Resveratrol Lowers Inflammatory Gene Signaling

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Human Study Proves Resveratrol Lowers Inflammatory Gene Signaling

Tuesday, August 03, 2010 - Byron J. s, CCN

http://www.wellnessresources.com/health/articles/human_study_proves_resveratrol_\

lowers_inflammatory_gene_signaling/

A common dietary supplement form of resveratrol, taken at the relatively low

dose of 40 mg of resveratrol per day for 6 weeks, could turn down the

primary inflammatory gene signal known as NF-kappaB and consequently lower

key markers of inflammation such as TNFa, IL6, and C-reactive protein.

Since the inflammatory problem is underlying the deteriorating health of

just about anyone, including the process of accelerated aging, this human

study data is very significant.

All diseases of aging, including cardiovascular disease, diabetes, cancer,

and cognitive decline are marked by the central inflammation gene signal,

NF-kappaB, in a condition of excessive pro-inflammatory signaling. The new

study adds more proof to the existing data that shows resveratrol is one

nutrient (there are others) that helpfully dampens NF-kappaB activation. In

turn this lowers the production of key inflammatory metabolic signals and

the adverse production of free radicals.

Nutrients hold a tremendous advantage of drugs in the proper regulation of

NF-kappaB. This core gene signal is vital to the survival of every cell in

your body. Indeed, it is the brain of every cell and has actual

intelligence in terms of how cell survival is guided, not only able to deal

with stress based on experience but being able to figure out a strategy for

dealing with new types of stress (such as man-made chemicals).

Thus, you cannot just obliterate NF-kappaB function with a drug in the name

of reducing inflammation as doing so knocks out the core survival system of

the cell. Nutrients are used by cells to enhance regulation. They don't

force regulation, rather they enable the cell to regulate more efficiently.

It appears cells do best when there are a variety of plant compounds that

enable NF-kappaB to work more efficiently. Resveratrol is one nutrient in

this category and one of the top choices in this category - making it a

powerful tool for natural support and potentially better quality of health.