Removal of adrenal gland

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Thanks trying to remember to us this more myself. It competes for aldosterone for the MCR. When it is activated it increases the synthesis of ENaC which promotes sodium reabsorbtion from urine, sweat, saliva and stool. K goes out in urine. May your pressure be low!Clarence E. Grim, BS, MS, MDSpecializing in Primary Aldosteronism the most common cause of "Difficult/Drug Resistant High Blood Pressure". Other research interests focus on the interactions of recent evolutionary forces on the body's ability to handle salt and the effect of dietary salt on blood pressure in populations today.Listed in Best Doctors of America 2009. On Oct 5, 2009, at 8:52 AM, wrote: A MineraloCorticoid Receptor Blocker i.e in our situation a drug that interferes with the expression of aldosterone which tries to retain sodium ( and water) and pushes up our blood pressure and other nasty long term consequences. The big two MCRBs are spironolactone and eplerenone (trade mark Inspra) AS > > > > > > From: Valarie <val@> > > Subject: RE: [hyperaldosteronism ] Removal of adrenal gland > > hyperaldosteronism > > Date: Monday, September 28, 2009, 3:10 PM > > > > > > > > > > > > > > > > > > Lori, there is no reason to have surgery if the adenoma is not over-producing aldosterone. You need to have adrenal vein sampling before you let any knives near you. Your 100 mg of spironolactone may still be much too little. > > > > Please tell us your test values, pre spiro for: > > aldosterone > > renin > > potassium > > > > > > Val > > > > From: hyperaldosteronism [mailto:hyperaldost eronism@gro ups.com] On Behalf Of Lori > > > > > > > > > > > > > > > > > > Hello, all ! I have a 3 cm x3 cm tumor on right adrenal. My aldosterone level at last check was 33 on 50 mg Spironolactone. It has been increased to 100 mg plus 60 meq potassium daily. I feel absolutely no difference in my symptoms. This is month number 4 on increased dose. I have extreme fatigue and "brain fog",edema, BP still elevated.I am literally so tired that I can barely put one foot in front of the other. I am seeing an endo who is supposed to consult with a surgeon about removal of tumor and gland.This has given me some hope that this will get better. Has anyone else here had an adrenalectomy ? If so, what it open or laparoscopic ? How soon before you noticed a difference in your symptoms ? How soon were you able to return to work ? Any input regarding this is very much appreciated ! Thanks in advance ! Lori > > > > >

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You could also apply to NIH to be studies in Bethesda MD.Mr. Binder is doing this now and can give you the link. May your pressure be low!Clarence E. Grim, BS, MS, MDSpecializing in Primary Aldosteronism the most common cause of "Difficult/Drug Resistant High Blood Pressure". Other research interests focus on the interactions of recent evolutionary forces on the body's ability to handle salt and the effect of dietary salt on blood pressure in populations today.Listed in Best Doctors of America 2009. On Oct 5, 2009, at 8:57 AM, Lori wrote: Yes, I know that Drospirenone is an analogue of spiro, which means that pharmaceutically it is nearly identical to it. Even if my insurance covers their portion of AVS, I still can't pay the remaining several thousand dollars. I will just see what my endo advises and maybe he knows some route to get it done at a lower cost. I imagine OU will be my next best bet . They have a long wait but that's fine w/ me. I figue I have lived w/ this for as long as I have now that a few more mos is a short amount of time in the grand scheme of things. How much was your AVS ? How much did you pay out of pocket ? The last thing I need is more medical bills. I have enough from my son that I am struggling to pay.-- On Mon, 10/5/09, a Hall <shahall > wrote: From: a Hall <shahall >Subject: Re: Re: Removal of adrenal glandhyperaldosteronism Date: Monday, October 5, 2009, 8:45 AM Yaz doesn't have spiro in it. It does contain Drospirenone, which is an analog of spiro and has many of its actions. I looked it up several months ago when my oldest niece, who was on 25 mg of spiro for acne, was told when she started Yaz to stop the spiro because her K might become too high on both. Just because your insurance company denied you once does not mean they won't approve it in the future. You have to have an excellent paper trail. You will probably need a few ARR's, 24 hour urines and possibly a saline suppression test. Of course a sky-high BP on several meds and low K really help, too. ;-) My insurance did not want to pay for mine either because U-M was out of network for me, regardless of the fact that it was the only place in the state that performed them. My PCP fought and argued with them until they finally agreed to pay. Good luck, a I'm fortunate that I'm able to be off work for the time being. I was working part-time in the past (2 years off-mat leave/mom lung cA) and was just starting to get back into the work force. Then, all my symptoms started... I have 3 kids and I can see how you must be finding it extremely difficult to cope. Your plate is full and PA debilitating symptoms on top of all that! Wow, you must be finding it rough. I've read that some patients (on other sites) have had an adrenal removed and have symptoms reoccur. Do you have an AVS booked yet? Take careChantal> > > From: Valarie <val@...>> Subject: RE: [hyperaldosteronism ] Removal of adrenal gland> hyperaldosteronism> Date: Monday, September 28, 2009, 3:10 PM> > > > > > > > > Lori, there is no reason to have surgery if the adenoma is not over-producing aldosterone. You need to have adrenal vein sampling before you let any knives near you. Your 100 mg of spironolactone may still be much too little.> > Please tell us your test values, pre spiro for:> aldosterone> renin> potassium> > > Val> > From: hyperaldosteronism [mailto:hyperaldost eronism@gro ups.com] On Behalf Of Lori > > > > > > > > > Hello, all ! I have a 3 cm x3 cm tumor on right adrenal. My aldosterone level at last check was 33 on 50 mg Spironolactone. It has been increased to 100 mg plus 60 meq potassium daily. I feel absolutely no difference in my symptoms. This is month number 4 on increased dose. I have extreme fatigue and "brain fog",edema, BP still elevated.I am literally so tired that I can barely put one foot in front of the other. I am seeing an endo who is supposed to consult with a surgeon about removal of tumor and gland.This has given me some hope that this will get better. Has anyone else here had an adrenalectomy ? If so, what it open or laparoscopic ? How soon before you noticed a difference in your symptoms ? How soon were you able to return to work ? Any input regarding this is very much appreciated ! Thanks in advance ! Lori> >

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I go up to 400/d. DASHING WILL decrease the dose needed. Tiped sad Send form miiPhone ;-)May your pressure be low!CE Grim MDSpecializing in DifficultHypertensionOn Oct 5, 2009, at 7:00 AM, Lori <lori_danielle7@...> wrote:

Thanks, I feel stupid !!! I appreciate your response. I am already on Spiro, 100 mg. I was advised by my PCP to go up to 200 over a 2 wk period. The spiro helps with my BP and the muscle spasm from low K+,has helped w/ some things at higher dose. I wonder what the highest doseage of Spiro is that anyone on this forum has taken ?

From: <amsc05blueyonder (DOT) co.uk>Subject: Re: Removal of adrenal glandhyperaldosteronism Date: Monday, October 5, 2009, 8:52 AM

A MineraloCorticoid Receptor Blockeri.e in our situation a drug that interferes with the expression of aldosterone which tries to retain sodium ( and water) and pushes up our blood pressure and other nasty long term consequences.The big two MCRBs are spironolactone and eplerenone (trade mark Inspra) AS> > > > > > From: Valarie <val@>> > Subject: RE: [hyperaldosteronism ] Removal of adrenal gland> > hyperaldosteronism> > Date: Monday, September 28, 2009, 3:10 PM> >

> > > > > > > > > > > > > > > > Lori, there is no reason to have surgery if the adenoma is not over-producing aldosterone. You need to have adrenal vein sampling before you let any knives near you. Your 100 mg of spironolactone may still be much too little.> > > > Please tell us your test values, pre spiro for:> > aldosterone> > renin> > potassium> > > > > > Val> > > > From: hyperaldosteronism [mailto:hyperaldost eronism@gro ups.com] On Behalf Of Lori > > > > > > > > > > > > > > > > > > Hello, all ! I have a 3 cm x3 cm tumor on right adrenal. My aldosterone level at last check was 33 on 50 mg Spironolactone. It has

been increased to 100 mg plus 60 meq potassium daily. I feel absolutely no difference in my symptoms. This is month number 4 on increased dose. I have extreme fatigue and "brain fog",edema, BP still elevated.I am literally so tired that I can barely put one foot in front of the other. I am seeing an endo who is supposed to consult with a surgeon about removal of tumor and gland.This has given me some hope that this will get better. Has anyone else here had an adrenalectomy ? If so, what it open or laparoscopic ? How soon before you noticed a difference in your symptoms ? How soon were you able to return to work ? Any input regarding this is very much appreciated ! Thanks in advance ! Lori> > > >>

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