established the research team with a sizable

> > donation.

> > > > > " Now we've moved from gossip to science and when you stop

> > gossiping

> > > > > and move

> > > > > to a scientific foundation . . . then you can start some

real

> > > > > progression

> > > > > because the medical community needs a scientifically

rigorous

> > > > study. "

> > > > > Like many parents of autistic children, Patchell-

took his

> > > > > daughter off

> > > > > wheat and dairy about a year after she was diagnosed on the

> > basis of

> > > > > anecdotal evidence that it could help.

> > > > > The difference, he said, was " night and day. She learns

> > better, she

> > > > pays

> > > > > better attention, her hyperactivity decreases, her

sociability

> > > > > increases . . .

> > > > > and she sleeps through the night. "

> > > > > The research team began looking into a possible link

between

> > autism

> > > > > and diet

> > > > > after hearing many accounts from parents claiming their

> > children had

> > > > > digestive problems.

> > > > > Patchell-' findings were similar to those of

thousands of

> > > > > parents, said

> > > > > MacFabe, who studied whether digestive upsets could worsen

> > autistic

> > > > > symptoms

> > > > > such as repetitive behaviours, social isolation and poor

> > impulse

> > > > > control.

> > > > > The team focused on a compound called propionic acid,

present

> > in

> > > > some

> > > > > foods

> > > > > such as refined wheat and dairy products.

> > > > > The acid is also produced by many types of digestive

bacteria,

> > > > > particularly

> > > > > those associated with antibiotic-associat ed diarrhea,

MacFabe

> > said.

> > > > > Scientists put the compound into the brains of lab rats,

which

> > > > became

> > > > > hyperactive and repetitive, showing signs of social

impairment

> > that

> > > > > resembles that

> > > > > in autistic patients.

> > > > > Repeated exposure showed worsening behavioural effects,

said

> > > > MacFabe,

> > > > > and

> > > > > brain changes that resemble seizures that often co-exist

with

> > > > autism.

> > > > > Then analysing the brains of these animals, researchers

showed

> > an

> > > > > inflammatory response closely resembling those found in a

> > recent

> > > >

> > > > > Hopkins study on

> > > > > autistic brain material.

> > > > > The UWO research team includes MacFabe, psychology chair

Dr.

> > Klaus-

> > > >

> > > > > Ossenkopp, Dr. Cain, Dr. Kavaliers, Dr.

> > > > > Hampson and Dr.

> > > > > Fred Possmayer.

> > > > > MacFabe and other team members are in Atlanta to present

their

> > study

> > > > > at a

> > > > > major neuroscience conference.

> > > > > Soon to appear in the prestigious biomedical journal

Behavioral

> > > > Brain

> > > > > Research, the study is garnering international attention

for

> > the

> > > > team.

> > > > > Some of the team's work has already been well received at a

> > Montreal

> > > > > conference, the International Meeting of Autism

Researchers.

> > > > > The paper has also attracted the attention of the Brain

> > Development

> > > > and

> > > > > Disorders Project at the Massachusetts Institute of

Technology

> > > > (MIT).

> > > > > " We need this kind of integrative research to understand

what

> > is

> > > > going

> > > > > on in

> > > > > autism and how the gut-brain axis is involved, " said

project

> > > > director Dr.

> > > > > Martha Herbert, who will be collaborating with MacFabe to

> > further

> > > > > examine this

> > > > > in human patients.

> > > > > The next step for the UWO group is to work with Queen's

> > > > University's Dr.

> > > > > Jeanette Holden, director of the Canadian-American Autism

> > Research

> > > > > Consortium.

> > > > >

> > > > > --- End forwarded message ---

> > > > >

> > > > >

> > > > >

> > > > >

> > > > >

> > > > > --

> > > > > No virus found in this incoming message.

> > > > > Checked by AVG Free Edition.

> > > > > Version: 7.1.408 / Virus Database: 268.13.4/480 - Release

Date:

> > > > 17/10/2006

> > > > >

> > > >

> > > >

> > > > ------------ --------- --------- --------- --------- --------

- -

> > -------

> > > >

> > > > No virus found in this incoming message.

> > > > Checked by AVG Free Edition.

> > > > Version: 7.1.408 / Virus Database: 268.13.5/484 - Release

Date:

> > 19/10/2006

> > > >

> > >

> >

> >

> > -----------------------------------------------------------------

-------

> >

> > No virus found in this incoming message.

> > Checked by AVG Free Edition.

> > Version: 7.1.408 / Virus Database: 268.13.10/491 - Release Date:

23/10/2006

> >

> >

>