Kids who are non-responders or are very sensitive

[Guest guest]

I saw this post and thought it might be of help for those who

have kids who do not seem to respond to treatments, or respond

negatively. Hope it helps shed some light...

Natasa

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The most important caveat in moving forward to step 2, which begins with

methylation support is the presence of a CBS up regulation. Children with

suspected CBS up regulations run the risk of creating additional sulfur

groups and ammonia in their system by methylation support if they have not

first addressed the ammonia/CBS issue. IF you suspect that your child does

have a CBS up regulation, I would suggest running a DDI urine AA test so

that you are able to look at ammonia levels as well as taurine levels. If

you are finding elevated taurine and ammonia in the high range of normal,

you should consider waiting to add methylation support until you have

confirmation of a CBS up regulation and have addressed this issue.

Children on low protein diets may not show elevated ammonia; however if a

urine AA test shows low levels of all amino acids, with the exception of

taurine and mid range ammonia levels this should also be considered

suspicious for a CBS up regulation. It is more difficult to discern a CBS

upregulation with low taurine. Suffice to say that if you are seeing

elevated ammonia regardless of taurine levels you should consider waiting

for the nutrigenomic results before progressing to step 2.

If you do suspect that your child has a CBS up regulation and have been

supplementing the methylation cycle, please don’t despair. It is okay if

you are doing this. I am trying to fine tune and make suggestions to

optimize programs. I am simply suggesting that there may be more ideal

supplements to use while you are waiting for your nutrigenomics if you

suspect that your child may have a CBS up regulation.

There are supplements beyond step 1 that CAN be used in the interim so

that you are moving forward while you wait. The use of the gut program, in

conjunction with CCK/BioThyro is an excellent choice for moving forward

before methylation support. This combination will aid in the

detoxification of aluminum and help to balance the gut while you are

waiting to address microbial and heavy metal detox.

The use of mitochondrial support is also helpful in supporting the system

for detox and energy support while waiting to add in methylation support.

Of course as I have repeatedly said in the past, take this time to be

certain that you have adequate step 1 support as described in the

Supplement video and the Boston DVDs.

If you believe that your child does have a CBS up regulation you may want

to consider limiting protein as well as the lipid supplements in the diet.

I find that children with CBS up regulations have trouble with lipid based

support as well as with sulfur based support and protein. I believe that

the lipid problem seems to stem from decreased BH4 activity regardless of

whether or not there is an A1298C mutation. The excess ammonia that is

generated via the CBS up regulation can be thought of as "using up" the

available BH4. This leaves less BH4 for other functions such as serotonin

and dopamine synthesis as well as to work with GEMO, a BH4 requiring

enzyme that is involved in lipid processing.

The CBS up regulation generates excess sulfur groups, so added sulfur

based supplementation is also not ideal until the CBS/ammonia issue has

been addressed..

If you find that your child does have a CBS up regulation, then I suggest

that you consider starting with the program to support the ammonia/CBS as

the very first step once you receive nutrigenomics that confirm this is

the case. Then you can look toward methylation support once you have

addressed the more major issue.

The CBS up regulation acts like a drain, pulling added methylation cycle

support (ie high dose folinic as well as even low dose folapro) down

through the transulfuration pathway to generate excess sulfur, ammonia and

drain the BH4 via the urea cycle. IF we first address the effect of the

CBS up regulation, then we are in a better position to support the

methylation cycle and other mutations in the pathway without generating

non ideal byproducts.

I hope this helps you to have a sense of how to move forward while waiting

for your GAR and nutrigenomic test results.