Vitamin D3 Considerably More Potent Than D2

[Guest guest]

Well, duh...!

A. Simpson, DC DABCOMedical Director, Vice PresidentThe CHP Group6600 SW 105th Ave, Suite 115Beaverton, OR  97008503-619-2041 O503-367-0872 C503-644-0442 F

 

www.medscape.com

From Reuters Health Information

Vitamin D3 Considerably More Potent Than D2

By

NEW YORK (Reuters Health) Jan 12 - Recent recommendations by the US Institute of Medicine (IOM) for a daily vitamin D intake of 600 to 800 IU may be too low, researchers say.

Based on blood levels, the IOM reported that the majority of Americans and Canadians are getting enough vitamin D. But the new study by Dr. P. Heaney and colleagues looked -- among other things -- not just at blood samples but at levels of vitamin D in body fat, too.

" In addition to showing once again that, unit for unit, vitamin D3 is substantially more potent than vitamin D2, this study is the first to quantify vitamin D storage in fat. It showed that, at doses of about 7000 IU/day, most of the vitamin was used by the body, and very little was left over to be stored, " Dr. Heaney told Reuters Health by email.

In their December 22nd online report in the Journal of Clinical Endocrinology & Metabolism, Dr. Heaney of Creighton University in Omaha, Nebraska, and colleagues describe how they randomly assigned 33 healthy participants to receive 50,000 IU of one or the other calciferol weekly for 12 doses. That dose, they note, is what's typically given to treat vitamin D deficiency.

Compliance appears to have been 100%. Blood samples were taken every 2 weeks and again at week 17. Paired fat biopsies were obtained from nine of the subjects, at baseline and at week 12.

Vitamin D3 was 56% to 87% more potent than vitamin D2 in raising serum 25(OH)D. It was more than three times as potent in increasing fat calciferol content.

The subcutaneous fat content of D2 rose by 50 mcg/kg in the D2-treated group, and D3 content rose by 104 mcg/kg in the D3-treated group.

Total calciferol in fat rose by 104 mcg/kg in the D3 group, compared to only 33 ng/kg in the D2 group.

For neither was there evidence of sequestration in fat, however. Extrapolating the results to total body fat D3, just 17% of the administered dose was being stored, the authors said

" This had been suspected previously, " Dr. Heaney said, " but without fat data, couldn't be clearly established. This fact alone shows clearly that the new IOM recommendations for vitamin D intake are low by at least an order of magnitude. "

At the doses used, the researchers point out, " most vitamin D is metabolically consumed. This is the first study, to our knowledge, to have quantified this issue. "

At the very least, they conclude, " Given its greater potency and lower cost, D3 should be the preferred treatment option when correcting vitamin D deficiency. "

J Clin Endocrinol Metab. Posted online December 22, 2010. Abstract

Reuters Health Information © 2011 

 

[Guest guest]

Yeh but ..... guess what the majority of the allopathic compounds are made of....................... 'give 'em just enough to quiet their owies but not enough to heal 'em'.....

meow

Sunny

Sunny Kierstyn, RN DC Fibromyalgia Care Center of Oregon 2677 Willakenzie Road, 7CEugene, Oregon, 97401541- 654-0850; Fx; 541- 654-0834www.drsunnykierstyn.com

From: csimpson@...Date: Fri, 21 Jan 2011 14:46:44 -0800Subject: Vitamin D3 Considerably More Potent Than D2

Well, duh...!

A. Simpson, DC DABCOMedical Director, Vice PresidentThe CHP Group6600 SW 105th Ave, Suite 115Beaverton, OR 97008503-619-2041 O503-367-0872 C503-644-0442 F

www.medscape.com

From Reuters Health Information

Vitamin D3 Considerably More Potent Than D2

By

NEW YORK (Reuters Health) Jan 12 - Recent recommendations by the US Institute of Medicine (IOM) for a daily vitamin D intake of 600 to 800 IU may be too low, researchers say.

Based on blood levels, the IOM reported that the majority of Americans and Canadians are getting enough vitamin D. But the new study by Dr. P. Heaney and colleagues looked -- among other things -- not just at blood samples but at levels of vitamin D in body fat, too.

"In addition to showing once again that, unit for unit, vitamin D3 is substantially more potent than vitamin D2, this study is the first to quantify vitamin D storage in fat. It showed that, at doses of about 7000 IU/day, most of the vitamin was used by the body, and very little was left over to be stored," Dr. Heaney told Reuters Health by email.

In their December 22nd online report in the Journal of Clinical Endocrinology & Metabolism, Dr. Heaney of Creighton University in Omaha, Nebraska, and colleagues describe how they randomly assigned 33 healthy participants to receive 50,000 IU of one or the other calciferol weekly for 12 doses. That dose, they note, is what's typically given to treat vitamin D deficiency.

Compliance appears to have been 100%. Blood samples were taken every 2 weeks and again at week 17. Paired fat biopsies were obtained from nine of the subjects, at baseline and at week 12.

Vitamin D3 was 56% to 87% more potent than vitamin D2 in raising serum 25(OH)D. It was more than three times as potent in increasing fat calciferol content.

The subcutaneous fat content of D2 rose by 50 mcg/kg in the D2-treated group, and D3 content rose by 104 mcg/kg in the D3-treated group.

Total calciferol in fat rose by 104 mcg/kg in the D3 group, compared to only 33 ng/kg in the D2 group.

For neither was there evidence of sequestration in fat, however. Extrapolating the results to total body fat D3, just 17% of the administered dose was being stored, the authors said

"This had been suspected previously," Dr. Heaney said, "but without fat data, couldn't be clearly established. This fact alone shows clearly that the new IOM recommendations for vitamin D intake are low by at least an order of magnitude."

At the doses used, the researchers point out, "most vitamin D is metabolically consumed. This is the first study, to our knowledge, to have quantified this issue."

At the very least, they conclude, "Given its greater potency and lower cost, D3 should be the preferred treatment option when correcting vitamin D deficiency."

J Clin Endocrinol Metab. Posted online December 22, 2010. Abstract

Reuters Health Information © 2011