Guest guest Posted June 1, 2005 Report Share Posted June 1, 2005 Joana, I have read some reports of L CARNITINE that found it to be beneficial in helping those with diabetic peripheral neuropathy, but haven't found any professional reports yet on it for CMT. Do you talk over your supplements with your doctor? ~ Gretchen Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 17, 2005 Report Share Posted October 17, 2005 Gretchen, Thank you so much for this article. Interesting really. I think ALC supplement could be good for us..regarding nerve fiber regeneration. I will have a look again here in Uk and find out more facts on this. Thanks for being so helpful! Hugs Joana > > Jo, > > Haven't ever seen anything about research on L carnitine and CMT, but > read below for something on diabetic neuropathy. You may find some > parellels. > > ~ Gretchen > > > Diabetes Care. 2005 Jan;28(1):89-94. > > Acetyl-L-carnitine improves pain, nerve regeneration, and vibratory > perception in patients with chronic diabetic neuropathy: an analysis > of two randomized placebo-controlled trials. > > Sima AA, Calvani M, Mehra M, Amato A; Acetyl-L-Carnitine Study Group. > > Department of Pathology, Wayne State University School of Medicine, > Detroit, Michigan 48201, USA. > > OBJECTIVE: We evaluated frozen databases from two 52-week randomized > placebo-controlled clinical diabetic neuropathy trials testing two > doses of acetyl-L-carnitine (ALC): 500 and 1,000 mg/day t.i.d. > > RESEARCH DESIGN AND METHODS: Intention-to-treat patients amounted to > 1,257 or 93% of enrolled patients. Efficacy end points were sural > nerve morphometry, nerve conduction velocities, vibration perception > thresholds, clinical symptom scores, and a visual analogue scale for > most bothersome symptom, most notably pain. The two studies were > evaluated separately and combined. > > RESULTS: Data showed significant improvements in sural nerve fiber > numbers and regenerating nerve fiber clusters. Nerve conduction > velocities and amplitudes did not improve, whereas vibration > perception improved in both studies. Pain as the most bothersome > symptom showed significant improvement in one study and in the > combined cohort taking 1,000 mg ALC. > > CONCLUSIONS: These studies demonstrate that ALC treatment is > efficacious in alleviating symptoms, particularly pain, and improves > nerve fiber regeneration and vibration perception in patients with > established diabetic neuropathy. > Quote Link to comment Share on other sites More sharing options...
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