Bone marrow stromal cells generate muscle cells + repair muscle degeneration

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Science. 2005 Jul 8;309(5732):314-7.

Bone marrow stromal cells generate muscle cells and repair muscle

degeneration.

Dezawa M, Ishikawa H, Itokazu Y, Yoshihara T, Hoshino M, Takeda S,

Ide C, Nabeshima Y.

Department of Anatomy and Neurobiology, Kyoto University Graduate

School of Medicine, Yoshidakonoecho, Sakyo-ku, Kyoto, 606-8501 Japan.

Bone marrow stromal cells (MSCs) have great potential as therapeutic

agents. We report a method for inducing skeletal muscle lineage cells

from human and rat general adherent MSCs with an efficiency of 89%.

Induced cells differentiated into muscle fibers upon transplantation

into degenerated muscles of rats and mdx-nude mice. The induced

population contained Pax7-positive cells that contributed to

subsequent regeneration of muscle upon repetitive damage without

additional transplantation of cells. These MSCs represent a more

ready supply of myogenic cells than do the rare myogenic stem cells

normally found in muscle and bone marrow.