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Re: sporadic new mutation severity

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Gretchen:

I read with concern the authors' last comment that severity was worse in

'sporadic' cases...Is this known from other studies or has anyone heard this

before? I'm concerned because Gavin's CMT-1A is a spontaneous new mutation or

'sporadic'..

Thanks

Sally

< In most of our cases the clinical course was very slow progressive. A

greater severity was seen in our sporadic cases.>

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