Cholestyramine as rash ointment

[Guest guest]

This is interesting. Cholestyramine was compounded into an ointment

and put on skin to solve rash believed to be caused by bile acids,

so it should be good for someone having rash due to liver toxicity

or liver function problems:

http://www.theannals.com/cgi/content/abstract/30/9/954

Cholestyramine ointment to treat buttocks rash and anal excoriation

in an infant

CM White, RA Gailey, and S Lippe

OBJECTIVE: To describe a novel treatment for perianal excoriation in

an infant receiving a promotility agent. CASE SUMMARY: A 2-month-old

boy with reflux, and regurgitation was treated with cisapride.

Shortly after cisapride therapy he developed a rash on his buttocks

and anal irritation that progressed in severity despite the use of

numerous topical products and extended diaper-free periods. A

topical cholestyramine ointment compound was prepared and

administered, resulting in complete resolution within 3 days.

DISCUSSION: Cisapride can decrease the gastrointestinal transit

time, which can lead to less time for bile acid reabsorption in the

distal ileum. If high concentrations of bile acids are contained in

the stool, they can irritate the anus and buttocks in a manner

similar to the skin irritation experienced by patients with

ostomies. Cholestyramine, a bile acid sequestrant, can irreversibly

bind the bile when applied topically and bring relief to the

patient. CONCLUSIONS: Topical cholestyramine ointment may be a safe

and efficacious treatment option for perianal irritation due to bile

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