Re: St. 's Wort / EAS Neurogain

[Guest guest]

Mel and others,

I happen to have a bottle of EAS' Neurogain at home. Since I have had

good results with DMAE and L-Tyrosine for my sprint training I was

wondering if Hypericum, which is part of Neurogain's formula, would

hinder the effect of the other two ingredients or actually improve it.

I have read conflicting opinions on that.

I mentioned that study so that people with more knowledge on biochemistry

could comment right away without having to do a search.

Best,

Carlo Buzzichelli

Siena, Italy

------------

Carlo Buzzichelli wrote:

> In the light of the following study, I would like to know if you

> think St. 's Wort is a useful supplement for power atheletes.

>

> <J Psychopharmacol 2001 Mar;15(1):47-54

>

> Hypericum perforatum (St 's Wort): a non-selective reuptake

> inhibitor? A review of the recent advances in its pharmacology.

>

> PJ.

>

> Hypericum [...] The most potent of all its action is the moderate

to

> high potency for inhibition of the reuptake of monoamines,

serotonin,

> dopamine and noradrenaline and the amino-acid neurotransmitters

GABA

> and glutamate. Unlike standard reuptake inhibitors, hypericum

exerts

> this reuptake inhibition non-competitively by enhancing

intracellular

> Na+ ion concentrations. At a receptor level, chronic treatment with

> hypericum downregulates beta1-adrenoceptor, upregulates post-

synaptic

> 5-HT1A receptors and 5-HT2 receptors. [...] >

>

> [The major application of hypericum is for treating depression.

Why do

> you think, on the basis of this study, that its effects on

neurochemical correlates

> of mood may be of special value to power athletes? Mel Siff ]