Re: Does Terazosin Lower GLUCF

[Guest guest]

Interesting observation and nice plots.With multiple drugs it is difficult to make conclusions. i wonder if dex dosing affects the metabolism of any of the other drugs. What one needs to do is to look at the way each drug is metabolized and see which drugs may increase or decrease metabolism of all the other drugs. It will be difficult to ferret this out. Also will need to ask do any of the drugs interfere with the glucose measurement itself. The manufacturer may be able to tell you (of the glucose machine).Were you using the same bottle of strips for testing during this perioddid exercise or diet change?What did the scan show? On Feb 21, 2010, at 11:48 PM, MaxJasper wrote:Hello Dr. Grim & all, It was couple of weeks I was taking my adrenal Scintiscan having Dexamethasone 2mg/d a week before and after injection with NP-59. While I was off Spirnolactone for a month, I was placed on Terazosin and I started with 1mg/d -> 2mg/d -> 3mg/d and had to increase it to 4mg/d to keep my BP<150 for the 2nd week of the Scintiscan. To my amazement I found that my GLUCF (8-hr fasting glucose) dropped to levels never seen before as shown in the following chart:So I decided to analyze which drug reduced my GLUCF. First I thought it might be due to Dexamethasone. But after analysis it appears that Dexamethasone has an increasing effect on my GLUCF. However, from the following Table it appears that Terazosin has had statistically significant lowering effect on my GLUCF (p<0.01) as well as Metformin(p<0.01) while Dexamethasone has increasing effects (p<0.05).I used to be on Metformin since last year so its dose did not change for adrenal Scintigraphy, and in place of Spiro I took Terazosin & increased my Ramipril. But Ramiprildoes not show any significant effect on my GLUCF while Terazosin does. QUESTIONs:Is it medically acceptable to consider that Terazosin has lowering effect on GLUCF?Amlodipine appears to raise my GLUCF (p<0.05). Is this medically known fact? I appreciate all comments and expert opinions with thanks. Max.

[Guest guest]

Yes, strips of same lot used for GLUCF.

Nothing changed except the medication and doses.

Three years ago I tried Terazosin 1mg/d (14 days) then 2mg/d (14 days) and noticed weight gain of about 10lbs! It also has marginal effect on lowering my BP. So my doc stopped Terazosin trial.

Of course I ignored effects of NP-59 on my GLUCF. It might have some effects too.

Max.

-----Original Message-----From: hyperaldosteronism [mailto:hyperaldosteronism ] On Behalf Of Clarence GrimSent: Sunday, February 21, 2010 23:33hyperaldosteronism Subject: Re: Does Terazosin Lower GLUCFInteresting observation and nice plots.

With multiple drugs it is difficult to make conclusions. i wonder if dex dosing affects the metabolism of any of the other drugs. What one needs to do is to look at the way each drug is metabolized and see which drugs may increase or decrease metabolism of all the other drugs. It will be difficult to ferret this out.

Also will need to ask do any of the drugs interfere with the glucose measurement itself. The manufacturer may be able to tell you (of the glucose machine).

Were you using the same bottle of strips for testing during this period

did exercise or diet change?

What did the scan show?

On Feb 21, 2010, at 11:48 PM, MaxJasper wrote:

[Guest guest]

NP 59 prob not too small of an amount.Weight gain with Teraz was reason i always start diuretic first then add others. You were prob not DASHing back the either. All drugs which lower BP except diuretics cause salt retention when BP goes down.CE Grim MDOn Feb 22, 2010, at 12:57 AM, MaxJasper wrote:Yes, strips of same lot used for GLUCF. Nothing changed except the medication and doses. Three years ago I tried Terazosin 1mg/d (14 days) then 2mg/d (14 days) and noticed weight gain of about 10lbs! It also has marginal effect on lowering my BP. So my doc stopped Terazosin trial. Of course I ignored effects of NP-59 on my GLUCF. It might have some effects too. Max. Re: Does Terazosin Lower GLUCFInteresting observation and nice plots.With multiple drugs it is difficult to make conclusions. i wonder if dex dosing affects the metabolism of any of the other drugs. What one needs to do is to look at the way each drug is metabolized and see which drugs may increase or decrease metabolism of all the other drugs. It will be difficult to ferret this out. Also will need to ask do any of the drugs interfere with the glucose measurement itself. The manufacturer may be able to tell you (of the glucose machine).Were you using the same bottle of strips for testing during this perioddid exercise or diet change?What did the scan show? On Feb 21, 2010, at 11:48 PM, MaxJasper wrote:

[Guest guest]

BP drugs that cause salt retention appear to defeat the purpose of the drug. Does that salt retention raise BP?

-----Original Message-----From: hyperaldosteronism [mailto:hyperaldosteronism ] On Behalf Of Clarence GrimSent: Monday, February 22, 2010 0:06hyperaldosteronism Subject: Re: Does Terazosin Lower GLUCFNP 59 prob not too small of an amount.

Weight gain with Teraz was reason i always start diuretic first then add others. You were prob not DASHing back the either. All drugs which lower BP except diuretics cause salt retention when BP goes down.

CE Grim MD

On Feb 22, 2010, at 12:57 AM, MaxJasper wrote:

[Guest guest]

yes, The reason is that in most the body has what is called a BP-blood volume set point. See any of Guyton's Texts of Medcial Physiology from the last 30 years. Must be a web site for this as well but have not looked it up.Anyway when pressure is lowered from this set point by a drug say the body retains salt. If BP goes above this set point say by eating too much salt the increased BP dumps salt. called pressure natriuresis.This is the reason that the BP effects of all drugs is potentiated by lowering diet salt or uring a diuretic. Also the reason a diuretic should almost always be the first drug given.CE Grim MDOn Feb 22, 2010, at 1:12 AM, MaxJasper wrote:BP drugs that cause salt retention appear to defeat the purpose of the drug. Does that salt retention raise BP? Re: Does Terazosin Lower GLUCFNP 59 prob not too small of an amount.Weight gain with Teraz was reason i always start diuretic first then add others. You were prob not DASHing back the either. All drugs which lower BP except diuretics cause salt retention when BP goes down.CE Grim MDOn Feb 22, 2010, at 12:57 AM, MaxJasper wrote:

[Guest guest]

84mg/L (4.6 mmol/L, does not even appear on my chart!)! What a wonderful number for 3-hrs glucose after a meal. What dose Doxa do you take? How about weight gain, any observations? If it was not for weight gain all I needed was a handful alpha-blocker daily!

Max.

-----Original Message-----From: On Behalf Of jwwrightSent: Monday, February 22, 2010 12:02hyperaldosteronism Subject: Re: Does Terazosin Lower GLUCF

I use doxazosin, and my recent blood test BG is 84 at 11 AM after eating bfast at 8 AM (3 hrs).

I wondered about that low a measurement.

Might be a valid association with an alpha blocker.

Recall these were developed at a time when drug design did not exclude other beneficial side effects.

An alpha blocker is also used in dementia treatment (calming).

Regards

[Guest guest]

I use doxazosin, and my recent blood test BG is 84 at 11 AM after eating bfast at 8 AM (3 hrs).

I wondered about that low a measurement.

Might be a valid association with an alpha blocker.

Recall these were developed at a time when drug design did not exclude other beneficial side effects.

An alpha blocker is also used in dementia treatment (calming).

Regards

Re: Does Terazosin Lower GLUCF

Interesting observation and nice plots.

With multiple drugs it is difficult to make conclusions. i wonder if dex dosing affects the metabolism of any of the other drugs. What one needs to do is to look at the way each drug is metabolized and see which drugs may increase or decrease metabolism of all the other drugs. It will be difficult to ferret this out.

Also will need to ask do any of the drugs interfere with the glucose measurement itself. The manufacturer may be able to tell you (of the glucose machine).

Were you using the same bottle of strips for testing during this period

did exercise or diet change?

What did the scan show?

On Feb 21, 2010, at 11:48 PM, MaxJasper wrote:

Hello Dr. Grim & all,

It was couple of weeks I was taking my adrenal Scintiscan having Dexamethasone 2mg/d a week before and after injection with NP-59.

While I was off Spirnolactone for a month, I was placed on Terazosin and I started with 1mg/d -> 2mg/d -> 3mg/d and had to increase it to 4mg/d to keep my BP<150 for the 2nd week of the Scintiscan.

To my amazement I found that my GLUCF (8-hr fasting glucose) dropped to levels never seen before as shown in the following chart:

So I decided to analyze which drug reduced my GLUCF. First I thought it might be due to Dexamethasone. But after analysis it appears that Dexamethasone has an increasing effect on my GLUCF. However, from the following Table it appears that Terazosin has had statistically significant lowering effect on my GLUCF (p<0.01) as well as Metformin(p<0.01) while Dexamethasone has increasing effects (p<0.05).

I used to be on Metformin since last year so its dose did not change for adrenal Scintigraphy, and in place of Spiro I took Terazosin & increased my Ramipril. But Ramiprildoes not show any significant effect on my GLUCF while Terazosin does.

QUESTIONs:

Is it medically acceptable to consider that Terazosin has lowering effect on GLUCF?

Amlodipine appears to raise my GLUCF (p<0.05). Is this medically known fact?

I appreciate all comments and expert opinions with thanks.

Max.

[Guest guest]

using 2 different measurement standards. One is mg/dl the US one and other is mM/L the international one the rest of the world uses. You can look up the conversion factor to convert mg of glucose to mM of glucose. On Feb 22, 2010, at 11:56 AM, MaxJasper wrote:84mg/L (4.6 mmol/L, does not even appear on my chart!)! What a wonderful number for 3-hrs glucose after a meal. What dose Doxa do you take? How about weight gain, any observations? If it was not for weight gain all I needed was a handful alpha-blocker daily! Max. Re: Does Terazosin Lower GLUCFI use doxazosin, and my recent blood test BG is 84 at 11 AM after eating bfast at 8 AM (3 hrs).I wondered about that low a measurement. Might be a valid association with an alpha blocker. Recall these were developed at a time when drug design did not exclude other beneficial side effects.An alpha blocker is also used in dementia treatment (calming). Regards