Creatine and CMT (1984 article)

[Guest guest]

Med Sci Sports Exerc. 1984 Oct;16(5):460-5. MENTIONS CMT and CREATINE.

Effect of training on the exercise responses of neuromuscular disease

patients.

Florence JM, Hagberg JM.

Patients with neuromuscular diseases have low levels of

cardiovascular fitness and they fatigue rapidly during daily

activities. The purpose of this investigation was to determine

whether patients with slowly-progressive or non-progressive

neuromuscular diseases could complete a 12-wk training program

without untoward responses, and develop cardiovascular training

adaptations.

All eight patients completed the training program with better than

90% compliance. Resting creatine kinase and myoglobin in the group as

a whole showed no change with training, though two patients did have

definite elevations after training. Their VO2max increased by 25 +/-

5% with training and their relative increase in VO2max was not

different from that of healthy subjects undergoing the same training.

Heart rate reductions during submaximal exercise were somewhat

delayed or non-existent in the two patients with Charcot-Marie-Tooth

disease, a hereditary neuropathy. However, the six patients with

myopathies had heart rate adaptations similar to those in healthy

subjects.

Thus, some patients with slowly-progressive or non-progressive

neuromuscular diseases can undergo exercise training and in many

cases demonstrate adaptations not different from those in healthy

subjects. Patients with different diseases, however, need not respond

uniformly, in terms of training adaptations or markers of muscle

damage. Therefore, each disease must be considered individually.