] plant flavonoids/ antiviral - OLE - long

[Guest guest]

Natasa,

Found that really interesting.

I know my son has herpes simplex from his viral panel, I suspect he also has

a measles issue as he had chicken pox before his mmr jab, which seems to be

implicated in the retention of measles within the intestine. It won't

therefor show on blood tests, but it is an issue. It's probably a reasonable

assumption that there are others virus's in his body that we aren't aware

of.

While we're on long articles.........

http://www.curezone.com/foods/oliveleaf.asp

This is very easy to read, talking about Olive Leaf Extract. It's one of

those where it claims it cures everything (even gives it tenuous biblical

proportions), what was interesting was

"

For the record, the researchers at Upjohn found calcium elenolate effective

in test tube experiments against the following viruses: herpes, vaccinia,

pseudorabies, Newcastle, sacloe A 21, encepthlomyocarditis, polio 1, 2,

and 3, vesicular stomititus, sindbis, reovirus, Moloney Murine leukemia,

Rauscher Murine leukemia, Moloney sarcoma, and many influenza and

parainfluenza types.

They found it effective against these bacteria and parasitic protozoans:

lactobacillus plantarum W50, brevis 50, pediococcus cerevisiae 39,

leuconostoc mesenteroides 42, staphylococcus aureus, bacillus subtilis,

enterobacteraerogenes NRRL B-199, E. cloacae NRRL B-414, E. coli,

salamonella tyhimurium, pseudomonas fluorescens, P. solanacearum, P.

lachrymans, erwinia carotovora, E. tracheiphila, xanthomonas vesicatoria,

corynesbacterium Michiganese, plasmodium falciparum, virax and malariae.

The researchers credit a number of unique properties possessed by the olive

leaf compound for the broad killing power:

An ability to interfere with critical amino acid production essential for

viruses.

An ability to contain viral infection and/or spread by inactivating viruses

or by preventing virus shedding, budding or assembly at the cell membrane.

The ability to directly penetrate infected cells and stop viral replication.

In the case of retroviruses, it is able to neutralize the production of

reverse transcriptase and protease. These enzymes are essential for a

retrovirus, such as HIV, to alter the RNA of a healthy cell.

It can stimulate phagocytosis, an immune system response in which cells

ingest harmful microorganisms and foreign matter.

The research suggests that this may be a " true anti-viral " compound because

it appears to selectively block an entire virus-specific system in the

infected host. It thus appears to offer healing effects not addressed by

pharmaceutical antibiotics

"

Most of the reading I've done up to now suggests the need for a combination

of antiviral agents.

We're startign on diflucan next week, then valtrex 2 weeks after. We'll see

how we go with that for a while, then I'll look to add in OLE, Lauricidin

and then probably the high vitamin a protocol at around 6 months. For the

flavonoids we're going to give juiced parsley, thyme, basil & celery.

I think this way we should get a broad coverage of viral issues. I'll post

any progress/issues as it happens.

I don't really know why I've sent this now I've typed it all, I was asked a

while ago to post anything I found out about Virus issues, so hopefully it

will be of interest/use to someone!

Stuart

>From: " natasa778 " <neno@...>

>Reply-Autism Treatment

>Autism Treatment

>Subject: antiviral effects of plant flavonoids

>Date: Sun, 25 Jun 2006 15:28:12 -0000

>

>Hi Anita and others, thought you might be interested in some of the info

>in this article (it is very long and very technical but has an

>intersting ANTIVIRAL section!)

>

>The Effects of Plant Flavonoids on Mammalian Cells:Implications for

>Inflammation, Heart Disease, and Cancer

>full article:

>http://pharmrev.aspetjournals.org/cgi/content/full/52/4/673#SEC5

>

>

>some of the antiviral bit:

>

>Naturally occurring flavonoids with antiviral activity have been

>recognized since the 1940s, but only recently have attempts been made to

>make synthetic modifications of natural compounds to improve antiviral

>activity.

>...

>

>In Belgium, pronounced antiviral activity noted in extracts of Euphorbia

>grantii was isolated in four related 3-methoxyflavones that exhibited

>significant activities against picornaviruses and vesicular stomatitis

>virus .... All of the active antiviral compounds were derivatives of

>3-O-methylquercetin. In tissue culture, 90% inhibition of polio type 1

>and coxsackie B viruses was achieved at concentrations of approximately

>0.01 mg/ml, as compared with a 50% cytotoxic concentration of 40 mg/ml.

>Mice were protected from viremia and lethal infection from coxsackie B4

>virus by 3-O-methylquercetin administered at a daily dose of 20 mg/kg

>for a period of 9 days (Van Hoof et al., 1984). The mechanism of action

>of 3-O-methylquercetin and 3,3'-dimethylquercetin, another active

>derivative, suggested these substances prevent a virally induced

>shutdown of host protein synthesis ...

>

>Further studies of the mechanism of action of 3-O-methylquercetin by

>Rombaut et al. (1985) led to a comparison of effects of the flavonoid

>and the antiviral agent arildone.... At an early stage of replication,

>polio viruses were inhibited by these compounds. Although arildone is

>known to inhibit uncoating of polio virus, other experiments revealed

>that 3-O-methylquercetin and arildone interacted directly with the virus

>capsid. Thermal denaturation of polio virions and the alkaline

>disruption of procapsids to smaller subunits were affected. In polio

>virus-infected cells, viral protein and RNA synthesis were markedly

>reduced provided that 3-O-methylquercetin was added between 1 and 2 h

>after infection with the virus (Vrijsen et al., 1987).

>

>Naturally occurring 4'-hydroxy-3-methoxyflavones possessed antiviral

>activity against rhino- and poliomyelitis viruses. ...

>

>Mucsi and Pragai (1985) demonstrated the inhibitory effect of four

>flavonoid compounds in human herpes simplex virus type I and Suid (a)

>herpes virus type I (Pseudorabies virus); t... A direct relationship

>between the antiviral activity of quercetin, quercitrin, rutin, and

>hesperedin and the ability to stimulate cyclic AMP synthesis in the

>cells seemed to exist. Quercetin and quercitrin were the most active

>compounds, although high concentrations were required.

>

>The effect of quercetin, naringin, hesperetin, and catechin on the

>infectivity and replication of HSV-1, polio virus type 1, parainfluenza

>virus type 3, and respiratory syncytial virus has been studied in cell

>culture monolayers using the technique of viral plaque reduction. Kaul

>et al. (1985) observed that quercetin caused a concentration-dependent

>reduction in the infectivity of each virus ...

>

>... Inhibition of HSV-1 replication in RK-13 cells was examined. ...

>Genistein (>25 µM) inhibited the replication of HSV-1 accompanied by

>phosphorylation of tyrosine residues in particular viral peptides (Yura

>et al., 1993). Daidzein was inactive, while prunetin, also a PTK

>inhibitor, showed activity similar to genistein.

>

>The possibility of synergistic antiviral effects when flavonoids are

>combined with other antiviral agents was suggested by the work of Mucsi

>(1984) and Veckenstedt et al. (1987). Quercetin in combination with

>5-ethyl-2'-deoxyuridine had antiviral activity on HSV-1 or pseudorabies

>infection in vitro; quercetin together with murine alpha /beta

>-interferon was also effective for the treatment of mice infected with

>Mengo virus. Enhanced antiviral activity against herpes viruses in cell

>culture could be achieved by combining acyclovir with flavonoids such as

>quercetin, quercitrin, and apigenin (Mucsi et al., 1992).

>

>An interesting interaction between ascorbate and quercetin was observed

>by Vrijsen et al. (1988). Quercetin exhibited antiviral activity only

>when oxidative degradation was inhibited by ascorbate. Luteolin was as

>active as ascorbate-stabilized quercetin.

>

>Among a large number of flavonoids isolated from Scutellaria

>baicalensis, two were found to have a remarkable ability to inhibit

>EBV-EA activation ... . The most active inhibitory flavones were

>5,7,2'-trihydroxy- and 5,7,2',3'-tetrahydroxyflavone (Konoshima et al.,

>1992).

>

>The biflavone ginkgetin from the leaves of Cephalotaxus drupacea

>possessed antiherpes virus activity as well as activity against human

>cytomegalovirus (Hayashi et al., 1992). Ginkgetin decreased viral

>protein synthesis and strongly suppressed transcription of

>immediate-early genes without evidence of cytotoxicity at low

>concentrations. Further studies from this group (Li et al., 1993)

>established that baicalin inhibited 1) syncytium formation on CEM-ss

>monolayer cells, 2) HIV-1-specific p24 core antigen expression, and 3)

>HIV-1 RT from infected 119 cells. Clearly, baicalin and related

>flavonoids require further clinical investigation.

>

>.... Overall, the antiviral studies suggest that selected dietary

>flavonoids may have prophylactic activity against certain viral

>infections. Epidemiological studies are warranted.

>

>

>

>

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